|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | An assessment of global ocean wave energy resources over the last 45 a显示文摘Against the background of the current world facing an energy crisis,and human beings puzzled by the problems of environment and resources,developing clean energy sources becomes the inevitable choice to deal with a climate change and an energy shortage.A global ocean wave energy resource was reanalyzed by using ERA-40 wave reanalysis data 1957–2002 from European Centre for Medium-Range Weather Forecasts(ECMWF).An effective significant wave height is defined in the development of wave energy resources(short as effective SWH),and the total potential of wave energy is exploratively calculated.Synthetically considering a wave energy density,a wave energy level probability,the frequency of the effective SWH,the stability and long-term trend of wave energy density,a swell index and a wave energy storage,global ocean wave energy resources were reanalyzed and regionalized,providing reference to the development of wave energy resources such as wave power plant location,seawater desalination,heating,pumping. | ZHENG Chongwei SHAO Longtan SHI Wenli SU Qin LIN Gang LI Xunqiang CHEN Xiaobin | 2014 | Acta Oceanologica Sinica2014，33，1： | 22 |
| 3 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 4 | Highly reversible lead-carbon battery anode with lead grafting on thecarbon surface显示文摘A novel C/Pb composite has been successfully prepared by electroless plating to reduce the hydrogen evolution and achieve the high reversibility of the anode of lead-carbon battery(LCB). The deposited lead on the surface of C/Pb composite was found to be uniform and adherent to carbon surface. Because lead has been stuck on the surface of C/Pb composite, the embedded structure suppresses the hydrogen evolution of lead-carbon anode and strengthens the connection between carbon additive and sponge lead.Compared with the blank anode, the lead-carbon anode with C/Pb composite displays excellent charge—discharge reversibility, which is attributed to the good connection between carbon additives and lead that has been stuck on the surface of C/Pb composite during the preparation process. The addition of C/Pb composite maintains a solid anode structure with high specific surface area and power volume, and thereby, it plays a significant role in the highly reversible lead-carbon anode. | Jian Yin Nan Lin Wenli Zhang Zheqi Lin Ziqing Zhang Yue Wang Jun Shi Jinpeng Bao Haibo Lin | 2018 | Journal of Energy Chemistry2018，27，6： | 6 |
| 5 | Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy显示文摘Nanoparticulate drug delivery systems(Nano-DDSs) have emerged as possible solution to the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are restricted by several drawbacks, such as low drug loading, premature drug leakage and carrier-related toxicity.Recently, pure drug nano-assemblies(PDNAs), fabricated by the self-assembly or co-assembly of pure drug molecules, have attracted considerable attention. Their facile and reproducible preparation technique helps to remove the bottleneck of nanomedicines including quality control, scale-up production and clinical translation. Acting as both carriers and cargos, the carrier-free PDNAs have an ultra-high or even100% drug loading. In addition, combination therapies based on PDNAs could possibly address the most intractable problems in cancer treatment, such as tumor metastasis and drug resistance. In the present review, the latest development of PDNAs for cancer treatment is overviewed. First, PDNAs are classified according to the composition of drug molecules, and the assembly mechanisms are discussed. Furthermore, the co-delivery of PDNAs for combination therapies is summarized, with special focus on the improvement of therapeutic outcomes. Finally, future prospects and challenges of PDNAs for efficient cancer therapy are spotlighted. | Shuwen Fu Guanting Li Wenli Zang Xinyu Zhou Kexin Shi Yinglei Zhai | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 4 |
| 6 | 2D/2D Bi_(2)MoO_(6)/g-C_(3)N_(4) S-scheme heterojunction photocatalyst with enhanced visible-light activity by Au loading显示文摘A novel 2D/2D Bi_(2)MoO_(6)/g-C_(3)N_(4) step-scheme(S-scheme)composite by loading Au as cocatalyst was successfully fabricated using a photoreduction and hydrothermal route.The obtained Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au photocatalysts were characterized by X-ray diffraction(XRD),transmission electron microscope(TEM),X-ray photo-electron spectroscopy(XPS),UV–vis diffuse reflectance spectra(UV–vis),Fourier transform infrared spectroscopy(FTIR),photoluminescence(PL),photocurrent response(I-t),and electrochemical impedance spectroscopy(EIS).The HRTEM images revealed that an intimate interface in composites were formed.The optimum photocatalytic activity of Rhodamine B degradation over Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au was about 9.7 times and 13.1 times as high as those of Bi_(2)MoO_(6) and g-C_(3)N_(4),respectively.The notably improved photocatalytic activity of Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au could be mainly ascribed to the abundant active sites and the enhanced separation efficiency of photogenerated carriers in Bi_(2)MoO_(6)/g-C_(3)N_(4) S-scheme system.Notably,Au nanoparticles could act as a co-catalyst to further promote electron transfer and separation from the conduction band of g-C_(3)N_(4).Additionally,a possible step-scheme photocatalytic reaction mechanism of Rh B degradation over Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au was tentatively proposed.PL and transient photocurrent analysis implied that Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au photocatalysts possessed the lower recombination rate of photogenerated carriers compared with pure Bi_(2) MoO_(6) and g-C_(3)N_(4),respectively.The present work is expected to provide useful information in designing 2D/2D S-scheme heterojunction photocatalysts. | Qiaoqiao Li Wenli Zhao Zicheng Zhai Kaixu Ren Tingyu Wang Hao Guan Haifeng Shi | 2020 | Journal of Materials Science & Technology2020，56，21： | 4 |
| 7 | Design and application of 60mer oligonucleotide microarray in SARS coronavirus detection显示文摘The 60mer oligonucleotide microarray was designed and applied to detecting of SARS (severe acute res-piratory syndrome) coronavirus. Thirty 60mer specific oligos were designed to cover the whole genome of the first submit-ted coronavirus strain, according to the sequence of TOR2 (GENEBANK Accession: AY274119). These primers were synthesized and printed into a microarray with 12×12 spots. RNAs were extracted from the throat swab and gargling fluid of SARS patients and reverse-transcripted into the double strand cDNAs. The cDNAs were prepared as re-stricted cDNA fragments by the restriction display (RD) technique and labeled by PCR with the Cy5-universal primer. The labeled samples were then applied to the oligo microar-ray for hybridization. The diagnostic capability of the mi-croarray was evaluated after the washing and scanning steps. The scanning result showed that samples of SARS patients were hybridized with multiple SARS probes on the microar-ray, and there is no signal on the negative and blank controls. These results indicate that the genome of SARS coronavirus can be detected in parallel by the 60mer oligonucleotide mi-croarray, which can improve the positive ratio of the diagno-sis. The oligo microarray can also be used for monitoring the behavior of the virus genes in different stages of the disease status. | SHI Rong MA Wenli WU Qinghua ZHANG Bao SONG Yanbin GUO Qiuye XIAO Weiwei WANG Yan ZHENG Wenling | 2003 | Chinese Science Bulletin2003，48，12： | 4 |
| 8 | Optimal sagittal gait with ZMP stability during complete walking cycle for humanoid robots显示文摘产生低精力步法因为单个、双的支持与零个时刻点(ZMP ) 分阶段执行稳定性的一个参量的方法被介绍。ZMP 稳定性条件被表示为限制到支持脚关节,和两个都走阶段的反的动力学的激活的转矩被调查。一个参量的优化方法被实现它接近由立方的花键功能的轨道在一致地分布式的时间连接了的关节系并且让优化参数仅仅包含描述关键姿势的有限分离状态。因此,步法优化被转变成一个平常的抑制非线性的编程问题。方法的 Theeffectiveness 通过在类人动物机器人 THBIP-I 模型上进行的数字模拟被验证。 | Zongying SHI Wenli XU Yisheng ZHONG Mingguo ZHAO | 2007 | 控制理论与应用(英文版)2007，5，2： | 3 |
| 9 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 10 | In situ growth of NiS_(2) nanosheet array on Ni foil as cathode to improve the performance of lithium/sodium-sulfur batteries显示文摘The NiS;nanosheet array on Ni foil(NiS2/NF)was prepared using an in situ growth strategy and sulfidation method and was used as the cathode of lithium sulfur battery.The unique nanostructure of the NiS;nanosheet array can provide abundant active sites for the adsorption and chemical action of polysulfides.Compared with the sulfur powder coated pure NF(pure NF-S)for lithium sulfur battery,the sulfur powder coated NiS_(2)/NF(NiS_(2)/NF-S)electrode exhibits superior electrochemical performance.Specifically,the NiS_(2)/NF-S delivered a high reversible capacity of 1007.5 m Ah g^(-1) at a current density of 0.1 C(1 C=1675 mA g^(-1))and kept 74.5% of the initial capacity at 1.0 C after 200 cycles,indicating the great promise of NiS_(2)/NF-S as the cathode of lithium sulfur battery.In addition,the NiS_(2)/NF-S electrode also showed satisfactory electrochemical performance when used as the cathode for sodium sulfur battery. | FAN MouPing CHEN YuanMao KE Xi HUANG ZeXi CHEN YouChen WU WenLi QU XiaoFeng SHI ZhiCong GUO ZaiPing | 2022 | Science China(Technological Sciences)2022，65，1： | 2 |
| 11 | Easy domain adaptation method for filling the species gap in deep learning-based fruit detection显示文摘Fruit detection and counting are essential tasks for horticulture research.With computer vision technology development,fruit detection techniques based on deep learning have been widely used in modern orchards.However,most deep learning-based fruit detection models are generated based on fully supervised approaches,which means a model trained with one domain species may not be transferred to another.There is always a need to recreate and label the relevant training dataset,but such a procedure is time-consuming and labor-intensive.This paper proposed a domain adaptation method that can transfer an existing model trained from one domain to a new domain without extra manual labeling.The method includes three main steps:transform the source fruit image(with labeled information)into the target fruit image(without labeled information)through the CycleGAN network;Automatically label the target fruit image by a pseudo-label process;Improve the labeling accuracy by a pseudo-label self-learning approach.Use a labeled orange image dataset as the source domain,unlabeled apple and tomato image dataset as the target domain,the performance of the proposed method from the perspective of fruit detection has been evaluated.Without manual labeling for target domain image,the mean average precision reached 87.5%for apple detection and 76.9%for tomato detection,which shows that the proposed method can potentially fill the species gap in deep learning-based fruit detection. | Wenli Zhang Kaizhen Chen Jiaqi Wang Yun Shi Wei Guo | 2021 | Horticulture Research2021，8，1： | 2 |
| 12 | MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3显示文摘Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-function mutations in human MKRN3,encoding a putative E3 ubiquitin ligase,were found to contribute to about 30%of cases of familial CPP.MKRN3 was thereby suggested to serve as a‘brake’of mammalian puberty onset,but the underlying mechanisms remain as yet unknown.Here,we report that genetic ablation of Mkrn3 did accelerate mouse puberty onset with increased production of hypothalamic GnRH1.MKRN3 interacts with and ubiquitinates MBD3,which epigenetically silences GNRH1 through disrupting the MBD3 binding to the GNRH1 promoter and recruitment of DNA demethylase TET2.Our findings have thus delineated a molecular mechanism through which the MKRN3-MBD3 axis controls the epigenetic switch in the onset of mammalian puberty. | Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu | 2020 | National Science Review2020，7，3： | 2 |
| 13 | Asymmetric Distribution of Convection in Tropical Cyclones over the Western North Pacific Ocean显示文摘Forecasts of the intensity and quantitative precipitation of tropical cyclones(TCs) are generally inaccurate, because the strength and structure of a TC show a complicated spatiotemporal pattern and are affected by various factors. Among these, asymmetric convection plays an important role. This study investigates the asymmetric distribution of convection in TCs over the western North Pacific during the period 2005–2012, based on data obtained from the Feng Yun 2(FY2)geostationary satellite. The asymmetric distributions of the incidence, intensity and morphology of convections are analyzed.Results show that the PDFs of the convection occurrence curve to the azimuth are sinusoidal. The rear-left quadrant relative to TC motion shows the highest occurrence rate of convection, while the front-right quadrant has the lowest. In terms of intensity, weak convections are favored in the front-left of a TC at large distances, whereas strong convections are more likely to appear to the rear-right of a TC within a 300 km range. More than 70% of all MCSs examined here are elongated systems, and meso-β enlongated convective systems(MβECSs) are the most dominant type observed in the outer region of a TC. Smaller MCSs tend to be more concentrated near the center of a TC. While semi-circular MCSs [MβCCSs, MCCs(mesoscale convective complexes)] show a high incidence rate to the rear of a TC, elongated MCSs [MβECSs, PECSs(persistent elongated convective systems)] are more likely to appear in the rear-right quadrant of a TC within a range of 400 km. | Lu YANG Jianfang FEI Xiaogang HUANG Xiaoping CHENG Xiangrong YANG Juli DING Wenli SHI | 2016 | Advances in Atmospheric Sciences2016，33，11： | 2 |
| 14 | Treatment of Irreducible Old Atlantoaxial Subluxation With Cable-Dragged Reduction and Cantilever Beam Internal Fixation显示文摘 | Xi Liu Hao Liu Tao Li Quan Gong Yueming Song Limin Liu Rui Shi Xiaodan Zhao Wenli Zhang Ganjun Feng Beiyu Wang | 2011 | Spine2011，，15： | 1 |
| 15 | Lead‑Carbon Batteries toward Future Energy Storage:From Mechanism and Materials to Applications显示文摘The lead acid battery has been a dominant device in large-scale energy storage systems since its invention in 1859.It has been the most successful commercialized aqueous electrochemical energy storage system ever since.In addition,this type of battery has witnessed the emergence and development of modern electricity-powered society.Nevertheless,lead acid batteries have technologically evolved since their invention.Over the past two decades,engineers and scientists have been exploring the applications of lead acid batteries in emerging devices such as hybrid electric vehicles and renewable energy storage;these applications necessitate operation under partial state of charge.Considerable endeavors have been devoted to the development of advanced carbon-enhanced lead acid battery(i.e.,lead-carbon battery)technologies.Achievements have been made in developing advanced lead-carbon negative electrodes.Additionally,there has been significant progress in developing commercially available lead-carbon battery products.Therefore,exploring a durable,long-life,corrosion-resistive lead dioxide positive electrode is of significance.In this review,the possible design strategies for advanced maintenance-free lead-carbon batteries and new rechargeable battery configurations based on lead acid battery technology are critically reviewed.Moreover,a synopsis of the lead-carbon battery is provided from the mechanism,additive manufacturing,electrode fabrication,and full cell evaluation to practical applications. | Jian Yin Haibo Lin Jun Shi Zheqi Lin Jinpeng Bao Yue Wang Xuliang Lin Yanlin Qin Xueqing Qiu Wenli Zhang | 2022 | Electrochemical Energy Reviews2022，5，3： | 1 |
| 16 | The Beaufort Gyre variation and its impacts on the Canada Basin in 2003–2012显示文摘The Beaufort Gyre(BG) was spun up in the last decade which is an important factor in regulating the variation of the upper ocean. The heat content and freshwater content of the upper ocean increased gradually in the Canada Basin, as did momentum input. Both the geostrophic wind curl and freshwater content could contribute to the spin-up of BG. However, even though there is no change of the wind field the increasing freshwater alone could result in the spin-up of BG. In this study we show that the Pacific Water is difficult to flow into the central basin as the BG spins up and the maximum temperature of the Pacific Summer Water(PSW) experienced a dramatic decrease inside the BG in 2005 and 2009 due to a change of flow pathway of PSW. The enhancement of Ekman Pumping(EP) contributed to the deepening of the Pacific Winter Water by piling up more freshwater. This change of water column dynamics has also contributed to the deepening ofthe Atlantic Water core after 2007. The EP decreased significantly in 2012(indicating a spin down of BG) and the direction of Ekman transport turned to the north, which favoured the release of freshwater that had resided in the basin for years. | ZHONG Wenli ZHAO Jinping SHI Jiuxin CAO Yong | 2015 | Acta Oceanologica Sinica2015，34，7： | 1 |
| 17 | Use low direct current electric field to augment nitrification and structural stability of aerobic granular sludge when treating low COD/NH4-N waste- water显示文摘 | Huang Wenli Wang Wenlong Shi Wansheng | 2014 | Bioresource Technology2014，171，1： | 1 |
| 18 | 2017年中国出现的H7N9高致病性病毒的快速进化显示文摘文章简介为了防控H7N9病毒,中国2017年9月开始对鸡进行了H5/H7二价禽流感灭活疫苗。为了解H7N9病毒在中国家禽中的分布情况,研究团队进行了系统的禽流感病毒监测。2017年2月至2017年5月之间在379个活禽市场和665个家禽养殖场共采集30201份样品(其中活禽市场采集12504份. | Jianzhong Shi Guohua Deng Shujie Ma Xianying Zeng Xin Yin Mei Li Bo Zhang Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Liling Liu Pucheng Chen Yongping Jiang Yuntao Guan Jinxiong Liu Wenli Gu Shuyu Han Yangming Song Libin Liang Zhiyuan Qu Yujie Hou Xiurong Wang Hongmei Bao Guobin Tian Yanbing Li Li Jiang Chengjun Li 陈化兰 | 2019 | 科学新闻2019，0，2： | 1 |
| 19 | Genome-wide identification of the CONSTANS-LIKE(COL)family and mechanism of fruit senescence regulation by PpCOL8 in sand pear(Pyrus pyrifolia)显示文摘Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and taste.However,the industrial development of pear fruit is significantly limited by its short shelf life.Salicylic acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf life.However,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly understood.In this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide analysis.These COL genes were divided into three subgroups according to the structural domains of the COL protein.Pp COL8,with two B-box motifs and one CCT domain,belonged to the first subgroup.In contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third subgroup.The four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit development.Moreover,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp COL9b.Interestingly,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its expression.While the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit senescence.In contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit senescence.The co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit senescence.The results of this study revealed that Pp COL8 can play a key role in pear fruit senescence by interacting with Pp MADS through the SA signaling pathway. | Yue Xu Shurui Song Huiying Wang Xilong Cao Xinran Zhao Wenli Wang Liyue Huo Yawei Li Misganaw Wassie Bin Lu Liang Chen Haiyan Shi | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 20 | Cerium oxide nanozymes alleviate oxidative stress in tenocytes for Achilles tendinopathy healing显示文摘Background:Reactive oxygen species(ROS)is considered as ubiquitous and highly active chemicals that influence tendon integrity and orchestrate tendon repair.With significant recent advances in nanomaterials,cerium oxide nanoparticles(CeO_(2)NPs)exhibit superoxide dismutase-and catalase-like activities.Herein,we introduced a therapeutic approach of CeO_(2)NPs for Achilles tendinopathy(AT)healing.Methods:CeO_(2)NPs were synthesized to examine their effect as ROS scavengers on AT healing in vitro and in vivo.The mRNA levels of inflammatory factors were evaluated in AT after CeO_(2)NPs treatment in vitro.The mechanisms underlying CeO_(2)NPs-mediated stimulation of NRF2 translocation and ERK signaling were verified through immunofluorescence and Western blot analysis.The efficacy of CeO_(2)NPs was tested in an AT rat model in comparison with the control.Results:CeO_(2)NPs not only significantly scavenged multiple ROS and suppressed ROS-induced inflammatory reactions but also protected cell proliferation under oxidative stress induced by tert-butyl hydroperoxide(TBHP).Moreover,CeO_(2)NPs could promote NRF_(2)nuclear translocation for anti-oxidation and anti-inflammation through the ERK signaling pathway.In a rat model of collagenase-induced tendon injuries,CeO_(2)NPs showed significant therapeutic efficacy by ameliorating tendon damage.Conclusion:The present study provides valuable insights into the molecular mechanism of CeO_(2)NPs to ameliorate ROS in tenocytes via the ERK/NRF_(2)signaling pathway,which underscores the potential of CeO_(2)NPs for application in the treatment of enthesopathy healing. | Xingquan Xu Rongliang Wang Yixuan Li Rui Wu Wenjin Yan Sheng Zhao Quanyi Liu Yan Du Wenli Gong Weitong Li Hui Wei Dongquan Shi | 2023 | Nano Research2023，16，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员