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| 1 | Dynamic rupture of metal sheet subjected to laser irradiation and tangential subsonic airflow显示文摘To reproduce the premature rupture process of metal sheet subjected to laser irradiation with subsonic airflow,which is an interesting phenomenon observed in the experiments given by Lawrence Livermore National Laboratory,a coupled numerical model considering the interaction and evolution of metal elastoplastic deformation and aerodynamic pressure profile is presented.With the thermal elastoplastic constitutive relationship and failure criterion,the simulated failure modes and dynamic rupture process are basically consistent with the experimental results,indicating plastic flow and multiple fracturing is the main failure mechanism.Compared with the case of non-airflow,subsonic airflow not only accelerates deformation,but also turns the bugle deformation,plastic strain and rupture mode into asymmetric. | Xiaodong Xing Te Ma Ruixing Wang Chenyu Cao Hongwei Song Chenguang Huang | 2018 | Theoretical & Applied Mechanics Letters2018，8，4： | 2 |
| 2 | Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo显示文摘 | Zhimei Song Runliang Feng Min Sun Chenyu Guo Yan Gao Lingbing Li Guangxi Zhai | 2010 | Journal of Colloid And Interface Science2010，，1： | 1 |
| 3 | Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder显示文摘Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD. | Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang | 2023 | National Science Review2023，10，11： | 1 |
| 4 | Profile and development of microsatellite primers for Acanthogobius ommaturus based on high-throughput sequencing technology显示文摘Acanthogobius ommaturus,a fish species of the Family Gobiidae,is a marine commercial fish perched on the bottom of seawater.In this study,Illumina high-throughput sequencing technology was applied to obtain the candidate microsatellite markers of A.ommaturus.A total of 4746 microsatellite-rich fragments were found,of which 4542 microsatellites are with primer fragments,containing 971 dinucleotide sequences,2643 trinucleotide sequences,569 tetranucleotide sequences,406 pentanucleotide sequences,and 212 hexanucleotide sequences.Based on the results of high-throughput sequencing,a total of 141 pairs of the microsatellite primers were designed and screened.And then 24 polymorphic primers were finally obtained by polyacrylamide gel electrophoresis.In total,271 alleles were detected in the 24 pairs of primers.The number of alleles for different primers ranged from 5 to 19.The average number of effective alleles(Na)was 11.292;the average observed heterozygosity(Ho)of the 24 pairs of primers was 0.665,the average expected heterozygosity(He)was 0.880,and the average polymorphic information content was 0.846.All sites were highly polymorphic(PIC>0.50). | SONG Chenyu FENG Ziyi LI Chunhou SUN Zhicheng GAO Tianxiang SONG Na LIU Lu | 2020 | Journal of Oceanology and Limnology2020，38，6： | 1 |
| 5 | Preparation and Characterization of 3D Printed Hydroxyapatite-Whisker-Strengthened Hydroxyapatite Scaffold Coated with Biphasic Calcium Phosphate显示文摘This study investigates the in vitro degradation of calcium-deficient hydroxyapatite powder after heat treatment at different temperatures and analyzes the calculated phase composition,particle size distribution,degradation rate,and bioactivity of the powder after heat treatment.A mixture of hydroxyapatite and��-tricalcium phosphate(BCP)coatings was prepared on the surface of a 3D-printed hydroxyapatite-whisker-strengthened hydroxyapatite scaf-fold(HAw/HA)by vacuum impregnation and ultraviolet light curing combined with an optimized heat treatment process.The performance of the coatings under different methods was characterized.The composite scaffolds with highly interconnected pores and excellent mechanical properties were prepared,and their biodegradation performance,bioactivity,osteoconductivity,and osteoinductivity of the scaffolds were improved.The results showed that calcium-deficient hydroxyapatite began to transform into BCP between 600℃and 800℃,and the powder treated at 800℃has better bioactivity.The BCP coating prepared by light curing was more uniform,resulting in a higher interfacial bonding strength,and has better osteoconductivity and osteoinductivity than that prepared by vacuum impregnation. | Chenyu Ma Qingfeng Zeng Luwang Yu Shuyin Yu Jiayin Song Yongjie Ma Xieping Dong | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，4： | 0 |
| 6 | Application of biocompatible custom ceria nanoparticles in improving the quality of liver grafts for transplantation显示文摘Liver transplantation(LT),an ultimate and vital method for treating end-stage liver disease,is often accompanied by ischemiareperfusion injury(IRI)resulting from warm or cold ischemia of the donor liver.Organ protection techniques are used to improve the quality of liver grafts(from retrieval to implantation).Reactive oxygen species(ROS)cause oxidative stress,which is considered a crucial factor in IRI after LT.Nano antioxidants capable of scavenging ROS alleviate IRI in multiple types of organs and tissues.In this study,we synthesized ceria nanoparticles(NPs)with antioxidant properties using a pyrolysis method and covered them with phospholipid-polyethylene glycol to improve their biocompatibility in vivo.We investigated the potential organprotective effect of ceria NPs and the underlying mechanisms.Ceria NPs promoted liver function recovery after LT by attenuating IRI in liver grafts in vivo.The protective effect of ceria NPs on liver grafts was investigated by applying hypothermic oxygenated machine perfusion ex vivo.Ceria NPs attenuated hypoxia reoxygenation-or H_(2)O_(2)-induced hepatocyte injury by enhancing mitochondrial activity and ROS scavenging in vitro.These effects may be associated with the activation of the nuclear factor erythroid-derived 2-related factor 2(Nrf2)/Kelch-like ECH-associated protein 1(Keap1)/heme oxygenase 1(HO-1)signaling pathway.In conclusion,ceria NPs may serve as a promising antioxidant agent for the treatment of hepatic IRI after LT. | Yinbiao Qiao Jianhui Li Suchen Bian Chenyue Zhan Jia Luo Li Jiang Haoyu Li Hao Wu Cheng Zhang Shusen Zheng Haiyang Xie Penghong Song | 2023 | Nano Research2023，16，4： | 0 |
| 7 | Specific Electrochemiluminescence of Aptamer-Functionalized Quantum Dots with Lysozyme and Hemin as Co-Triggers显示文摘这个工作基于 hemin/G-quadruplex 混血儿为溶解酵素的特定的察觉建议了没有标签、划算、相当敏感的 electrogenerated 化合光(ECL ) 策略。当吸附 thiolated 的底层捕获,金 nanoparticles 被散布到薄电影的 chitosan 上:组织发卡的 DNA,集成双头尾巴连接了功能的领域:为为 hemin (铁(III )proto 卟啉 IX ) 的溶解酵素和其它的一个 aptamer 序列。面对两个,发卡符合构造展开了并且转变了成 hemin/G-quadruplex 主题,它作为内长的 coreactant 经由溶解的氧的消费显著地熄灭了 underlaid 量点的 ECL 排放。这构造启用了宽线性回答到溶解酵素,从 20 pg·mL −1到有象 4.95 pg·mL −1 一样低的察觉限制的 5 µg·mL −1,( 例如在 bioanalysis 表明 DNA 技术的未来的利用的 9.4 pmol·L −1), 。 | Xubo Ji Chuanguang Yao Ying Wan Hongxin Song Peng Xin Hongda Cui Chenyu Zheng Shengyuan Deng | 2016 | Chinese Journal of Chemistry2016，34，3： | 0 |
| 8 | Protective effects and mechanisms of Lizhong decoction(理中汤) against non-alcoholic fatty liver disease in a rat model显示文摘OBJECTIVE: To investigate the protective effects and molecular mechanisms of Lizhong decoction( 理中汤, LZD) against non-alcoholic fatty liver disease(NAFLD). METHODS: Male Wistar rats were fed a high-fat diet for four weeks to induce NAFLD, and were administered LZD by gavage for four weeks. Potential therapeutic targets for NAFLD were analyzed using network pharmacology. Liver pathology was evaluated using Oil Red O and hematoxylin-eosin staining. Furthermore, mitochondrial function, lipid metabolism, oxidative stress, and inflammatory response were examined. RESULTS: Rats with NAFLD exhibited high levels of hepatic damage and cholesterol deposition. Moreover, apoptosis was increased, superoxide dismutase and glutathione content were reduced, malondialdehyde content was increased, and the protein expression of inflammatory cytokines and p-c-Jun N-terminal kinase was increased. The LZD treatment ameliorated mitochondrial dysfunction, reduced liver damage,inhibited oxidative stress and inflammatory response, upregulated peroxisome proliferator-activated receptor(PPAR)-γ expression, and suppressed dipeptidyl peptidase 4(DPP4) expression in the liver. CONCLUSION: It was found that LZD alleviates NAFLD by activating PPAR-γ and inhibiting DPP4. | YANG Jiayao TAO Dongqing MA Wei LIU Song LIAO Yan SHU Lei ZHANG Shu LI Chenyu DU Nianlong | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 9 | Long-term fundus fluorescence angiography and real-time diagnosis of retinal diseases in non-human primate-animal models显示文摘Fluorescein angiography(FA)is a standard imaging modality for evaluating vascular abnormalities in retina-related diseases,which is recognized as the major cause of vision loss.Long-term and real-time fundus angiography is of great importance in preclinical research,nevertheless remaining big challenges up to present.In this study,we demonstrate that long-term fluorescence imaging of retinal vessels is enabled through a kind of fluorescent nanoagents,which is made of small-sized(hydrodynamic diameter:∼3 nm)silicon nanoparticles(SiNPs)featuring strong fluorescence,robust photostability,lengthened blood residency and negligible toxicity.In particular,the presented SiNPs-based nanoagents are capable of imaging retinal capillaries in∼10 min,which is around 10-fold longer than that(∼1 min)of fluorescein sodium(FS,known as the most widely used contrast agents for FA in clinic).Taking cynomolgus macaques as non-human primate-animal model,we further demonstrate the feasibility of real-time diagnosis of retinal diseases(e.g.,age-related macular degeneration(AMD))through dynamic monitoring of vascular dysfunction. | Miaomiao Tang Lu Zhang Bin Song Xiaoyuan Ji Chenyu Wang Houyu Wang Hua Xu Yuanyuan Su Yao He | 2021 | Nano Research2021，14，11： | 0 |
| 10 | Discordant patterns of genetic variation between mitochondrial and microsatellite markers in Acanthogobius ommaturus across the coastal areas of China显示文摘Acanthogobius ommaturus, which belongs to the family Gobiidae, is a euryhaline and demersal fish that is widely distributed in the coastal areas, harbors, and estuaries of China, D. P. R. Korea and Japan. In this study, the genetic diversity and genetic structure of five geographical populations of A. ommaturus was assessed using the mitochondrial hypervariable region gene and microsatellite markers. The results of the two genetic markers indicated that the A. ommaturus populations had a high level of genetic diversity. The mitochondrial marker detected weak genetic differentiation among populations, and the Neighbor-Joining tree showed that there was no obvious pedigree branches and geographic structure as well. However, population of Zhoushan showed significant genetic differentiation with other populations by microsatellite markers. The population of A.ommaturus has not experienced bottleneck effect recently. We speculated that the Pleistocene climate change and juvenile fish dispersal played an important role in the population differentiation of A. ommaturus. | Chenyu Song Zhong Tu Na Song | 2023 | Acta Oceanologica Sinica2023，42，4： | 0 |
| 11 | Construction of comprehensive gene network for human mitochondria显示文摘By combining the knowledge from KEGG database and literatures, we construct a comprehensive gene network for human mitochondria. The network comprises 2442 genes of 9 functional categories, including metabolism, development, immune, and apoptosis, etc. Topological analysis reveals that the network is scale free. The hubs of high degrees are mostly the genes of apoptosis. Three big modules are found in the network, which represent development and cell growth, metabolism, immune and apoptosis respectively, suggesting the multiplicity of functions and the complexity of gene regulation in mitochondria. | LI Jie GAO Song WANG Jin ZHANG ChenYu | 2010 | Chinese Science Bulletin2010，55，22： | 0 |
| 12 | Metal-phenolic networks modified polyurethane as periosteum for bone regeneration显示文摘Treatment of bone defects still poses a great challenge in orthopedic clinics, and the vital role of periosteum in such processes has attracted widespread attention. However, studies focusing on the oxidative stress micro-environment with an artificial periosteum at the site of defect have been scarce. The intrinsic anti-oxidative properties and therapeutic potential for bone defects of metal-phenolic networks(MPNs)have provided a potential solution to this. Herein, we have developed a protocatechualdehyde + zinc ion(PCA+Zn^(Ⅱ)) MPN coating on a thermoplastic polyurethane membrane with a one-pot method to fabricate a new-type of periosteum with meritorious biocompatibility and abilities of modulating oxidative stress condition and promoting osteogenesis and mineralization for better bone regeneration, which has shown to be a promising strategy for constructing artificial periosteum with various MPNs. | Qingyi Zhang Kai Huang Jie Tan Xiongxin Lei Liping Huang Yuting Song Qianjin Li Chenyu Zou Huiqi Xie | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
| 13 | States of graphene oxide and surface functional groups amid adsorption of dyes and heavy metal ions显示文摘Water pollution regarding dyes and heavy metal ions is crucial facing the world.How to effectively separate these contaminants from water has been a key issue.Graphene oxide(GO)promises the greenwater world as a long-lasting spotlight adsorbent material and therefore,harnessing GO has been the research hotspot for over a decade.The state of GO as well as its surface functional groups plays an important role in adsorption.And the way of preparation and structural modification matters to the performance of GO.In this review,the significance of the state of existence of stock GO and surface functional groups is explored in terms of preparation,structural modification,and adsorption.Besides,various adsorbates for GO adsorption are also involved,the discussion of which is rarely established elsewhere. | Zhaoyang Han Ling Sun Yingying Chu Jing Wang Chenyu Wei Qianlei Jiang Changbao Han Hui Yan Xuemei Song | 2023 | Chinese Journal of Chemical Engineering2023，63，11： | 0 |
| 14 | Monitoring Surface Water Change in Northeast China in 1999–2020:Evidence from Satellite Observation and Refined Classification显示文摘As a typical region with high water demand for agricultural production,understanding the spatiotemporal surface water changes in Northeast China is critical for water resources management and sustainable development.However,the long-term variation characteristics of surface water of different water body types in Northeast China remain rarely explored.This study investigated how surface water bodies of different types(e.g.,lake,reservoir,river,coastal aquaculture,marsh wetland,ephemeral water) changed during1999–2020 in Northeast China based on various remote sensing-based datasets.The results showed that surface water in Northeast China grew dramatically in the past two decades,with an equivalent area increasing from 24 394 km^(2) in 1999 to 34 595 km^(2) in 2020.The surge of ephemeral water is the primary driver of surface water expansion,which could ascribe to shifted precipitation pattern.Marsh wetlands,rivers,and reservoirs experienced a similar trend,with an approximate 20% increase at the interdecadal scale.By contrast,coastal aquacultures and natural lakes remain relatively stable.This study is expected to provide a more comprehensive investigation of the surface water variability in Northeast China and has important practical significance for the scientific management of different types of surface water. | LIU Kai ZHANG Dapeng CHEN Tan CUI Peipei FAN Chenyu SONG Chunqiao | 2024 | Chinese Geographical Science2024，34，1： | 0 |
| 15 | Reconstructing Centennial-Scale Water Level of Large Pan-Arctic Lakes Using Machine Learning Methods显示文摘The pan-Arctic region has the largest number of lakes in the world,which is rather sensitive to changing climate.It is urgently needed to understand how these lakes were changing in the long term.However,there are few lakes with long-term historical monitoring of water level,understanding the hydrologic changes of pan-Arctic lakes over the past century requires the data reconstruction by state-of-art techniques.This study used machine learning algorithms to reconstruct the water level of pan-Arctic lakes on a centennial scale.It further investigated their relationship with long-term hydrological and climatic variables.Comparison of the reconstructed results by four different machine learning models shows that the extreme gradient boosting tree(XGBoost) is better than other three models.Overall,the centennial-scale reconstruction using the XGBoost model performs best for most study lakes.Based on the reconstructed results,we can observe that water level changes of several North American lakes are correlated with potential evapotranspiration,followed by precipitation,while the Eurasian lakes are more strongly associated with temperature and wet day frequency.The water level dynamics of pan-Arctic lakes could be largely attributed to Arctic Oscillation and Atlantic Multidecadal Oscillation.This study is expected to advance our understanding of the pan-Arctic lake water level changes in the past century and to provide a feasible method for reconstructing the regional lake water level in the long term. | Xinge Liang Chunqiao Song Kai Liu Tan Chen Chenyu Fan | 2023 | Journal of Earth Science2023，34，4： | 0 |
| 16 | Visit by the Russian Association of Sinologists显示文摘Visit by the Russian Association of SinologistsVisitbytheRussianAssociationofSinologists￥bySongChenyuInvitedbytheChineseAssoc... | by Song Chenyu | 1997 | International Understanding1997，，Z1： | 0 |
| 17 | Wheat bran inclusion level impacts its net energy by shaping gut microbiota and regulating heat production in gestating sows显示文摘An accurate estimation of net energy(NE)of wheat bran is essential for precision feeding of sows.However,the effects of inclusion level on NE of wheat bran have not been reported.Inclusion level was hypothesized to impact NE of wheat bran by regulating gut microbiota and partitioning of heat production.Therefore,twelve multiparous sows(Yorkshire×Landrace;2 to 4 parity)were assigned to a replicated 3×6 Youden square with 3 successive periods and 6 diets in each square.The experiment included a corn-soybean meal diet(WB0)and five diets including 9.8%(WB10),19.5%(WB20),29.2%(WB30),39.0%(WB40)and 48.7%wheat bran(WB50),respectively.Each period included 6 d of adaptation to diets followed by 6 d for heat production measurement using open-circuit respiration chambers.Compared with other groups,WB30,WB40,and WB50 enriched different fiber-degrading bacteria genera(P<0.05).Apparent total tract digestibility of neutral detergent fiber and acid detergent fiber of wheat bran were greater in WB30 and WB40(P<0.05).Physical activity(standing and sitting)decreased as inclusion level increased(P=0.04),which tended to decrease related heat production(P=0.07).Thermic effect of feeding(TEF)was higher in WB50 than other treatments(P<0.01).Metabolizable energy of wheat bran was similar among treatment groups(except for WB10).NE of wheat bran conformed to a quadratic regression equation with inclusion level(R^(2)=0.99,P<0.01)and peaked at an inclusion level of 35.3%.In conclusion,increasing inclusion level decreased energy expenditure of sows on physical activity and promoted growth of fiber-degrading bacteria,which improved energy utilization of fiber.Fermentation of wheat bran fiber by Prevotellaceae_UCG-003 and norank_f_Paludibacteraceae might increase TEF.Consequently,sows utilized energy in wheat bran most efficiently at an inclusion level of 35.3%. | Song Xu Zirou Yu Zongliang Li Zijie Wang Chenyu Shi Jian Li Fenglai Wang Hu Liu | 2023 | Animal Nutrition2023，，4： | 0 |
| 18 | Prevalence of hepatic steatosis and metabolic associated fatty liver disease among female breast cancer survivors显示文摘To the Editor:Non-alcoholic fatty liver disease(NAFLD)comes to prevail in Asia and,the prevalence in China is reported tobe24%to36%.lilThe prevalence ofNAFLD and its associated medical burden might be underestimated.The diagnosis of NAFLD led to the exclusion of other chronic liver diseases including“excess”alcohols,thus the population with alcoholic consumptions or other liver diseases might be neglected.In March 2020,the international expert consensus proposed a new concept,“metabolic associated fatty liver disease(MAFLD),”“and replaced the earlier term” of NAFLD.2As themost prevalent female malignancy,breast cancer(BC)shares similar risk factors to MAFLD.Higher levels of obesity and physical inactivity are closely correlated to BC and are significant drive for the increasing trends in the prevalence of BC.Some BC survivors may receive chemotherapy and endocrine therapy,both of which are reported to increase the risk of hepatic steatosis(HS),which is the fundamental criteria of the diagnosis of MAFLD. | Shen Tian Hao Li Renhua Li Liang Ran Shu Li Juan Wu Zhou Xu Xinyu Liang Yuling Chen Jun Xiao Jiaying Wei Chenyu Ma Jingyu Song Ruiling She Kainan Wu Lingquan Kong | 2022 | Chinese Medical Journal2022，135，19： | 0 |
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