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| 1 | Regulation of Stamen Development by Coordinated Actions of Jasmonate, Auxin, and Gibberellin in Arabidopsis显示文摘合适的雄蕊开发是必要的让植物完成他们的生命周期。在雄蕊开发的缺点将引起 malesterility。研究努力的一个广阔数组被使理解雄蕊发展过程和规章的 mechanismsover 过去的十年。包括 jasmonate,植物生长素,赤霉素, brassinosteroid,和细胞激动素,植物激素在雄蕊开发的规定起必要作用,这到目前为止被报导。这评论将简短在 Arabidopsis.Key 词由 jasmonate,植物生长素,和赤霉素为雄蕊开发的协调规定总结 molecularbasis: | Susheng Song Tiancong Qi Huang Huang Daoxin Xie | 2013 | Molecular Plant2013，6，4： | 29 |
| 2 | Knockdown of OsHox33, a member of the class III homeodomain-leucine zipper gene family, accelerates leaf senescence in rice显示文摘The class III homeodomain-leucine zipper(HD-Zip III)gene family plays important roles in plant growth and development,including regulation of apical embryo patterning,embryonic shoot meristem formation,leaf polarity,vascular development,and meristem function,with a particularly crucial function in leaf development.Although HD-Zip III members are highly conserved in land plants,previous studies,such as genetic analyses based on multiple mutants in Arabidopsis and other plants,suggest that various HD-Zip III family genes have evolved with distinct functions and pleiotropic effects on plant growth and development.In this study,we analyzed a HD-Zip III member,OsHox33,and demonstrated that it plays an important role in age-dependent leaf senescence in rice.We constructed two specific RNAi vectors derived from the 5′-end region and 3′-UTR of OsHox33 to knockdown its expression.Transgenic plants harboring either RNAi construct displayed similar phenotypes of precocious leaf senescence symptoms,suggesting that knockdown of OsHox33 accelerates leaf senescence in rice.pOsHox33::GUS fusion expression and RT-PCR revealed that OsHox33 is highly expressed in young organs,especially in young meristems such as shoot apical meristems,intercalary meristems,and young callus.In addition,real-time PCR indicated that OsHox33 was more highly expressed in young leaves than in old leaves.To further investigate OsHox33 function,we analyzed chloroplast ultrastructure in different-aged leaves of RNAi plants,and found that OsHox33 knockdown accelerated chloroplast degradation,which is consistent with RNAi phenotypes.Finally,real-time PCR studies showed that OsHox33 can regulate the expression of GS1 and GS2,two senescence-associated genes.Taken together,the work presented here provides new insights into the function of HD-Zip III members in plants. | LUAN WeiJiang SHEN Ao JIN ZhiPing SONG SuSheng LI ZhengLong SHA AiHua | 2013 | Science China(Life Sciences)2013，56，12： | 13 |
| 3 | Amino acid substitutions of GLY98,LEU245 and GLU543 in COI1 distinctively affect jasmonate-regulated male fertility in Arabidopsis显示文摘 | HUANG Huang WANG CuiLi TIAN HaiXia SUN Yu XIE DaoXin SONG SuSheng | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 4 | Arabidopsis ENOR3 regulates RNAi-mediated antiviral defense显示文摘Viruses can infect host plants to cause severe diseases and substantial agricultural loss, while plants have evolved RNA interference(RNAi) strategy to defend against viral infection. Despite enormous efforts, only a few host proteins in RNAi pathway were shown to mediate antiviral defense, including RNA-dependent RNA polymerase 1(RDR1), RDR6, DICER-LIKE 2(DCL2) and DCL4. In this study, we carried out a genetic screen for antiviral factors of RNAi pathway in Arabidopsis rdr6 background via inoculation with a 2 bdeficient Cucumber Mosaic Virus(CMV-D2b). We identified a mutant susceptible to CMV-D2b, referred to as enhancer of rdr6(enor) 3-1 rdr6, and found that ENOR3 encodes a functionally unknown protein with high homology to the mammalian Non Imprinted in Prader-Willi/Angelman(NIPA) magnesium transporters. ENOR3 inhibits accumulation of CMV-D2b and acts additively with RDR1, RDR6, DCL2 and DCL4 in antiviral defense. These results uncover that ENOR3 is a key component in antiviral RNAi pathway, and provide new insights into antiviral immunity. | Hua Gao Mai Yang Haitao Yang Yue Qin Biyun Zhu Gang Xu Chengyuan Xie Dewei Wu Xiaolin Zhang Wanxiang Li Jianbin Yan Susheng Song Tiancong Qi Shou-Wei Ding Daoxin Xie | 2018 | Journal of Genetics and Genomics2018，45，1： | 2 |
| 5 | S-1 and Cisplatin With or Without Nimotuzumab for Patients With Untreated Unresectable or Metastatic Gastric Cancer: A Randomized, Open-Label Phase 2 Trial显示文摘 | Feng Du Zhaoxu Zheng SuSheng Shi Zhichao Jiang Tao Qu Xinhua Yuan Yongkun Sun Yan Song Lin Yang Jiuda Zhao Jinwan Wang Yihebali Chi | 2015 | Medicine2015，，23： | 1 |
| 6 | The jasmonate- ZIM domain proteins interact wittl the R2R3-MYB transcrip- tion factors MYB21 and MYB24 to affect jasmonate-regulated stamen development in Arabidopsis显示文摘 | Song Susheng Qi Tiancong Huang Huang | 2011 | Plant Cell2011，23，3： | 1 |
| 7 | Jasmonate signaling and crosstalk with gibberellin and ethylene显示文摘 | Susheng Song Tiancong Qi Claus Wasternack Daoxin Xie | 2014 | Current Opinion in Plant Biology2014，，： | 1 |
| 8 | A molecular framework for signaling crosstalk between jasmonate and ethylene in anthocyanin biosynthesis,trichome development,and defenses against insect herbivores in Arabidopsis显示文摘The phytohormones ethylene(ET)and jasmonate(JA)regulate plant development,growth,and defense responses;however,the molecular basis for their signaling crosstalk is unclear.Here,we show that JA-ZIM-domain(JAZ)proteins,which repress JA signaling,repress trichome initiation/branching and anthocyanin accumulation,and inhibit the transcriptional activity of the basic helix-loop-helix(bHLH)-MYBmembers(GLABRA3(GL3)-GL1 and TRANSPARENT TESTA 8(TT8)-MYB75)of WD-repeat/bHLH/MYB(WBM)complexes.The ET-stabilized transcription factors ETHYLENEINSENSITIVE3(EIN3)and EIN3-LIKE1(EIL1)were found to bind to several members of WBM complexes,including GL3,ENHANCER OF GLABRA3(EGL3),TT8,GL1,MYB75,and TRANSPARENT TESTA GLABRA1(TTG1).This binding repressed the transcriptional activity of the b HLH-MYB proteins and inhibited anthocyanin accumulation,trichome formation,and defenses against insect herbivores while promoting root hair formation.Conversely,the JA-activated b HLH members GL3,EGL3,and TT8 of WBM complexes were able to interact with and attenuate the transcriptional activity of EIN3/EIL1 at the HOOKLESS1 promoter,and their overexpression inhibited apical hook formation.Thus,this study demonstrates a molecular framework for signaling crosstalk between JA and ET in plant development,secondary metabolism,and defense responses. | Susheng Song Bei Liu Junqiao Song Shihai Pang Tianxue Song Shang Gao Yue Zhang Huang Huang Tiancong Qi | 2022 | Journal of Integrative Plant Biology2022，64，9： | 1 |
| 9 | The SlWRKY57-SlVQ21/SlVQ16 module regulates salt stress in tomato显示文摘Salt stress is a major abiotic stress which severely hinders crop production.However,the regulatory network controlling tomato resistance to salt remains unclear.Here,we found that the tomato WRKY transcription factor WRKY57 acted as a negative regulator in salt stress response by directly attenuating the transcription of salt-responsive genes(Sl RD29B and Sl DREB2)and an ion homeostasis gene(Sl SOS1).We further identified two VQ-motif containing proteins Sl VQ16 and Sl VQ21as Sl WRKY57-interacting proteins.Sl VQ16 positively,while Sl VQ21 negatively modulated tomato resistance to salt stress.Sl VQ16 and Sl VQ21 competitively interacted with Sl WRKY57 and antagonistically regulated the transcriptional repression activity of Sl WRKY57.Additionally,the Sl WRKY57-Sl VQ21/Sl VQ16 module was involved in the pathway of phytohormone jasmonates(JAs)by interacting with JA repressors JA-ZIM domain(JAZ)proteins.These results provide new insights into how the Sl WRKY57-Sl VQ21/Sl VQ16 module finely tunes tomato salt tolerance. | Jilin Ma Chonghua Li Lulu Sun Xuechun Ma Hui Qiao Wenchao Zhao Rui Yang Susheng Song Shaohui Wang Huang Huang | 2023 | Journal of Integrative Plant Biology2023，65，11： | 0 |
| 10 | Chinese expert consensus on multidisciplinary diagnosis and treatment of pancreatic neuroendocrine liver metastases显示文摘Many management strategies are available for pancreatic neuroendocrine neoplasms with liver metastases.However,a lack of biological,molecular,and genomic information and an absence of data from rigorous trials limit the validity of these strategies.This review presents the viewpoints from an international conference consisting of several expert working groups.The working groups reviewed a series of questions of particular interest to clinicians taking care of patients with pancreatic neuroendocrine neoplasms with liver metastases by reviewing the existing management strategies and literature,evaluating the evidence on which management decisions were based,developing internationally acceptable recommendations for clinical practice,and making recommendations for clinical and research endeavors.The review for each question will be followed by recommendations from the panel. | Yihebali Chi Liming Jiang Susheng Shi Shun He Chunmei Bai Dan Cao Jianqiang Cai Qichen Chen Xiao Chen Yiqiao Deng Shunda Du Zhen Huang Li Huo Yuan Ji Jie Li Wenhui Lou Jie Luo Xueying Shi Lijie Song Bei Sun Huangying Tan Feng Wang Xuan Wang Zhewen Wei Wenming Wu Dianrong Xiu Jianming Xu Huadan Xue Yi Yang Fei Yin Chunhui Yuan Yefan Zhang Weixun Zhou Dongbing Zhao Hong Zhao | 2023 | Journal of Pancreatology2023，6，4： | 0 |
| 11 | Targeting UBE2C for degradation by bioPROTACs based on bacterial E3 ligase显示文摘UBE2C(Ubiquitin conjugating enzyme E2 C), a key regulator of cell cycle progression, is a promising target for discovery of antitumor agents. However, it is challenging to develop inhibitors of UBE2C owing to its lack of “druggable” pockets. Bio PROTACs(biological proteolysis targeting chimeras) are a kind of protein-based degraders by fusing an adaptor to a subunit of E3 ligase for ubiquitination and subsequent proteasome-dependent degradation of target protein. We report herein the design and biological evaluation of a UBE2C-targeting bio PROTAC based on the NEL(novel E3 ligase) domain of bacterial E3 ligase Ipa H9.8 and the UBE2C-binding WHB(winged-helix B) domain of APC_(2)(anaphase promoting complex subunit 2). The in vitro ubiquitination test and Mass Spectrometry analysis showed that the bio PROTAC could transfer ubiquitin to surface exposed lysines on UBE2C and catalyzed the formation of polyubiquitin chains. In addition, the transient co-expression experiment showed that the bio PROTAC could promote proteasomal degradation of heterologous UBE2C and rescue its downstream substrates in mammalian cells. | Jinpeng Wang Min Zhang Susheng Liu Zhipeng He Rui Wang Minchan Liang Yuhao An Chenran Jiang Chunli Song Zigong Ning Feng Yin Hao Huang Zigang Li Yuxin Ye | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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