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| 1 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 2 | Human avian influenza A (H5N1) virus infection in China显示文摘Highly pathogenic influenza A (H5N1) virus causes a widespread poultry deaths worldwide. The first human H5N1 infected case was reported in Hong Kong Special Administrative Region of China in 1997. Since then, the virus re-emerged in 2003 and continues to infect people worldwide. Currently, over 400 human infections have been reported in more than 15 countries and mortality rate is greater than 60%. H5N1 viruses still pose a potential pandemic threat in the future because of the continuing global spread and evolution. Here, we summarize the epidemiological, clinical and virological characteristics of human H5N1 infection in China monitored and identified by our national surveillance systems. | XU CuiLin, DONG LiBo, XIN Li, LAN Yu, CHEN YongKun, YANG LiMei & SHU YueLong State Key Laboratory for Viral Genetic and Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China | 2009 | Science China(Life Sciences)2009，52，5： | 14 |
| 3 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 4 | A comparative study of calcium sulfate artificial bone graft versus allograft in the reconstruction of bone defect after tumor curettage显示文摘 | Yang Yongkun Niu Xiaohui Zhang Qing Hao Lin Ding Yi Xu Hairong | 2014 | Chinese Medical Journal2014，，17： | 11 |
| 5 | Investigation Into the Electromagnetic Impulses From Long- Pulse Laser Illuminating Solid Targets Inside a Laser Facility显示文摘电磁的脉搏(EMP ) 的排放在这个工作用一条锥天线由于在激光设备的激光目标相互作用被评估了。当有几几千焦耳的长脉搏的激光照亮了稳固的目标时,在从几百 MHz 到 2 GHz 的频率的微波被记录,同时,到 4 V 的从 1 V 的电压信号作为激光精力和背光激光的函数被捕获,在相应电场力量被与进行数学进程(有 L 曲线的 Tiknohov 规则化)在联合模仿锥天线获得的地方。所有典型联合电压摆动显示了多重山峰并且在腐烂进 EMP 产生的噪音和机制前有多达 80 ns 的持续时间图解地在实际测量环境的基础被解释。结果的数据被期望提供基本诀窍完成惯性的监禁熔化。 | Tao YI Jinwen YANG Ming YANG Chuanke WANG Weiming YANG Tingshuai LI Shenye LIU Shaoen JIANG Yongkun DING Shaoqiu XIAO | 2016 | Photonic Sensors2016，6，3： | 11 |
| 6 | Current Status of Neuromodulatory Therapies for Disorders of Consciousness显示文摘Treatment for disorders of consciousness(DOCs) is still a Gordian knot. Evidence-based guidelines on the treatment of DOC patients are not currently available, while neuromodulation techniques are seen as a potential treatment. Multiple neuromodulation therapies have been applied. This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients. Both invasive and noninvasive brain stimulation is discussed. Significant behavioral improvements in prolonged DOCs under neuromodulation therapies are rare. The efficacy of various such therapies remains a matter of debate. Further clinical investigations of existing techniques in larger samples properly controlling for spontaneous recovery are needed,and new approaches are awaited. | Xiaoyu Xia Yi Yang Yongkun Guo Yang Bai Yuanyuan Dang Ruxiang Xu Jianghong He | 2018 | Neuroscience Bulletin2018，34，4： | 10 |
| 7 | A review of extractive distillation from an azeotropic phenomenon for dynamic control显示文摘Extractive distillation is an effective method for separating azeotropic or close boiling point mixtures by adding a third component.Various technologies for performing the extractive distillation process have been explored to protect the environment and save resources.This paper focuses on the improvement of these advanced technologies in recent years.Extractive distillation is retrieved and analyzed from the view of phase equilibrium,selection of solvent in extractive distillation,process design,energy conservation,and dynamic control.The quantitative structure–property relationship used in extractive distillation is discussed,and the future development of extractive distillation is proposed to determine how the solvent affects the relative volatility of the separated mixture.In the steady state design,the relationship between the curvature of the residue curve and parameters of the optimal steady state is also highlighted as another field worthy of further study to simplify the distillation process. | Yixin Ma Peizhe Cui Yongkun Wang Zhaoyou Zhu Yinglong Wang Jun Gao | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 9 |
| 8 | PhaseⅠdose-finding study of sorafenib with FOLFOX4 as firstline treatment in patients with unresectable locally advanced or metastatic gastric cancer显示文摘Objective: To determine the maximum tolerated dose(MTD), dose-limiting toxicity(DLT) and efficacy of sorafenib in combination with FOLFOX4(oxaliplatin/leucovorin(LV)/5-fluorouracil) as first-line treatment for advanced gastric cancer, we performed a phase I dose-finding study in nine evaluable patients with unresectable locally advanced or metastatic gastric cancer or gastroesophageal junction adenocarcinoma. Methods: According to modified Fibonacci method, the design of this study was to guide elevation of the sorafenib dosage to the next level(from 200 mg twice daily to 400 mg twice daily and then, if tolerated, 600 mg twice daily). If the patient achieved complete response(CR), partial response(PR) or stable disease(SD) after eight cycles of treatment, combination chemotherapy was scheduled to be discontinued and sorafenib monotherapy continued at the original dose until either disease progression or unacceptable toxicity. Results: In sorafenib 200 mg twice daily group, DLT was observed in 1 of 6 patients, and in 400 mg twice daily group, it was observed in 2 of 3 patients. Seven of 9(77.8%) evaluable patients achieved PR, with a median overall survival(OS) of 11.8 [95% confidence interval(CI): 8.9-14.7] months. Common adverse effects include hand-foot syndrome, leukopenia, neutropenia, anorexia, and nausea.Conclusions: Twice-daily dosing of sorafenib 200 mg in combination with FOLFOX4 was proven effective and safe for the treatment of advanced gastric cancer, and could be an appropriate dosage for subsequent phase II clinical studies. | Yihebali Chi Jianliang Yang Sheng Yang Yongkun Sun Bo Jia Yuankai Shi | 2015 | Chinese Journal of Cancer Research2015，27，3： | 6 |
| 9 | Comparison of Dryland Climate Change in Observations and CMIP5 Simulations显示文摘A comparison of observations with 20 climate model simulations from the Coupled Model Intercomparison Project, Phase5(CMIP5) revealed that observed dryland expansion amounted to 2.61 × 106km2 during the 58 years from 1948 to 2005,which was four times higher than that in the simulations(0.55 × 106km2). Dryland expansion was accompanied by a decline in aridity index(AI)(drying trend) as a result of decreased precipitation and increased potential evapotranspiration across all dryland subtype areas in the observations, especially in the semi-arid and dry subhumid regions. However, the CMIP5multi-model ensemble(MME) average performed poorly with regard to the decreasing trends of AI and precipitation. By analyzing the factors controlling AI, we found that the overall bias of AI in the simulations, compared with observations, was largely due to limitations in the simulation of precipitation. The simulated precipitation over global drylands was substantially overestimated compared with observations across all subtype areas, and the spatial distribution of precipitation in the MME was largely inconsistent in the African Sahel, East Asia, and eastern Australia, where the semi-arid and dry subhumid regions were mainly located. | JI Mingxia HUANG Jianping XIE Yongkun LIU Jun | 2015 | Advances in Atmospheric Sciences2015，32，11： | 5 |
| 10 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 11 | Qualitative and quantitative assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream by HPLC-TOF-MS and HPLC显示文摘Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS qualitative method was developed for the analysis of related substances in this preparation with a quick and easy extraction procedure. Besides the active pharmaceutical ingredients, two compounds named ketoconazole impurity B′ optical isomer and ketoconazole impurity E were identified. Furthermore, a new HPLC method for qualitative and quantitative assessment on related substances and degradation products, which were found in the stability test, was established and validated. The single standard to determine multi-components method was applied in the quantitative analysis, which was an effective way for reducing cost and improving accuracy. This study can provide a creative idea for routine analysis of quality control of the Compound Ketoconazole and Clobetasol Propionate Cream. | Wenling Yang Xiaomei Yang Fanghua Shi Zhigang Liao Yongkun Liang Liangzhong Yu Ruixun Wang Qing Li Kaishun Bi | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 4 |
| 12 | Investigation and assessment of micropollutants and associated biological effects in wastewater treatment processes显示文摘Currently,the wastewater treatment plants(WWTPs)attempt to achieve the shifting from general pollution parameters control to reduction of organic micropollutants discharge.However,they have not been able to satisfy the increasing ecological safety needs.In this study,the removal of micropollutants was investigated,and the ecological safety was assessed for a local WWTP.Although the total concentration of 31 micropollutants detected was reduced by 83%using the traditional biological treatment processes,the results did not reflect chemicals that had poor removal efficiencies and low concentrations.Of the five categories of micropollutants,herbicides,insecticides,and bactericides were difficult to remove,pharmaceuticals and UV filters were effectively eliminated.The specific photosynthesis inhibition effect and non-specific bioluminescence inhibition effect from wastewater were detected and evaluated using hazardous concentration where 5%of aquatic organisms are affected.The photosynthesis inhibition effect from wastewater in the WWTP was negligible,even the untreated raw wastewater.However,the bioluminescence inhibition effect from wastewater which was defined as the priority biological effect,posed potential ecological risk.To decrease non-specific biological effects,especially of macromolecular dissolved organic matter,overall pollutant reduction strategy is necessary.Meanwhile,the ozonation process was used to further decrease the bioluminescence inhibition effects from the secondary effluent;≥0.34 g O 3/g DOC of ozone dose was recommended for micropollutants elimination control and ecological safety. | Xiaoyan Y.Ma Ke Dong Lei Tang Yongkun Wang Xiaochang C.Wang Huu Hao Ngo Rong Chen Na Wang | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 13 | Protective mechanisms of Agrimonia pilosa Ledeb in dextran sodium sulfate-induced colitis as determined by a network pharmacology approach显示文摘Previous studies reported that Agrimonia pilosa (AP) Ledeb possessed diverse biological activities, including anti-inflammatory, antioxidant, and anti-tumor activities. However, the effect of AP on ulcerative colitis (UC) remains unclear. In this study, we investigated the therapeutic effect and mechanisms of AP on dextran sodium sulfate (DSS)-induced colitis. The potential constituents of AP were investigated by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). A total of 13 compounds were recognized by UPLC-Q-TOF/MS chromatogram. Furthermore, a network pharmacology approach revealed that there are 297 candidate targets of UC and 549 common targets for the 13 active ingredients of AP. GO enrichment and KEGG pathway analysis indicated that AP might have a protective effect on UC through the nuclear factor κB (NF-κB) and nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathways. Subsequent experimental validation in a DSS-induced colitis model revealed that AP alleviated the severity of DSS-induced colitis, reduced the production of proinflammatory factors, and protected against the loss of intestinal integrity. Moreover, AP inhibited the phosphorylation of NF-κB p65 and the activation of the NLRP3 inflammasome. In conclusion, AP ameliorated DSS-induced colitis through suppressing the activation of the NLRP3 inflammasome and NF-κB signaling pathways. | Chen Li Meng Wang Junkang Sui Yongkun Zhou Wei Chen | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 3 |
| 14 | Landslides Triggered by the 2020 Qiaojia M_(w)5.1 Earthquake, Yunnan, China: Distribution, Influence Factors and Tectonic Significance显示文摘On May 18, 2020, an M_(w)5.1 earthquake occurred in Qiaojia County, Yunnan Province, China. This moderate-sized event triggered massive coseismic landslides, resulting in some damage. In this work, through visual interpretation of high-resolution(0.8–2 m) Gaofen satellite images before and after the earthquake, 167 landslides were delineated, 18 of which were inspected in the field. Using the landslide number density(LND) and landslide area percentage(LAP), we characterized the spatial distribution of these landslides, and analyzed their possible influence factors and tectonic significance. The results show that these landslides are distributed mostly in the NW-SE direction, roughly parallel to the long axis of seismic intensity zones and the strike of the Xiaohe-Baogunao fault(XBF). The LND and LAP decrease with increasing distances to the fault and from the epicenter to fault ends of the XBF. These permit to suggest that the seismogenic fault of the Qiaojia earthquake is likely a hidden branch of the XBF. All of the landslides induced by this event occurred in the region with the seismic intensity of six degrees or greater of the 2014 M_(w)6.2 Ludian earthquake. Therefore, it was inferred that the 2020 Qiaojia earthquake was probably the subsequent release of accumulated elastic strain after the 2014 Ludian earthquake in a same tectonic stress regime. | Xiangli He Chong Xu Wenwen Qi Yuandong Huang Jia Cheng Xiwei Xu Qi Yao Yongkun Lu Boyang Dai | 2021 | Journal of Earth Science2021，32，5： | 2 |
| 15 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 16 | Recent diagnostic developments at the 100 kJ-level laser facility in China显示文摘A 100 kJ-level laser facility has been designed to study inertial confinement fusion physics in China.This facility incorporates various diagnostic techniques,including optical,x-ray imaging,x-ray spectrum,and fusion product diagnostics,as well as general diagnostics assistance systems and central control and data acquisition systems.This paper describes recent developments in diagnostics at the facility. | Feng Wang Shaoen Jiang Yongkun Ding Shenye Liu Jiamin Yang Sanwei Li Tianxuan Huang Zhurong Cao Zhenghua Yang Xin Hu Wenyong Miao Jiyan Zhang Zhebin Wang Guohong Yang Rongqing Yi Qi Tang Longyu Kuang Zhichao Li Dong Yang Yulong Li Xiaoshi Peng Kuan Ren Baohan Zhang | 2020 | Matter and Radiation at Extremes2020，5，3： | 2 |
| 17 | Spatial variability and temporal stability of actual evapotranspiration on a hillslope of the Chinese Loess Plateau显示文摘Actual evapotranspiration(ETa)is a key component of water balance.This study aimed to investigate the spatial variability and time stability of ETa along a hillslope and to analyze the key factors that control the spatiotemporal variability of ETa.The potential evaporation,surface runoff and 0–480 cm soil water profile were measured along a 243 m long transect on a hillslope of the Loess Plateau during the normal(2015)and wet(2016)water years.ETa was calculated using water balance equation.Results indicated that increasing precipitation during the wet water year did not alter the spatial pattern of ETa along the hillslope;time stability analysis showed that a location with high time stability of ETa could be used to estimate the mean ETa of the hillslope.Time stability of ETa was positively correlated with elevation(P<0.05),indicating that,on a hillslope in a semi-arid area,elevation was the primary factor influencing the time stability of ETa. | ZHANG Yongkun HUANG Mingbin | 2021 | Journal of Arid Land2021，13，2： | 2 |
| 18 | Existence of positive periodic solutions for difference equations with feedback control显示文摘 | Li Yongkun Zhu Lifei | 2005 | Applied Mathematics Letters2005，18，： | 1 |
| 19 | Oscillation of nonlinear hyperbolic equations with deviating arguments显示文摘 | LI Yongkun HUANG Yongming | 1997 | J of Yunnan Univ1997，19，5： | 1 |
| 20 | Anti-periodic solutions for Cohen-Grossberg neural networks with bounded and unbounded delay显示文摘 | Li Yongkun Yang Li | | 0，，07： | 1 |
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