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| 1 | Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity显示文摘We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimetics to block the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 histone methyltransferase activity.Our study has yielded cyclic peptidomimetics with very high binding affinities to WDR5(Kivalues <1 nmol/L) and function as antagonists of the MLL1 histone methyltransferase activity. | Hacer Karatas Shirley Y.Lee Elizabeth C.Townsend Fang Cao Jing Xu Denzil Bernard Liu Liu Yali Dou Shaomeng Wang | 2015 | Chinese Chemical Letters2015，26，4： | 3 |
| 2 | Study on the radial sheet beam electron optical system显示文摘 | Wang Shaomeng Gong Yubin Wei Yanyu | 2012 | IEEE Trans on Plasma Sci- ence2012，40，12： | 1 |
| 3 | Preclinicalstudies of a nonpeptidic small-moleculeinhibitor of Bcl-2 and Bcl-XL against diffuse large cell lymphoma显示文摘 | MOHAMMAD R M WANG Shaomeng ABOUKAMEEL A | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 4 | A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells显示文摘 | Hui Song Renxiao Wang Shaomeng Wang | 2005 | PNAS2005，102，13： | 1 |
| 5 | THz trapped ion model and THz spectroscopy detection of potassium channels显示文摘Advanced molecular dynamics(MD)simulation and infrared(IR)spectroscopy have been widely adopted to reveal the detailed dynamic process of high-speed selective permeability of potassium channels.Yet these MD simulations cannot avoid the choice of empirical molecular force fields and high transmembrane voltages(as driving electric fields for ions)far exceeding physiological levels.Moreover,the IR spectroscopy method usually requires isotope labels for carbonyl groups of the channels,which may change the original permeation process.Here,we build the terahertz(THz)trapped ion model for the selectivity filter(SF)of potassium channels KcsA based on the density functional theory(DFT)calculation of ion potentials.In this model,the zero-point energy of trapped ions and quantum tunneling effect provide the physical basis for near diffusion limited permeation rates of ions and explain the high driving electric field in MD simulations.Quantitative calculations of zero-point energy and tunneling probability show that the quantum effect assisted knock-on mechanism may help to realize the physiological functions of potassium channels.Furthermore,based on the trapped ion model,we calculated the ion decoherence timescale under the influence of protein environmental noise.We use the quantum optics method to describe the interaction between THz waves and the trapped ion.Then the novel THz spectroscopy approaches through the THz resonance fluorescence and the intense field non-resonant effect are presented theoretically.These are expected to be isotope label-free detective methods of the rapid ion permeation dynamics. | Kaicheng Wang Shaomeng Wang Lixia Yang Zhe Wu Baoqing Zeng Yubin Gong | 2022 | Nano Research2022，15，4： | 1 |
| 6 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 7 | Competitive and Reversible Binding of a Guest Molecule to Its Host in Aqueous Solution through Molecular Dynamics Simulatio: Benzyl Alcohol/b-Cyclodextrin System显示文摘 | Varady Judith Wu Xiongwu Wang Shaomeng | 2002 | J Phys Chem B2002，106，： | 1 |
| 8 | Research on thermal risk and decomposition behavior of methyl nitrite显示文摘The thermal hazards of methyl nitrite(MN)were investigated in the present study.The determination and evaluation of MN decomposition were conducted using a C600 micro thermometer.The thermal runaway reaction characteristics of the compound under different initial pressures were obtained using a VSP2 calorimeter.The kinetic parameters of MN were obtained by regression fitting and calculation of the microthermal experimental data.The experimental and calculated results demonstrated that the potential explosion risk of MN is very high.In addition,there was a high energy barrier in the early stage of the uncontrolled decomposition of MN;however,once the decomposition reaction was initiated,the subsequent decomposition was easily conducted.Under the conditions of adiabatic simulation,the possibility that the reaction was uncontrolled increases with the initial temperature and pressure of the system,and there is a great potential safety risk. | Haoyu Zhai Shaomeng Wang Diankun Chen Xuanying Cheng Chuanxin Xie | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 1 |
| 9 | Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2and Bcl-XL against diffuse large cell lymphoma显示文摘 | MOHAMMAD R M WANG Shaomeng ABOUKAMEEL A | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 10 | 20736-node weighted max-cut problem solving by quadrature photonic spatial Ising machine显示文摘The max-cut problem is one of the fundamental NP-hard problems in combinatorial optimization,which can describe the practical applications such as data clustering,machine scheduling,and image recognition.This problem can be formulated into an equivalent Ising model without local fields. | Xin YE Wenjia ZHANG Shaomeng WANG Xiaoxuan YANG Zuyuan HE | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
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