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| 1 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway显示文摘 | Youjun Li Hao Zhou Fengzhi Li Siew Wee Chan Zhijie Lin Zhiyi Wei Zhou Yang Fusheng Guo Chun Jye Lim Wancai Xing Yuequan Shen Wanjin Hong Jiafu Long Mingjie Zhang | 2015 | Cell Research2015，25，7： | 9 |
| 2 | Mouse models of colorectal cancer显示文摘Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer. | Yunguang Tong Wancai Yang H. Phillip Koeffler | 2011 | Chinese Journal of Cancer2011，30，7： | 7 |
| 3 | Bridging the US and China together to conquer cancer: report of the 4th annual meeting of the US Chinese Anti-Cancer Association (USCACA)显示文摘A global collaborative effort is pivotal to conquer cancer. Themed 'Emerging role of China in global clinical development of novel anti-cancer drugs', the US Chinese Anti-Cancer Association (USCACA) held its 4th annual meeting in Chicago on June 2, 2012, in conjunction with the American Society of Clinical Oncology (ASCO) annual meeting to further bridge the US and China together to outsmart cancer. Although a young organization, USCACA has made significant contributions to this goal in the 3 years since its inception through extensive collaboration with academic organizations, the pharmaceutical industry, and governmental agencies. USCACA has engaged various stakeholders in developing translational and personalized medical strategies to facilitate new anti-cancer drug development and clinical trials in China. USCACA has initiated and implemented the USCACA-National Foundation for Cancer Research (NFCR) scholarship to encourage overseas returnees to continue cancer research in China. USCACA announced the Hengrui-USCACA scholarship to fund clinical trial staff from China to conduct the observation of early oncologic clinical trials in the US. During the annual meeting, distinguished panelists and the audience discussed the following critical topics:(1) oncologic translational research and early development capabilities in China;(2) novel chemical entity development and partnership with Chinese companies; and (3) Chinese participation in global anti-cancer drug development. USCACA will continue to promote collaborations among cancer researchers and clinicians in the US and China by engaging in more frequent communications and joint efforts across fields, disciplines, and countries, diligently working together toward curing and eliminating cancers. | Wancai Yang Lingjie Guan | 2012 | Chinese Journal of Cancer2012，31，7： | 5 |
| 4 | Dehydration at subduction zones and the geochemistry of slab fluids显示文摘Subducting oceanic slabs undergo metamorphic dehydration with the increase of temperature and pressure during subduction.Dehydration is an essential step for element recycling,and slab fluids are critical agents for mediating slab-mantle interaction.Dehydration is mainly controlled by the thermal structure of subduction zones and the stability of hydrous minerals.At fore-arc depths,slab dehydration produces aqueous fluid with dissolved salts such as NaCl.As subduction proceeds deeper,the content of silicate components increases.At sub-arc and post-arc depths,a hydrous silicate melt is likely to form,or a supercritical fluid could arise from complete miscibility between silicates and H_(2)O.The partitioning of elements between slab fluid and the residual solid rock is controlled by the type of fluid,and generally it is the supercritical fluid that is the most capable of mobilizing trace elements,being an effective carrier even for high field strength elements.Understanding the chemistry of slab fluids relies on sophisticated integration of experiments,theoretical computation and investigation of natural rock samples.This contribution focuses on the content and speciation of key volatiles,including carbon,nitrogen and sulfur,in slab fluids as well as important fluid properties such as oxygen fugacity and acidity.The properties of slab fluids show complicated variation under the control of mineral assemblages and T-P conditions.Slab fluids at great depths of subductions have been inferred to be modestly alkaline and not necessarily very oxidizing as often assumed.Further progress in the research of slab dehydration and the chemistry and properties of slab fluids demands urgently the development of innovative experimental and computational technology including in situ analytical methods at high T-P. | Wancai Li Huaiwei Ni | 2020 | Science China Earth Sciences2020，63，12： | 3 |
| 5 | Metal ion-promoted fabrication of melanin-like poly(L-DOPA)nanoparticles for photothermal actuation显示文摘Melanin-inspired polymers are currently the focus of growing interest for a wide range of applications ranging from energy to biomedical area.Whilst researchers have made numerous attempts to prepare and utilize polydopamine nanoparticles(PDA NPs),they have made limited progress in developing and discovering another typical functional mimic of natural melanin,poly(levodopa)(P(L-DOPA))NPs,probably due to the lack of facile synthetic strategies towards satisfactory structural and functional control of melanin-like NPs.Herein,we reported a one-pot preparation method towards P(L-DOPA)NPs with good yields and controllable size/property in an aqueous solution assisted by various metal ions(i.e.,Ni(II),Mg(II),Ca(II),Fe(III),Mn(II),Co(II),Zn(II)and Cd(II)).Interestingly,the resulting P(L-DOPA)NPs exhibited enhanced light absorption and photothermal behaviors compared with well-established PDA NPs,which can be employed to further fabricate kinds of photothermal composite actuators with promising performances such as folding,switching,and forward-moving.This study offers a facile and robust way to synthesize new synthetic melanins beyond PDA,and facilitates further functional discovery and evolution of melanin-inspired polymers and composites. | Xianheng Wang Lei Yang Peng Yang Wancai Guo Quan-Ping Zhang Xianhu Liu Yiwen Li | 2020 | Science China Chemistry2020，63，9： | 3 |
| 6 | Biological functions of decorin in cancer显示文摘Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells. Accumulating evidence suggests that decorin affects the biology of various types of cancer by directly or indirectly targeting the signaling molecules involved in cell growth, survival, metastasis, and angiogenesis. More recent studies show that decorin plays important roles during tumor development and progression and is a potential cancer therapeutic agent. In this article, we summarize recent studies of decorin in cancer and discuss decorin′s therapeutic and prognostic value. | Xiu-Li Bi Wancai Yang | 2013 | Chinese Journal of Cancer2013，32，5： | 3 |
| 7 | Giant enhancement of photoluminescence quantum yield in 2D perovskite thin microplates by graphene encapsulation显示文摘The optoelectronic performances of the layered materials are strongly dependent on the thickness of the samples due to the surface effect.As the size of the samples decreases to few nanometers,the surface depletion field and surface defect density are prominent arising from the large surface to volume ratio.For instance,thin two-dimensional(2D)organic-inorganic hybrid perovskite microplates usually exhibit a rather low photoluminescence quantum yield(PLQY),owning to the strong surface effect.Here,we report that the PLQY can be enhanced as large as 28 times in(iso-BA)2Pbl4(BA=C4H9NH3)2D perovskite thin microplates encapsulated by graphene,resulting in that the PLQY is more than 18%for the microplate with a thickness of 6.7 nm at 78 K.As the thickness of the 2D perovskite microplate increases,the enhancement is gradually reduced and finally vanishes.This observation is in striking contrast to that in monolayer transition metal dichalcogenides(TMDs),when the PLQY is quenched by covering a layer of graphene due to the efficient charge transfer.The enhancement of PLQY in 2D perovskites can be mainly ascribed to the reduced quantum confined Stark effect(QCSE)due to the reduced surface depletion field after covering graphene flake,resulting in the enhanced radiative recombination efficiency.Our findings provide a cost-effective approach to enhance the luminescence,which may pave the way toward high performance light emitting devices based on 2D perovskites. | Wancai Li Jiaqi Ma Xue Cheng Dehui Li | 2021 | Nano Research2021，14，6： | 3 |
| 8 | ON EXTREMALITY AND UNIQUE EXTREMALITY OF TEICHMULLER MAPPINGS显示文摘ONEXTREMALITYANDUNIQUEEXTREMALITYOFTEICHMULLERMAPPINGS￥LAIWANCAI;WUZHEMINAbstract:ConsidertheTeichmullermappingfassociatedwit... | LAI WANCAI WU ZHEMIN(Department of Applied Mathematics, Hua Qiao Universityl Quanzhou 362011, Fujian, China.) | 1995 | Chinese Annals of Mathematics,Series B1995，16，3： | 2 |
| 9 | Methodological progress in trace amounts of structural water in nominally anhydrous minerals显示文摘In the deep Earth, hydrogen mainly occurs as structural hydroxyl and molecular water in minerals and melts, constituting mobile and immobile aqueous components. Hydrous minerals contain hydrogen which occupies a specific structural position and constitutes an indispensable component of chemical formulae. On the other hand, nominally anhydrous minerals do not contain hydrogen in their chemical formulae, but can host trace amounts of water in structural position and lattice defect. The molecular water may occur in the lattice defect as fluid/melt inclusions in minerals. Even though the water content of nominally anhydrous minerals is very limited generally in the order of ppm(parts per million), they may play a significant role in influencing the physicochemical properties of mineral and rock systems. With the continuous improvement of modern instrumentations, the analytical methodology exhibits trends for higher spatial resolution, lower detection limit and integral multiple methods on the water amount and its isotopic ratio. Among these methods, Fourier transform infrared spectrometry remains the most widely used, while secondary ion mass spectrometry, continuous flow mass spectrometry, elastic recoil detection analysis and Raman spectrometry are promising. This paper provides a brief review on the methodological progress and their applications to the analysis of structural water in nominally anhydrous minerals. | SHENG YingMing GONG Bing LI WanCai XIA Mei | 2016 | Science China Earth Sciences2016，59，5： | 2 |
| 10 | The USCACA hosted symposiums at the 7th CACA annual meeting and the 15th CSCO annual meeting in Beijing显示文摘In September 2012,the US Chinese Anti-Cancer Association(USCACA) hosted two symposiums in Beijing.The USCACA hosted the first joint session at the 7th annual meetings of the Chinese Anti-Cancer Association(CACA),themed on 'Collaboration between the US and China in Cancer Research.' Six experts from the United States and China presented their latest work on basic and translational cancer research.During this symposium,5 young Chinese scholars,returnees after their training in the United States,were honored the'AFCR-USCACA Scholarships Award.' The USCACA hosted a second symposium during the 15th annual meeting of the Chinese Society of Clinical Oncology(CSCO),focused on the 'US-China Collaboration in Cancer Drug Clinical Development.' An international delegation of oncology experts presented the innovative clinical trial strategies and discussed the biomarkers for cancer early detection and clinical trials,targeted therapy,and new drug development.The Oncology Drug Clinical Development and Safety Evaluation Committee was also launched to promote an innovative environment and to provide a collaborative platform for anti-cancer drug development in China. | Michael Shi Wancai Yang Pascal Qian Li Yan | 2012 | Chinese Journal of Cancer2012，31，11： | 2 |
| 11 | A review of water resources utilization and protection in Southwest China显示文摘Yunnan and Guizhou are two provinces in Southwest China where in recent years drought disasters have occurred due to natural and human factors. This paper reviewed literature and summarized the related achievements of water resources utilization and protection in Yunnan and Guizhou provinces. This included characters and utilization of precipitation, rivers, and karst ground water in the two provinces, and also the various explanations of drought(climate and human factors) and strategies for coping with droughts. Our concluding remarks highlight three lines of future studies: inequalities and equitable use of water distribution, better evaluation systems, and raising awareness through conservation practices. | CuiFang Wu Steve Déry WanCai Wu XueBin Liu JinHui Xiong WenQi Gao | 2015 | Research in Cold and Arid Regions2015，7，6： | 2 |
| 12 | Transforming growth factor-β1 induces glutathione peroxidase-1 and protectsfrom H2O2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1αpathway显示文摘 | Ying Huang Wenfeng Fang Yulei Wang Wancai Yang Bin Xiong | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 13 | On developing long-term meteorological prediction re search of crop pests and diseases prevailing in China显示文摘 | Huo Zhiguo(霍治国) Liu Wancai(刘万才) Shao Zhenrun(邵振润 ) | 2000 | Journal of Natural Disasters(自憝灾害学报)2000，9，1： | 1 |
| 14 | General image classification method based on semi-supervised generative adversarial networks显示文摘Generative adversarial networks(GANs) have become a competitive method among computer vision tasks. There have been many studies devoted to utilizing generative network to do generative tasks, such as images synthesis. In this paper, a semi-supervised learning scheme is incorporated with generative adversarial network on image classification tasks to improve the image classification accuracy. Two applications of GANs are mainly focused on: semi-supervised learning and generation of images which can be as real as possible. The whole process is divided into two sections. First, only a small part of the dataset is utilized as labeled training data. And then a huge amount of samples generated from the generator is added into the training samples to improve the generalization of the discriminator. Through the semi-supervised learning scheme, full use of the unlabeled data is made which may contain potential information. Thus, the classification accuracy of the discriminator can be improved. Experimental results demonstrate the improvement of the classification accuracy of discriminator among different datasets, such as MNIST, CIFAR-10. | 苏磊 Xu Xiangyi Lu Qiyu Zhang Wancai | 2019 | High Technology Letters2019，25，1： | 1 |
| 15 | Genomic analysis,trajectory tracking,and field surveys reveal sources and long-distance dispersal routes of wheat stripe rust pathogen in China显示文摘Identifying sources of phytopathogen inoculum and determining their contributions to disease outbreaks are essential for predicting disease development and establishing control strategies.Puccinia striiformis f.sp.tritici(Pst),the causal agent of wheat stripe rust,is an airborne fungal pathogen with rapid virulence variation that threatens wheat production through its long-distance migration.Because of wide variation in geographic features,climatic conditions,and wheat production systems,Pst sources and related dispersal routes in China are largely unclear.In the present study,we performed genomic analyses of 154 Pst isolates from all major wheat-growing regions in China to determine Pst population structure and diversity.Through trajectory tracking,historical migration studies,genetic introgression analyses,and field surveys,we investigated Pst sources and their contributions to wheat stripe rust epidemics.We identified Longnan,the Himalayan region,and the Guizhou Plateau,which contain the highest population genetic diversities,as the Pst sources in China.Pst from Longnan disseminates mainly to eastern Liupan Mountain,the Sichuan Basin,and eastern Qinghai;that from the Himalayan region spreads mainly to the Sichuan Basin and eastern Qinghai;and that from the Guizhou Plateau migrates mainly to the Sichuan Basin and the Central Plain.These findings improve our current understanding of wheat stripe rust epidemics in China and emphasize the need for managing stripe rust on a national scale. | Yuxiang Li Jichen Dai Taixue Zhang Baotong Wang Siyue Zhang Conghao Wang Jiguang Zhang Qiang Yao Mingju Li Chengyun Li Yuelin Peng Shiqin Cao Gangming Zhan Fei Tao Haifeng Gao Weili Huang Xiaojun Feng Yingwen Bai Zhuoma Qucuo Hongsheng Shang Chong Huang Wancai Liu Jiasui Zhan Xiangming Xu Xianming Chen Zhensheng Kang Xiaoping Hu | 2023 | Plant Communications2023，4，4： | 1 |
| 16 | Proanthocyanidins extracted from grape seeds inhibit the growth of hepatocellular carcinoma cells and induce apoptosis through the MAPK/AKT pathway显示文摘Proanthocyanidins naturally occur in various fruits,some vegetables and beverages.Increasing evidence has shown that dietary intake of proanthocyanidins is a promising alternative to tumor chemoprevention or chemotherapy.Grape seeds are the most abundant source of proanthocyanidins,and grape seed proanthocyanidins(GSPs)show an anticancer effect on hepatocellular carcinoma(HCC),which accounts for approximately 85-90%of all primary liver malignancies.Although an increasing number of studies have investigated the effects of GSPs on HCC and the associated mechanisms,the precise mechanism of GSP therapy in HCC remains unclear.This study aimed to understand the cytotoxic effect of GSPs on HepG2 cells by investigating morphology and growth inhibition.Cell proliferation and apoptosis were estimated by an MTT assay and flow cytometry,and the protein expression of HepG2 cells was determined through Western blotting.The results indicated that GSPs could markedly inhibit HepG2 liver cancer cells and induce apoptosis,with the effects varying by dose and treatment time.Furthermore,GSPs inhibited the phosphorylation of extracellular regulated protein kinases(ERK),c-Jun NH2-terminal kinase(JNK),p38 mitogen-activated protein kinase(p38 MAPK),IκBα,pyruvate dehydrogenase kinase 1(PDK1),glycogen synthase kinase-3 beta(GSK3β)and protein kinase B(AKT),which accounted for the inactivation of mitogen-activated protein kinase/AKT(MAPK/AKT)pathways.These results indicate that GSPs are a potential source of natural chemopreventive agents for the treatment of HCC. | Wancai Zheng a Yujing Feng Yujia Bai Zuoshan Feng Xijuan Yang Bin Dang Ming Xiao Jianmei Zhang Sheng-Qiang Han | 2022 | Food Bioscience2022，45，1： | 1 |
| 17 | Quasisymmetric boundary correspondence and Grtzsch problem显示文摘Two necessary and sufficient conditions for the validity of the conjecture K 0(h)=K 1(h) are given, which are independent of the complex dilatations of extremal quasiconformal mappings, where K 0(h) is the maximal conformal modulus dilatation of the boundary homeomorphism h, K 1(h) is the maximal dilatation of extremal quasiconformal mappings that agree with h on the boundary. In addition, when the complex dilatation of an extremal quasiconformal mapping is known, the proof of the result simplifies Reich and Chen Jixiu-Chen Zhiguo’s result. | WU Zemin 1 and LAI Wancai 2 1. Department of Applied Mathematics, Shanghai Jiaotong University, Shanghai 200240, China 2. Department of Mathematics, Huaqiao University, Quanzhou 362011, China | 1998 | Chinese Science Bulletin1998，43，12： | 1 |
| 18 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 19 | Soy isoflavones and prostate cancer: a review of molecular mechanisms显示文摘 | Mahmoud Abeer M Yang Wancai Bosland Maarten C | 2014 | The Journal of Steroid Biochemistry and Molecular Biology2014，140，： | 1 |
| 20 | Soy isoflavones and prostate cancer: A review of molecular mechanisms显示文摘 | Abeer M. Mahmoud Wancai Yang Maarten C. Bosland | 2013 | Journal of Steroid Biochemistry and Molecular Biology2013，，： | 1 |
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