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| 1 | Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea显示文摘在内耳的感觉毛细胞为健全识别负责。因为这些房间不能再生,在成年哺乳动物的毛细胞的损坏引起永久听觉缺陷。由对比,因为各种各样的发信号的小径的活跃参予,新生的哺乳动物拥有有限再生能力,包括 Wnt 并且槽口发信号。Wnt 和槽口小径高度复杂、保存表明控制为感觉毛细胞的形成必要的多重细胞的事件的小径。两个都发信号的小径允许支持房间在新生的蜗改革毛细胞的居民。在这方面, Wnt 并且槽口发信号在毛细胞新生获得了增加的研究注意。这评论在内耳的听觉的部分介绍 Wnt 和槽口发信号小径的当前的理解并且讨论与毛细胞命运限定词 Atoh1 控制这些小径在哺乳动物的蜗调整毛细胞新生的可能性。 | Muhammad Waqas Shasha Zhang Zuhong He Mingliang Tang Renjie Chai | 2016 | Frontiers of Medicine2016，10，3： | 7 |
| 2 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 3 | Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia-reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination显示文摘Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention(PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling significantly contribute to poor prognosis and rehabilitation in AMI patients. We revealed the effects of HSP47 on myocardial ischemia-reperfusion injury(IRI) and shed light on the underlying molecular mechanism.We generated adult mice with lentivirus-mediated or miRNA(mi1/133TS)-aided cardiac fibroblastselective HSP47 overexpression. Myocardial IRI was induced by 45-min occlusion of the left anterior descending(LAD) artery followed by 24 h reperfusion in mice, while ischemia-mediated cardiac remodeling was induced by four weeks of reperfusion. Also, the role of HSP47 in fibrogenesis was evaluated in cardiac fibroblasts following hypoxia-reoxygenation(HR). Extensive HSP47 was observed in murine infarcted hearts, human ischemic hearts, and cardiac fibroblasts and accelerated oxidative stress and apoptosis after myocardial IRI. Cardiac fibroblast-selective HSP47 overexpression exacerbated cardiac dysfunction caused by chronic myocardial IRI and presented deteriorative fibrosis and cell proliferation.HSP47 upregulation in cardiac fibroblasts promoted TGFβ1-Smad4 pathway activation and Smad4 deubiquitination by recruiting ubiquitin-specific peptidase 10(USP10) in fibroblasts. However, cardiac fibroblast specific USP10 deficiency abolished HSP47-mediated fibrogenesis in hearts. Moreover, blockage of HSP47 with Col003 disturbed fibrogenesis in fibroblasts following HR. Altogether, cardiac fibroblast HSP47 aggravates fibrosis post-myocardial IRI by enhancing USP10-dependent Smad4 deubiquitination,which provided a potential strategy for myocardial IRI and cardiac remodeling. | Saiyang Xie Yun Xing Wenke Shi Min Zhang Mengya Chen Wenxi Fang Shiqiang Liu Tong Zhang Xiaofeng Zeng Si Chen Shasha Wang Wei Deng Qizhu Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 4 | Fabrication and luminescence of KGdF_4:Yb^(3+)/Er^(3+) nanoplates and their improving performance for polymer solar cells显示文摘Solar energy remains the most abundant renewable energy resource available to us[1].Continuous efforts have been invested to enhance the conversion of light to electricity by the diverse range of applications[2].Especially,polymer solar cells(PSCs)have reminded extensive attention own to flexibility,light-weight | Jiqing Jiao Yao Li Wenfei Shen Shasha Gai Jianguo Tang Yao Wang Linjun Huang Jixian Liu Wei Wang Laurence A.Belfiore | 2018 | Science Bulletin2018，63，4： | 2 |
| 5 | Humidity-control assists high-efficient coal fly ash removal by PTFE membrane显示文摘In the present study,the effects of relative humidity on filtrating coal-fired fly ash with hydrophobic poly tetra fluoroethylene(PTFE) membranes were investigated.The intergranular force of particulate matter at different RH conditions was measured by analyzing the critical angle between particles.Effects of humidity(from 30% to 70%) on filtration pressure drop and membrane fouling conditions were characterized.It was found the membrane showed optimal filtration resistance of 530 Pa at RH of 60% and the gas permeance can be maintained at 1440 m^(3)·m^(-2)·h^(-1)·kPa^(-1).Moreover,to optimize the operation parameters for this filtration system,effects of fly ash concentration,diameter,membrane pore size,and gas velocities were systematically investigated. | Dongyan Li Xi Tang Shasha Feng | 2021 | Chinese Journal of Chemical Engineering2021，34，12： | 2 |
| 6 | Influence of Spatial-Temporal and Environmental Factors on Larimichthys polyactis, Octopus variabilis, and Species Aggregated Set-Net CPUEs in Haizhou Bay, China显示文摘Set-nets are common alongshore fishing gear used in Haizhou Bay, which rely on flow to catch fish. The catch per unit effort(CPUE) of set-net is affected by spatial-temporal and environmental factors but no research has been conducted on this subject. In this study, we used generalized additive models(GAMs) to explore the influence of spatial-temporal and environmental factors on CPUEs of species aggregated, small yellow croaker(Larimichthys polyactis), and octopus(Octopus variabilis) based on logbooks investigations conducted at 4 stations in an alongshore area of Haizhou Bay from 2011 to 2012. The results showed that all CPUEs exhibited significant spatial-temporal differences at various scales. Aggregated CPUE was high when the sea surface temperature(SST) was 15-18℃ and 20-23℃, which was mainly determined by life history traits of the octopus and small yellow croaker(optimal SSTs 14-17℃ and 19-24℃, respectively). Chlorophyll-a concentration had significant influences on the aggregated, small yellow croaker and octopus CPUEs at optimal ranges of 3.8-6.2 mg m^(-3), 4.2-4.8 mg m^(-3) and 4.5-5.5 mg m^(-3), respectively. Flow through the net had positive relationships with CPUEs. The approximate logarithmic trends in regression curves had a critical point of 2.5 Mm^3 d^(-1), which was the dividing point that differentiated whether the major factor affecting CPUEs was the flow velocity or the fishery resource. Our results from this study will help guide fishery production and improve catch rate of set-net fishing in Haizhou Bay. | TANG Yanli MA Shuyang LIU Changdong WANG Xinmeng CHENG Shasha | 2018 | Journal of Ocean University of China2018，17，4： | 2 |
| 7 | A comparative study on the pollen viability and storage conditions of the nuclear and non - nuclear varieties显示文摘The fresh dried pollen of grape and seedless grape varieties were used as the research material. Each cultivar was stored at room temperature, 5 C, 0 C,-18 C and -40 C respectively. Sucrose 200g / L + boric acid 50mg / L + agar 8g / L as the nutrient substrate, and the comparative study on the germination and culture of the nuclear breed and the seedless cultivar. The results showed that the pollen viability decreased with the increase of storage time at diff erent temperatures. The pollen viability decreased at -18 C and -40 , and the pollen viability decreased at the same temperature The There was a signifi cant diff erence in pollen viability between diff erent cultivars at the beginning of storage, and the pollen viability of the kernel breed was higher than that of the seedless grape. | Shasha Tang Yuling Huang Xiao Fu | 2018 | Trends in Horticulture2018，1，1： | 1 |
| 8 | Transplantation of neural progenitor cells differentiated from adipose tissue-derived stem cells for treatment of sciatic nerve injury显示文摘Objectives: Currently, the clinical repair of sciatic nerve injury remains difficult.Previous studies have confirmed that transplantation of adipose tissue-derived stem cells promotes nerve regeneration and restoration at peripheral nerve injury sites. Methods: In this study, adipose tissue-derived stem cells were induced to differentiate into neural progenitor cells, transfected with a green fluorescent protein-containing lentivirus, and then transplanted into the lesions of rats with sciatic nerve compression injury. Results: Fluorescence microscopy revealed that the transplanted cells survived,migrated, and differentiated in rats. At two weeks post-operation, a large number of transplanted cells had migrated to the injured lesions; at six weeks post-operation, transplanted cells were visible around the injured nerve and several cells were observed to express a Schwann cell marker. Sciatic function index and electrophysiological outcomes of the transplantation group were better than those of the control group. Cell transplantation promoted the recovery of motor nerve conduction velocity and compound muscle action potential amplitude, and reduced gastrocnemius muscle atrophy.Conclusions: Our experimental findings indicate that neural progenitor cells,differentiated from adipose tissue-derived stem cells, are potential seed stem cells that can be transplanted into lesions to treat sciatic nerve injury. This provides a theoretical basis for their use in clinical applications. | Shasha Dong Na Liu Yang Hu Ping Zhang Chao Pan Youping Zhang Yingxin Tang Zhouping Tang | 2016 | Translational Neuroscience and Clinics2016，2，2： | 1 |
| 9 | Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells显示文摘 | Qingning Bian Shasha Gao Jilin Zhou Jian Qin Allen Taylor Elizabeth J. Johnson Guangwen Tang Janet R. Sparrow Dennis Gierhart Fu Shang | 2012 | Free Radical Biology and Medicine2012，，6： | 1 |
| 10 | The synthesis of MOF derived carbon and its application in water treatment显示文摘In recent years,since water pollution has aroused great public concern,various carbon materials have already been widely applied for water treatment.In this respect,tremendous effort has been made to provide different synthesis methods of carbon materials.Among all carbon materials,metal-organic framework(MOF)derived carbon has always been favored as it possesses several appealing merits such as high specific surface area,large pore volume,and outstanding chemical stability.This review presents the latest development of MOFs as templates and precursors for the fabrication of various carbon materials,including porous carbon,nanocarbon,and graphene,which are pyrolyzed at different temperatures.The article also emphasizes on their future trends and perspectives on the application of water treatment. | Jiani Ding Yijian Tang Shasha Zheng Songtao Zhang Huaiguo Xue Qingquan Kong Huan Pang | 2022 | Nano Research2022，15，8： | 1 |
| 11 | Enhancing the cycling stability of Na-ion batteries by bonding MoS2 on assembled carbon-based materials显示文摘Room temperature Na-ion batteries(SIBs) show great potential for use as renewable energy storage systems.However, the large-scale application of SIBs has been hindered by the lack of an ideal SIBs anode material. We synthesized MoS2 on carbonized graphene-chitosan(G-C) using the hydrothermal method. The strong interaction between the MoS2 and the G-C greatly improved the electron transport rate and maintained the structural stability of the electrode, which lead to both an excellent rate capability and long cycle stability. The G-C monolith was proven to enhance the electrical conductivity of the composites and served as a matrix for uniformly dispersing active MoS2 nanosheets(NSs), as well as being a buffer material to adapt to changes in volume during the cycle.Serving as an anode material for SIBs, the MoS2-G-C electrode showed good cycling stability(527.3mAh g-1 at100 m A g-1 after 200 cycles), excellent rate capability, and a long cycle life(439.1 m Ah g-1 at 1 A g-1 after 200 cycles). | Pin Song Jun Di Lixing Kang Manzhang Xu Bijun Tang Jun Xiong Jiewu Cui Qingsheng Zeng Jiadong Zhou Yongmin He Qundong Fu Juan Peng Shasha Guo Bo Lin Jingyu Zhang Peng Meng Zheng Liu | 2019 | Nano Materials Science2019，1，4： | 0 |
| 12 | Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2显示文摘Protein kinase CK2 consists of two catalytic subunits (CK2α) and two regulatory subunits (CK2β). Here, we report the crystal structures of rat CK2α mutant (rCK2α-△C, 1—335) and CK2β (rCK2β). The overall topology of rCK2α-△C and rCK2β are very similar to the human enzyme, although large structural differences could be observed in the N-terminal domain of rCK2α-△C. Our reported structure of rCK2α-△C is in the close conformation state while the counterpart hCK2α is in the open conformation state, indi- cating the conformation of CK2α molecule has high plasticity. The structure of rCK2β represents the conformation of free CK2β. Upon CK2α binding, the C-terminal region undergoes a drastic conformational change. The major region of interaction within the interface of CK2α/CK2β may serve as a bridge to transmit the conformational change and thus regulate the activity of CK2α. | ZHOU WeiHong QIN XiaoHong YAN XiaoJie XIE XingQiao LI Liang FANG ShaSha LONG JiaFu ADELMAN John TANG Wei-Jen SHEN YueQuan | 2009 | Chinese Science Bulletin2009，54，2： | 0 |
| 13 | Risk factors of major intraoperative bleeding and postoperative bleeding associated with endoscopic submucosal dissection for gastric neoplasms显示文摘Background:Endoscopic resection bleeding(ERB)classification was proposed by the authors’team to evaluate the severity of intraoperative bleeding(IB)during endoscopic submucosal dissection(ESD).This study aimed to evaluate the application of ERB classification and to analyze the risk factors of major IB(MIB)and postoperative bleeding(PB)associated with ESD for gastric neoplastic lesions.Methods:We retrospectively enrolled a total of 1334 patients who underwent ESD between November 2006 and September 2019 at The First Medical Center of Chinese People’s Liberation Army General Hospital.All patients were divided into the non-MIB group(including ERB-0,ERB-controlled 1[ERB-c1],and ERB-c2)and the MIB group(including ERB-c3 and ERB-uncontrolled[ERB-unc])according to the ERB classification.Risk factors of major MIB and risk factors of PB were analyzed using a logistic regression model.Results:Among the 1334 patients,773(57.95%)had ERB-0,477(35.76%)had ERB-c1,77(5.77%)had ERB-c2,7(0.52%)had ERB-c3,and no patients had ERB-unc.The rate of PB in patients with IB classifications of ERB-0,ERB-c1,ERB-c2,and ERB-c3 were 2.20%(17/773),3.35%(16/477),9.09%(7/77),and 2/7,respectively.In multivariate analysis,proximal location(odds ratio[OR]:1.488;95%confidence interval[CI]:1.045-3.645;P=0.047)was the only significant risk factor of MIB.Chronic kidney disease(CKD)(OR:7.844;95%CI:1.637-37.583;P=0.010)and MIB(ERB-c3)(OR:13.932;95%CI:2.585-74.794;P=0.002)were independent risk factors of PB.Conclusions:Proximal location of lesions was a significant risk factor of MIB.Additionally,CKD and MIB(ERB-c3)were independent risk factors of PB.More attention should be paid to these high-risk patients for MIB and PB. | Shanshan Xu Ningli Chai Xiaowei Tang Enqiang Linghu Shasha Wang | 2022 | Chinese Medical Journal2022，，3： | 0 |
| 14 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 15 | AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina显示文摘Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and choroid.Interestingly,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in RPE.To date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating HDAC1.Consequently,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−mice.Methods:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6J mice.The thicknesses of their choroid were evaluated by immunohistochemistry.Meanwhile,Q-PCR,western blot and choroid sprout assay were performed.In vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for treatments.Results:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of choroid.In the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their controls.For Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity assay.Conclusions:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the subretina.This novel discovery sheds new light on the relationship between metabolism and epigenetic modification. | Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv Suna Jung Francois Duhamel Houda Tahiri Samy Omri Baraa Noueihed Xin Hou JoséCarlos Rivera Mathieu Nadeau-Vallée Pierre Lachapelle Sylvain Chemtob | 2018 | Annals of Eye Science2018，，1： | 0 |
| 16 | Energy band engineering of Bi_(2)O_(2.33)–CdS direct Z-scheme heterojunction for enhanced photocatalytic reduction of CO_(2)显示文摘In this work,a Bi_(2)O_(2.33)–CdS direct Z-scheme heterojunction was fabricated based on energy band engineering.The Bi_(2)O_(2.33)core nanoflakes were first synthesized by electrodeposition which was followed by an annealing process to fabricate this heterojunction.Then the Cd S shell was deposited on Bi_(2)O_(2.33)nanoflakes utilizing the solution method,during which a suitable concentration of Cd Clsolution was used for forming a homogeneous and continuous integrated CdS shell.A space charge region and an internal electric field from CdS(+)to Bi_(2)O_(2.33)(-),which drove a direct Z-scheme charge transfer process,were formed at the interface.The Bi_(2)O_(2.33)–CdS exhibited excellent photocatalytic performance for CO_(2)reduction mainly attributed to the satisfactory photoinduced charge separation and transport efficiency in the direct Z-scheme heterojunction.The photocatalytic CO_(2)reduction ability of Bi_(2)O_(2.33)–CdS was significantly enhanced compared with single Bi_(2)O_(2.33)or Cd S,with a CO_(2)yield rate of ca.2.9μmol/(cm^(2)h)under a 300 W Xe lamp.The reduction of CO_(2)to CO_(2)demonstrated 94.0%selectivity. | Guojing Wang Zhiwei Tang Jing Wang Shasha Lv Yunjie Xiang Feng Li Chong Liu | 2022 | Journal of Materials Science & Technology2022，，16： | 0 |
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