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| 1 | Impact of lymph node micrometastasis in hilar bile duct carcinoma patients显示文摘瞄准:组织化学地在门胆汁管癌(HBDC ) 并且到检验微转移和 VEGF-C 表示到免疫评估结果的临床的意义。方法:从有节点否定的 HBDC 的 25 个病人的 361 个地区性的淋巴节点的一个总数是对 cytokeratins 与抗体染色的免疫 8 和 18 (凸轮 5.2 ) ,并且免疫 VEGF-C 的组织化学的染色在 34 个主要 resected 肿瘤被执行。结果:淋巴节点微转移在 6 被检测(24%) 25 个病人并且 10 (2.8%) 361 个淋巴节点。没有,有微转移的病人比那些显示出显著地更差的幸存率(P = 0.025 ) 。VEGF-C 表示是积极的在里面(50%) 17 与淋巴节点转移 34 HBDC,并且显著地相关(P = 0.042 ) 并且显微镜的静脉的侵略(P = 0.035 ) 。结论:免疫组织化学地检测了微转移影响的淋巴节点,这被建议 HBDC 的结果。VEGF-C 表示高度在 HBDC 与淋巴节点转移被相关并且可能因此是一个有用预言者。 | Kentaro Taniguchi Taku Iida Tomohide Hori Shintaro Yagi Hiroshi Imai Taizo Shiraishi Shinji Uemoto | 2006 | World Journal of Gastroenterology2006，12，16： | 9 |
| 2 | Triple pelvic osteotomy: Report of our mid-term results and review of literature显示文摘A wide variety of pelvic osteotomies have been developed for the treatment of developmental dysplasia of the hip(DDH). In the present paper, we present a detailed review of previous studies of triple osteotomy as an alternative treatment for DDH. We also report our experience treating 6 adult cases of DDH by triple osteotomy in order to highlight the various aspects of this procedure.The mean age of our patients was 31.2 years with a mean follow-up period of 6 years. We assessed range of motion, center-edge angle, acetabular index angle, Sharp angle, acetabulum head index, head lateralization index, Japanese Orthopedic Association score, Harris hip score, patient satisfaction, and the difference between lower limb lengths before and after the procedure. At final follow-up, clinical scores were significantly improved and radiographic parameters also showed good correction of acetabulum. | Tomohiro Mimura Kanji Mori Taku Kawasaki Shinji Imai Yoshitaka Matsusue | 2014 | World Journal of Orthopedics2014，5，1： | 4 |
| 3 | Intracystic hemorrhage of a simple liver cyst mimicking a biliary cystadenocarcinoma显示文摘 | Yasuhiro Kitajima Yasutaka Okayama Masaaki Hirai Kazuki Hayashi Hideto Imai Tetsu Okamoto Shigeru Aoki Shinji Akita Kazuo Gotoh Hirotaka Ohara Tomoyuki Nomura Takashi Joh Yoshifumi Yokoyama Makoto Itoh | 2003 | Journal of Gastroenterology2003，，2： | 1 |
| 4 | Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin显示文摘 | Tsugiko Oze Naoki Hiramatsu Changho Song Takayuki Yakushijin Sadaharu Iio Yoshinobu Doi Masahide Oshita Hideki Hagiwara Eiji Mita Toshifumi Ito Yoshiaki Inui Taizo Hijioka Shinji Tamura Harumasa Yoshihara Atsuo Inoue Yasuharu Imai Eijiro Hayashi Michio Ka | 2012 | Journal of Gastroenterology2012，，3： | 1 |
| 5 | Design, synthe- sis, and evaluation of cyclic amide/imide-bearinghydroxamic acid derivatives as class-selective histone deacetylase ( HDAC ) inhibitors 显示文摘 | SHINJI C MAEDA S IMAI K | 2006 | Bioorg Med Chem2006，14，22： | 1 |
| 6 | Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility显示文摘 | Heikki Rauvala Henri J. Huttunen Carole Fages Marko Kaksonen Tarja Kinnunen Shinji Imai Erkki Raulo Ilkka Kilpel?inen | 2000 | Matrix Biology2000，，5： | 1 |
| 7 | Rc-cormtruction method after plications 显示文摘 | Shinji Osada Hisashi Imai Yoshiyuki Sasaki | 2012 | J Pancreas2012，13，1： | 1 |
| 8 | A mutated superantigen SEA D227A fusion diabody specific to MUC1 and CD3 in targeted cancer immunotherapy for bile duct carcinoma显示文摘 | Shin-ichi Takemura Toshio Kudo Ryutaro Asano Masanori Suzuki Kouhei Tsumoto Naoki Sakurai Yu Katayose Hideaki Kodama Hiroshi Yoshida Shinji Ebara Hisaaki Saeki Kohzoh Imai Seiki Matsuno Izumi Kumagai | 2002 | Cancer ImmunologyImmunotherapy2002，，1： | 1 |
| 9 | Extracellular signal-regulated kinase and Akt activation play a criticalrole in the process of hepatocyte growth factor-induced epithelial-mesenchymaltransition显示文摘 | Toshiyuki Tanahashi Shinji Osada Atsuko Yamada Junko Kato Kazunori Yawata Ryutaro Mori Hisashi Imai Yoshiyuki Sasaki Shiro Saito Yoshihiro Tanaka Kenichi Nonaka Kazuhiro Yoshida | 2013 | International Journal of Oncology2013，，2： | 1 |
| 10 | Intracystic hemorrhage of a simple liver cyst mimicking a biliary cystadenocarcinoma显示文摘 | Yasuhiro Kitajima Yasutaka Okayama Masaaki Hirai Kazuki Hayashi Hideto Imai Tetsu Okamoto Shigeru Aoki Shinji Akita Kazuo Gotoh Hirotaka Ohara Tomoyuki Nomura Takashi Joh Yoshifumi Yokoyama Makoto Itoh | 2003 | Journal of Gastroenterology2003，，2： | 1 |
| 11 | Extracellular signal-regulated kinase and Akt activation play a criticalrole in the process of hepatocyte growth factor-induced epithelial-mesenchymaltransition显示文摘 | Toshiyuki Tanahashi Shinji Osada Atsuko Yamada Junko Kato Kazunori Yawata Ryutaro Mori Hisashi Imai Yoshiyuki Sasaki Shiro Saito Yoshihiro Tanaka Kenichi Nonaka Kazuhiro Yoshida | 2013 | International Journal of Oncology2013，，2： | 1 |
| 12 | Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors 显示文摘 | SHINJI C MAEDA S IMAI K | 2006 | Bioorganic & Medicinal Chemistry2006，14，22： | 1 |
| 13 | Spinal glioblastoma multiforme of the conus medullaris with holocordal and intracranial spread in a child: a case report and review of the literature显示文摘 | Kanji Mori Shinji Imai Junji Shimizu Takashi Taga Mitsuaki Ishida Yoshitaka Matsusue | 2012 | The Spine Journal2012，，1： | 1 |
| 14 | Design, synthe- sis, and evaluation of cyclic amide/imide--bearing hydroxamie acid derivatives as class- selective histone deacetyIase (HDAC) in- hibitors 显示文摘 | Chihiro Shinji Satoko Maeda Keisuke Imai | 2006 | Bioorganic 8 Medicinal Chemistry2006，14，： | 1 |
| 15 | Preoperative assessment of para-aortic lymph node metastasis in patients with pancreatic cancer显示文摘 | Hisashi Imai Ryuichiro Doi Hiroyuki Kanazawa Naoko Kamo Masayuki Koizumi Toshihiko Masui Yasuhiro Iwanaga Yoshiya Kawaguchi Yasutsugu Takada Hiroyoshi Isoda Shinji Uemoto | 2010 | International Journal of Clinical Oncology2010，，3： | 1 |
| 16 | IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions显示文摘AIM:To investigate insulin-like growth factor 2(IGF2)differentially methylated region(DMR)0 hypomethylation in relation to clinicopathological and molecular features in colorectal serrated lesions.METHODS:To accurately analyze the association between the histological types and molecular features of each type of serrated lesion,we consecutively collected1386 formalin-fixed paraffin-embedded tissue specimens that comprised all histological types[hyperplastic polyps(HPs,n=121),sessile serrated adenomas(SSAs,n=132),traditional serrated adenomas(TSAs,n=111),non-serrated adenomas(n=195),and colorectal cancers(n=827)].We evaluated the methylation levels of IGF2 DMR0 and long interspersed nucleotide element-1(LINE-1)in HPs(n=115),SSAs(n=120),SSAs with cytological dysplasia(n=10),TSAs(n=91),TSAs with high-grade dysplasia(HGD)(n=15),non-serrated adenomas(n=80),non-serrated adenomas with HGD(n=105),and CRCs(n=794).For the accurate quantification of the relative methylation levels(scale 0%-100%)of IGF2 DMR0 and LINE-1,we used bisulfite pyrosequencing method.Tumor specimens were analyzed for microsatellite instability,KRAS(codons 12 and 13),BRAF(V600E),and PIK3CA(exons 9and 20)mutations;MLH1 and MGMT methylation;and IGF2 expression by immunohistochemistry.RESULTS:The distribution of the IGF2 DMR0 methylation level in 351 serrated lesions and 185 non-serrated adenomas(with or without HGD)was as follows:mean61.7,median 62.5,SD 18.0,range 5.0-99.0,interquartile range 49.5-74.4.The IGF2 DMR0 methylation level was divided into quartiles(Q1≥74.5,Q2 62.6-74.4,Q3 49.6-62.5,Q4≤49.5)for further analysis.With regard to the histological type,the IGF2 DMR0 methylation levels of SSAs(mean±SD,73.1±12.3)were significantly higher than those of HPs(61.9±20.5),TSAs(61.6±19.6),and non-serrated adenomas(59.0±15.8)(P<0.0001).The IGF2 DMR0 methylation level was inversely correlated with the IGF2 expression level(r=-0.21,P=0.0051).IGF2 DMR0 hypomethylation was less frequently detected in SSAs compared with HPs,TSAs,and non-serrated adenomas(P<0.0001).Multivariate logistic regression analysis also showed that IGF2 DMR0 hypomethylation was inversely associated with SSAs(P<0.0001).The methylation levels of IGF2 DMR0 and LINE-1 in TSAs with HGD(50.2±18.7and 55.7±5.4,respectively)were significantly lower than those in TSAs(61.6±19.6 and 58.8±4.7,respectively)(IGF2 DMR0,P=0.038;LINE-1,P=0.024).CONCLUSION:IGF2 DMR0 hypomethylation may be an infrequent epigenetic alteration in the SSA pathway.Hypomethylation of IGF2 DMR0 and LINE-1 may play a role in TSA pathway progression. | Takafumi Naito Katsuhiko Nosho Miki Ito Hisayoshi Igarashi Kei Mitsuhashi Shinji Yoshii Hironori Aoki Masafumi Nomura Yasutaka Sukawa Eiichiro Yamamoto Yasushi Adachi Hiroaki Takahashi Masao Hosokawa Masahiro Fujita Toshinao Takenouchi Reo Maruyama Hiromu Suzuki Yoshifumi Baba Kohzoh Imai Hiroyuki Yamamoto Shuji Ogino Yasuhisa Shinomura | 2014 | World Journal of Gastroenterology2014，20，29： | 0 |
| 17 | Micropulse laser trabeculoplasty under maximal tolerable glaucoma eyedrops:treatment effectiveness and impact of surgical expertise显示文摘AIM:To evaluate the effectiveness of micropulse laser trabeculoplasty(MLT)for eyes with open angle glaucoma(OAG)under maximal tolerable glaucoma eyedrops and to assess the effect of expertise performing MLT on its clinical effectiveness.METHODS:Medical records of 42 consecutive eyes of 34 patients diagnosed with OAG who underwent MLT were retrospectively reviewed.The effectiveness was determined using the Kaplan-Meier survival analysis.Failure was defined as an intraocular pressure(IOP)reduction of<20%from baseline,an IOP>21 mm Hg during two consecutive follow-up visits,or surgical intervention for OAG.To determine the impact of MLT surgical expertise on clinical effectiveness,the eyes were divided into two groups according to whether the procedure was conducted by an experienced specialist(defined as a glaucoma specialist who had conducted at least ten MLT procedures)or a less experienced glaucoma specialist.The difference in expertise was determined using a log-rank test.RESULTS:MLT was conducted by three glaucoma specialists.The overall survival rates were 0.76,0.48,and 0.44 at 1,3,and 6 mo,respectively.The survival rates for MLT performed by a less experienced glaucoma specialist were 0.62,0.31,and 0.25(n=21 eyes)at 1,3,and 6 mo,respectively,whereas the survival rates for MLT performed by an experienced glaucoma specialist were 0.90,0.64,and 0.64(n=21 eyes)at 1,3,and 6 mo,respectively.The log-rank test showed a significant difference in the survival curves of the two groups(P=0.0061).CONCLUSION:The 6-month effectiveness of MLT for controlling IOP is relatively limited in eyes with OAG using maximal tolerable glaucoma eyedrops.However,its effectiveness may be improved if performed by a glaucoma specialist with sufficient MLT experience. | Shinji Kakihara Takao Hirano Akira Imai Taihei Kurenuma Yoshiaki Chiku Toshinori Murata | 2021 | International Journal of Ophthalmology(English edition)2021，14，3： | 0 |
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