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| 1 | Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer显示文摘Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer(DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection,change of inflammatory responses, lack of extracellular matrix(ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient(API)or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing(ND)that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU. | Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 10 |
| 2 | Effect of Shengmai Yin on the DNA methylation status of nasopharyngeal carcinoma cell and its radioresistant strains显示文摘Shengmai Yin(SMY)is a Chinese herbal decoction that effectively alleviates the side effects of radiotherapy in various cancers and helps achieve radiotherapy’s clinical efficacy.In this study,we explored the interaction mechanism among SMY,DNA methylation,and nasopharyngeal carcinoma(NPC).We identified differences in DNA methylation levels in NPC CNE-2 cells and its radioresistant cells(CNE-2R)using the methylated DNA immunoprecipitation array and found that CNE-2R cells showed genomewide changes in methylation status towards a state of hypomethylation.SMY may restore its original DNA methylation status,and thus,enhance radiosensitivity.Furthermore,we confirmed that the differential gene Tenascin-C(TNC)was overexpressed in CNE-2R cells and that SMY downregulated TNC expression.This downregulation of TNC inhibited NPC cell radiation resistance,migration,and invasion.Furthermore,we found that TNC was hypomethylated in CNE-2R cells and partially restored to a hypermethylated state after SMY intervention.DNA methyltransferases 3 a may be the key protein in DNA methylation of TNC. | Shiya Liu Zhiyuan Wang Daoqi Zhu Jiabin Yang Dandan Lou Ruijiao Gao Zetai Wang Aiwu Li Ying Lv Qin Fan | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 4 |
| 3 | Microbiologically influenced corrosion of Cu by nitrate reducing marine bacterium Pseudomonas aeruginosa显示文摘The microbiologically influenced corrosion(MIC) mechanisms of copper by Pseudomonas aeruginosa as a typical strain of nitrate reducing bacteria(NRB) was investigated in this lab study.Cu was immersed in deoxygenated LB-NO3 seawater inoculated with P.aeruginosa and incubated for 2 weeks.Results showed that this NRB caused pitting and uniform corrosion.The maximum pit depths after 7 d and 14 d in125 mL anaerobic vials with 50 mL broth were 5.1 μm and 9.1 μm,accompanied by specific weight losses of 1.3 mg/cm2(7 d) and 1.7 mg/cm2(14 d),respectively.Electrochemical measurements corroborated weight loss and pit depth data trends.Experimental results indicated that extracellular electron transfer for nitrate reduction was the main MIC mechanism and ammonia secreted by P.aeruginosa could also play a role in the overall Cu corrosion process. | Yanan Pu Wenwen Dou Tingyue Gu Shiya Tang Xiaomei Han | 2020 | Journal of Materials Science & Technology2020，47，12： | 3 |
| 4 | Recent advances in fire-retardant carbon-based polymeric nanocomposites through fighting free radicals显示文摘Polymeric materials are ubiquitously utilized in modern society and continuously improve quality of life.Unfortunately,most of them suffer from intrinsic flammability,significantly limiting their practical applications.Fundamentally,free-radical reaction is a critical“trigger”for their thermal pyrolysis and following combustion process regardless of the anaerobic thermal pyrolysis in the condensed phase or aerobic combustion of polymers in the gaseous phase.The addition of free radical scavengers represents a promising and effective means to enhance the fire safety of polymeric materials.This review aims to offer a state-of-the-art overview on the creation of fire-retardant polymeric nanocomposites by adding fire retardants with an ability to trap free radicals.Their specific modes of action(condensed-phase action,gaseous-phase action,and dual-phases action)and performances in some typical polymers are reviewed and discussed in detail.Following this,some key challenges associated with these free-radical capturers are discussed,and design strategies are also proposed.This review provides some insights into the modes of action of free radical capturing agents and paves the avenue for the design of advanced fire-retardant polymeric nanocomposites for expanded real-world applications in industries. | Ting Sai Shiya Ran Zhenghong Guo Pingan Song Zhengping Fang | 2022 | SusMat2022，2，4： | 2 |
| 5 | Mechanistic study of copper-catalyzed intramolecular ortho-C-H activation/carbon-nitrogen and carbon-oxygen cyclizations显示文摘Intramolecular ortho-C-H activation and C-N/C-O cyclizations of phenyl amidines and amides have recently been achieved under Cu catalysis. These reactions provide important examples of Cu-catalyzed functionalization of inert C-H bonds, but their mechanisms remain poorly understood. In the present study the several possible mechanisms including electrophilic aromatic substitution, concerted metalation-deprotonation (CMD), Friedel-Crafts mechanism, radical mechanism, and protoncoupled electron transfer have been theoretically examined. Cu(Ⅱ)-assisted CMD mechanism is found to be the most feasible for both C-O and C-N cyclizations. This mechanism includes three steps, i.e. CMD with Cu(Ⅱ), oxidation of the Cu(Ⅱ) intermediate, and reductive elimination from Cu(Ⅲ). Our calculations show that Cu(Ⅱ) mediates the C-H activation through an six-membered ring CMD transition state similar to that proposed for many Pd-catalyzed C-H activation reactions. It is also interesting to find that the rate-limiting steps are different for C-N and C-O cyclizations: for the former it is concerted metalation-deprotonation with Cu(Ⅱ), whereas for the latter it is reductive elimination from Cu(Ⅲ). The above conclusions are consistent with the experimental kinetic isotope effects (1.0 and 2.1 for C-O and C-N cyclizations, respectively), substituent effects, and the reactions under O2 -free conditions. | TANG ShiYa GONG TianJun FU Yao | 2013 | Science China Chemistry2013，56，5： | 2 |
| 6 | A multi-generation sublethalI assay of phenols using the nematode Caenorhabditis elegans显示文摘 | NOBUAKI T SHIYA K TAISEN I | 2003 | Journal of Health Science2003，49，6： | 1 |
| 7 | Effects of pH on the deconjugation of conjugated bilirubin in human bile显示文摘 | SHIYA F TOSHIMA T TAKAHASHI W | 1985 | Tohoku J Exp Med1985，147，： | 1 |
| 8 | Inhibitory eflbct of fcrulic acid and isofcrulic acid on murine intcrlcukin-8 production in response to influenza virus in vitro and in vivo 显示文摘 | Tatsuji H Hiroshi O Shiya S | 1995 | Phmta Med1995，61，3： | 1 |
| 9 | Time/Wavelength Fiber Bragg Grating Multiplexing Sensor Array显示文摘A novel time/wavelength-multiplexed fiber Bragg grating sensor array is presented. This type of sensor array has the advantages of more points for multi-point measurement, simple structure and low cost. | Shiya He, Shuyang Hu, Qida Zhao, Kuanxin Yu, Jinfeng Zhou, Li Wang Science College, Beijing University of Technology, Beijing 100022, P.R. China | 2003 | 光学学报2003，23，S1： | 1 |
| 10 | Changes in hemodynamics and coronary blood flow during left ventricular assistance with Hemopump显示文摘 | Shiya N Zelinsky R Deleuze PH | 1992 | Ann Thorac Surg1992，53，： | 1 |
| 11 | Two-dimensional multichannel aeousto-optic modulation and acousto-optic matrix-vector multiplication显示文摘 | Zhao Qida He Shiya Yu Kuanxin | 1996 | Proc SPIE1996，2897，： | 1 |
| 12 | Multifunctional tubular carbon nanofibers/polyurethane electromagnetic wave absorber with room-temperature self-healing and recyclable performance显示文摘Incorporating self-healing and recyclable capabilities into microwave absorbing materials is expected to facilitate the life extension,cost reduction,and performance stability,thereby meeting the practical applications.In this research,a recycling and room-temperature self-healing electromagnetic wave(EMW)absorber is designed,in which linear polyurethane cross-linked by aromatic disulfide bonds is used as healable matrix,and tubular carbon nanofibers(TCNFs)are employed to attenuate microwave.The resultant composites with a TCNFs content of 7 wt.%harvest a minimum reflection loss(RLmin)of−39.0 dB and an effective absorption bandwidth(EAB)of 2.9 GHz at a matching thickness of 4.0 mm.Driven by the reversible dynamic bonds including hydrogen bonds and aromatic disulfide bonds,the high healing efficiency of 88.7%at 25°C and 93.2%at 60°C is presented.Impressively,even after three repairing cycles at room temperature,a healable efficiency of 86.4%is acquired,and RLmin can still reach−39.1 dB at the same thickness,together with an EAB of 3.0 GHz.Additionally,the results of solvent recycling experiment manifest that the recycled specimen achieves the almost similar mechanical and microwave dissipation properties as original one.These attractive characteristics make the designed self-healing and recyclable composites promising for next-generation EMW consumption devices. | Shuai Kang Shiya Qiao Yutong Cao Zuming Hu Na Li Junrong Yu Yan Wang | 2023 | Nano Research2023，16，1： | 1 |
| 13 | Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancer显示文摘 | Yaginuma Y Yarnashita T I shiya T | 2000 | Mol Carcinog2000，27，5： | 1 |
| 14 | Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models显示文摘 | Masaki N Takeshi Y Shiya K | 2005 | Cancer Letters2005，217，2002： | 1 |
| 15 | Photocatalytic behavior of titanium oxide-perovskite type SrZr1-xYxO3 composite particles显示文摘 | Takahisa Omata Shiya Otsuka-Yao-Matsuo | 2003 | Journal of Photochemistry and Photobiology A:Chemistry2003，156，： | 1 |
| 16 | Char barrier effect of graphene nanoplatelets on the flame retardancy and thermal stability of high‐density polyethylene flame‐retarded by brominated polystyrene显示文摘 | Shiya Ran Chao Chen Zhenghong Guo Zhengping Fang | 2014 | J. Appl. Polym. Sci2014，，15： | 1 |
| 17 | Effect of Friedel–Crafts reaction on the thermal stability and flammability of high‐density polyethylene/brominated polystyrene/graphene nanoplatelet composites显示文摘 | Shiya Ran Zhenghong Guo Ligang Han Zhengping Fang | 2014 | Polym. Int2014，，10： | 1 |
| 18 | Karyotype of Scorzonera Austrica Wild of China by using Fluorescence in situ hybridization显示文摘 | Shiya I Katsuhiko K Hong D Y | 1996 | La Kromosomo1996，8384，： | 1 |
| 19 | A mhi gneration slblethal asay of penols uing the nematode Caenorhabditis elegans 显示文摘 | Tominaga N Shiya K Taisen I | 2003 | Journal of Health Science2003，49，6： | 1 |
| 20 | Secondary aortoenteric fistula显示文摘 | Yoshimoto K Shiya N Onodera Y | 2005 | J Vasc Surg2005，42，4： | 1 |
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