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| 1 | Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function显示文摘Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently,m RNAs and micro RNAs(mi RNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal mi RNAs, since the mi RNA profiles of exosomes may differ from those of the parent cells. Exosomal mi RNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal mi RNAs, and briefly describe how exosomes and their mi RNAs function in recipient cells.Finally, we will discuss the potential applications of these mi RNA-containing vesicles in clinical settings. | Jian Zhang Sha Li Lu Li Meng Li Chongye Guo Jun Yao Shuangli Mi | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 162 |
| 2 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 3 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 4 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 5 | Predicting TBM penetration rate in hard rock condition:A comparative study among six XGB-based metaheuristic techniques显示文摘A reliable and accurate prediction of the tunnel boring machine(TBM)performance can assist in minimizing the relevant risks of high capital costs and in scheduling tunneling projects.This research aims to develop six hybrid models of extreme gradient boosting(XGB)which are optimized by gray wolf optimization(GWO),particle swarm optimization(PSO),social spider optimization(SSO),sine cosine algorithm(SCA),multi verse optimization(MVO)and moth flame optimization(MFO),for estimation of the TBM penetration rate(PR).To do this,a comprehensive database with 1286 data samples was established where seven parameters including the rock quality designation,the rock mass rating,Brazilian tensile strength(BTS),rock mass weathering,the uniaxial compressive strength(UCS),revolution per minute and trust force per cutter(TFC),were set as inputs and TBM PR was selected as model output.Together with the mentioned six hybrid models,four single models i.e.,artificial neural network,random forest regression,XGB and support vector regression were also built to estimate TBM PR for comparison purposes.These models were designed conducting several parametric studies on their most important parameters and then,their performance capacities were assessed through the use of root mean square error,coefficient of determination,mean absolute percentage error,and a10-index.Results of this study confirmed that the best predictive model of PR goes to the PSO-XGB technique with system error of(0.1453,and 0.1325),R^(2) of(0.951,and 0.951),mean absolute percentage error(4.0689,and 3.8115),and a10-index of(0.9348,and 0.9496)in training and testing phases,respectively.The developed hybrid PSO-XGB can be introduced as an accurate,powerful and applicable technique in the field of TBM performance prediction.By conducting sensitivity analysis,it was found that UCS,BTS and TFC have the deepest impacts on the TBM PR. | Jian Zhou Yingui Qiu Danial Jahed Armaghani Wengang Zhang Chuanqi Li Shuangli Zhu Reza Tarinejad | 2021 | Geoscience Frontiers2021，12，3： | 10 |
| 6 | Velocity and pressure distributions in discharge tunnel of rotary-obstruction composite inner energy dissipation显示文摘On the basis of model test and theoretical analysis of velocity and pressure distributions,an hypothesis is presented that the distribution of tangential velocity in radial direction seems to be a combinational distribution of a quasi-free vortex and a quasi-forced vortex for the discharge tunnel of rotary-obstruction composite inner energy dissipation.The variations of corresponding parameters about the hypothesis are obtained under test conditions in this paper.The formula of pressure distribution in radial direction is deduced theoretically,and the theoretical values of pressure distribution computed by the formula are well consistent with the measured ones,showing that the formula is correct and can be applied to the computation and analysis of pressure distribution of this discharge tunnel. | CAO ShuangLi 1,NIU ZhengMing 1,YANG Jian 2 & LU HongBo 1 1 Xi’an University of Technology,Xi’an 710048,China 2 China Water Resources Pearl River Planning,Surveying & Designing Co.Ltd,Guangzhou 510610,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 10 |
| 7 | Isolation of 2019-nCoV from a Stool Specimen of a Laboratory- Confirmed Case of the Coronavirus Disease 2019 (COVID-19)显示文摘The novel coronavirus(2019-nCoV)is spreading very fast in Hubei Province of China.As of February 14,2020,51,986 confirmed cases(including laboratory-confirmed cases and clinically-confirmed cases)were reported in Hubei Province,and 1,318 of them died.Respiratory droplets and contact transmission are considered to be the most important routes of transmission of 2019-nCoV,but do not fully account for the occurrence of all coronavirus disease 2019(COVID-19)cases,previously known as novel coronavirus pneumonia(NCP),and the reasons for the rapid spread of this virus(1). | Yong Zhang Cao Chen Shuangli Zhu Chang Shu Dongyan Wang Jingdong Song Yang Song Wei Zhen Zijian Feng Guizhen Wu Jun Xu Wenbo Xu | 2020 | China CDC weekly2020，2，8： | 9 |
| 8 | Transition-Metal-Free TEMPO Catalyzed Aerobic Oxidation of Alcohols to Carbonyls Using an Efficient Br2 Equivalent under Mild Conditions显示文摘有效 transition-metal-free 催化系统为白酒的氧气的氧化被开发。使用溴化物使与臬化合联合, H2SO4,和 NaNO2 的催化数量,和面对空气的 2,2,6,6-tetramethylpiperidine N-oxyl 基(速度) ,各种各样的白酒能被变换成相应的醛或酉同类在对在温和条件下面的优秀孤立的收益好。 | Jie Zhang Zengqiang Jiang Dan Zhao Guozhen He Shuangli Zhou Shiqing Han | 2013 | Chinese Journal of Chemistry2013，31，6： | 4 |
| 9 | Estimation of the TBM advance rate under hard rock conditions using XGBoost and Bayesian optimization显示文摘The advance rate(AR)of a tunnel boring machine(TBM)under hard rock conditions is a key parameter in the successful implementation of tunneling engineering.In this study,we improved the accuracy of prediction models by employing a hybrid model of extreme gradient boosting(XGBoost)with Bayesian optimization(BO)to model the TBM AR.To develop the proposed models,1286 sets of data were collected from the Peng Selangor Raw Water Transfer tunnel project in Malaysia.The database consists of rock mass and intact rock features,including rock mass rating,rock quality designation,weathered zone,uniaxial compressive strength,and Brazilian tensile strength.Machine specifications,including revolution per minute and thrust force,were considered to predict the TBM AR.The accuracies of the predictive models were examined using the root mean squares error(RMSE)and the coefficient of determination(R^(2))between the observed and predicted yield by employing a five-fold cross-validation procedure.Results showed that the BO algorithm can capture better hyper-parameters for the XGBoost prediction model than can the default XGBoost model.The robustness and generalization of the BO-XGBoost model yielded prominent results with RMSE and R^(2) values of 0.0967 and 0.9806(for the testing phase),respectively.The results demonstrated the merits of the proposed BO-XGBoost model.In addition,variable importance through mutual information tests was applied to interpret the XGBoost model and demonstrated that machine parameters have the greatest impact as compared to rock mass and material properties. | Jian Zhou Yingui Qiu Shuangli Zhu Danial Jahed Armaghani Manoj Khandelwal Edy Tonnizam Mohamad | 2021 | Underground Space2021，6，5： | 4 |
| 10 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 11 | Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus—Sichuan Province,China,2019显示文摘What is already known about this topic?After the type 2 strain of the live,attenuated poliovirus vaccine was withdrawn globally in 2016,any identification of a type 2 poliovirus is a Public Health Emergency of International Concern.A vaccinederived type 2 poliovirus(VDPV2)was identified in Sichuan,prompting an urgent,comprehensive investigation and response.What is added by this report?Type 2 monovalent,live,attenuated oral poliovirus vaccine(mOPV2)is being used to respond to the numerous VDPV2 outbreaks seen around the world.In contrast,the response in Sichuan used Sabin strain inactivated poliovirus(sIPV)to stop circulation of the VDPV2.In the 6 months following the vaccination response,there have been no VDPV2s detected in Sichuan,despite extensive search.What are the implications for public health practices?Further search for the VDPV2 must continue in order to determine whether transmission has been stopped.The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks. | Jiushun Zhou Ning Wen Yong Zhang Qi Qi Chunxiang Fan Dongmei Yan Xiaoping Zhu Lixin Hao Shuangli Zhu Yu Liu Xiaozhen Ma Chao Ma Lei Nan Yong Chen Qianli Ma Cheng Wang Kun Deng Lei Cao Ge Shao Xianxiang Ding Hong Yang Zhijie An Lance ERodewald Aiqiang Xu Huaqing Wang Zijian Feng Zundong Yin Xianping Wu Wenbo Xu | 2020 | China CDC weekly2020，2，11： | 3 |
| 12 | Three-type MJO Initiation processes over the Western Equatorial Indian Ocean显示文摘Thirty strong Madden–Julian Oscillation(MJO) events in boreal winter 1982–2001 are selected to investigate the triggering processes of MJO convection over the western equatorial Indian Ocean(IO).These MJO events are classified into three types,according to their dynamic and thermodynamic precursor signals in situ.In Type I,a remarkable increase in low-level moisture occurs,on average,7 days prior to the convection initiation.This low-level moistening is mainly due to the advection of the background mean moisture by easterly wind anomalies over the equatorial IO.In Type II,lower-tropospheric ascending motion anomalies develop,on average,4 days prior to the initiation.The cause of this ascending motion anomaly is attributed to the anomalous warm advection,set up by a suppressed MJO phase in the equatorial IO.In Type III,there are no clear dynamic and thermodynamic precursor signals in situ.The convection might be triggered by energy accumulation in the upper layer associated with Rossby wave activity fluxes originated from the midlatitudes. | MEI Shuangli Tim LI CHEN Wen | 2015 | Advances in Atmospheric Sciences2015，32，9： | 2 |
| 13 | Geochemical characteristics and source analysis of inflow of mine water in Wang’ershan Gold Mine, Shandong显示文摘Through a systematic observation of water level and temperature, and a comprehensive analysis of the data on major/trace elements, nitrite, hydrogen-oxygen isotopes, the conclusion has been drawn that there are two relatively independent groundwater systems (cool water and hot water), and the geochemical indicators of hot/cool waters are described. The cool water system is relatively enriched in Ca2+, Mg2+ and HCO3-. Its TDS is relatively low, about 1400–1800 mg/L. The hot water system is relatively enriched in K+, Na+, Cl- and SO42-. Its TDS is relatively high, about 2200–2300 mg/L. The cool water system is enriched in Ba, Ga, Cd, and the hot water system is enriched in B, Ti, Cr, Ni, Cu, Mo, Rb, and Cs, relatively. Especially, the contents of Rb and Cs in the hot water system are more than five times as high as those in the cool water system. The NO3- contents of cool water discharged from the gold mine are relatively high, and those of hot water are extremely low. The δD and δ18O values follow an increasing order of surface water>mine cool water>mine hot water. The cool water comes mainly from the lateral supply of phreatic water, while the hot water comes mainly from the vertical supply of deeply circulating structure-fracture water. The ratio of cool water over hot water was estimated to be about 1:1 by a water quality model.. | QIAN Jianping LI Shuangli CAO Chao | 2008 | Chinese Journal Of Geochemistry2008，27，1： | 2 |
| 14 | Type I vaccine-derived polioviruses in China from 1995 to 2019显示文摘A nation-wide case surveillance was conducted in China since 1995 for the objective of identifying acute flaccid paralysis(AFP)in children so that potential wild polioviruses and vaccine-derived poliovirus(VDPV)could be identified on time.Two outbreaks associated with type I circulating VDPVs,eight native independent type I ambiguous VDPVs(aVDPV),and one imported aVDPV were identified during the AFP case surveillance in China from 1995 to 2019.The VP1 coding region of the Chinese type I VDPVs differed from the polio vaccine strain by 1.00%–3.75%(9–34 substitutions in 906 nucleotides).Most of the Chinese type I VDPV strains shared 4 amino acid substitutions in the neutralizing antigenic(NAg)sites:3 located at the BC loop,which formed the NAg site 1,and another at NAg site 3a.All of the Chinese type I VDPVs identified during the AFP case surveillance were young VDPVs,which indicated a limited viral replication resulted from the administration of the initiating oral polio vaccine(OPV)dose.VDPVs can emerge and spread in isolated communities with immunity gaps and the circulation ceases following a mass immunization with OPV.As such,high-quality surveillance permitted very early detection and response and it played a key role in stalling the widespread circulation of the emergent cVDPV strains in China. | Yong Zhang Shuangli Zhu Dongmei Yan Dongyan Wang Xiaolei Li Hui Zhu Hongqiu An Wenbo Xu | 2019 | Biosafety and Health2019，1，3： | 2 |
| 15 | Design and preliminary experimental research on a new biogas fermentation system by solar heat pipe heating显示文摘Biogas fermentation requires appropriate temperature,while the biogas fermentation can be affected by the low ambient temperature in winter.In order to overcome the negative effects of low temperature fermentation,a new type of solar heat pipe biogas fermentation heating system was designed and a preliminary experiment research on this system was conducted using cow manure as the raw material at 6%concentration and total fermentation volume of 175 L.The experimental results showed that when the system was in normal operation,the fermentation temperature rose every day by gradient.This gradient will gradually become smaller with the increase of fermentation liquid temperature,and the temperature can reach 38°C after stability.Using this solar heat pipe heating system,the fermentation liquid temperature can be increased by 5°C every sunny day.This solar heat pipe heating system plays a significant role in biogas fermentation.The results of economic analysis show that the system can realize the fermentation at constant temperatures of 25°C and 35°C respectively,and it can also save standard coal equivalent of 40 kg and 80 kg in winter and spring,respectively. | Jiao Youzhou Li Pengfei Li Gang Zhang Quanguo Ding Pan Wang Shaopeng Gao Zan Du Shuangli He Chao | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 2 |
| 16 | MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia显示文摘 | Shuangli Mi Jun Lu Miao Sun | 2007 | Proc Natl Acad Sci USA2007，104，19： | 1 |
| 17 | Chemosensitization of bladder cancer cells by survivin-directed antisense oligodeoxynucleotides and siRNA显示文摘 | Susanne Fuessel Jana Hen'mann Shuangli Ning | | 0，，： | 1 |
| 18 | Systematic in vitro evaluation of survivin directed antisense oligodeoxynucleotides in bladder cancer cells显示文摘 | Fuessel S Kueppers B Shuangli N | 2004 | J Urol2004，171，61： | 1 |
| 19 | Failure Assessment of Aero-engine Support Structure due to Blade-off显示文摘Aero-engine blade-off event could cause serious malfunction and endanger flight safety,which is an important issue widely concerned for a long period.This paper presents a comprehensive review on the regulation requirements,the major research methods and status at home and abroad.Firstly,the relevant certification regulations and standards about aero-engine structure safety due to blade-off event were overviewed and the research gaps between the abroad and the domestic were compared.Then,the simulation and experimental methodologies on aero-engine supporting structures undertake abnormal load due to blade-off event were discussed as major issue.Finally,the safety certification verification technology system for aero-engine support structures during blade-off event was proposed. | Liu Shuangli Chen Wei Chen Minghao | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，5： | 1 |
| 20 | Antioxidant and immunoregulatory a ctivity of different polysaccharide fractions from tuber of ophiopogon japonicus显示文摘 | Xiong Shuangli Li Anlin Huang Ni | 2011 | Carbohydrate Polymers2011，86，3： | 1 |
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