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| 1 | A current perspective of autophagosome biogenesis显示文摘Autophagy 是象滋养的饥饿那样的细胞的压力导致的一个体积降级系统。它的功能依靠泡把 autophagosomes 称为的双膜的形成。不同于看起来稳定地在房间存在的另外的细胞器, autophagosomes 在需求上被形成,并且一旦他们的形成被开始,它很快令人惊讶地继续。这动态 autophagosome 形成怎么并且在哪儿发生在 1990 年代的 Atg 蛋白质的一个长期的问题,而是发现显著地被加速了我们理解 autophagosome 生物的续生说。在这评论,我们将简短介绍每 Atg 在与 autophagosome 生物的续生说的关系的功能的单位,然后与处理这个问题的选择最近的研究的介绍讨论 autophagosomal 膜的起源。 | Shusaku T Shibutani | 2014 | Cell Research2014，24，1： | 41 |
| 2 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 18 |
| 3 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 4 | Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy显示文摘An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed. | Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki Takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara | 2012 | World Journal of Gastroenterology2012，18，1： | 11 |
| 5 | Microstructure and performance of biodegradable magnesium alloy tubes fabricated by local-heating-assisted dieless drawing显示文摘Magnesium(Mg)alloy stents are expected to be the next generation of stents because of good biocompatibility and biodegradability.Compared with cold drawing,dieless drawing with local heating is an effective method for manufacturing the Mg alloy microtubes since a large reduction in area can be achieved in a single pass.However,the microstructure and properties of dieless drawn tubes have not been clarified,leading to the problems in practical application of dieless drawn tubes.In this study,the microstructure and performance of dieless drawn tubes are clarified.The results show that temperature and speed in the dieless drawing process are two factors in determining the grain size of dieless drawn tubes since decreasing the temperature or increasing the speed promotes the generation of fine-grained microstructure.Twins are also generated during the dieless drawing process,which 1)disintegrates grains leading to refinement and 2)causes Hall-Petch law effect on dieless drawn tubes.Tensile tests show that grain size is the main factor in determining the mechanical properties of dieless drawn tubes,namely,0.2%proof stress 135-180MPa,ultimate tensile strength(UTS)200-250MPa,and elongation 8-12%.In 0.9 wt%NaCl solution,localized corrosion is the key factor in initiating the corrosion of dieless drawn tubes,but refined grains and fewer twins can alleviate local corrosion.These results imply that dieless drawn tubes are promising in the clinical application of Mg alloy stents for cardiovascular disease. | Peihua Du Shusaku Furusawa Tsuyoshi Furushima | 2020 | Journal of Magnesium and Alloys2020，8，3： | 2 |
| 6 | Studies on the green liber in cultured red bream fed low level and non-fish meal diets: Relationship between hepatic taurine and biliverdin levels显示文摘 | Takanobu Goto Shusaku Takagi Toshiaki Ichiki | 2001 | Fisheries Science2001，67，： | 1 |
| 7 | Effect of lysine and methionine supplementation to a soy protein concentrate diet for red sea bream Pagrus major显示文摘 | Shusaku T Sadao S Hidetsuyo H | 2001 | Fisheries Science2001，67，： | 1 |
| 8 | Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats显示文摘 | Mitsuaki Okayama Shusaku Hayashi Yoko Aoi Hikaru Nishio Shinichi Kato Koji Takeuchi | 2007 | Digestive Diseases and Sciences2007，，9： | 1 |
| 9 | Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapy显示文摘 | Junichi Hasegawa Tatsuo Kanda Seiichi Hirota Masafumi Fukuda Akiko Nishitani Tsuyoshi Takahashi Isao Kurosaki Shusaku Tsutsui Katsuyoshi Hatakeyama Toshirou Nishida | 2007 | International Journal of Clinical Oncology2007，，3： | 1 |
| 10 | The WASP and WAVE family proteins显示文摘 | Shusaku K Tadaomi T | 2009 | Genome Biol2009，10，6： | 1 |
| 11 | Mining diagnostie rules from clinical databases using rough sets and medical diagnostic model显示文摘 | SHUSAKU T | 2004 | Information Sciences2004，162，2： | 1 |
| 12 | Local Resection by Combined Laparoendoscopic Surgery for Duodenal Gastrointestinal Stromal Tumor显示文摘 | Motohiko Kato Kiyokazu Nakajima Toshirou Nishida Makoto Yamasaki Tsutomu Nishida Shusaku Tsutsui Hideharu Ogiyama Shunsuke Yamamoto Takuya Yamada Masaki Mori Yuichiro Doki Norio Hayashi Isidoro Di Carlo | 2011 | Diagnostic and Therapeutic Endoscopy2011，，： | 1 |
| 13 | Novel CD9-targeted therapies in gastric cancer显示文摘There are 33 human tetraspanin proteins,emerging as key players in malignancy,the immune system,fertilization,cellular signaling,adhesion,morphology,motility,proliferation,and tumor invasion.CD9,a member of the tetraspanin family,associates with and influences a variety of cell-surface molecules.Through these interactions,CD9 modifies multiple cellular events,including adhesion,migration,proliferation,and survival.CD9 is therefore considered to play a role in several stages during cancer development.Reduced CD9 expression is generally related to venous vessel invasion and metastasis as well as poor prognosis.We found that treatment of mice bearing human gastric cancer cells with anti-CD9 antibody successfully inhibited tumor progression via antiproliferative,proapoptotic,and antiangiogenic effects,strongly indicating that CD9 is a possible therapeutic target in patients with gastric cancer.Here,we describe the possibility of CD9 manipulation as a novel therapeutic strategy in gastric cancer,which still shows poor prognosis. | Yoko Murayama Kenji Oritani Shusaku Tsutsui | 2015 | World Journal of Gastroenterology2015，21，11： | 1 |
| 14 | Utilization of soy protein concentrate in a diet for red sea bream, Pagrus major显示文摘 | SHUSAKU T HIDETSUYO H SADAO S | 1999 | Suisan Zoshoku1999，47，1： | 1 |
| 15 | Utilization of corn gluten meal in a diet for red sea bream(Pagrus major)显示文摘 | Takagi Shusaku Hosokawa | 2000 | Bulletin of the Japanese Society of Scientific Fisheries2000，66，3： | 1 |
| 16 | Verification of fission product release model form high temperature engineering test reactor fuel显示文摘 | Kazuhiro Sawa Shusaku Shiozawa Kousaku Fukuda | 1992 | Journal of Nuclear Science and Technology1992，29，9： | 1 |
| 17 | Mining Diagnostic Rules from Clinical Databases Using Rough Sets and Medical Diagnostic Model显示文摘 | Shusaku Tsumoto | 2004 | Information Sciences2004，，162： | 1 |
| 18 | Use of a metallic‐wall stent in the magnet compression anastomosis technique for bile duct obstruction after liver transplantation显示文摘 | Hirofumi Akita Hayato Hikita Eigoro Yamanouchi Shigeru Marubashi Hiroaki Nagano Koji Umeshita Keizo Dono Shusaku Tsutsui Norio Hayashi Morito Monden | 2007 | Liver Transpl2007，，1： | 1 |
| 19 | Replace- ment of fish meal by combined inclusion of alternative protein sources in a diet for yearling red sea bream, Pagrus major显示文摘 | SHUSAKU T SADAO S HIDETSUYO H | 2000 | Suisan Zoshoku2000，48，3： | 1 |
| 20 | Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats显示文摘 | Mitsuaki Okayama Shusaku Hayashi Yoko Aoi Hikaru Nishio Shinichi Kato Koji Takeuchi | 2007 | Digestive Diseases and Sciences2007，，9： | 1 |
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