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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | On the timing of the East Asian summer monsoon maximum during the Holocene Does the speleothem oxygen isotope record reflect monsoon rainfall variability?显示文摘The evolution of the East Asian summer monsoon(EASM) during the Holocene has long been of significant interest.Knowledge of past EASM variability not only increases our understanding of monsoon dynamics on a long timescale,but it also provides an environmental and climatic background for research into Chinese cultural development.However,the timing of the EASM maximum remains controversial.The popular concept of an 'early Holocene maximum' is mainly based on speleothemδ^(18)O(δ^(18)O_c) records from caves in southern China;however,the interpretation of δ^(18)O_C as a reliable proxy for EASM intensity is being increasingly challenged.The present paper is a critical review of the climatic significance of the δ^(18)O_C record from China.Firstly,we suggest that precipitation in northern China is an appropriate index of EASM intensity,the variation of which clearly indicates a mid-Holocene monsoon maximum.Secondly,an interregional comparison demonstrates that the precipitation record in northern China is quite different from that in southern China on a range of timescales,and is inconsistent with the spatial similarity exhibited by speleothem oxygen isotope records.Furthermore,both modeling and observational data show that the δ^(18)O_C records from southern China indeed reflect changes in precipitation δ^(18)O(δ^(18)O_P) rather than precipitation amount,and therefore that their use as an EASM proxy is inappropriate.Finally,we address several significant monsoon-related issues-including the driving mechanism of the EASM on an orbital timescale,the climatic significance of speleothem oxygen isotopes,and the relationship between atmospheric circulation and precipitation in monsoonal regions. | CHEN JianHui RAO ZhiGuo LIU JianBao HUANG Wei FENG Song DONG GuangHui HU Yu XU QingHai CHEN FaHu | 2016 | Science China(Information Sciences)2016，59，12： | 18 |
| 3 | Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction显示文摘间充质的干细胞(MSC ) 广泛地被申请了在尖锐心肌的梗塞(AMI ) 以后的 cardiomyocytes 损失的恢复。然而,在 ischemic 心疾病的 MSC 的最佳的治疗学的功效被他们的差的幸存和低区分的率妨碍了。因此, MSC 幸存的改进和区分的率被保证并且为在 AMI 的 MSC 的功效批评。在这份报纸,从腹股沟的胖纸巾作为脂肪质导出被称为间充质的干细胞(ASC ) 的老鼠孤立的 MSC,和 ASC 的第四个段落被文化 co 在一个 transwell 系统与 cardiomyocytes 预先指定作为 co-ASCs 称为。十四天以后, GATA-4 (一个抄写因素) 和心脏的 troponin -- 我被细胞的 immunofluorescence 检测。Atorvastatin (Ator 组) 或车辆(控制组) 在老鼠在 AMI 生产以后为开始的 24 h 被管理。十四天以后,煽动性的参数和心脏的功能被评估。另外的幸存老鼠与 1 普物敭 ? 潴戠 ? 的一个总数被注射 ? 楤敲瑣琠牡敧 ? 敧敮漠 ? 業??? 祢攠桮湡散 ? 牧敥 ? 汦潵敲 ' 諟?牰瑯楥? 敲潰瑲牥攠灸牥浩湥吗? | Anping Cai Dongdan Zheng Yugang Dong Ruofeng Qiu Yuli Huang Yuanbin Song Zhigao Jiang Shaoqi Rao Xinxue Liao Jian Kuang Gang Dai Weiyi Mai | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 16 |
| 4 | Evolution of blood lipids and risk factors of dyslipidemia among people living with human immunodeficiency virus who had received first-line antiretroviral regimens for 3 years in Shenzhen显示文摘Background:Lipid abnormalities are prevalent among people living with human immunodeficiency virus(HIV)(PLWH)and contribute to increasing risk of cardiovascular events.This study aims to investigate the incidence of dyslipidemia and its risk factors in PLWH after receiving different first-line free antiretroviral regimens.Methods:PLWH who sought care at the Third People’s Hospital of Shenzhen from January 2014 to December 2018 were included,and the baseline characteristics and clinical data during the follow-up were collected,including total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C).The risk factors of dyslipidemia after antiretroviral therapy were analyzed with the generalized estimating equation model.Results:Among the 7623 PLWH included,the mean levels of TC,HDL-C and LDL-C were 4.23±0.85 mmol/L,1.27±0.29 mmol/L and 2.54±0.65 mmol/L,respectively,and the median TG was 1.17(IQR:0.85-1.68)mmol/L.Compared with that in PLWH receiving tenofovir disoproxil fumarate(TDF)+lamivudine(3TC)+ritonavir-boosted lopinavir(LPV/r),zidovudine(AZT)+3TC+efavirenz(EFV),and AZT+3TC+LPV/r,the incidence of dyslipidemia was lower in PLWH receiving TDF+3TC+EFV.In multivariate analysis,we found that the risks of elevations of TG,TC,and LDL-C were higher with TDF+3TC+LPV/r(TG:odds ratio[OR]=2.82,95%confidence interval[CI]:2.55-3.11,P<0.001;TC:OR=1.24,95%CI:1.14-1.35,P<0.001;LDL:OR=1.06,95%CI:1.00-1.12,P=0.041),AZT+3TC+EFV(TG:OR=1.41,95%CI:1.28-1.55,P<0.001;TC:OR=1.43,95%CI:1.31-1.56,P<0.001;LDL:OR=1.18,95%CI:1.12-1.25,P<0.001),and AZT+3TC+LPV/r(TG:OR=3.08,95%CI:2.65-3.59,P<0.001;TC:OR=2.40,95%CI:1.96-2.94,P<0.001;LDL:OR=1.52,95%CI:1.37-1.69,P<0.001)than with TDF+3TC+EFV,while treatment with TDF+3TC+LPV/r was less likely to restore HDL-C levels compared with TDF+3TC+EFV(OR=0.95,95%CI:0.92-0.97,P<0.001).In addition to antiretroviral regimens,antiretroviral therapy duration,older age,overweight,obesity and other traditional factors were also important risk factors for dyslipidemia.Conclusion:The incidence of dyslipidemia varies with different antiretroviral regimens,with TDF+3TC+EFV having lower risk for dyslipidemia than the other first-line free antiretroviral regimens in China. | Li-Qin Sun Jia-Ye Liu Yun He Yang Zhou Liu-Mei Xu Lu-Kun Zhang Fang Zhao Xiao-Ning Liu Ying Song Ting-Zhi Cao Yi-Mei Tian Man Rao Hui Wang | 2020 | Chinese Medical Journal2020，，23： | 9 |
| 5 | Thermal history of the Sichuan Basin,SW China:Evidence from deep boreholes显示文摘The Sichuan Basin is a superimposition basin composed of terrestrial and marine sediments that is well known for its abundant petroleum resources. Thermal history reconstruction using paleogeothermal indicators, including vitrinite reflectance and thermochronological data, shows that different structural subsections of the Sichuan Basin have experienced various paleogeothermal episodes since the Paleozoic. The lower structural subsection comprising the Lower Paleozoic to Middle Permian(Pz–P_2) successions experienced a high paleogeothermal gradient(23.0–42.6°C/km) at the end of the Middle Permian(P_2), whereas the upper structural subsection comprising Late Permian to Mesozoic strata underwent a relatively lower paleogeothermal gradient(13.2–26.9°C/km) at the beginning of the denudation(Late Cretaceous or Paleocene in the different regions). During the denudation period, the Sichuan Basin experienced a successive cooling episode. The high paleogeothermal gradient resulted from an intensive thermal event correlated to the Emeishan mantle plume. The heat flow value reached 124.0 m W/m^2 in the southwestern basin near the center of the Emeishan large igneous province. The low geothermal gradient episode with heat flow ranging from 31.2 to 70.0 m W/m^2 may be related to the foreland basin evolution. The cooling event is a result of the continuous uplift and denudation of the basin. | ZHU Chuan Qing HU ShengBiao QIU NanSheng RAO Song YUAN YuSong | 2016 | Science China Earth Sciences2016，59，1： | 9 |
| 6 | Bartonella Species Detected in the Plateau Pikas(Ochotona curzoiae) from Qinghai Plateau in China显示文摘Bartonella 种类能感染许多哺乳动物的主人并且在人引起许多疾病,但是在那里有不是在 Ochotonidae 的 Bartonella 感染的报告。这是第一研究在 Qinghai 高原在高原一种短耳野兔检测 Bartonella,提供为对在这个区域的人的 Bartonella 感染的风险评价的基线数据。我们与 18.99% 的积极的率在 Qinghai 的 Binggou 和 Maixiu 区域从 79 只一种短耳野兔获得了 15 Bartonella 紧张。基于基因定序的 Bartonella 柠檬酸盐 synthase (gltA ) 的种系发生的分析,大多数紧张是仔细与 B 有关。taylorii (3/15 ) 和 B。grahamii (12/15 ) 。后者是在人的病原的紧张。我们的结果建议相应预防和控制策略应该在 Qinghai 省被考虑。 | RAO Hua Xiang YU Juan GUO Peng MA Yong Cheng LIU Qi Yong JIAO Ming MA Zhong Wen GE Hua WANG Chun Xiang SONG Xiu Ping SHI Yan LI Dong Mei | 2015 | Biomedical and Environmental Sciences2015，28，9： | 8 |
| 7 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 8 | 中国男性良性前列腺增生与体重指数和代谢综合征的关系显示文摘研究表明糖尿病,代谢综合征和肥胖患者罹患良性前列腺增生(BPH)的风险显著增高。本研究的目的是在中国湖南地区的男性人群中评估良性前列腺增生与肥胖和代谢综合征的关系。在这项横断面研究中,共纳入904名50-59岁之间的男性。评价的指标包括代谢综合征的各项指标,国际前列腺症状评分(IPSS),前列腺特异抗原水平(PSA),前列腺总体积(TPV),残余尿(PVR)和最大尿流率(Qmax)。结果显示代谢综合征与TPV(P=0.048),PVR(P=0.004)和IPSS(P=0.011)相关,而与BPH进展的其他危险因子PSA和Qmax无关。代谢综合征与排尿症状相关(P 〈0.05)而与贮尿期症状无关。此外,体重指数和空腹血糖水平与TPV呈正相关(相关系数分别为 r=0.416,P 〈0.001;和 r=0.310, P =0.011)。总之,研究结果提示代谢综合征与更大的前列腺体积,更高的前列腺症状评分以及排尿期症状相关,但是与前列腺增生的其他指标如PSA水平和最大尿流率无关。改变生活方式,包括体育活动和预防代谢综合征,可能对预防良性前列腺增生的进展是有用的,但需要更进一步的研究。 | Zhuo Yin Jin-Rui Yang Jian-Ming Rao Wei Song Ke-Qin Zhou | 2015 | Asian Journal of Andrology2015，17，5： | 6 |
| 9 | Profile and Flatness Control Technology With a Long Shifting Stroke on Wide Non-Oriented Electrical Steel Sheets显示文摘In order to solve the difficult profile and flatness control problem of wide non-oriented electrical steel sheets,the factors such as the relationship between strip crown control and strip width,the relationship between the maximum wearing value of work roll and the number of a rolling campaign and the wear contour change of work roll were analyzed on the basis of industrial test.Through analyzing the rolling process characteristics of non-oriented electrical steel sheets,the ASR(asymmetry self-compensating work rolls) shape control technology and its roll shifting strategy of the wider non-oriented electrical steel sheets was proposed and developed.When the technology was applied,the number of the wide non-oriented electrical steel(2.3 mm×1 280 mm) in one rolling campaign rose from 40 coils of the trial production to 70 coils of the industrial production,the ratio of the measured strip crown less than 45 μm was increased from 50.0% to 94.9%,and the ratio of the measured strip crown more than 60 μm was decreased from 20.0% to 0.7%. | YANG Guang-hui CAO Jian-guo ZHANG Jie SONG Ping YAN Tan-li RAO Ke-feng | 2012 | Journal of Iron and Steel Research(International)2012，19，1： | 5 |
| 10 | Etiological features of cirrhosis inpatients in Beijing, China显示文摘 | SONG Guang-jun FENG Bo RAO Hui-ying WEI Lai | 2013 | Chinese Medical Journal2013，，13： | 5 |
| 11 | Direct observation of metastable face-centered cubic Sb2Te3 crystal显示文摘尽管阶段变化记忆技术在过去的二十年急速地发展了,关键切换材料的认知仍然忽视一个重要成员,以脸为中心的立方的 Sb 2 Te 3 。除了著名平衡六角形的 Sb 2 Te 3 水晶,我们证明亚稳的以脸为中心的立方的 Sb 是 2 Te 3 阶段确实存在。如此的亚稳的晶体包含随机占据 cationic 格子地点的空缺的大集中。以脸为中心对 Sb 2 Te 3, 由空缺聚集伴随了,与 Ge 2 Sb 2 Te 5 合金。我们证明像共有原子价的契约在亚稳的 Sb 2 Te 3 水晶,从理想的反响的特征背离。如果一种合适的做技术被采用,亚稳的 Sb 2 Te 3 阶段能为认识到 reversibly 快速、低精力的阶段变化存储器应用程序是有希望的。我们的学习可以在新奇阶段变化材料的设计提供新卓见进商品化的 Ge-Sb-Te 系统和帮助增加阶段变化存储器设备的表演。 | Yonghui Zheng Mengjiao Xia Yan Cheng Feng Rao Keyuan Ding Weili Liu Yu Jia Zhitang Song Songlin Feng | 2016 | Nano Research2016，9，11： | 5 |
| 12 | Cryo-EM structure of human ATR-ATRIP complex显示文摘ATR (变异毛细管扩张、 Rad3 相关的混乱) 蛋白质 kinase 并且(交往 ATR 蛋白质) 起锚形成建筑群并且响应复制应力和 DNA 损坏起一个关键作用。这里,我们决定了在 4.7 点 ATR 起锚复杂的人的 cryo 电子显微镜学(他们) 结构吗?分辨率并且造了 ATR 的 C 终端催化核心的一个原子模型(残余 1 521-2 644 ) 在 3.9 点?分辨率。建筑群采用空心形状,由在不同符合构造的二 ATR 单体组成。他们地图为起锚表明 14 热在扩大 S 形状重复。ATR 的 conformational 灵活性起锚允许适当地锁二 ATR 单体的 N 终点赞成 ATR 起锚复杂的形成和功能的差异。孤立的头头和尾巴尾巴各个采用假 2 褶层对称。外面的催化衣袋脸和底层存取没被禁止的元素限制。我们的研究为理解集会提供一个结构的基础 ATR 起锚,为描绘调停 ATR 的 DNA 的建筑群和一个框架修理小径。 | Qinhui Rao Mengjie Liu Yuan Tian Yuhan Hao Lei Song Zhaoyu Qin Chen Ding Hong-Wei Wang Jiawei Wang Yanhui Xu | 2018 | Cell Research2018，28，2： | 4 |
| 13 | Optical rogue wave in random fiber laser显示文摘The famous demonstration of optical rogue waves(RWs),a powerful tool to reveal the fundamental physics in different laser scenarios,opened a flourishing time for temporal statistics.Random fiber laser(RFL)has likewise attracted wide attention due to its great potential in multidisciplinary demonstrations and promising applications.However,owing to the distinctive cavity-free structure,it is a scientific challenge to achieve temporal localized RWs in RFLs,whose feedback arises from multiple scattering in disordered medium.Here,we report the exploration of RW in the highly skewed,transient intensity of an incoherently pumped RFL for the first time,to our knowledge,and unfold the involved kinetics successfully.The corresponding frequency domain measurements demonstrate that the RW event arises from a crucial sustained stimulated Brillouin scattering process with intrinsic stochastic nature.This investigation highlights a novel path to fully understanding the complex physics,such as photon propagation and localization,in disordered media. | JIANGMING XU JIAN WU JUN YE JIAXIN SONG BAICHENG YAO HANWEI ZHANG JINYONG LENG WEILI ZHANG PU ZHOU YUNJIANG RAO | 2020 | Photonics Research2020，8，1： | 4 |
| 14 | Paleogeothermal Reconstruction and Thermal Evolution Modeling of Source Rocks in the Puguang Gas Field, Northeastern Sichuan Basin显示文摘The thermal history and organic matter maturity evolution of the source rocks of boreholes in the Puguang gas field were reconstructed. An integrated approach based on vitrinite reflectance and apatite fission track data was used in the reconstruction. Accordingly, the geothermal conditions of gas accumulation were discussed in terms of the geological features of reservoirs in the northeastern Sichuan Basin. The strata reached their maximum burial depth in the Late Cretaceous era and were then uplifted and denuded continuously to the present day. The geothermal gradient and heat flow in the Late Cretaceous era were approximately 30.0 °C/km and 66 mW/m^2, respectively, which were both higher than those at present. The tectonothermal evolution from the Late Cretaceous era to the present is characterized by denudation and cooling processes with an erosion thickness of ~2.7 km. In addition to the Triassic era, the Jurassic era represents an important hydrocarbon generation period for both Silurian and Permian source rocks, and the organic matter maturity of these source rocks entered into a dry gas period after oil generation. The thermal conditions are advantageous to the accumulation of conventional and unconventional gas because the hydrocarbon generation process of the source rocks occurs after the formation of an effective reservoir cap. In particular, the high geothermal gradient and increasing temperature before the denudation in the Late Cretaceous era facilitated the generation of hydrocarbons, and the subsequent cooling process favored its storage. | Chuanqing Zhu Nansheng Qiu Huanyu Cao Song Rao Shengbiao Hu | 2016 | Journal of Earth Science2016，27，5： | 4 |
| 15 | Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase显示文摘 | Song Guangjun Rao Huiying Feng Bo Wei Lai | 2014 | Chinese Medical Journal2014，，9： | 4 |
| 16 | Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity显示文摘In this study,three new germacranolide sesquiterpenes(1–3),together with six related known analogues(4–9)were isolated from the whole plant of Carpesium cernuum.Their structures were established by a combination of extensive NMR spectroscopic analysis,HR-ESIMS data,and ECD calculations.The anti-leukemia activities of all compounds towards three cell lines(HEL,KG-1a,and K562)were evaluated in vitro.Compounds 1–3 exhibited moderate cytotoxicity with IC50 values ranging from 1.59 to 5.47μmol·L^(−1).Mechanistic studies indicated that 2 induced apoptosis by decreasing anti-apoptotic protein Bcl-2 and activating the caspase family in K562 cells.These results suggest that compound 2 is a potential anti-leukemia agent. | YAN Chen LONG Qun ZHANG Yun-Dong BABU Gajendran KRISHNAPRIYA Madhu Varier QIU Jian-Fei SONG Jing-Rui RAO Qing YI Ping SUN Mao LI Yan-Mei | 2021 | Chinese Journal of Natural Medicines2021，19，7： | 3 |
| 17 | Spatial differences in soybean bioactive components across China and their influence by weather factors显示文摘Bioactive components are partially responsible for the nutritional and health benefits of soybeans. Four major bioactive components: isoflavones, oligosaccharides, phospholipids,and saponins, were quantified in 763 soybean samples collected from widely distributed regions across China from 2010 to 2013. A majority of the tested bioactive components showed generally declining trends from the north(high latitude) to the south(low latitude).A positive relationship between total oligosaccharides(TO) and altitude was observed. Total isoflavones(TI), phospholipids(TP) and TO were negatively correlated with cumulative temperature above or equal to 15 °C(AT15) and mean daily temperature(MDT), but positively correlated with diurnal temperature range(DTR) and hours of sunshine(HS).Total saponins(TS) were negatively correlated with MDT but positively correlated with rainfall(RF), whereas TO were negatively correlated with RF. Path-coefficient analysis showed that, besides genotype differences, temperature and HS during the reproductive period influenced TI and TP contents, while temperature and RF influenced TS and TO. The effects of weather factors on soybean bioactive components in diverse regions of China were characterized. These findings will be helpful in promoting soybean production for functional food purposes. | Wenwen Song Ruping Yang Xiushi Yang Shi Sun Srinivasa Rao Mentreddy Bingjun Jiang Tingting Wu Shiyan Tian Enoch Sapey Cunxiang Wu Wensheng Hou Guixing Ren Tianfu Han | 2018 | The Crop Journal2018，6，6： | 3 |
| 18 | Changes of Ghrelin/GOAT axis and m TOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats显示文摘AIM To examine the changes of the ghrelin/ghrelin O-acyltransferase(GOAT) axis and the mammalian target of rapamycin(m TOR) pathway in the hypothalamus after sleeve gastrectomy.METHODS A total of 30 obese type-2 diabetes Sprague-Dawley(SD) rats, 6 wk of age, fed with high-sugar and highfat fodder for 2 mo plus intraperitoneal injection of streptozotocin were randomly divided into three groups: non-operation group(S0 group, n = 10), sham operation group(Sh group, n = 10) and sleeve gastrectomy group(SG group, n = 10). Data of body mass, food intake, oral glucose tolerance test(OGTT), acylated ghrelin(AG) and total ghrelin(TG) were collected and measured at the first day(when the rats were 6 wk old), preoperative day 3 and postoperative week 8. The m RNA expression of preproghrelin, GOAT and neuropeptide Y(NPY), and protein expression of ghrelin, GOAT, GHSR and the m TOR pathway(p-Akt, p-m TOR and p-S6) were measured in the hypothalamus.RESULTS SG can significantly improve metabolic symptoms by reducing body mass and food intake. The obese rats showed lower serum TG levels and no change in AG, but the ratio of AG/TG was increased. When compared with the S0 and Sh groups, the SG group showed decreased TG(1482.03 ± 26.55, 1481.49 ± 23.30 and 1206.63 ± 52.02 ng/L, respectively, P < 0.05), but unchanged AG(153.06 ± 13.74, 155.37 ± 19.30 and 144.44 ± 16.689 ng/L, respectively, P > 0.05). As a result, the ratio of AG/TG further increased in the SG group(0.103 ± 0.009, 0.105 ± 0.013 and 0.12 ± 0.016, respectively, P < 0.05). When compared with the S0 group, SG suppressed m RNA and protein levels of preproghrelin(0.63 ± 0.12 vs 0.5 ± 0.11, P < 0.05) and GOAT(0.96 ± 0.09 vs 0.87 ± 0.08, P < 0.05), but did not change NPY m RNA expression(0.61 ± 0.04 vs 0.65 ± 0.07, P > 0.05) in the hypothalamus. The protein levels of p-Akt, p-m TOR and p-S6 were higher in the SG group, which indicated that the hypothalamic m TOR pathway was activated after SG at the postoperative week 8. CONCLUSION The reduction of ghrelin expression and activation of the m TOR pathway might have opposite effects on food intake, as SG improves obesity and T2 DM. | Qiang Wang Wei Tang Wen-Sheng Rao Xin Song Cheng-Xiang Shan Wei Zhang | 2017 | World Journal of Gastroenterology2017，23，34： | 3 |
| 19 | PROTACs: great opportunities for academia and industry显示文摘Although many kinds of therapies are applied in the clinic,drug-resistance is a major and unavoidable problem.Another disturbing statistic is the limited number of drug targets,which are presently only 20–25%of all protein targets that are currently being studied.Moreover,the focus of current explorations of targets are their enzymatic functions,which ignores the functions from their scaffold moiety.As a promising and appealing technology,PROteolysis TArgeting Chimeras(PROTACs)have attracted great attention both from academia and industry for finding available approaches to solve the above problems.PROTACs regulate protein function by degrading target proteins instead of inhibiting them,providing more sensitivity to drug-resistant targets and a greater chance to affect the nonenzymatic functions.PROTACs have been proven to show better selectivity compared to classic inhibitors.PROTACs can be described as a chemical knockdown approach with rapidity and reversibility,which presents new and different biology compared to other gene editing tools by avoiding misinterpretations that arise from potential genetic compensation and/or spontaneous mutations.PRTOACs have been widely explored throughout the world and have outperformed not only in cancer diseases,but also in immune disorders,viral infections and neurodegenerative diseases.Although PROTACs present a very promising and powerful approach for crossing the hurdles of present drug discovery and tool development in biology,more efforts are needed to gain to get deeper insight into the efficacy and safety of PROTACs in the clinic.More target binders and more E3 ligases applicable for developing PROTACs are waiting for exploration. | Xiuyun Sun Hongying Gao Yiqing Yang Ming He Yue Wu Yugang Song Yan Tong Yu Rao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 3 |
| 20 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
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