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| 1 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 2 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 3 | Location patterns of urban industry in Shanghai and implications for sustainability显示文摘瓷器经济经历了快速的转变并且工业重构。术语城市的工业在中国城市经历重构以内描述工业的一种特别类型。给也从城市中心关门了或重定位到城市的穗并且在以外的工业公司的高百分比,突现的全球城市象上海那样,为本地经济、城市的开发正在实现策略,它在城市中心和城市的穗包含城市的工业升级的众多的公司。这研究试图用 2008 微地理的数据在上海城市的区域以内分析七个城市的工业扇区的地点模式。为了避免统一问题(MAUP ) 问题,包括最近的邻居分析的四项基于距离的措施,核密度评价, K 功能和合作地点的可修改的 Areal,商广泛地被使用了分析并且比较在七个部门之间的集中和合作地点。结果揭示也与距离和有趣的合作地点变化的迥异的模式。结果如下:城市中心和城市的穗从城市中心与 20-30 km 有城市的工业公司,而是地区的最高的紧张是为大多数范畴的一个分水岭;集中的度与距离变化,在更短的距离更弱,增加直到 30 km 的最大的距离然后减少直到 50 km;为所有城市的工业,有模式的三种类型,在距离的一个改变的范围的聚类的、随机、分散的分发的混合。因而,这份报纸主张城市的工业的地点模式思考阶段特定的工业重构和空间转变,由可持续性目的调节了。 | CAO Weidong LI Yingying CHENG Jianquan Steven MILLINGTON | 2017 | Journal of Geographical Sciences2017，27，7： | 5 |
| 4 | FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling显示文摘Incomplete recovery from episodes of acute kidney injury(AKI)can predispose patients to develop chronic kidney disease(CKD).Although hypoxia-inducible factor-1α(HIF-1α)is a master regulator of the response to hypoxia/ischemia,the role of HIF-1α in CKD progression following incomplete recovery from AKI is poorly understood.Here,we investigated this issue using moderate and severe ischemia/reperfusion injury(I/RI)mouse models.We found that the outcomes of AKI were highly associated with the time course of tubular HIF-1α expression.Sustained activation of HIF-1α,accompanied by the development of renal fibrotic lesions,was found in kidneys with severe AKI.The AKI to CKD progression was markedly ameliorated when PX-478(a specific HIF-1α inhibitor,5 mg·kg^(−1)·d^(−1),i.p.)was administered starting on day 5 after severe I/RI for 10 consecutive days.Furthermore,we demonstrated that HIF-1α C-terminal transcriptional activation domain(C-TAD)transcriptionally stimulated KLF5,which promoted progression of CKD following severe AKI.The effect of HIF-1α C-TAD activation on promoting AKI to CKD progression was also confirmed in in vivo and in vitro studies.Moreover,we revealed that activation of HIF-1αC-TAD resulted in the loss of FIH-1,which was the key factor governing HIF-1α-driven AKI to CKD progression.Overexpression of FIH-1 inhibited HIF-1α C-TAD and prevented AKI to CKD progression.Thus,FIH-1-modulated HIF-1α C-TAD activation was the key mechanism of AKI to CKD progression by transcriptionally regulating KLF5 pathway.Our results provide new insights into the role of HIF-1α in AKI to CKD progression and also the potential therapeutic strategy for the prevention of renal diseases progression. | Zuo-lin Li Bin Wang Lin-li Lv Tao-tao Tang Yi Wen Jing-yuan Cao Xiao-xiao Zhu Song-tao Feng Steven DCrowley Bi-cheng Liu | 2021 | Acta Pharmacologica Sinica2021，42，12： | 3 |
| 5 | Regional Lymphadenectomy Is Indicated in the Surgical Treatment of Pancreatic Neuroendocrine Tumors (PNETs)显示文摘 | Yassar M. Hashim Kathryn M. Trinkaus David C. Linehan Steven S. Strasberg Ryan C. Fields Dengfeng Cao William G. Hawkins | 2014 | Annals of Surgery2014，，2： | 2 |
| 6 | Analysis of Long-term Outcomes of 3200 Liver Transplantations Over Two Decades: A Single-Center Experience显示文摘 | Ronald W. Busuttil Douglas G. Farmer Hasan Yersiz Jonathan R. Hiatt Sue V. McDiarmid Leonard I. Goldstein Sammy Saab Steven Han Francisco Durazo Michael Weaver Carlos Cao Tony Chen Gerald S. Lipshutz Curtis Holt Sherilyn Gordon Jeffery Gornbein Farin Amer | 2005 | Annals of Surgery2005，，6： | 2 |
| 7 | A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study显示文摘Brain radiomics can reflect the characteristics of brain pathophysiology.However,the value of T1-weighted images,quantitative susceptibility mapping,and R2*mapping in the diagnosis of Parkinson’s disease(PD)was underestimated in previous studies.In this prospective study to establish a model for PD diagnosis based on brain imaging information,we collected high-resolution T1-weighted images,R2*mapping,and quantitative susceptibility imaging data from 171 patients with PD and 179 healthy controls recruited from August 2014 to August 2019.According to the inclusion time,123 PD patients and 121 healthy controls were assigned to train the diagnostic model,while the remaining 106 subjects were assigned to the external validation dataset.We extracted 1408 radiomics features,and then used data-driven feature selection to identify informative features that were significant for discriminating patients with PD from normal controls on the training dataset.The informative features so identified were then used to construct a diagnostic model for PD.The constructed model contained 36 informative radiomics features,mainly representing abnormal subcortical iron distribution(especially in the substantia nigra),structural disorganization(e.g.,in the inferior temporal,paracentral,precuneus,insula,and precentral gyri),and texture misalignment in the subcortical nuclei(e.g.,caudate,globus pallidus,and thalamus).The predictive accuracy of the established model was 81.1±8.0%in the training dataset.On the external validation dataset,the established model showed predictive accuracy of 78.5±2.1%.In the tests of identifying early and drug-naïve PD patients from healthy controls,the accuracies of the model constructed on the same 36 informative features were 80.3±7.1%and 79.1±6.5%,respectively,while the accuracies were 80.4±6.3%and 82.9±5.8%for diagnosing middle-to-late PD and those receiving drug management,respectively.The accuracies for predicting tremor-dominant and non-tremor-dominant PD were 79.8±6.9%and 79.1±6.5%,respectively.In conclusion,the multiple-tissue-specific brain radiomics model constructed from magnetic resonance imaging has the ability to discriminate PD and exhibits the advantages for improving PD diagnosis. | Xiao-Jun Guan Tao Guo Cheng Zhou Ting Gao Jing-Jing Wu Victor Han Steven Cao Hong-Jiang Wei Yu-Yao Zhang Min Xuan Quan-Quan Gu Pei-Yu Huang Chun-Lei Liu Jia-Li Pu Bao-Rong Zhang Feng Cui Xiao-Jun Xu Min-Ming Zhang | 2022 | Neural Regeneration Research2022，17，12： | 2 |
| 8 | New Era of Liver Transplantation for Hepatitis B: A 17-Year Single-Center Experience显示文摘 | Dean M. Anselmo Rafik M. Ghobrial Lee Chan Jung Michael Weaver Carlos Cao Sammy Saab Greg Kunder Pauline W. Chen Douglas G. Farmer Hasan Yersiz Angeles Baquerizo Sunil Geevarghese Steven H. Han Leonard Goldstein Curtis D. Holt Jeffrey A. Gornbein Ronald W | 2002 | Annals of Surgery2002，，5： | 1 |
| 9 | Effects of DL-alpha-lipoie acid on peripheral nerve conduction, blood flow, energy metabolism, and ox- idative stress in experimental diabetic neuropathy显示文摘 | Stevens M J Obrosova I Cao X | 2000 | Diabetes2000，49，： | 1 |
| 10 | Effects of DL-alpha-lipoie acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy 显示文摘 | Stevens M J Obrosova I Cao X | 2000 | Diabetes2000，49，6： | 1 |
| 11 | IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy显示文摘 | Mike W. Helms Jennifer A. Prescher Yu-An Cao Steven Schaffert Christopher H. Contag | 2010 | Cancer Immunology Immunotherapy2010，，9： | 1 |
| 12 | Synthesis of cadmium tungstate films via sol-gel processing 显示文摘 | KIRK L STEVEN J L CAO Guozhong | 2003 | Thin Solid Films2003，434，12： | 1 |
| 13 | Effects of DL - alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidation stress in experimental diabetic neuropathy显示文摘 | Stevens MJ Obrosoval I Cao X | 2000 | Diabetes2000，49，： | 1 |
| 14 | Interplay between Two Epigenetic Marks显示文摘 | Lianna M. Johnson Xiaofeng Cao Steven E. Jacobsen | 2002 | Current Biology2002，，16： | 1 |
| 15 | New Era of Liver Transplantation for Hepatitis B: A 17-Year Single-Center Experience显示文摘 | Dean M. Anselmo Rafik M. Ghobrial Lee Chan Jung Michael Weaver Carlos Cao Sammy Saab Greg Kunder Pauline W. Chen Douglas G. Farmer Hasan Yersiz Angeles Baquerizo Sunil Geevarghese Steven H. Han Leonard Goldstein Curtis D. Holt Jeffrey A. Gornbein Ronald W | 2002 | Annals of Surgery2002，，5： | 1 |
| 16 | Effect of DL-alpha-lipic acid on peripheral nerve conduction,blood flow,energy metabolism,and oxidative stress in experimental diabetic neuropathy显示文摘 | Stevens MJ Obrosova I Cao X | 2000 | Diatbetes2000，49，10： | 1 |
| 17 | Effects of DL-alpha-lipoicacid on peripheral nerve conduction, blood flow, energy me -tabolis, and oxidative stress in experimental diabetic neuropa-thy显示文摘 | Stevens MJ Obrosova I Cao X | 2000 | Diabetes2000，49，： | 1 |
| 18 | IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy显示文摘 | Mike W. Helms Jennifer A. Prescher Yu-An Cao Steven Schaffert Christopher H. Contag | 2010 | Cancer Immunology, Immunotherapy2010，，9： | 1 |
| 19 | Conversion of biomass syngas to DME using a microchannel reactor显示文摘 | HU J WANG Y CAO C ELLIOTT D C STEVENS D J WHITE J F | 2005 | Ind Eng Chem Res2005，44，6： | 1 |
| 20 | Effects of DL- alpha - lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stressing experimental diabetic neuropathy显示文摘 | Stevens MJ Obrosova l Cao X | 2000 | Diabetes2000，49，6： | 1 |
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