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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 3 | Retraction Note to:SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion显示文摘The authors have retracted this article1.After the publication of this article,it came to the authors attention that in order to support the conclusions of the study,the authors should have used primary T cells instead of T-cell lines.In addition,there are concerns that the flow cytometry methodology applied here was flawed.These points resulted in the conclusions being considered invalid. | Xinling Wang Wei Xu Gaowei Hu Shuai Xia Zhiping Sun Zezhong Liu Youhua Xie Rong Zhang Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，8： | 5 |
| 4 | Increased Expression of Intercellular Adhesion Molecule-1,Vascular Cellular Adhesion Molecule-1 and Leukocyte Common Antigen in Diabetic Rat Retina显示文摘Purpose: To understand the expression and distribution of intercellular adhesion molecule- 1(ICAM- 1),vascular cellular adhesion molecule- 1 (VCAM- 1)and CD45 (Leukocyte Common Antigen) in the control nondiabetic and various courses of diabetic rats retina. To explore the role of adhesion molecules (Ams) and the adhesion of leukocytes to vascular endothelial cells via Ams in diabetic retinopathy(DR).Methods: Sixty healthy adult male Wistar rats were randomly divided into diabetic groups(induced by Streptozotocin, STZ) and normal control groups. Rats in these two groups were further randomly divided into 3, 7, 14, 30, 90 and 180 days-group,including 5 rats respectively. The immunohistochemical studies of ICAM-1, VCAM-1 and CD45 were carried out in the retinal digest preparations or retinal paraffin sections, and the results were analyzed qualitatively, semi-quantitatively.Results: No positive reaction of VCAM-1 was found, and weak reactions of ICAM-1,CD45 were found in nondiabetic rats retina. The difference of 6 control groups had no statistical significance(P > 0.05). The increased ICAM-1 and CD45 staining pattern were detectable 3 days after diabetes induction, and a few VCAM-1 positive cells were observed in the retinal blood capillaries. The difference of diabetes and control is significant( P < 0.05).Following the course, the expressions of ICAM-1, VCAM-1 and CD45 were increasingly enhanced, reaching a peak at the 14th day.Conclusion: Increased expression of ICAM-1, VCAM-1 and leukocytes adhering and stacking in retinal capillaries are the very early events in DR. Coherence of expression and distribution of the three further accounts for it is the key point for the onset of DR that Ams mediates leukocytes adhesion and endothelial cell injury. | Ningyan Bai, Shibo Tang~#, Jing Ma, Yan Luo, Shaofeng Lin Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2003 | Eye Science2003，19，3： | 4 |
| 5 | Immunogenicity and tumor-inhibiting effects of HSP-antigen peptide complex in melanoma B16 cells in mice显示文摘目的 :黑色素瘤 B1 6细胞热休克蛋白 -抗原肽复合物 (HACs)及其粗提物 (HAC- CEs)的制备 ,以及它们的免疫原性和抑瘤效应的研究。方法 :应用 Sephacryl S- 2 0 0凝胶过滤制备HAC- CEs,应用亲和层析纯化 HACs,并测其免疫功能和抑瘤效应。结果 :应用凝胶过滤制备的HAC- CE3、HAC- CE4、HAC- CE5和应用亲和层析纯化的 HAC60 ,HAC75和 HAC97均不同程度地降低肿瘤发生率、延迟肿瘤发生时间和减少移植黑色素瘤 C57BL/6J小鼠死亡率 ;同时 ,伴有小鼠脾细胞 IFN-γ和 IL- 2分泌活性及 CTL杀伤率的增加。结论 :分子量为 60 0 0 0~ 970 0 0的 HACs具有免疫原性和抑瘤效应 ,本研究为制备肿瘤疫苗提供重要的实验依据。 | Gong Shouliang Yang Ying Fu Shibo Li Xiujuan Sun Zuyue Li Xiuyi | 2000 | 白求恩医科大学学报2000，26，5： | 3 |
| 6 | Photodegradation of methylmercury in the water body of the Three Gorges Reservoir显示文摘Biogeochemical cycling of mercury in the young Three Gorges Reservoir(TGR), China, is strongly considered. Although methylmercury(MMHg) photodegradation(PD) is an important process involved in mercury cycling in this zone, little is known about this process. In situ incubation experiments were therefore performed to quantify the effect of different wavelength radiations and environmental factors on the PD process of MMHg in the water bodies of TGR. It was found that the effect of solar radiation on MMHg PD was highly dependent on wavelength and water depth. All PD-rate constants resulting from each wavelength range decreased rapidly with water depth. For surface water, UV-A radiation(320?400 nm) was the key driver, accounting for 49%?62% of MMHg PD. For the entire water column, both photosynthetically active radiation(PAR, 400?700 nm) and UV-A were responsible for MMHg PD. MMHg PD fluxes peaked in summer(7.5?18 ng m?2 d?1), followed by spring(3.3?8.0 ng m?2 d?1), autumn(1.0?2.7 ng m?2 d?1), and winter(0.060?0.15 ng m?2 d?1). The annual fluxes of MMHg PD were estimated to be 1.1?2.8 μg m?2 a?1. Filtering the reservoir water and amending it with chemicals(i.e., Cl?, NO3?, and dissolved organic matter(DOM)) showed significant effects on MMHg PD rate constants. Stepwise regression analysis showed that intensity of solar radiation, suspended particulate matter(SPM), DOM, Cl?, and NO3? were involved in the PD process. Path analysis clarified the relationship between MMHg PD rate constants and environmental variables, as well as the comparative strength of direct and indirect relationships among variables. The results are of great importance for understanding MMHg cycling characteristics in TGR and also facilitate the understanding of the underlying process, MMHg PD, in natural waters. | Rongguo Sun Dingyong Wang Wen Mao Shibo Zhao Cheng Zhang Xiang Zhang | 2015 | Science China Chemistry2015，58，6： | 3 |
| 7 | Photodegradation of methylmercury in Jialing River of Chongqing, China显示文摘Photodegradation(PD) of methylmercury(MMHg) is a key process of mercury(Hg) cycling i water systems, maintaining MMHg at a low level in water systems. However, we posses little knowledge of this important process in the Jialing River of Chongqing, China. In sit incubation experiments were thus performed to measure temporal patterns and influencin factors of MMHg PD in this river. The results showed that MMHg underwent a ne demethylation process under solar radiation in the water column, which predominantl occurred in surface waters. For surface water, the highest PD rate constants were observed i spring(12 × 10-3± 1.5 × 10^(-3)m^2/E), followed by summer(9.0 × 10^(-3)± 1.2 × 10^(-3)m^2/E), autum(1.4 × 10^(-3)± 0.12 × 10^(-3)m^2/E), and winter(0.78 × 10^(-3)± 0.11 × 10^(-3)m^2/E). UV-A radiatio(320–400 nm), UV-B radiation(280–320 nm), and photosynthetically active radiation(PAR400–700 nm) accounted for 43%–64%, 14%–31%, and 16%–45% of MMHg PD, respectively. PD rat constants varied substantially with the treatments that filtered the river water and amended with chemicals(i.e., Cl-, NO_3^-, dissolved organic matter(DOM), Fe(III)), which reveals tha suspended particulate matter and water components are important factors in affecting the PD process. For the entire water column, the PD rate constant determined for each wavelengt range decreased rapidly with water depth. UV-A, UV-B, and PAR contributed 27%–46%, 6.2%12%, and 42%–65% to the PD process, respectively. PD flux was estimated to be 4.7 μg/(m^2·yea in the study site. Our results are very important to understand the cycling characteristics o MMHg in the Jialing River of Chongqing, China. | Rongguo Sun Dingyong Wang Wen Mao Shibo Zhao Cheng Zhang | 2015 | Journal of Environmental Sciences2015，27，6： | 2 |
| 8 | Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation显示文摘The COVID-19 pandemic poses a global threat to public health and economy.The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines.In this study,we identified that EK1 and cholesterol-coupled derivative of EK1,EK1C4,as pan-CoV fusion inhibitors,exhibit potent antiviral activity against SARS-CoV-2 infection in both lung-and intestine-derived cell lines(Calu-3 and Caco2,respectively).They are also effective against infection of pseudotyped SARS-CoV-2 variants B.1.1.7(Alpha)and B.l.1.248(Gamma)as well as those with mutations in S protein,including N417T,E484K,N501Y,and D614G,which are common in South African and Brazilian variants.Crystal structure revealed that EK1 targets the HR1 domain in the SARS-CoV-2 S protein to block virus-cell fusion and provide mechanistic insights into its broad and effective antiviral activity.Nasal administration of EK1 peptides to hACE2 transgenic mice significantly reduced viral titers in lung and intestinal tissues.EK1 showed good safety profiles in various animal models,supporting further clinical development of EK1-based pan-CoV fusion inhibitors against SARS-CoV-2 and its variants. | Shuai Xia Qiaoshuai Lan Yun Zhu Chao Wang Wei Xu Yutang Li Lijue Wang Fanke Jiao Jie Zhou Chen Hua Qian Wang Xia Cai Yang Wu Jie Gao Huan Liu Ge Sun Jan Munch Frank Kirchhoff Zhenghong Yuan Youhua Xie Fei Sun Shibo Jiang Lu Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 9 | Roles of chloride ion in photo-reduction/oxidation of mercury显示文摘Photo-reduction of divalent mercury(Hg(II)) in aquatic systems plays a key role in global biogeochemistry cycling of mercury(Hg) in the Earth's surface environment. The mechanisms of this process with various Clconcentrations([Cl-]) under different pH values and irradiation wavelength ranges are still unclear. In this work,photo-reduction and photo-oxidation experiments of Hg with different [Cl-] and pH values under various light conditions were conducted. The results show that photoreduction rate constants of Hg(II) decrease with the increasing of [Cl-] in neutral solution under full light spectrum. Photo-reduction rate constants of Hg(II) with Cl-is highly dependent on Hg(II) species, which is determined by [Cl-] and pH value. Irradiation wavelength ranges have significant effects on reaction processes of photo-reduction of Hg(II) and photo-oxidation of Hg(0) in the presence of Cl-. When cut off ultraviolet(UV) radiation(280–400 nm), the reduction rate constants decrease without Cl-, and increase with higher [Cl-], and the photooxidation rates of Hg(0) decrease with or without Cl-.Except Cl-complexation stabilize the reducible Hg ions in solutions, photo-oxidation is an important reason for Cllowering photo-reduction rate of Hg(II). The results are of great importance for understanding the photo-redox characters of Hg(II) with Cl-. | Rongguo Sun Dingyong Wang Wen Mao Shibo Zhao Cheng Zhang | 2014 | Chinese Science Bulletin2014，59，27： | 1 |
| 10 | Management of Post-traumatic Aniridia with Retinal Detachment显示文摘Purpose: To reconstruct the anatomic and functional impairment in patients with post-traumatic aniridia, aphakia, and retinal detachment.
Methods: Four patients with unilateral aniridia and aphakia as well as retinal detachment as results of severe eye injuries underwent scleral buckling, vitrectomy, membrane peeling, endolaser photocoagulation, silicone oil or gas temponade, combined with iris diaphragm-IOL implantation.
Results: All four patients achieved successfully anatomic and functional reconstruction after surgery. During five to 22 months postoperative follow-up, all retinas remained attached. The final visual acuity increased from finger counting to 0.1 ~ 0.3.
Conclusions: The combination of vitreoretinal surgery and iris diaphrgm-IOL implantation is an effective method for post-traumatic aniridia, aphakia and traumatic retinal detachment. It could ameliorate photophobia and improve the biocular vision.Furthermore, artificial iris diaphragm implantation could prevent silicone oil-endothelia contact and salvage silicone keratopathy. Eye Science 2001; 17:35 ~ 38. | Shibo Tang, Guanting Qiu, Pei Wang, Xiaoling LiangZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China | 2001 | Eye Science2001，17，1： | 1 |
| 11 | Spatial variations of heavy metals in the soils of vegetable-growing land along urban-rural gradient of Nanjing, China显示文摘 | FANG Shibo HU Hao SUN Wanchun | 2011 | International Journal of Environmental Research and Public Health2011，8，6： | 1 |
| 12 | The Preliminary Report of Pathological Changes of Epiretinal Membranes and Internal Limiting Membrane Removed during Idiopathic Macular Hole Surgery显示文摘Purpose:To investigate the pathological changes of epiretinal membranes(ERM)and internal limiting membrane (ILM) removed during idiopathic macular hole surgery.Methods:Ten consecutive patients with a unilateral idiopathic macular hole underwent pars plana vitrectomy(PPV) with the surgical removal of the ERMs overlying the hole and ILM surrounding the hole. The pathological features of the excised tissues were examined under the microscope. Results:According to the morphological changes, four ERMs showed cellular elements which looked like glia cells, macrophages, plasma cells, lymphocytes and fibroblast cells. Two of the ILM appeared as transparent membranes without cellular elements. The other eight ILM showed cellular elements on the transparent membranes.Conclusion: Our study supports the hypothesis that the tangential traction of vitreous and proliferative cellular elements on the inner surface of ILM causes idiopathic macular holes. Removal of the posterior cortical vitreous, ILM and proliferative cellular tissue is a valid treatment for IMH. | Jiaqing Li, Shibo Tang, Yan Luo, Jie Zhang, Shaofen LinZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 1 |
| 13 | Gross-selhng se- quentially ordered products: an application to consumer banking services 显示文摘 | Li Shibo Sun Baohong Wilcox R T | 2005 | Journal of Marketing Research2005，42，2： | 1 |
| 14 | MnS hollow microspheres combined with carbon nanotubes for enhanced performance sodium-ion battery anode显示文摘MnS as anode material for sodium-ion batteries(SIBs)has recently attracted great attention because of the high theoretical capacity,great natural abundance,and low cost.However,it suffers from inferior electrical conductivity and large volume expansion during the charge/discharge process,leading to tremendous damage of electrodes and subsequently fast capacity fading.To mitigate these issues,herein,a three-dimensional(3D)interlaced carbon nanotubes(CNTs)threaded into or between MnS hollow microspheres(hollow MnS/CNTs composite)has been designed and synthesized as an enhanced anode material.It can effectively improve the electrical conductivity,buffer the volume change,and maintain the integrity of the electrode during the charging and discharging process based on the synergistic interaction and the integrative structure.Therefore,when evaluated as anode for SIBs,the hollow MnS/CNTs electrode displays enhanced reve rsible capacity(275 mAh/g at 100 mA/g after 100 cycles),which is much better than that of pure MnS electrode(25 mAh/g at 100 mA/g after 100 cycles)prepared without the addition of CNTs.Even increasing the current density to 500 mA/g,the hollow MnS/CNTs electrode still delivers a five times higher reversible capacity than that of the pure MnS electrode.The rate performance of the hollow MnS/CNTs electrode is also superior to that of pure MnS electrode at various current densities from 50 mA/g to 1000 mA/g. | Na Zhang Xin Li Tianyi Hou Jinze Guo Anran Fan Shibo Jin Xiaohong Sun Shu Cai Chunming Zheng | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 15 | Cross-selling sequentially ordered products:An application to consumer banking services显示文摘 | Li Shibo Sun Baohong Wilcox R | 2004 | Journal of Marketing Research2004，42，2： | 1 |
| 16 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 17 | An ultrapotent pan-β-coronavirus lineage B(β-CoV-B)neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope显示文摘New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design.Here,we identified a receptorbinding domain(RBD)-binding antibody,XG014,which potently neutralizesβ-coronavirus lineage B(β-CoV-B),including SARS-CoV-2,its circulating variants,SARSCoV and bat SARSr-CoV WIV1.Interestingly,antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibodydependent SARS-CoV-2 spike(S)protein-mediated cellcell fusion,suggesting a unique mode of recognition by XG014.Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional“down”conformation,while its family member XG005 directly competes with ACE2 binding and position the RBD“up”.Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in vivo.Our findings suggest the potential to develop XG014 as pan-β-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines againstβ-CoV-B and newly emerging SARS-CoV-2 variants of concern. | Zezhong Liu Wei Xu Zhenguo Chen Wangjun Fu Wuqiang Zhan Yidan Gao Jie Zhou Yunjiao Zhou Jianbo Wu Qian Wang Xiang Zhang Aihua Hao Wei Wu Qianqian Zhang Yaming Li Kaiyue Fan Ruihong Chen Qiaochu Jiang Christian TMayer Till Schoofs Youhua Xie Shibo Jiang Yumei Wen Zhenghong Yuan Kang Wang Lu Lu Lei Sun Qiao Wang | 2022 | Protein & Cell2022，13，9： | 1 |
| 18 | Experimental Study on the Effect of Perfluorodecalin on Rabbit Corneas显示文摘Purpose: To study the effects of perfluorodecalin on the cornea of the rabbit eyes. Methods: Perfluorodecalin (0.05 ml/each) was injected into the anterior chambers of eighteen rabbit eyes. Corneal morphology and endothelial cells were monitored clinically by slit-lamp biomicroscope and specular microscope for 26 weeks. Animals were sacrificed in 1 st, 2nd, 4th, 10th, 16th, 22nd, and 26th week after injection, respectively, and the corneas were examined under the light microscope. Results: Perfluorodecalin droplets looking like “ fish eggs ” were found at about 1/4-1/2 of the corneal height in the inferior anterior chamber. Corneal opacification on the area contacted with perfluorodecalin was observed in five eyes five weeks after injection, and all in the 22nd week. Mutton fat KPs in one eye were seen in the 6th week firstly, and in all eyes in the 7th week. Corneal pannus formation in one eye was present in the 4th week, two eyes in the 5th week and three eyes in the 6th week. Retrocorneal fibrous membrane in one eye was detected at the 6th week and 3 eyes at the 7th week respectively. After injection of perfluorodecalin, endothelial cell density was sighificantly decreased (2789 ± 192 vs. 2341 ± 658, P < O. O1 ) and corneal thickness was increased. Conclusions: Perfluorodecalin injected into anterior chamber can lead to corneal damage and inflammatory reaction. Eye Sciemce 2001; 17:16 - 20. | Fenghe Lu, Shibo Tang, Xiaobo Zhu, Jie Zhang, Hiding ZhengZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China | 2001 | Eye Science2001，17，1： | 1 |
| 19 | Optimal flow control for utility-lifetime tradeoff in wireless sensor networks显示文摘 | CHEN Jiming HE Shibo SUN Youxian | 2009 | Computer Networks Elsevier2009，53，18： | 1 |
| 20 | Potential recombination between SARS-CoV-2 and MERSCoV:calls for the development of Pan-CoV vaccines显示文摘In a recent study published in Nature,Yan and colleagues demonstrated that NeoCoV,a potential MERS-CoV ancestor in bats,can use bat ACE2 as its entry receptor and that NeoCoV S pseudotyped virus,which contains a T510F mutation in the receptor-binding domain(RBD),enters cells expressing human ACE2(hACE2).1 The findings reveal a potential zoonotic threat that MERS-CoV could,during its evolution,be gaining the ability to use hACE2 as an entry receptor and,thus,could also coinfect ACE2-expressing cells with SARS-CoV-2. | Qiao Wang Lujia Sun Shibo Jiang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
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