|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characteristics of eletromagnetic wave radiated from corona discharge 显示文摘 | Sun Youlin Xie Hengkun | 2001 | IEEE EMC International Symposium Record2001，2，： | 1 |
| 2 | Effects of Er^3+ concentration on UV/blue upconverted luminescence and a three-photon process in the cubic nanocrystalline Y2O5 : Er^3+ 显示文摘 | Wang Xin Shah Guiye Chao Kefu Zhang Youlin Liu Ruilin Feng Liyun Zeng Qinghui Sun Yajuan Liu Yichun Kong Xianggui | 2006 | Materials Chemistry and Physics2006，99，23： | 1 |
| 3 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 4 | Preliminary study of lateral variation in crustal structure of Northeast China from teleseismic receiver functions显示文摘We conducted comprehensive receiver function analyses for a large amount of high-quality broadband teleseismic waveforms data recorded at 19 China National Digital Seismic Network (CNDSN) stations deployed in Northeast China.An advanced H-κ domain search method was adopted to accurately estimate the crustal thickness and vP/vS ratio.The crust has an average thickness of about 34.4 km.The thinnest crust occurs in the central region of Northeast China,while the thickest crust is beneath the Yanshan belt.The v P /v S ratio is relatively uniform with an average of about 1.733.The highest vP/vS ratio is found beneath the Changbaishan,likely associated with its volcanic activities.We found significant lateral heterogeneity beneath three stations CN2,MDJ,and MIH located along the Suolon suture from the back-zimuthal dependence of Moho depth.The velocity modeling from receiver functions indicated complicated Earth structure beneath these stations with large crust-mantle transition zone,noticeable velocity jump in upper mantle,and low velocity zone in middle crust.Dipping velocity interface in the crust with strike approximately parallel to the Suolon suture and down-dip to the south or southeast might explain the observed lateral heterogeneity. | Youlin Chen Ruifeng Liu Zhibin Huang Li Sun | 2011 | Earthquake Science2011，24，1： | 0 |
| 5 | Multifactor dimensionality reduction analysis of syndrome characteristics of chronic persistent asthma显示文摘Objective:To analyze the syndrome characteristics in patients with chronic persistent asthma.Methods:365 patients(121 males,244 females,60.829.1 years old)with chronic persistent asthma were enrolled in this cross-sectional study.The information of syndrome,symptoms,signs,tongue coating and pulse were collected from all patients.The syndrome characteristics of chronic persistent asthma were examined through the multifactor dimensionality reduction(MDR)analysis and the results were verified by the Chi-square test.Results:The results of the MDR analysis and the Chi-square test showed the following positive correlation of the interaction among:the deficiency syndrome of the lung and spleen and deep pulse,disinclination to talk due to lack of qi,fatigue,lassitude and thick tongue coating;the deficiency syndrome of the lung and kidney and dizziness and disinclination to talk due to lack of qi,fatigue,lassitude and pallid complexion;the syndrome of phlegm-heat obstructing the lung and rapid pulse,abdominal distension,disinclination to talk due to lack of qi,frequent urination and lassitude;the syndrome of phlegm-dampness obstructing the lung and disinclination to talk due to lack of qi,greasy coating,fatigue and lassitude.(P<.05 for all).Conclusion:The syndrome of chronic persistent asthma is characterized by fatigue and lassitude due to dysfunction of the lung,spleen and kidney. | Yanyan Meng Aiping Chen Qi Shi Yue Yan Chaolumen Han Huiyuan Sun Youlin Li | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 0 |
| 6 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员