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| 1 | Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues显示文摘Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments.The mechanotransduction process requires a range of special proteins termed mechanotransducers to convert mechanical forces into biochemical signals in cells.The Piezo proteins are mechanically activated nonselective cation channels and the largest plasma membrane ion channels reported thus far.The regulation of two family members,Piezol and Piezo2#has been reported to have essential functions in mechanosensation and transduction in different organs and tissues.Recently,the predominant contributions of the Piezo family were reported to occur in the skeletal system,especially in bone development and mechano-stimulated bone homeostasis.Here we review current studies focused on the tissue-specific functions of Piezol and Piezo2 in various backgrounds with special highlights on their importance in regulating skeletal cell mechanotransduction.In this review,we emphasize the diverse functions of Piezol and Piezo2 and related signaling pathways in osteoblast lineage cells and chondrocytes.We also summarize our current understanding of Piezo channel structures and the key findings about PIEZO gene mutations in human diseases. | Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao | 2021 | Bone Research2021，9，4： | 14 |
| 2 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 3 | Investigation of Ancient and Large Tree Resources in Green Spaces of Urban Parks: A Case Study of Yunqizhujing Park in Hangzhou, China显示文摘Conservation of ancient and large trees in domestic and overseas cities was compared, ancient and large trees were regarded as important cultural relics playing an important role in optimizing urban natural environment and enriching urban humanistic and natural landscapes, and they were also important contents of urban garden works symbolizing urban parks. A case study was carried out Yunqizhujing Park to study conservation of ancient and large trees in park green spaces of Hangzhou City, solutions to current problems were proposed, and constructive suggestions were given for the conservation of ancient and large trees in urban park green spaces. | CHU Jiamiao LAI Shuifang ZHONG Tailin LI Yuan | 2012 | Journal of Landscape Research2012，4，10： | 5 |
| 4 | Genetic diversity analysis of Sinojackia microcarpa, a rare tree species endemic in China, based on simple sequence repeat markers显示文摘Although most Sinojackia species are endangered, they contribute greatly to the biodiversity of local ecosystems. Sinojackia microcarpa, an endangered species, is distributed only in three provinces of eastern China. Determining the genetic diversity of S. microcarpa provides key information for germplasm evaluation and species conservation. Here we used simple sequence repeat (SSR) markers to investigate the genetic diversity of eight natural populations of S. microcarpa. Leaf samples were collected from 144 individuals in 8 wild populations. The 156 bands were generated from 14 pairs of informative SSR primers, with an average percentage of polymorphic bands of 45.67%. The average values of Nei’s genetic diversity (He) and Shannon’s diversity index (I) were 0.1007 and 0.1658, respectively. The total genetic variation of S. microcarpa existed mainly within the eight populations, rather than among populations, and reached 86.41%. A cluster analysis showed that the eight wild populations of S. microcarpa could be classified into four groups, at a threshold of 4.0, based on an analysis of the SSR genotypes. Furthermore, there was a significant association between the phylogenetic relationships and the geographic locations of the S. microcarpa populations. In particular, populations from Fuyang, Jiande, and Lin’an in Zhejiang Province had close phylogenetic relationships and geographic distances. In addition, these three populations had the highest genetic diversity and the most individuals, suggesting that these three locations may be the S.microcarpa distribution center. This study serves as a model for studying the genetic diversity of endangered plant species. | Tailin Zhong Guangwu Zhao Yongfeng Lou Xinchun Lin Xiaomin Guo | 2019 | Journal of Forestry Research2019，30，3： | 2 |
| 5 | Application of oxygen-sensing technology to measure seed quality of Ginkgo biloba显示文摘Germination tests are currently the most widely used method to evaluate seed quality of Ginkgo biloba L., but they are time-consuming and labor intensive. Oxygensensing technology, based on the principle of fluorescence quenching to detect oxygen and assess seed quality was used to rapidly evaluate seed quality of two varieties(Shandong Tancheng 202 and Zhejiang Dafoshou) of G. biloba from five mother plants. Fifteen samples of three vigor levels were produced by accelerated aging treatments. This process was applied in duplicate. A portable oxygen-sensing detector was employed to measure oxygen content during seed germination in a closed system at 25 °C each day until day 14. Four oxygen metabolism indices were calculated: oxygen consumption index, oxygen consumption rate, critical oxygen concentration, and theoretical germination time(TGT).Additionally, we tested laboratory germination and field emergence. The results of a one-way analysis of variance and correlation analysis showed that TGTwas the candidate index to evaluate seed quality of G. biloba. Therefore, the TGT value was used to validate the reliability of oxygen-sensing evaluation for Zhejiang Dafoshou seeds kept under four storage conditions. The trend in the change in oxygen metabolism agreed completely agreement with that of seed germination under all storage conditions. The oxygensensing test reliably and rapidly assessed seed quality of G.biloba. The germination rate of Zhejiang Dafoshou was accurately predicted by TGT. | Tailin Zhong Guangwu Zhao | 2017 | Journal of Forestry Research2017，28，4： | 2 |
| 6 | Jigsaw-like mini-pillar platform for multi-mode biosensing显示文摘The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional mini-pillar platform to perform multi-mode(electrochemical,fluorescence,surface-enhanced Raman scattering(SERS)and colorimetric)sensing in individual microdroplets.Each mini-pillar connector can parallelize together by specific concave-convex interface to form integrated jigsaw-like platform for multi-mode sensing,and each specific mini-pillar can be modified into the individual sensing unit to read the prescribed signals.We successfully implemented electrochemical,fluorescence,SERS and colorimetric detection by multiple signals coupling to reduce the false positive analysis.Such platform brings a promising clue of in-situ analysis and point-of-care testing for disease diagnosis and health monitoring. | Yongchao Song Dongdong Wang Zehua Li Lirong Wang Chuan Fan Xuecheng He Tailin Xu Xueji Zhang | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 7 | Nitric oxide released from iNOS in polymorphonuclear leukocytes make them deformable in an autocrine manner显示文摘 | Tailin C Miyuki A | 2002 | Nitrite Oxide2002，7，： | 1 |
| 8 | An adaptive edge detection method based on canny operator显示文摘 | Baihe Lang Lingyun Shen Tailin Han and Yuqun Chen | 2011 | Advanced Materials Research2011，，255260： | 1 |
| 9 | Antioxidative and growth-promoting effect of selenium on senescing lettuce显示文摘 | Tailin Xue Helin? Hartikainen Vieno Piironen | 2001 | Plant and Soil2001，，1： | 1 |
| 10 | Promotive effect of selenium on plant growth as triggered by ultraviolet irradiation显示文摘 | Hartikainen Helina Xue Tailin | 1999 | Journal of Environment Quality1999，28，4： | 1 |
| 11 | Artificial intelligence biosensors for continuous glucose monitoring显示文摘Artificial intelligence(AI)algorithms in combination with continuous monitoring technologies have the potential to revolutionize chronic disease management.The recent innovations in both continuous glucose monitoring(CGM)and the closed-loop highlight the far-reaching potential of AI biosensors for individual healthcare.This review summarizes some of the most advanced progress made in CGM biosensing.We will focus on three main applications of AI algorithms in diabetes management:closed-loop control algorithms,glucose predictions,and calibrations.The challenges and opportunities of AI technologies for CGM in individualized and proactive medicine will also be discussed. | Xiaofeng Jin Andrew Cai Tailin Xu Xueji Zhang | 2023 | Interdisciplinary Materials2023，2，2： | 1 |
| 12 | Near-infrared light-driven yolk@shell carbon@silica nanomotors for fuel-free triglyceride degradation显示文摘Yolk@shell mesoporous nanoparticles have received close attention due to their controllable structures and integrated functions.However,most yolk@shell nanosystems lack self-propulsion.Herein,yolk@spiky-shell structured carbon@silica nanomotors are fabricated with near-infrared(NIR)light self-thermophoretic propulsion as lipase nanocarriers for fuel-free triglyceride degradation.The light propulsion accelerates the accumulation of nanomotors on the droplet interface,and the efficient lipase loading further facilitates the rapid degradation of tributyrin droplets.By adjusting the yolk and spiky structure,the obtained semi-yolk@spiky-shell structured nanomotors exhibit the highest capacity of lipase(442 mg/g)and the highest light-driven diffusion coefficient(ca.55%increase under 2 W/cm^(2 )irradiation),thus improving the degradation efficiency of triglyceride(93.1%under NIR light vs.66.7%without NIR light within 20 min).This work paves the way to rationally design yolk@shell structured nanomotors for diverse applications. | Yi Xing Songsong Tang Xin Du Tailin Xu Xueji Zhang | 2021 | Nano Research2021，14，3： | 1 |
| 13 | Retraction notice to:M1 macrophage-derived exosomes moderate the differentiation of bone marrow mesenchymal stem cells显示文摘The published article titled“M1 macrophage-derived exosomes moderate the differentiation of bone marrow mesenchymal stem cells”,has been retracted from journal BIOCELL,Vol.46,No.2,2022,pp.495-503. | TAILIN WU XIANG ZHOU CANHUA YE WENCAN LU HAITAO LIN YANZHE WEI ZEKAI KE ZHENGJI HUANG JIANZHOU LUO HUIREN TAO CHUNGUANG DUAN | 2022 | BIOCELL2022，46，4： | 1 |
| 14 | Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint显示文摘Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring.Here,we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers including urea,lactate,and pH in sweat.A miniature,thin plasmonic metasurface with homogeneous mushroom-shaped hot spots and high surface-enhanced Raman scattering(SERS)activity is designed and integrated into a microfluidics platform.Compared to conventional wearable SERS platforms with the risk of mixed effect between new and old sweat,the microfluidic SERS system allows sweat administration in a controllable and high temporal-resolution fashion,providing refreshable SERS analysis.We use a portable and customized Raman analyzer with a friendly human-machine interface for portable recognition of the spectroscopic signatures of sweat biomarkers.This study integrates epidermal microfluidics with portable SERS molecular recognition,presenting a controllable,handy,and dynamical biofluid sensing system for personalized medicine. | Xuecheng He Chuan Fan Yong Luo Tailin Xu Xueji Zhang | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 15 | Antioxidative and growth-promoting effect of selenium on senescing lettuce显示文摘 | Tailin Xue Helin? Hartikainen Vieno Piironen | 2001 | Plant and Soil2001，，1： | 1 |
| 16 | Biosensor Sensitive to Hydrogen Peroxide via Methylene Blue Incorporated into Nafion Film as an Electron Transfer Mediator显示文摘1IntroductionThedetectionandquantitativedeterminationofhydrogenperoxideplaysanimportantroleinseveralfieldsincludingindustry,b... | Wu Xinxin Ying Tailin Sun Kang (School of Chemistry and Chemical Engineering) | 1998 | Advances in Manufacturing1998，，2： | 1 |
| 17 | A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis显示文摘Ischemic stroke is the second leading cause of death worldwide with limited medications and neuroinflammation was recognized as a critical player in the progression of stroke,but how to control the overactive neuroinflammation is still a long-standing challenge.Here,we designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and primary mouse microglia,which were abolished by silencing SIRT6.RNA-seq screening identified the forkhead box C1 (Foxc1) is a key gene evoked by MDL-811stimulation and is required for the anti-inflammatory effects of MDL-811.We found MDL-811-activated SIRT6 directly interacted with enhancer of zeste homolog 2 (EZH2) and promoted deacetylation of EZH2 which could bind to the promoter of Foxc1 and upregulate its expression to modulate inflammation.Moreover,our data demonstrated that MDL-811 not only ameliorated sickness behaviors in neuroinflammatory mice induced by LPS,but also markedly reduced the brain injury in ischemic stroke mice in addition to promoting long-term functional recovery.Importantly,MDL-811 also exhibited strong anti-inflammatory effects in human monocytes isolated from ischemic stroke patients,underlying an interesting translational perspective.Taken together,MDL-811 could be an alternative therapeutic candidate for ischemic stroke and other brain disorders associated with neuroinflammation. | Tailin He Jialin Shang Chenglong Gao Xin Guan Yingyi Chen Liwen Zhu Luyong Zhang Cunjin Zhang Jian Zhang Tao Pang | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 1 |
| 18 | Ventricular septal defect with secondary left ventricular to right atrial shunt in associated with ahighter risk for infective endocarditis an lower late chance of closure显示文摘 | Wei Hwanwu Jou Kouwang Ming Tailin | 2011 | Pediatrics2011，117，： | 1 |
| 19 | A Study on Photosynthetic Physiological Characteristics of Six Rare and Endangered Species显示文摘The parameters of gas exchange and chlorophyll fluorescence in leaves of six rare and endangered species Neolitsea sericea, Cinnamomum japonicum var.chenii, Sinojackia microcarpa, Discocleidion glabrum var. trichocarpum, Parrotia subaequalis, Cercidiphyllum japonicum were measured in fields. The results showed that there were significant differences in photosynthetic capacity, intrinsic water use efficiency(WUEi), the efficiency of primary conversion of light energy of PSⅡ and its potential activity, the quantum yield of PSⅡ electron transport, and the potential capacity of heat dissipation among the six species. However, there was no significant difference in WUE. The highest values of net photosynthetic rate(Pn), transpiration rate(Tr) and stomatal conductance(gs) occurred in D. glabrum var. trichocarpum and the lowest in S. microcarpa. On the contrary, D. glabrum var. trichocarpum had the lowest WUE, intrinsic water use efficiency(WUEi) and S. microcarpa had the highest. The results indicated that D. glabrum var. trichocarpum had higher photosynthetic capacity and poorer WUE, while S. microcarpa had lower photosynthetic capacity and greater WUE. Furthermore, the mean values of maximal fluorescence(Fm), potential efficiency of primary conversion of light energy of PS Ⅱ(Fv/Fm),ΦPSⅡ, actual efficiency of primary conversion of light energy of PSⅡ(F′v/F′m)and non-photochemical quenching coefficient(NPQ) were the highest in S. microcarpa, indicating that its PS Ⅱ had higher capacity of heat dissipation and could prevent photosynthetic apparatus from damage by excessive light energy. Correlation analysis showed that there were significant correlations among photosynthetic physiological parameters. However, the initial fluorescence(Fo) was not significantly correlated with any other parameters. This study also revealed the extremely significant positive correlations between Pn and Tr, gs, apparent quantum yield(AQY), between Tr and gs, between light saturation point(LSP) and AQY, between Fv/Fm and Fm, between ΦPSⅡ and photochemical quenching coefficient(qp), between Tr,gs and LSP, AQY. However, WUEiwas significantly negatively correlated with Tr,gs, Pn, LSP and AQY. | Tailin ZHONG Guangwu ZHAO Jiamiao CHU Xiaomin GUO Genyou LI | 2014 | Agricultural Science & Technology2014，15，8： | 1 |
| 20 | Arbitration: The Best Effective Means Resolving Chinese Futures Operation Dissension显示文摘 | Tailin Liu Huiping Liu | 2005 | China-USA Business Review2005，4，7： | 0 |
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