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| 1 | Lushan M_S7.0 earthquake:A blind reserve-fault event显示文摘In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas. | XU XiWei WEN XueZe HAN ZhuJun CHEN GuiHua LI ChuanYou ZHENG WenJun ZHNAG ShiMin REN ZhiQun XU Chong TAN XiBin WEI ZhanYu WANG MingMing REN JunJie HE ZhongTai LIANG MingJian | 2013 | Chinese Science Bulletin2013，58，28： | 35 |
| 2 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 3 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 4 | Effect of ursodeoxycholic acid on TGF betal/Smad signaling pathway in rat hepatic stellate cells显示文摘背景肝的纤维变性到 cirrhosis.Ursodeoxycholic 酸( UDCA )的从肝的损害的病理学的进步的关键阶段作为在研究试图在转变生长因素 beta1 ( TGF1 ) /Smad 的发信号的小径上学习 UDCA 的效果并且讨论的长期的肝 diseases.Our 上有重要临床的治疗学的效果被知道了它禁止肝的 fibrosis.Methods 的可能的分子的机制老鼠肝的星形的房间在 vitro 是有教养的并且随机把 gr 分到 4 组 A 是控制组,与仅仅文化媒介使用了的 DMEM,并且组织 B, C, D 是试验性的组,与 UDCA 的不同剂量(1.0 mmol/L, 0.5 mmol/L 和 0.25 mmol/L 分别地) 增加了进他们 24 个小时和 48 个小时的进一步的文化的 DMEM 文化媒介。TGF1 的蛋白质表情, TGF 类型我受体, Smad3, Smad4 和 Smad7 被西方的弄污,以及 TGF1, Smad3, Smad7 和营地反应元素(CREB ) 的表情测量由即时 PCR 的有约束力的蛋白质(CBP ) mRNA。社会科学统计套装软体 11.5 统计包裹与控制组,相比为数据 analyses.Results 被采用在为 24 个小时和 48 个小时的高、中间的 UDCA 剂量组的 TGF1 的 mRNA 表达式显著地减少了( P < 0.05 ),在为 48 个小时的二个上面的组并且在为 24 个小时的高剂量组的 TGF1 的蛋白质表达式显著地减少了( P < 0.05 )。在为 24 个小时和 48 个小时的每个 UDCA 剂量组的 Smad3 的蛋白质和 mRNA 表情显著地减少了,与在不同 UDCA 亲密的组之中的重要差别,在 24 的之间,小时和 48 个小时观察了(P < 0.05 ) 。在高、中间的 UDCA 的 Smad7 的蛋白质和 mRNA 表情关上组显著地增加的 24 个小时和 48 个小时。在为 24 个小时和 48 个小时的每个 UDCA 剂量组的 CBP mRNA 表示显著地减少了( P < 0.05 ),与在不同 UDCA 之中的重要差别,剂量组观察了( P < 0.05 ) .Conclusion UDCA 能通过由禁止 TGF1 , Smad3 和 CBP 的表情并且增加 Smad7 的表示影响 TGF1/Smad 的发信号的小径限制肝的纤维变性的发展。 | LIANG Tie-jun YUAN Jun-hua TAN Yan-rong REN Wan-hua HAN Guo-qing ZHANG Jie WANG Lai-cheng QIN Cheng-yong | 2009 | Chinese Medical Journal2009，，10： | 23 |
| 5 | Phase I trial of icotinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, in Chinese patients with non-small cell lung cancer显示文摘 | WANG Hart-ping ZHANG Li WANG Yin-xiang TAN Fen-lai XIA Ying REN Guan-jun HU Pei JIANG Ji WANG Meng-zhao XIAO Yi | 2011 | Chinese Medical Journal2011，，13： | 23 |
| 6 | Trends in cancer mortality in China from 2004 to 2018:A nationwide longitudinal study显示文摘Background:The long-term trend in cancer death in a rapidly developing country provides information for cancer prophylaxis.Here,we aimed to identify the trends in cancer mortality in China during the 2004-2018 period.Methods:Using raw data from the national mortality surveillance system of China,we assessed the mortalities of all cancer and site-specific cancers during the 2004-2018 period.The participants were divided into three age groups:≥65 years,40-64 years,and≤39 years.Changing trends in cancer death by gender,residency,and tumor location were estimated using fitting joinpoint models to log-transformed crude mortality rates(CMRs)and age-standardizedmortality rates(ASMRs).Results:Cancer death accounted for 24% of all-cause of death in China during 2014-2018.The CMR of all cancer was 150.0 per 100,000 persons.Cancer was the leading cause of death in the population<65 years.The six major cancer types(lung/bronchus cancer,liver cancer,stomach cancer,esophagus cancer,colorectal cancer,and pancreas cancer)accounted for 75.85% of all cancer deaths.The CMR of all cancer increased while the ASMR decreased during 2014-2018(P<0.001).Lung/bronchus cancer and liver cancer were the leading causes of cancer death in the population<65 years,accounting for 45.31%(CMR)and 44.35%(ASMR)of all cancer death,respectively.The ASMR of liver cancer was higher in the 40-64 years population than in the≥65 years population,in contrast to the other five major cancers.The ASMRs of liver cancer,stomach cancer,and esophagus cancer decreased although they were higher in rural residents than in urban residents;the ASMRs of lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents although they were higher in urban residents than in rural residents during 2014-2018.Conclusion:Although the ASMR of all cancer decreased in China during 2004-2018,lung/bronchus cancer and liver cancer remained the leading causes of cancer-related premature death.Lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents. | Dongming Jiang Lijuan Zhang Wenbin Liu Yibo Ding Jianhua Yin Rongbing Ren Qi Li Yifan Chen Jiaying Shen Xiaojie Tan Hongwei Zhang Guangwen Cao | 2021 | Cancer Communications2021，41，10： | 23 |
| 7 | The oncoprotein p28^GANK establishes a positive feedback loop in p-catenin signaling显示文摘 | Li-wei Dong Guang-zhen Yang Yu-fei Pan Yao Chen Ye-xiong Tan Rong-yang Dai Yi-bin Ren Jing Fu Hong-yang Wang | 2011 | Cell Research2011，21，8： | 19 |
| 8 | SHRIMP zircon U-Pb ages and tectonic implications for Indosinian granitoids of southern Zhuguangshan granitic composite, South China显示文摘The large southern Zhuguangshan granitic batholith composite consists of granites with ages varying from the Caledonian through Indosinian to Yanshanian. Based on K-Ar dating data, the ages of the major parts of this composite were previously regarded as Yanshanian. In this study, the SHRIMP zircon U-Pb dating method has been adopted for six plutons, Ledong, Longhuashan, Dawozi, Zhaidi, Baiyun and Jiangnan, in the southern Zhuguangshan composite, in which the four plutons other than Baiyun and Jiangnan were previously regarded as Yanshanian granites. Magmatic zircons from these six plutons, dated by this study, have yielded ages of 239±5 Ma (MSWD = 2.5), 239±5 Ma (MSWD = 2.5), 239±2 Ma (MSWD = 1.7), 239±4 Ma (MSWD = 3.2), 231±2 Ma (MSWD = 0.81) and 231±3 Ma (MSWD = 1.8), respectively. The results indicate that these plutons were formed by early Indosinian magmatism. Geochemical characteristics suggest that these granites were formed in an extensional tectonic environment. Therefore, the Indosinian period granites in the southern Zhuguangshan composite were formed by partial melting of the Paleo-Mesoproterozoic crustal components during the collapse of thickened lithosphere after the collision between the South China and Indosinian plates. | DENG Ping REN JiShun LING HongFei SHEN WeiZhou SUN LiQiang ZHU Ba TAN ZhengZhong | 2012 | Chinese Science Bulletin2012，57，13： | 19 |
| 9 | Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis显示文摘Septic acute liver injury is one of the leading causes of fatalities in patients with sepsis.Toll-like receptor 4(TLR4)plays a vital role in response to lipopolysaccharide(LPS)challenge,but the mechanisms underlying TLR4 function in septic injury remains unclear.In this study,we investigated the role of TLR4 in LPS-induced acute liver injury(ALI)in mice with a focus on inflammation and apoptosis.Wild-type(WT)and TLR4-knockout(TLR4^(−/−))mice were challenged with LPS(4 mg/kg)for 6 h.TLR4 signaling cascade markers(TLR4,MyD88,and NF-κB),inflammatory markers(TNFα,IL-1β,and IL-6),and apoptotic markers(Bax,Bcl-2,and caspase 3)were evaluated.We showed that LPS challenge markedly increased the levels of serum alanine aminotransferase(ALT)/aspartate aminotransferase(AST)and other liver pathological changes in WT mice.In addition,LPS challenge elevated the levels of liver carbonyl proteins and serum inflammatory cytokines,upregulated the expression of TLR4,MyD88,and phosphorylated NF-κB in liver tissues.Moreover,LPS challenge significantly increased hepatocyte apoptosis,caspase 3 activity,and Bax level while suppressing Bcl-2 expression in liver tissues.These pathological changes were greatly attenuated in TLR4^(−/−)mice.Similar pathological responses were provoked in primary hepatic Kupffer cells isolated from WT and TLR4^(−/−)mice following LPS(1μg/mL,6 h)challenge.In summary,these results demonstrate that silencing of TLR4 attenuates LPS-induced liver injury through inhibition of inflammation and apoptosis via TLR4/MyD88/NF-κB signaling pathway.TLR4 deletion confers hepatoprotection against ALI induced by LPS,possibly by repressing macrophage inflammation and apoptosis. | Sai-nan Chen Ying Tan Xiao-chan Xiao Qian Li Qi Wu You-you Peng Jun Ren Mao-long Dong | 2021 | Acta Pharmacologica Sinica2021，42，10： | 17 |
| 10 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 11 | A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice显示文摘Pentatricopeptide 重复(PPR ) 蛋白质在更高的植物包括一个大家庭并且在 organellar RNA 新陈代谢的各种各样的方面调制 organellar 基因表示 byparticipating。在米饭,家庭包含他们的功能仍然是的 477 个成员,和 majorityof 不清楚。在这研究,我们孤立并且描绘米饭变异的、白条纹叶(wsl ) ,它在开发早的显示萎黄病有条纹或刻痕之状态。基于地图的克隆表明 WSL 编码指向叶绿体的最新识别的米饭 PPR 蛋白质。在 wsl 异种,锐气依赖者质体基因表示是显著地下面调整的,并且质体 rRNAs 和翻译 productsaccumulate 到很底层。一致地与观察, wsl 在叶绿体抄本 rpl2 拼接显示出一个强壮的缺点,在异种导致异常抄本累积和它的产品减小。wsl 显示出提高的敏感到骆驼毛的织物,咸度,和糖,并且它积累更多的 H 2 O 2 比野类型。这些结果建议减少的翻译效率可以影响异种的反应到 abioticstress.Key 词: | Junjie Tan Zhenhua Tan Fuqing Wu Peike Sheng Yueqin Heng Xinhua Wang Yulong Ren Jiulin Wang Xiuping Guo Xin Zhang Zhijun Cheng Ling Jiang Xuanming Liu Haiyang Wang Jianmin Wan | 2014 | Molecular Plant2014，7，8： | 15 |
| 12 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 13 | Fields experiments in North China show no decrease in winter wheat yields with night temperature increased by 2.0-2.5°C显示文摘The trends of daily maximum and minimum temperature in global warming indicated that the daily minimum temperature (Tmin) has risen more than twice as fast as the daily maximum temperature (Tmax) during the 20th century. Most researchers have focused on how the crops respond to daily mean temperature, whereas few controlled experiments were carried out to investigate how the crops respond to the Tmin rise. In particular, no experiment research has reported on how crops respond to the higher night temperature, which was the main trend in the climate warming. Taking winter wheat as the test crop, we investigated how the winter wheat growth and yields responded to the higher night temperature. In the field experiments, infrared heaters were used to increase higher night temperature (HNT) by about 2.5°C in contrast to the normal night temperature (CK) in two whole growth durations of winter wheat in 2008-2009 and 2009-2010 in North China. The results indicated that, compared to the CK treatment, winter wheat yield did not decline in HNT treatment, which increased temperatures by 2.0 2.5°C in both Warmer year (WY) and Colder year (CY). Furthermore, winter wheat yield in CY increased significantly in HNT treatment. HNT treatment in CY could significantly promote tillering and increase the effective panicles, which increased grain yield significantly (by more than 30% compared with CK). HNT treatment in CY contributed to an increase in the effective panicles and Kernels significantly, although making a significant reduction in 1000-grain weight, but did not lead to the yield decline. Under the HNT treatment, the whole growth duration of the winter wheat was shortened and the phenological dates were earlier except for the beginning of overwintering; the beginnings of the overwintering phase were postponed substantially and the ends of the overwintering phase were ahead of date compared to CK, which shortened the duration of overwintering considerably. We draw on our own studies to show examples of higher night temperature impact on winter wheat in a relatively cold year and relatively warm year in North China. Our results refer to winter wheat in North China, not all main winter wheat producing regions, in Huang-Huai and Southwest of China. Some uncertainties of our predictions derive from fast progress in crop breeding, the variability of climate, and the role of adaptive actions in the future. As expected, the adaptation measures should be considered to cope with the impacts of global warming on crops, and further research and assessments should be conducted. | FANG ShiBo TAN KaiYan REN SanXue ZHANG XinShi ZHAO JunFang | 2012 | Science China Earth Sciences2012，55，6： | 13 |
| 14 | MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma显示文摘MicroRNAs(miRNAs) are endogenous small non-coding RNAs that repress their targets at post transcriptional level.Existing studies have shown that miRNAs are important regulatory genes in hepatocellular carcinoma(HCC),as either tumor suppressors or oncogenes.MiR-122 is normally downregulated in HCC and regarded as a tumor suppressor.Recently miR-122 has been reported to be regulated by CEBPA,which is then involved in a novel pathway to influence proliferation of tumor cells.However it is unknown whether CEBPA is regulated by miRNAs in HCC.In this study,we find that miR-182 is upregulated in HCC model rat,and represses CEBPA in both rat and human.This further improves the current CEBPA/miR-122 pathway that controls the proliferation of tumor cells.These results suggest that miR-182 is a potential oncogene in HCC and could be used as a diagnostic marker and drug target of HCC. | Chenggang Wang Ren Ren Haolin Hu Changjun Tan Miao Han Xiaolin Wang Yun Zheng | 2014 | Chinese Journal of Cancer Research2014，26，1： | 13 |
| 15 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 16 | Application of contrast-enhanced ultrasound after livertransplantation:Current status and perspectives显示文摘Liver transplantation is an effective treatment for patients with end-stage liver disease. Accurate imaging evaluation of the transplanted patient is critical for ensuring that the limited donor liver is functioning appropriately. Ultrasound contrast agents(UCAs), in combination with contrastspecific imaging techniques, are increasingly accepted in clinical use for the assessment of the hepatic vasculature, bile ducts and liver parenchyma in pre-, intra- and posttransplant patients. We describe UCAs, their technical requirements, the recommended clinical indications, image interpretation and the limitations for contrastenhanced ultrasound applications in liver transplantation. | Jie Ren Tao Wu Bo-Wen Zheng Ying-Yi Tan Rong-Qin Zheng Gui-Hua Chen | 2016 | World Journal of Gastroenterology2016，22，4： | 11 |
| 17 | Evaluation of Harvest Aid Chemicals for the Cotton-Winter Wheat Double Cropping System显示文摘Timing of harvest is critical for mechanical picking in cotton production, especially in those regions with double cropping system. Appropriate and safe harvest aids will improve timing and facilitate harvest of cotton in the double cropping system. Three defoliants (dimethipin, thidiazuron, and thidiazuron-diuron) and one boll opener (ethephon) were included in this research. They were evaluated for their effects on defoliation, boll opening, seedcotton yield, seed quality, and fiber quality of field grown cotton when used alone or as a mixture in 2009 and 2010. Defoliation and/or boll opening were increased by all three defoliants and ethephon, especially by mixtures of a defoliant and ethephon. First harvest of seedcotton was significantly increased with defoliant-ethephon mixtures. No significant adverse effects were observed on boll weight, lint percentage, seed quality, and fiber properties. It was estimated that tank mixes of ethephon and one of the three defoliants can improve the adjusted gross revenue. Boll opening can be used as an alternative indicator for the adjusted gross revenue, because, it was linearly and positively correlated with the relative adjusted gross revenue and convenient in measurements. Wheat seedling growth was not affected by thidiazuron, whereas its seedling emergence, root dry weight, relative water content, and electrolyte leakage were adversely affected by dimethipin and thidiazuron-diuron when concentration was above 340 and 100 g (a.i.) ha-1, respectively. 90% defoliation and 80% boll opening were observed with the high rate of thidiazuron-ethephon mixture, but no adverse effects on winter wheat. The results suggested that tank mixes of ethephon with thidiazuron can be used effectively and safely in the cotton-winter wheat double cropping system to improve yield without adverse effects on seed quality and fiber quality. | DU Ming-wei REN Xiao-ming TIAN Xiao-li DUAN Liu-sheng ZHANG Ming-cai TAN Wei-ming LI Zhao-hu | 2013 | Journal of Integrative Agriculture2013，12，2： | 11 |
| 18 | Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro显示文摘The activation of the PI3K/AKT/m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/m TOR signaling pathway and inducing cell cycle arrest and apoptosis. | Yunlang Cai Xiaoqiang Tan Jun Liu Yang Shen Di Wu Mulan Ren Peilin Huang Dandan Yu | 2014 | Chinese Journal of Cancer Research2014，26，5： | 11 |
| 19 | RESEARCH OF INNER FLOW IN A DOUBLE BLADES PUMP BASED ON OPENFOAM显示文摘The inner flow analysis of centrifugal pumps has gradually become an important issue for the hydraulic design and performance improvement.Nowadays,CFD simulation toolbox of pump inner flow mainly contains commercial tools and open source tools.There are some defects for commercial CFD software for the numerical simulation of 3-D turbulent internal flow in pump,especially in capturing the flow characteristics under the off-design operating conditions.Additionally,it is difficult for researchers to do further investigation because of the undeclared source.Therefore,an open source software like Open Field Operation and Manipulation (OpenFOAM) is increasingly popular with researchers from all over the world.In this paper,a new computational study was implemented based on the original solver and was used to directly simulate the steady-state inner flow in a double blades pump,with the specific speed is 111.In order to disclose the characteristics deeply,three research schemes were conducted.The ratios () of the flow rate are 0.8,1.0 and 1.2,respectively.The simulation results were verified with the Particle Imaging Velocimetry (PIV) experimental results,and the numerical calculation results agree well with the experimental data.Meanwhile,the phenomena of flow separation under the off-design operating conditions are well captured by OpenFOAM.The results indicate that OpenFOAM possesses obvious strong predominance in computing the internal flow field of pump.The analysis results can also be used as the basis for the further research and the improvement of centrifugal pump. | LIU Hou-lin REN Yun WANG Kai WU Deng-hao RU Wei-min TAN Ming-gao | 2012 | Journal of Hydrodynamics2012，24，2： | 11 |
| 20 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
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