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| 1 | Discovery of the Longriba Fault Zone in Eastern Bayan Har Block, China and its tectonic implication显示文摘Re-measured GPS data have recently revealed that a broad NE trending dextral shear zone exists in the eastern Bayan Har block about 200 km northwest of the Longmenshan thrust on the eastern margin of the Qinghai-Tibet Plateau. The strain rate along this shear zone may reach up to 4-6 mm/a. Our interpretation of satellite images and field observations indicate that this dextral shear zone corresponds to a newly generated NE trending Longriba fault zone that has been ignored before. The northeast segment of the Longriba fault zone consists of two subparallel N54°±5°E trending branch faults about 30 km apart, and late Quaternary offset landforms are well developed along the strands of these two branch faults. The northern branch fault, the Longriqu fault, has relatively large reverse component, while the southern branch fault, the Maoergai fault, is a pure right-lateral strike slip fault. According to vector synthesizing principle, the average right-lateral strike slip rate along the Longriba fault zone in the late Quaternary is calculated to be 5.4±2.0 mm/a, the vertical slip rate to be 0.7 mm/a, and the rate of crustal shortening to be 0.55 mm/a. The discovery of the Longriba fault zone may provide a new insight into the tectonics and dynamics of the eastern margin of the Qinghai-Tibet Plateau. Taken the Longriba fault zone as a boundary, the Bayan Har block is divided into two sub-blocks: the Ahba sub-block in the west and the Longmenshan sub-block in the east. The shortening and uplifting of the Longmenshan sub-block as a whole reflects that both the Longmenshan thrust and Longriba fault zone are subordinated to a back propagated nappe tectonic system that was formed during the southeastward motion of the Bayan Har block owing to intense resistance of the South China block. This nappe tectonic system has become a boundary tectonic type of an active block supporting crustal deformation along the eastern margin of the Qinghai-Tibet Plateau from late Cenozoic till now. The Longriba fault zone is just an active fault zone newly-generated in late Quaternary along this tectonic system. | XU XiWei WEN XueZe CHEN GuiHua YU GuiHua | 2008 | Science China Earth Sciences2008，51，9： | 46 |
| 2 | Lushan M_S7.0 earthquake:A blind reserve-fault event显示文摘In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas. | XU XiWei WEN XueZe HAN ZhuJun CHEN GuiHua LI ChuanYou ZHENG WenJun ZHNAG ShiMin REN ZhiQun XU Chong TAN XiBin WEI ZhanYu WANG MingMing REN JunJie HE ZhongTai LIANG MingJian | 2013 | Chinese Science Bulletin2013，58，28： | 35 |
| 3 | Rupture segmentation and slip partitioning of the mid-eastern part of the Kunlun Fault,north Tibetan Plateau显示文摘The Kunlun Fault,an active fault on the border between the Bayan Har and Kunlun-Qaidam blocks,is one of the major left lateral strike-slip faults in the Tibetan Plateau.Previous research has not reached a consensus on agreeable slip rates along much of its length and the slip rate gradient along the eastern part,both of which play critical roles in a range of models for the eastward extrusion and thickened crust of the Tibetan Plateau.New slip rates have been determined at sites along the eastern part of the Kunlun Fault by dating deposits and measuring atop displaced fluvial terrace risers.Field investigations and interpretation of satellite images reveal geometrical features of the fault and the late Quaternary offset,new earthquake ruptures and surface-rupturing segmentation,from which long-term slip rates and earthquake recurrence intervals on the fault are estimated.The tectonic geomorphology method has determined that the long-term horizontal slip rates on the Tuosuohu,Maqin and Maqu segments from west to east are 11.2±1,9.3±2,and 4.9±1.3 mm/a while their vertical slip rates are 1.2±0.2,0.7±0.1,and 0.3 mm/a in the late Quaternary.Results indicate that the slip rates regularly decrease along the eastern ~300 km of the fault from >10 to <5 mm/a.This is consistent with the decrease in the gradient such that at the slip rate break point is at the triple point intersection with the transverse fault,which in turn is transformed to the Awancang Fault.The vector decomposition for this tectonic transformation shows that the western and eastern branches of the Awancang Fault fit the slip-partitioning mode.The slip rate of the southwestern wall is 4.6 mm/a relative to the northeastern wall and the slip direction is 112.1°.The mid-eastern part of the Kunlun Fault can be divided into three independent segments by the A'nyêmaqên double restraining bend and the Xigongzhou intersection zone,which compose the surface rupture segmentation indicators for themselves as well as the ending point of the 1937 M7.5 Tuosuohu earthquake.The average recurrence interval of the characteristic earthquakes are estimated to be 500-1000 a,respectively.The latest earthquake ruptures occurred in AD 1937 on the western Tuosuohu segment,as compared to ~514-534 a BP on the Maqin segment,and ~1055 to 1524 a BP on the Maqu segment.This may indicate a unidirectional migration for surface rupturing earthquakes along the mid-eastern Kunlun Fault related to stress triggered between these segments.Meanwhile,the long-term slip rate is obtained through the single event offset and the recurrence interval,which turn out to be the same results as those determined by the offset tectonic geomorphology method,i.e.,the decreasing gradient corresponds to the geometrical bending and the fault's intersection with the transverse fault.Therefore,the falling slip rate gradient of the mid-eastern Kunlun Fault is mainly caused by eastward extension of the fault and its intersection with the transverse fault. | LI ChenXia XU XiWei WEN XueZe ZHENG RongZhang CHEN GuiHua YANG Hu AN YanFen GAO Xiang | 2011 | Science China Earth Sciences2011，54，11： | 33 |
| 4 | Parameters of Coseismic Reverse- and Oblique-Slip Surface Ruptures of the 2008 Wenchuan Earthquake,Eastern Tibetan Plateau显示文摘在 2008 年 5 月 12 日, M w 7.9 Wenchuan 地震破裂了同时,, Longmenshan 的中间的片断插入了的 Beichuan, Pengguan 和 Xiaoyudong 差错在西藏的高原的东方边缘系上带子。领域调查抑制与 Wenchuan 地震有关的表面破裂模式,长度和偏移量。Beichuan 差错有趋势 NE 有 240 km 的全部的长度的权利侧面的反向的破裂。重估产出 6.5 ±的最大的垂直偏移量 0.5 m 和 4.9 ±的最大的权利侧面的偏移量为它的北片断的 0.5 m,它最大的偏移量被发现;最大的垂直偏移量是 6.2 ±为它的南部的片断的 0.5 m。Pengguan 差错有趋势 NE 纯反向的破裂与大约 3.5 m 的最大的垂直偏移量长的大约 72 km。Xiaoyudong 差错有在 Beichuan 和 Pengguan 之间长的大约 7 km 指责的 NW 惹人注目的左侧面的反向的破裂,与 3.4 m 的最大的垂直偏移量和 3.5 m 的左侧面的偏移量。多重 co 地震的表面破裂的这个模式在之中最近的大地震和礼品最复杂大得多的危险比如果他们个别地破裂了。破裂长度最长因为反向的指责事件曾经报导了。 | XU Xiwei YU Guihua CHEN Guihua RAN Yongkang LI Chenxia CHEN Yuegau CHANG Chungpai | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 30 |
| 5 | Effect of scraping therapy on Interleukin-1 in serum of rats with lumbar disc herniation显示文摘OBJECTIVE:To explore the effect of scraping therapy on the Interleukin-1 (IL-1) levels of rats with lumbar disc herniation (LDH). METHODS: Fifty male rats were devided into a blank group (A), a sham operation group (B), a model group (C), a scraping group (D), and a drug group (E). The rats in the group B were treated with sham operation, and groups C, D and E were made into the LDH model by operation. After operation group C were treated with no interventions, D were given scraping and E were fed with azathioprine Then the IL-1 levels of different groups were detected by enzyme-linked immuno sorbent assay method. And the transplanted coccygeal vertebra discs were observed by pathological section. RESULTS: The IL-1 levels in the groups C, D, and E were significantly higher than those in the groups A and B (all P<0.01), which proved the operationwas successful.The IL-1 levels in the groups D and E at different periods had statistical significance (F= 414.158, P<0.01). The treatment periods and interventions have interation (F=46.613, P<0.01). Multiple comparison results showed that the IL-1 levels in the groups D and E was significantly lower than that in the group C (P<0.01), while the IL-1 levels between the groups D and E had no statistical significance (P>0.05). Moreover, pathological section indicated that immuno-inflammatory response was hardly found in coccygeal vertebra discs in the groups A and B, while local immuno-inflammatory responses of the groups D and E were much lighter than that of the group C. CONCLUSION: Scraping therapy could inhibit the immuno-inflammatory responses in the rats with LDH caused by transplantation of autologous nu cleus pulposus. | Rongrong Jiang Guihua Xu Hua Chen Jie Li Tao Yang Yang Guo | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 23 |
| 6 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 7 | Discussion of rupture mechanisms on the seismogenic fault of the 2008 M_s8.0 Wenchuan earthquake显示文摘The May 12, 2008, Ms8.0 Wenchuan earthquake was the outcome of a recent movement of an active intra-continental thrust fault zone. The seismogenic fault of this earthquake underwent oblique-slip faulting along the central fault and pure thrust faulting along the range-front fault of the Longmenshan fault zone. The former had a steep dip and large vertical displacement, and the latter had a gentle dip and little vertical displacement. The fault zone consisted of compressive double fault ramps rup turing with right-lateral strike-slip components resulting from strain partitioning of a deep oblique slip fault in the brittle zone of the upper crust. The kinematic pattern and rupture mechanisms are complex for the seismogenic fault, as indicated by the geometric pattern of its surface ruptures, the coseismic displacement distribution and focal mechanisms of the main shock and aftershocks. As a tear fault, the NW-trending, left-lateral, strike-slip Xiaoyudong fault zone has accommodated NE-trending displacements with different shortening amounts. However, because of intense compression on the southwestern segment of the seismogenic fault, the left-lateral, strike-slip Xiaoyudong fault also carries a clear compression component. Normal faulting with a strike-slip component controls the formation of a fault-trough along the central fault, which is characterized by thrusting with a strike-slip component and strike-slip with thrusting. The fault-troughs are the product of the interaction of slip and grav ity on the seismogenic fault under specific geological and geomorphic conditions. Gravitational force exaggerated the vertical component of fault displacement, which by no means represents the actual maximum vertical displacement of the seismogenic fault. | DENG QiDong CHEN GuiHua ZHU AiLan | 2011 | Science China Earth Sciences2011，54，9： | 19 |
| 8 | Late Quaternary Slip-rates and Slip Partitioning on the Southeastern Xianshuihe Fault System, Eastern Tibetan Plateau显示文摘Quantitative analysis of the kinematics of the active faults distributed around the QinghaiTibetan Plateau is critical to understand current tectonic processes of the plateau. Chronological analysis, based on the comparison among regional climate and geomorphology, digital photogrammetry, offset landforms, and the tectonics were adopted in this study on the Xianshuihe fault in the eastern Tibetan plateau. Two or more offset-age data were obtained for each segment of the Xianshuihe and theYunongxi faults. The offset landforms, including river terrace, alluvial fan and glacial moraine, provide constraints for the late Quaternary slip rate of the Xianshuihe fault. The left-lateral strike slip rate of the Xianshuihe fault decreases from 17 mm/a on the northwest segment to 9.3 mm/a on the southeast segment. Regarding the Xianshuihe fault zone and its adjacent blocks as a regional tectonic system, vector analysis was used to quantitatively analyze the longitudinal kinematical transformation and transversal slip partitioning on the fault zone in terms of the kinematical parameters of the main faults within the zone. The results show that there is a distributed vertical uplift at a rate of 6.1 mm/yr caused by shortening across the Gongga Mountains region. Based on these results, we established a model of the slip partitioning for the southeastern segment of the Xianshuihe fault zone. | CHEN Guihua XU Xiwei WEN Xueze CHEN Yue-Gau | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 16 |
| 9 | Colorectal cancer burden and trends:Comparison between China and major burden countries in the world显示文摘Objective:To summarize the colorectal cancer(CRC)burden and trend in the world,and compare the difference of CRC burden between other countries and China.Methods:Incidence and mortality data were extracted from the GLOBOCAN2018 and Cancer Incidence in Five Continents.Age-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were calculated.Results:About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide,including 0.52 million(28.20%)new cases and 0.25 million(28.11%)deaths in China.Hungary had the highest age-standardized incidence and mortality rates in the world,while for China,the incidence and mortality rates were only half of that.CRC incidence and mortality were highly correlated with human development index(HDI).Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia,the age-standardized incidence rates by world standard population in China and Norway were rising gradually.The age-specific incidence rate in the age group of 50-59 years in China was increasing rapidly,while in Republic of Korea and Canada,the fastest growing age group was 30-39 years.Conclusions:The variations of CRC burden reflect the difference of risk factors,as well as levels of HDI and screening(early detection activities).The burden of CRC in China is high,and the incidence of CRC continues to increase,which may lead to a sustained increase in the burden of CRC in China in the future.Screening should be expanded to control CRC,and focused on young people in China. | Jiachen Zhou Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Ru Chen Kexin Sun Minjuan Li Jianhua Gu Guihua Zhuang Wenqiang Wei | 2021 | Chinese Journal of Cancer Research2021，33，1： | 16 |
| 10 | Novel detection method for infrared small targets using weighted information entropy显示文摘This paper presents a method for detecting the small infrared target under complex background. An algorithm, named local mutation weighted information entropy (LMWIE), is proposed to suppress background. Then, the grey value of targets is enhanced by calculating the local energy. Image segmentation based on the adaptive threshold is used to solve the problems that the grey value of noise is enhanced with the grey value improvement of targets. Experimental results show that compared with the adaptive Butterworth high-pass filter method, the proposed algorithm is more effective and faster for the infrared small target detection. | Xiujie Qu He Chen Guihua Peng | 2012 | Journal of Systems Engineering and Electronics2012，23，6： | 13 |
| 11 | Evaluating efficacy of screening for upper gastrointestinal cancer in China:a study protocol for a randomized controlled trial显示文摘Objective: To evaluate the efficacy and feasibility of screening procedure for upper gastrointestinal cancer in both high-risk and non-high-risk areas in China.Setting: Seven cities/counties, representing three economical-geographical regions(Eastern, Central and Western) in China, were selected as screening centers: three in high-risk areas and four in non-high-risk areas.Participants: Villages/communities in these seven centers regarded as clusters were randomly assigned to either intervention group(screening by endoscopic examination) or control group(with normal community care) in a 1:1ratio stratified by each center. Eligible participants are local residents aged 40–69 years in the selected villages/communities with no history of cancer or endoscopic examination in the latest 3 years who are mentally and physically competent. Those who are not willing to take endoscopic examination or are unwilling to sign the consent form are excluded from the study. Totally 140,000 participants will be enrolled.Interventions: In high-risk areas of upper gastrointestinal cancer, all subjects in screening group will be screened by endoscopy. In non-high-risk areas, 30% of the subjects in screening group, identified through a survey,will be screened by endoscopy.Primary and secondary outcome measures: The primary outcome is the mortality caused by upper gastrointestinal cancer. The secondary outcomes include detection rate, incidence rate, survival rate, and clinical stage distribution. Additional data on quality of life and cost-effectiveness will also be collected to answer important questions regarding screening effects.Conclusions: Screening strategy evaluated in those areas with positive findings may be promoted nationally and applied to the majority of Chinese people. On the other hand, negative findings will provide scientific evidence for abandoning a test and shifting resources elsewhere.Trial registration: The study has been registered with the Protocol Registration System in Chinese Clinical Trial Registry. | wanqing chen hongmei zeng ru chen ruyi xia zhixun yang changfa xia rongshou zheng wenqiang wei guihua zhuang xueqin yu jie he | 2017 | Chinese Journal of Cancer Research2017，29，4： | 11 |
| 12 | Application of Cellulose Nanofibril as a Wet-end Additive in Papermaking:A Brief Review显示文摘Recently,cellulose nanofibril(CNF)has emerged as a promising,sustainable reinforcement with outstanding potential in material science.Owing to the properties of CNF,it has been explored in food,cosmetic,and pharmaceutical applications,as well as in industrial applications such as paints,drill muds,packaging,and papermaking.The application of CNF in papermaking is expected to be implemented in the near future to broaden the commercial market of cellulose.Numerous studies and patents have reported on the manufacturing,properties,and applications of nanocellulose.This present paper focuses on the recent progresses in the application of CNF as a wet-end additive in papermaking. | Guihua Yang Guangrui Ma Ming He Xinxiang Ji Hye Jung Youn Hak Lae Lee Jiachuan Chen | 2020 | Paper And Biomaterials2020，5，2： | 9 |
| 13 | Advances in research of the mid-deep South China Sea circulation显示文摘The South China Sea(SCS)is a large marginal sea connecting the Indian and Pacific oceans.Under the factors of monsoons,strait transport,and varied bathymetry,the SCS presents a three-layer structure and strong diapycnal mixing which is far greater than that in the open ocean.Theoretical analysis and observations reveal that internal tides,internal solitary waves,and strong winds are the sources of the strong mixing in the northern SCS.A major consequence of the strong mixing is an active mid-deep circulation system.This system promotes exchange of water between the SCS and adjacent oceans,and also regulates the upper layer of wind-driven circulation,making the 3 dimensional SCS circulation clearly different from that in other tropical and subtropical marginal seas.The mass transport capacity of the mid-deep circulation has a substantial impact on marine sedimentation,the biogeochemical cycle,and other processes in the SCS.This paper summarizes the recent advances in middeep sea circulation dynamics of the SCS,and discusses the opportunities and challenges in this area. | Dongxiao WANG Qiang WANG Shuqun CAI Xiaodong SHANG Shiqiu PENG Yeqiang SHU Jingen XIAO Xiaohui XIE Zhiwei ZHANG Zhiqiang LIU Jian LAN Dake CHEN Huijie XUE Guihua WANG Jianping GAN Xinong XIE Rui ZHANG Hui CHEN Qingxuan YANG | 2019 | Science China Earth Sciences2019，62，12： | 8 |
| 14 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 15 | Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats显示文摘门高血压(PHT ) gastropathy 是肝肝硬化的经常的复杂并发症,带之一从肝硬化死亡引起。Apoptosis 广泛地被认为从坏死的房间死亡是房间死亡和一个不同实体的一个活跃精力依赖者模式。胃的 mucosal apoptosis 是否涉及 PHT gastropathy,是不清楚的。通过 cyclooxygenase (艇长) 生产的前列腺素(PG ) 被认为从损害和 apoptosis 在胃肠的 mucosa 的保护起一个关键作用。然而,在 PHT gastropathy 的艇长的角色仍然不清楚地被理解。这研究的目的是调查(1 ) 胃的 mucosal apoptosis 是否涉及 PHT gastropathy,(2 ) 艇长的 downregulation 贡献这 apoptosis。在这研究,当 mucosal 增长在 PHT 老鼠被禁止时,我们证明胃的 mucosal apoptosis 显著地被增加。胃的 mucosal COX-1 显著地在 mRNA 和蛋白质层次被压制,并且 PGE2 在 PHT 老鼠被减少。进一步, PGE2 处理在 PHT 老鼠压制了胃的 mucosal apoptosis。然而,胃的 mucosal COX-2 层次没在假冒操作老鼠和 PHT 老鼠之间不同。肿瘤坏死因素的胃的 mucosal 层次 --(TNF-) 并且船边交货 ligand,然而并非 TNF 相关的导致 apoptosis ligand,被增加,并且激活的 caspase-8 和 caspase-3 层次是在 PHT 老鼠的 upregulated。到 cytosol 的从线粒体的细胞色素 c 的版本没在 PHT 老鼠被观察。我们的数据显示 COX-1 的 downregulation 经由死亡涉及胃的 mucosal apoptosis 调停信号的类型 -- 我在 PHT 老鼠的房间死亡。 | Bin Wu Lixian Zeng Ying Lin Zhuofu Wen Guihua Chen Ryuichi Iwakiri Kazuma Fujimoto | 2009 | Cell Research2009，19，11： | 6 |
| 16 | Nanofibrillation of a Bleached Acacia Pulp by Grinding with Carboxymethylation Pretreatment显示文摘In this study,carboxymethylation,which introduces carboxyl groups to hydroxyl sites in pulp fibers,was used as a pretreatment before mechanical nanofibrillation.The carboxyl group content of the pulp fibers was greatly affected by the dosage of chloroacetic acid and the reaction temperature.During the following fibrillation process,it was found that pulp fibers with higher carboxyl group content exhibited higher water holding capacities and smaller dimensions.A more homogenous structure with a higher amount of individual fibrils was also observed in FE-SEM images of pulp fibers with high carboxyl group content.This can be explained by a high ionic group content in the fiber wall resulting in lower delamination resistance,making the fibrils easier to separate.Carboxymethylation pretreatment as a facilitator of fibrillation in cellulosic pulps is an efficient way to obtain cellulose nanofibrils and consequently decrease the energy consumption of the process. | Ming He GuiHua Yang JiaChuan Chen FanGong Kong Qiang Wang | 2018 | Paper And Biomaterials2018，3，3： | 6 |
| 17 | Activin A prevents neuron-like PC12 cell apoptosis after oxygen-glucose deprivation显示文摘In this study, PC12 cells were induced to differentiate into neuron-like cells using nerve growth facto and were subjected to oxygen-glucose deprivation. Cells were treated with 0, 10, 20, 30, 50, 100 ng/mL exogenous Activin A. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide assay and Hoechst 33324 staining showed that the survival percentage of PC12 cells significantly decreased and the rate of apoptosis significantly increased after oxygen-glucose deprivation. Exogenous Activin A significantly increased the survival percentage of PC12 cells in a dose-dependent manner. Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased. Our experimental findings indicate that exogenous Activin A plays an anti-apoptotic role and protects neurons by means of activating the Activin A/Smads signaling pathway. | Guihua Xu Jinting He Hongliang Guo Chunli Mei Jiaoqi Wang Zhongshu Li Han Chen Jing Mang Hong Yang Zhongxin Xu | 2013 | Neural Regeneration Research2013，8，11： | 5 |
| 18 | Seismotectonics of the 2008 and 2009 Qaidam Earthquakes and its Implication for Regional Tectonics显示文摘Three magnitude >6 earthquakes struck Qaidam, Qinghai province, China, in November 10th 2008, August 28th and 31st 2009 respectively. The Zongwulongshan fault has often been designated as the active seismogenic structure, although it is at odd with the data. Our continuous GPS station (CGPS), the Xiao Qaidam station, located in the north of the Qaidam basin, is less than 30 km to the southwest of the 2008 earthquake. This CGPS station recorded the near field co-seismic deformation. Here we analyzed the co-seismic dislocation based on the GPS time series and the rupture processes from focal mechanism for the three earthquakes. The aftershocks were relocated to constrain the spatial characteristics of the 2008 and 2009 Qaidam earthquakes. Field geological and geomorphological investigation and interpretation of satellite images show that the Xitieshan fault and Zongwulongshan fault were activated as left lateral thrust during the late Quaternary. Evidence of folding can also be identified. Integrated analyses based on our data and the regional tectonic environment show that the Xitieshan fault is the fault responsible for the 2008 Qaidam earthquake, which is a low dip angle thrust with left lateral strike slip. The Zongwulongshan fault is the seismogenic fault of the 2009 earthquakes, which is a south dipping back thrust of the northern marginal thrust system of the Qaidam basin. Folding takes a significant part of the deformation in the northern marginal thrust system of the Qaidam basin, dominating the contemporary structure style of the northern margin of the Qaidam basin and Qilianshan tectonic system. In this region, this fault and fold system dominates the earthquake activities with frequent small magnitude earthquakes. | CHEN Guihua XU Xiwei ZHU Ailan ZHANG Xiaoqing YUAN Renmao Yann KLINGER Jean-Mathieu NOCQUET | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 5 |
| 19 | Integration of meta-QTL discovery with omics: Towards a molecular breeding platform for improving wheat resistance to Fusarium head blight显示文摘Fusarium head blight(FHB) is a global wheat disease that devastates wheat production. Resistance to FHB spread within a wheat spike(type Ⅱ resistance) and to mycotoxin accumulation in infected kernel(type Ⅲ resistance) are the two main types of resistance. Of hundreds of QTL that have been reported, only a few can be used in wheat breeding because most show minor and/or inconsistent effects in different genetic backgrounds. We describe a new strategy for identifying robust and reliable meta-QTL(mQTL)that can be used for improvement of wheat FHB resistance. It involves integration of mQTL analysis with mQTL physical mapping and identification of single-copy markers and candidate genes. Using metaanalysis, we consolidated 625 original QTL from 113 publications into 118 genetic map-based mQTL(gmQTL). These gmQTL were further located on the Chinese Spring reference sequence map. Finally, 77 high-confidence mQTL(hcmQTL) were selected from the reference sequence-based mQTL(smQTL).Locus-specific single nucleotide polymorphism(SNP) and simple sequence repeat(SSR) markers and17 genes responsive to FHB were then identified in the hcmQTL intervals by combined analysis of transcriptomic and proteomic data. This work may lead to a comprehensive molecular breeding platform for improving wheat resistance to FHB. | Tong Zheng Chen Hua Lei Li Zhengxi Sun Minmin Yuan Guihua Bai Gavin Humphreys Tao Li | 2021 | The Crop Journal2021，9，4： | 4 |
| 20 | Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy显示文摘,治疗学的代理人主要在肿瘤学被使用的抗体在淋巴瘤,乳癌或颜色由他们的应用说明了表面的癌症。这评论为癌症治疗提供单音的同种细胞的抗体的发展的一个简短历史的图案并且迄今为止为建立最好的试剂总结最重要的临床的数据。改进抗体治疗的反肿瘤功效也讨论策略,包括抗体基因治疗和骨髓的利用作为抗体基因 transporter 导出主要间充质的干细胞。 | Qi Zhang Guihua Chen Xinyuan Liu Qijun Qian | 2007 | Cell Research2007，17，2： | 4 |
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