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| 1 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
| 2 | A review of the estimation of downward surface shortwave radiation based on satellite data:Methods, progress and problems显示文摘The estimation of downward surface shortwave radiation(DSSR)is important for the Earth’s energy budget and climate change studies.This review was organised from the perspectives of satellite sensors,algorithms and future trends,retrospects and summaries of the satellite-based retrieval methods of DSSR that have been developed over the past 10 years.The shortwave radiation reaching the Earth’s surface is affected by both atmospheric and land surface parameters.In recent years,studies have given detailed considerations to the factors which affect DSSR.It is important to improve the retrieval accuracy of cloud microphysical parameters and aerosols and to reduce the uncertainties caused by complex topographies and high-albedo surfaces(such as snow-covered areas)on DSSR estimation.This review classified DSSR retrieval methods into four categories:empirical,parameterisation,look-up table and machine-learning methods,and evaluated their advantages,disadvantages and accuracy.Further efforts are needed to improve the calculation accuracy of atmospheric parameters such as cloud,haze,water vapor and other land surface parameters such as albedo of complex terrain and bright surface,organically combine machine learning and other methods,use the new-generation geostationary satellite and polar orbit satellite data to produce highresolution DSSR products,and promote the application of radiation products in hydrological and climate models. | Husi LETU Jiancheng SHI Ming LI Tianxing WANG Huazhe SHANG Yonghui LEI Dabin JI Jianguang WEN Kun YANG Liangfu CHEN | 2020 | Science China Earth Sciences2020，63，6： | 8 |
| 3 | Investigation of the consistency of atmospheric CO_2 retrievals from different space-based sensors: Intercomparison and spatiotemporal analysis显示文摘In recent years,global warming caused by emission of CO2has attracted considerable attention from the public.Although the measurements from AIRS,GOSAT,SCIAMACHY and IASI have been frequently used to derive atmospheric CO2concentration,comprehensive quantification of the differences among these CO2products is still not fully investigated yet.In this paper,a series of strategies have been proposed to allow the CO2products from different instruments to be physically inter-comparable.Based on this,these CO2products are inter-compared in terms of magnitude and their spatiotemporal distributions.The results reveal that the correlations among these CO2products are relatively weak,and some discrepancies are detected in terms of the CO2spatiotemporal characteristics,demonstrating more efforts should be made in the future to improve the retrievals of CO2.Their spatial coverage differences reflected in this study imply the great necessity to generate consistent products with improved spatial and temporal continuities by combining these CO2measurements. | WANG TianXing SHI JianCheng JING YingYing XIE YanHui | 2013 | Chinese Science Bulletin2013，58，33： | 4 |
| 4 | Non-contact cylindrical rotating triboelectric nanogenerator for harvesting kinetic energy from hydraulics显示文摘Hydraulics provide a unique and widely existed mechanical energy source around us,such as in water or oil pipes,and sewers.Here,a non-contact cylindrical rotating triboelectric nanogenerator(TENG)was developed to harvest the mechanical energy from water flows.Operation of the TENG was based on the non-contact free-rotating between a curved Cu foil and a flexible nanostructured fluorinated ethylene propylene(FEP)polymer film.The free-standing distance between two rotating interfaces avoided abrading of electrode materials.The TENG was able to effectively convert mechanical energy of the water flow into electricity.When driven by water flow,the output voltage and current of the TENG reached 1,670 V and 13.4 uA,respectively.Without any energy storage component,the produced electricity could instantaneously power 12 white light emitting diodes(LEDs)bulbs and a digital timer.This non-contact rotating TENG would provide new opportunities for harvesting energy from many types of hydraulics as a self-sustainable power source for sensing,detection,and protection. | Nan Zhang Cheng Qin Tianxing Feng Jun Li Zhirui Yang Xiupeng Sun Erjun Liang Yanchao Mao Xudong Wang | 2020 | Nano Research2020，13，7： | 4 |
| 5 | Algorithm of Micro-Grooving and Imaging Processing for the Generation of High-Resolution Structural Color Images显示文摘The use of submicron structures for structural coloration of surfaces has broad applications for color filters,projection displays,virtual reality,and anti-counterfeiting.Currently,structural color images lack high resolution due to low manufacturing accuracy.In this study,the axial-feed fly cutting(AFC)method is proposed to fabricate submicron grooves for the diffraction of visible light to create structural color images.We establish the relationship between the color information in the pixels of the original image and the parameters of the array units corresponding to the pixels.An algorithm to determine groove spacing and the tool path is established,and array units with the desired groove spacing are machined to reproduce the structural color images.The submicron grooves fabricated by AFC have high quality and good consistency.Due to the excellent diffraction performance of the machined grooves,images with high saturation and resolution can be reproduced.It is verified that images with various colors can be efficiently fabricated using the proposed method and algorithm. | Tianfeng Zhou Yupeng He Tianxing Wang Xiaobin Dong Peng Liu Wenxiang Zhao Yao Hu Jiwang Yan | 2020 | Nanomanufacturing and Metrology2020，3，3： | 4 |
| 6 | A review of the techniques for the mold manufacturing of micro/nanostructures for precision glass molding显示文摘Micro/nanostructured components play an important role in micro-optics and optical engineering,tribology and surface engineering,and biological and biomedical engineering,among other fields.Precision glass molding technology is the most efficient method of manufacturing micro/nanostructured glass components,the premise of which is meld manufacturing with complementary micro/nanostructures.Numerous mold manufacturing methods have been developed to fabricate extremely small and high-quality micro/nanostructures to satisfy the demands of functional micro/nanostructured glass components for various applications.Moreover,the service performance of the mold should also be carefully considered.This paper reviews a variety of technologies for manufacturing micro/nanostructured molds.The authors begin with an introduction of the extreme requirements of mold materials.The following section provides a detailed survey of the existing micro/nanostructured mold manufacturing techniques and their corresponding mold materials,including nonmechanical and mechanical methods.This paper concludes with a detailed discussion of the authors recent research on nickel-phosphorus(Ni-P)mold manufacturing and its service performance. | Tianfeng Zhou Yupeng He Tianxing Wang Zhanchen Zhu Ruzhen Xu Qian Yu Bin Zhao Wenxiang Zhao Peng Liu Xibin Wang | 2021 | International Journal of Extreme Manufacturing2021，3，4： | 3 |
| 7 | Association between metabolic syndrome and body constitution of traditional Chinese medicine:A systematic review and meta-analysis显示文摘Background:The constitution theory of traditional Chinese medicine(TCM)states that body constitution and disease are associated;therefore,the identification of body constitution can provide reference for disease prevention and treatment.A series of clinical studies evaluating the association between TCM constitution and metabolic syndrome(MetS)have been conducted in recent years.The aim of this systematic review is to summarize and evaluate the clinical evidence of the relationship between constitution and MetS.Methods:The PubMed,Embase,China National Knowledge Infrastructure(CNKI),Chongqing VIP,and Wanfang Data electronic databases were searched from April 2009 to July 2020.The search terms included“metabolic syndrome,”“constitution,”and“Chinese medicine.”Observational studies evaluating the relationship between body constitution of TCM and MetS were included.The primary outcome included the distribution of constitutional types in the MetS population,and odds ratio(OR)or relative risk(RR)between constitution and MetS.Effect size was expressed as proportion or OR with 95%confidence interval(CI).Methodological quality of included studies was evaluated by the NewcastleeOttawa Scale(NOS)or the American Agency for Healthcare Research and Quality(AHRQ)criteria.Results:Three caseecontrol and 26 cross-sectional studies involving 30435 cases were included.Phlegm-dampness,qi-deficiency,and damp-heat were the main constitution types in patients with MetS,accounting for 29%(22%e39%),18%(13%e24%),and 12%(9%e17%)of the population,respectively;the risk of MetS in people with phlegm-dampness and qi-deficiency constitution was 1.74[1.27,2.38]and 1.29[1.01,1.65]times higher than that in those with other constitutions.There were sex-and age-related differences in the distribution of TCM constitution in patients with MetS.Conclusion:Phlegm-dampness and qi-deficiency were associated with the occurrence of MetS.Welldesigned cohort and caseecontrol studies are needed to provide evidence for the use of TCM to prevent and treat MetS. | Hui Luo Lingru Li Tianxing Li Xing Liao Qi Wang | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，4： | 3 |
| 8 | Wearing Face Masks--the Simple and Effective Way to Block the Infection Source of COVID-19显示文摘The key difference between the coronavirus disease 2019(COVID-19)and previous coronaviruses such as SARS and MERS is that some infected people do not display obvious symptoms but are contagious during the incubation period for 14 days(1)or longer.Recently,there are many discussions about whether all persons should wear masks when they go out during the COVID-19 pandemic.The main reasons for the opposition are that the effectiveness of masks in preventing infection is not clear,ordinary people rarely wear masks correctly,everyone wearing masks may cause social panic,there are not enough masks,etc.(2–3). | Tianxing Jiang Hao Wang George F.Gao Xiaoming Jiang | 2020 | China CDC weekly2020，2，16： | 2 |
| 9 | One-step nanoarchitectonics of a multiple functional hydrogel based on cellulose nanocrystals for effective tumor therapy显示文摘Hypoxia is a huge barrier for the development of photodynamic therapy(PDT).Chemodynamic therapy(CDT)could provide a possible solution to this dilemma.In this work,a controlled Schiff-base reaction was conducted between amido groups on the surface of carbon dots(CDs)and aldehyde groups on aldehyde-modified cellulose nanocrystals(mCNCs)as well as aldehydemCNCs decorated with Fe_(3)O_(4)nanoparticles.In this process,the mCNCs not only prevent the agglomeration of Fe_(3)O_(4)but also form hydrogels with CDs.The CDs act as both photothermal agent and photosensitizer.The hypoxia could be effectively relieved through the Fenton reaction due to the addition of Fe_(3)O_(4),and the·OH produced in the reaction further induces CDT and enhances tumor therapy efficiency.The therapy performance was further verified through in vitro cell experiments and in vivo animal experiments.This convenient method provides inspirations for the design and preparation of advanced biomaterials with multiple functions for cancer therapy. | Tianxing Chen Tengteng Yao Hui Pan Hui Peng AndrewKWhittaker Yao Li Shenmin Zhu Zhaoyang Wang | 2022 | Nano Research2022，15，9： | 2 |
| 10 | Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5,BQ.1,BQ.1.1,BF.7 and BA.2.75.2显示文摘Dear Editor,Recently,a number of new Omicron subvariants related to BA.4/5 and BA.2.75 have emerged and shown remarkable antibody evasion capacities,in particular BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5.1 Unsurprisingly,these new subvariants are quickly gaining prevalence worldwide.In fact,some of them have outcompeted BA.5 in the USA according to CDC’s national genomic surveillance data in which,as of 6th February 2023,XBB.1.5,BQ.1.1,BQ.1,XBB and BF.7 have achieved a dominance of 66.4%,19.9%,7.3%,2.3%and 0.5%in the USA,as compared to 0.5%for BA.5.In this report,using plasma samples collected from individuals following different vaccination strategies and COVID-19 convalescent donors,we performed pseudoviral neutralization assays to confirm severe reductions in neutralization titers against BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5 in comparison to other Omicron sub-lineages.XBB and XBB.1.5 were shown to be remarkably resistant to plasma neutralization in all tested cohorts.By comparing the differential neutralization profiles,we found that a heterologous booster with an aerosolized vaccine following 2 doses of inactivated vaccine seemed to be superior to other vaccination strategies. | Airu Zhu Peilan Wei Miao Man Xuesong Liu Tianxing Ji Jiantao Chen Canjie Chen Jiandong Huo Yanqun Wang Jincun Zhao | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 11 | Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma显示文摘Background and Aims:Numerous studies have explored the important role of N6-methyladenosine(m^(6)A)in cancer.Nonetheless,the interaction between m^(6)A and long noncoding RNAs(lncRNAs)is poorly investigated.Herein,we systematically analyzed the role and prognostic value of m^(6)A-related lncRNAs in hepatocellular carcinoma(HCC).Methods:The m^(6)A-related lncRNAs were identified based on the correlation coefficients with m^(6)A-related genes in HCC from The Cancer Genome Atlas.Subsequently,a novel risk score model was determined using the least absolute shrinkage and selection operator Cox regression analyses.Univariate and multivariate Cox analyses were used to identify independent prog-nostic factors for overall survival(OS)of HCC;thereafter,a prognostic nomogram was constructed.Results:A total of 259 lncRNAs showed significant correlations with m^(6)A in HCC,while 29 lncRNAs had prognostic significance.Further,six critical m^(6)A-related lncRNAs(NRAV,SNHG3,KDM4A-AS1,AC074117.1,AC025176.1,and AL031985.3)were screened out to construct a novel risk score model which classified HCC patients into high-and low-risk groups.Survival analy-ses revealed that patients in the high-risk group exhibited worse OS,both in the training and validation groups.The risk score was also identified as an independent prognostic factor of OS,and a nomogram was established and verified with superior prediction capacity.Besides,the risk score signifi-cantly correlated with the expression of immune checkpoint genes and immune subtypes.Conclusions:These findings indicated the significant role of m^(6)A-related lncRNAs in HCC and the potential application of the novel risk score model for prognostic prediction. | Tianxing Dai Jing Li Linsen Ye Haoyuan Yu Mingbin Deng Wei Liu Hua Li Yang Yang Guoying Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 1 |
| 12 | Combination of induced autolysis and sodium hypocblorite oxidation for the production of Sac- charomyces cerevisiae (1-3)-fl-D-glucan显示文摘 | WANG Yajun YAO Shanjing WU Tianxing | 2003 | World Journal of Microbi- ology and Bioteehnology2003，19，9： | 1 |
| 13 | Combination of induced autolysis and sodium hypochlorite oxidation for the production of Saccharomyces cerevisiae (1→3)-β-D-glucan显示文摘 | WANG Yajun Yao Shanjing WU Tianxing | 2003 | World J Microb Biot2003，19，9： | 1 |
| 14 | Preparation, characterization, release kinetics, and in vitro cytotoxicity of calcium silicate cement as a risedronate delivery system显示文摘 | Tianxing Gong Zhiqin Wang Yubiao Zhang Changshan Sun Quanzu Yang Tom Troczynski Urs O. H?feli | 2014 | J Biomed Mater Res2014，，7： | 1 |
| 15 | Growth and in situ transformation of TiO2 and HTiOF3 crystals on chitosan-polyvinyl alcohol co-polymer substrates under vapor phase hydrothermal conditions显示文摘拥有的 chitosan 聚乙烯化合物的白酒(CS/PVA ) 共聚物底层很多氨基并且氢氧根组被用作底层导致直接生长并且在 situ 在 HF 蒸汽阶段下面的 titanate 晶体的顺序的转变热水的条件。这个过程包含四个不同形成 / 转变阶段。有明确的六角形的形状的 HTiOF 3 晶体在舞台期间被形成我,并且随后被转变成 { 001 } faceted 锐钛矿 TiO 2 水晶 nanosheets 在阶段 II 期间。有趣地,形成的锐钛矿 TiO 2 晶体进一步分别地在阶段 III 和 IV 期间被转变成十字形、空的 squareshaped HTiOF 3 晶体。尽管在热水的条件下面的 TiO 2 水晶阶段和方面转变以前被报导了,在在不同 titanate 之间的 situ 水晶转变,混合物一直不是广泛地报导了。如此的水晶形成 / 转变由于在 CS/PVA 底层的大量氨基的组的存在是可能的。当拥有仅仅氢氧根组的纤维素被用作底层时,直接形成 { 001 } faceted TiO 2 nanocrystal 表被观察(而非任何顺序的水晶转变) 。这底层器官的功能的导致组的水晶形成 / 转变途径能对另外的材料系统适用。 | Tianxing Wu Guozhong Wang Xiaoguang Zhu Porun Liu Xian Zhang Haimin Zhang Yunxia Zhang Huijun Zhao | 2016 | Nano Research2016，9，3： | 1 |
| 16 | Characteristics of alveolar macrophages in bronchioalveolar lavage fluids from active tuberculosis patients identified by single-cell RNA sequencing显示文摘Tuberculosis(TB),is an infectious disease caused by Mycobacterium tuberculosis(M.tuberculosis),and presents with high morbidity and mortality.Alveolar macrophages play an important role in TB pathogenesis although there is heterogeneity and functional plasticity.This study aimed to show the characteristics of alveolar macrophages from bronchioalveolar lavage fluid(BALF)in active TB patients.Single-cell RNA sequencing(scRNA-seq)was performed on BALF cells from three patients with active TB and additional scRNA-seq data from three healthy adults were established as controls.Transcriptional profiles were analyzed and compared by differential gene expression and functional enrichment analysis.We applied pseudo-temporal trajectory analysis to investigate correlations and heterogeneity within alveolar macrophage subclusters.Alveolar macrophages from active TB patients at the single-cell resolution are described.We found that TB patients have higher cellular percentages in five macrophage subclusters.Alveolar macrophage subclusters with increased percentages were involved in inflammatory signaling pathways as well as the basic macrophage functions.The TB-increased alveolar macrophage subclusters might be derived from M1-like polarization state,before switching to an M2-like polarization state with the development of M.tuberculosis infection.Cell-cell communications of alveolar macrophages also increased and enhanced in active TB patients.Overall,our study demonstrated the characteristics of alveolar macrophages from BALF in active TB patients by using scRNA-seq. | Qianqian Chen Chunmei Hu Wei Lu Tianxing Hang Yan Shao Cheng Chen Yanli Wang Nan Li Linling Jin Wei Wu Hong Wang Xiaoning Zeng Weiping Xie | 2022 | The Journal of Biomedical Research2022，36，3： | 1 |
| 17 | Distribution and transportation of nitrogen in Miyun reservoir waters显示文摘The Miyun reservoir is an important water supply for Beijing city. The distribution laws of nitrogen in the Miyun reservoir waters and the transportation factors have been systematically analyzed in space and time by using water monitoring data sampled in the high-water and low-flow periods in 2001 and 2002. The nitrogen in east and west reservoir waters is distributed differently in space. It shows the change characteristics in high-water and low-flow periods and is affected by the source of nitrogen, runoff conditions, hydrodynamic conditions, precipitation and the control of bed mud, of which the source of nitrogen controls the change of concentration of nitrogen, the peripheral runoff controls the distribution law of nitrogen, bed mud controls the vertical distribution of nitrogen, and the contents of nitrogen and its change in the surrounding environment directly cause the change of concentration of total nitrogen in the waters. The improvement and protection of the waters in the Miyun reservoir basically rests with the amelioration of the peripheral environment. | LIANG Xiujuan, XIAO Changlai, YANG Tianxing, WANG Jing & LIU Xiaoduan College of Environment and Resources, Jilin University, Changchun 130026, China College of Geo-exploration Science and Technology, Jilin University, Changchun 130026, China National Research Center for Geoanalysis, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，z2： | 1 |
| 18 | Evaluation of antimicrobial and anticancer activities of three peptides identified from the skin secretion of Hylarana latouchii显示文摘The skins of frogs of the family Ranidae are particularly rich sources of biologically active peptides, among which antimicrobial peptides (AMPs) constitute the major portion. Some of these have attracted the interest of researchers because they possess both antimicrobial and anticancer activities. In this study, with ‘shotgun’ cloning & MS/MS fragmentation, three AMPs, homologues of family brevinin-1 (brevinin-1HL), & temporin (temporin-HLa and temporin-HLb), were discovered from the skin secretion of the broad-folded frog, Hylarana latouchii. They exhibited various degrees of antimicrobial & antibiofilm activities against test microorganisms & hemolysis on horse erythrocytes. It was found that they could induce bacteria death through disrupting cell membranes & binding to bacterial DNA. In addition, they also showed different potencies towards human cancer cell lines. The secondary structure & physicochemical properties of each peptide were investigated to preliminarily reveal their structure–activity relationships. Circular dichroism spectrometry showed that they all adopted a canonical α-helical conformation in membrane-mimetic solvents. Notably, the prepropeptide of brevinin-1HL from H. latouchii was highly identical to that of brevinin-1GHd from Hylarana guentheri, indicating a close relationship between these two species. Accordingly, this study provides candidates for the design of novel anti-infective & antineoplastic agents to fight multidrug-resistant bacteria & malignant tumors & also offers additional clues for the taxonomy of ranid frogs. | Yan Lin Tianxing Lin Ningna Cheng Shuting Wu Jiancai Huang Xiaoling Chen Tianbao Chen Mei Zhou Lei Wang Chris Shaw | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 0 |
| 19 | A study of plasmon-driven catalytic 4-NBT to DMAB in the dry film by using spatial Raman mapping spectroscopy显示文摘Plasmon-driven catalytic reaction(PDCR)as a part of photocatalysis has attracted immense attention.Due to the collective oscillation of free electrons at the surface of metallic nanostructures,the charge distributions store energy from the incident light that could transfer energy to molecules that promote photocatalysis.As an environment-friendly and green photocatalysis process,PDCR illustrates a brilliant future.In this study,the PDCR efficiency of photo-reducing 4-nitro-benzenthiol(4-NBT)dry film to p,p'-dimercaptoazobenzene(DMAB)in ambient conditions has been studied by using Ag nanodiscs(NDs)and Ag nanoparticles(NPs)as catalysts.The distribution of catalytic efficiency of 4-NBT to DMAB using an individual Ag ND catalyst has been illustrated using spatial Raman mapping.The result is direct evidence that the PDCR efficiency has a positive correlation with plasmon-induced electromagnetic field intensity.Additionally,time-dependent surface-enhanced Raman scattering(SERS)experiments reveal that the PDCR of 4-NBT to DMAB is reciprocal.The discovery in this research will aid to improve the PDCR performance and modulate the catalysis reaction for a high reduction of 4-NBT in industrial. | Yansheng Liu Junpeng Deng Zhicheng Jin Tianxing Liu Jin Zhou Feng Luo Guofu Wang | 2022 | Nano Research2022，15，7： | 0 |
| 20 | A biosensing system employing nanowell microelectrode arrays to record the intracellular potential of a single cardiomyocyte显示文摘Electrophysiological recording is a widely used method to investigate cardiovascular pathology,pharmacology and developmental biology.Microelectrode arrays record the electrical potential of cells in a minimally invasive and highthroughput way.However,commonly used microelectrode arays primarily employ planar microelectrodes and cannot work in applications that require a recording of the intracellular action potential of a single cell.In this study,we proposed a novel measuring method that is able to record the intracellular action potential of a single cardiomyocyte by using a nanowell patterned microelectrode array(NWMEA).The NWMEA consists of five nanoscale wells at the center of each circular planar microelectrode.Biphasic pulse electroporation was applied to the NWMEA to penetrate the cardiomyocyte membrane,and the intracellular action potential was continuously recorded.The intracellular potential recording of cardiomyocytes by the NWMEA measured a potential signal with a higher quality(213.76±25.85%),reduced noise root-mean-square(~33%),and higher signal-to-noise ratio(254.36±12.61%)when compared to those of the extracellular recording.Compared to previously reported nanopillar microelectrodes,the NWMEA could ensure single cell electroporation and acquire high-quality action potential of cardiomyocytes with reduced fabrication processes.This NWMEA-based biosensing system is a promising tool to record the intracellular action potential of a single cell to broaden the usage of microelectrode arrays in electrophysiological investigation. | Yuting Xiang Haitao Liu Wenjian Yang Zhongyuan xu Yue Wu Zhajian Tang Zhjing Zhu Zhiyong Zeng Depeng Wang Tianxing Wang Ning Hu Diming Zhang | 2022 | Microsystems & Nanoengineering2022，8，3： | 0 |
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