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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Risk factors for colonoscopic perforation: A population-based study of 80118 cases显示文摘AIM: To assess the incidence and risk factors associated with colonic perforation due to colonoscopy. METHODS: This was a retrospective cross-sectional study. Patients were retrospectively eligible for inclusion if they were 18 years and older and had an inpatient or outpatient colonoscopy procedure code in any facility within the Geisinger Health System during the period from January 1, 2002 to August 25, 2010. Data are presented as median and inter-quartile range, for continuous variables, and as frequency and percentage for categorical variables. Baseline comparisons across those with and without a perforation were made using the two-sample t -test and Pearson's χ2 test, as appropriate.RESULTS: A total of 50 perforations were diagnosed out of 80118 colonoscopies, which corresponded to an incidence of 0.06% (95%CI: 0.05-0.08) or a rate of 6.2 per 10000 colonoscopies. All possible risk factors associated with colonic perforation with a P -value < 0.1 were checked for inclusion in a multivariable logbinomial regression model predicting 7-d colonic perforation. The final model resulted in the following risk factors which were significantly associated with risk of colonic perforation: age, gender, body mass index, albumin level, intensive care unit (ICU) patients, inpatient setting, and abdominal pain and Crohn's disease as indications for colonoscopy. CONCLUSION: The cumulative 7 d incidence of colonic perforation in this cohort was 0.06%. Advanced age and female gender were significantly more likely to have perforation. Increasing albumin and BMI resulted in decreased risk of colonic perforation. Having a colonoscopy indication of abdominal pain or Crohn's disease resulted in a higher risk of colonic perforation. Colonoscopies performed in inpatients and particularly the ICU setting had substantially greater odds of perforation. Biopsy and polypectomy did not increase the risk of perforation and only three perforations occurred with screening colonoscopy. | Uzair Hamdani Raza Naeem Fyeza Haider Pardeep Bansal Michael Komar David L Diehl H Lester Kirchner | 2013 | World Journal of Gastroenterology2013，19，23： | 9 |
| 3 | Identification of microRNA-like RNAs in Ophiocordyceps sinensis显示文摘Ophiocordyceps sinensis is well known as a traditional Chinese medicine and has widely been used for over 2,000 years to stimulate immune system, decrease blood pressure and to inhibit tumor growth. While miRNAs are increasingly recognized for their roles in post-transcriptional regulation of gene expression in animals and plants, miRNAs in fungi were less studied until the discovery of microRNA-like RNA(milRNA). High-throughput sequencing and bioinformatics approaches were used to identify conserved and novel milRNAs in O. sinensis. 40 conserved milRNAs were identified, while 23 pre-miRNA candidates encoding 31 novel milRNAs were predicted. Furthermore, the potential target genes of milRNAs in human were predicted and gene ontology analysis was applied to these genes. Enrichment analysis of GO-represented biological process showed that target genes of both conserved and novel milRNAs are involved in development, metabolic and immune processes, indicating the potential roles of milRNAs of O. sinensis in pharmacological effects as health food and traditional Chinese medicine. This study is the first report on genome-wide analysis of milRNAs in O. sinensis and it provides a useful resource to further study the potential roles of milRNAs as active components of O. sinensis in health food or traditional Chinese medicine. | Wen Zhang Xiaona Li Lina Ma Uzair Urrehman Xilinqiqige Bao Yujing Zhang Chen-Yu Zhang Dongxia Hou Zhen Zhou | 2019 | Science China(Life Sciences)2019，62，3： | 6 |
| 4 | Transcranial magnetic stimulation in animal models of neurodegeneration显示文摘Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation(TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, and there are few reports on the incisive recovery mechanisms through brain stimulation. Although several studies have recommended the use of non-invasive brain stimulation in clinical neuroscience, with a special emphasis on TMS, the suggested mechanisms of action have not been confirmed directly at the neural level. Insights into the neural mechanisms of non-invasive brain stimulation would unveil the strategies necessary to enhance the safety and efficacy of this progressive approach. Therefore, animal studies investigating the mechanisms of TMSinduced recovery at the neural level are crucial for the elaboration of non-invasive brain stimulation. Translational research done using animal models has several advantages and is able to investigate knowledge gaps by directly targeting neuronal levels. In this review, we have discussed the role of TMS in different animal models, the impact of animal studies on various disease states, and the findings regarding brain function of animal models after TMS in pharmacology research. | Mohammad Uzair Turki Abualait Muhammad Arshad Woo-Kyoung Yoo Ali Mir Reem Fahd Bunyan Shahid Bashir | 2022 | Neural Regeneration Research2022，17，2： | 4 |
| 5 | Vertical axis wind turbine – A review of various configurations and design techniques显示文摘 | Muhammad Mahmood Aslam Bhutta Nasir Hayat Ahmed Uzair Farooq Zain Ali Sh. Rehan Jamil Zahid Hussain | 2011 | Renewable and Sustainable Energy Reviews2011，，4： | 3 |
| 6 | A Robust Zero-Watermarking Based on SIFT-DCT for Medical Images in the Encrypted Domain显示文摘Remote medical diagnosis can be realized by using the Internet,but when transmitting medical images of patients through the Internet,personal information of patients may be leaked.Aim at the security of medical information system and the protection of medical images,a novel robust zero-watermarking based on SIFT-DCT(Scale Invariant Feature Transform-Discrete Cosine Transform)for medical images in the encrypted domain is proposed.Firstly,the original medical image is encrypted in transform domain based on Logistic chaotic sequence to enhance the concealment of original medical images.Then,the SIFT-DCT is used to extract the feature sequences of encrypted medical images.Next,zero-watermarking technology is used to ensure that the region of interest of medical images are not changed.Finally,the robust of the algorithm is evaluated by the correlation coefficient between the original watermark and the attacked watermark.A series of attack experiments are carried out on this method,and the results show that the algorithm is not only secure,but also robust to both traditional and geometric attacks,especially in clipping attacks. | Jialing Liu Jingbing Li Yenwei Chen Xiangxi Zou Jieren Cheng Yanlin Liu Uzair Aslam Bhatti | 2019 | Computers, Materials & Continua2019，，7： | 3 |
| 7 | A split target detection and tracking algorithm for ballistic missile tracking during the re-entry phase显示文摘In the re-entry phase of a ballistic missile,decoys can be deployed as a mean to overburden enemy defenses.This results in a single track being split into multiple track-lets.Tracking of these track-lets is a critical task as any miss in the tracking procedure can become a cause of a major threat.The tracking process becomes more complicated in the presence of clutter.The low detection rate is one of the factors that may contribute to increasing the difficulty level in terms of tracking in the cluttered environment.This work introduces a new algorithm for the split event detection and target tracking under the framework of the joint integrated probabilistic data association(JIPDA)algorithm.The proposed algorithm is termed as split event-JIPDA(SE-JIPDA).This work establishes the mathematical foundation for the split target detection and tracking mechanism.The performance analysis is made under different simulation conditions to provide a clear insight into the merits of the proposed algorithm.The performance parameters in these simulations are the root mean square error(RMSE),confirmed true track rate(CTTR)and confirmed split true track rate(CSTTR). | Muhammad Asad Sumair Khan Ihsanullah Zahid Mehmood Yifang Shi Sufyan Ali Memon Uzair Khan | 2020 | Defence Technology(防务技术)2020，16，6： | 2 |
| 8 | Molecular detection of Anaplasma infections in ixodid ticks from the Qinghai-Tibet Plateau显示文摘Anaplasma species are tick-transmitted obligate intracellular bacteria that infect many wild and domestic animals and humans.The prevalence ofAnaplasma spp.in ixodid ticks of Qinghai Province is poorly understood.In this study,a total of 1104 questing adult ticks were investigated for the infection ofAnaplasma species.As a result,we demonstrated the total infection rates of 3.1,11.1,5.6,and 4.5%forA.phagocytophilum,A.bovis,A.ovis andA.capra,respectively.All of the tick samples were negative forA.marginale.The positive rates ofA.phagocytophilum,A.ovis andA.capra in different tick species were significantly different.The positive rates ofA.capra andA.bovis in the male ticks were significantly higher than that in the female ticks.Sequence analysis ofA.ovis showed 99.5-100%identity to the previous reported isolates.The sequences ofA.phagocytophilum had 100%identity to strains Ap-SHX21,JC3-3 and ZAM dog-181 from sheep,Mongolian gazelles,and dogs.Two genotypes ofA.capra were found based on 16S rRNA,citrate synthase(gltA)gene and heat shock protein(groEL)gene analysis.In conclusion,A.bovis,A.ovis,A.phagocytophilum,andA.capra were present in the ticks in Qinghai Province.Anaplasma infection is associated with tick species,gender and distribution.These data will be helpful for understanding prevalence status ofAnaplasma infections in ticks in Qinghai-Tibet Plateau. | Rong Han Ji-Fei Yang Muhammad Uzair Mukhtar Ze Chen Qing-Li Niu Yuan-Qing Lin Guang-Yuan Liu Jian-Xun Luo Hong Yin Zhi-Jie Liu | 2019 | Infectious Diseases of Poverty2019，8，1： | 2 |
| 9 | Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases显示文摘Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes(e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA-and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging. | Syed Aoun Mehmood Sherazi Asim Abbasi Abdullah Jamil Mohammad Uzair Ayesha Ikram Shanzay Qamar Adediji Ayomide Olamide Muhammad Arshad Peter J.Fried Milos Ljubisavljevic Ran Wang Shahid Bashir | 2023 | Neural Regeneration Research2023，18，5： | 2 |
| 10 | 水稻窄叶突变体nal20的表型分析与基因定位显示文摘叶片作为植物光合作用的主要器官,其面积的大小影响着光能利用率和最终产量。为了研究水稻叶片形态建成的分子机制,利用60Co-γ射线诱变粳稻品种春江06,在M2代中得到1份窄叶突变体,命名为narrow leaf20(nal20)。该突变体叶片变窄、株高降低、分蘖增多、茎节间缩短、抽穗期提前。本研究重点调查了3片功能叶的形态,发现突变体叶片宽度减少了50%,叶片长度变化较小。细胞学观察表明,叶片变窄主要是由于表皮细胞数目的减少,而细胞大小变化不大。遗传分析表明,该突变体表型受1对隐性基因控制。利用具有多态性的In Del分子标记及nal20与Dular配制的F2定位群体,将该基因定位于第7染色体着丝粒区1.9 Mb范围内。二代测序结果表明,在该范围内有455 kb的大片段缺失。本研究结果为窄叶基因NAL20的克隆和功能分析奠定了良好基础,也为水稻株型改良提供了基因资源和育种材料。 | 龙海馨 邱海阳 Muhammad UZAIR 房静静 赵金凤 李学勇 | 2018 | 作物学报2018，44，9： | 2 |
| 11 | Anti-nociceptive, anti-inflammatory and sedative activities of the extracts and chemical constituents of Diospyros lotus L.显示文摘 | Ghias Uddin Abdur Rauf Bina S. Siddiqui Naveed Muhammad Ajmal Khan Syed Uzair Ali Shah | 2014 | Phytomedicine2014，，： | 1 |
| 12 | An efficient algorithm for ethemet topology discovery in large multi-subnet显示文摘 | Umer Uzair Hafiz Farooq Ahmad Arshad All | 2007 | System of Systems Engineering2007，4，： | 1 |
| 13 | Zero Watermarking Algorithm for Medical Image Based on Resnet50-DCT显示文摘Medical images are used as a diagnostic tool, so protecting theirconfidentiality has long been a topic of study. From this, we propose aResnet50-DCT-based zero watermarking algorithm for use with medicalimages. To begin, we use Resnet50, a pre-training network, to draw out thedeep features of medical images. Then the deep features are transformedby DCT transform and the perceptual hash function is used to generatethe feature vector. The original watermark is chaotic scrambled to get theencrypted watermark, and the watermark information is embedded into theoriginal medical image by XOR operation, and the logical key vector isobtained and saved at the same time. Similarly, the same feature extractionmethod is used to extract the deep features of the medical image to be testedand generate the feature vector. Later, the XOR operation is carried outbetween the feature vector and the logical key vector, and the encryptedwatermark is extracted and decrypted to get the restored watermark;thenormalized correlation coefficient (NC) of the original watermark and therestored watermark is calculated to determine the ownership and watermarkinformation of the medical image to be tested. After calculation, most ofthe NC values are greater than 0.50. The experimental results demonstratethe algorithm’s robustness, invisibility, and security, as well as its ability toaccurately extract watermark information. The algorithm also shows goodresistance to conventional attacks and geometric attacks. | Mingshuai Sheng Jingbing Li Uzair Aslam Bhatti Jing Liu Mengxing Huang Yen-Wei Chen | 2023 | Computers, Materials & Continua2023，，4： | 1 |
| 14 | Clinical and echocardiographic analysis of patients suffering from recurrent takotsubo cardiomyopathy显示文摘takotsubo 心肌症(TTC ) 的复发是著名复杂并发症。然而,当前的文学列出仅仅一些孤立的盒子。我们试图决定发生和周期性的 TTC.Methods 与组成的 ResultsOur 机构的数据库的临床的意义一自从 2003,与 TTC 诊断的 114 个病人集体。这些病人的靠近的后续在这些中的七个揭示了 TTC 的复发(6.1%) 。在索引事件和它的复发之间的时间间隔在六个月和六年之间变化了。动脉的高血压是与非复发组相比在 TTC 的复发组揭示的更多,(P = 0.02 ) 。长期的妨碍的肺的疾病或气喘是在复发组诊断的更多,(P = 0.04 ) 。临床的事件喜欢恰好室的参与, TTC 相关复杂并发症象威胁生活的心律不齐那样,肺的拥挤并且在医院里,死亡在周期性的事件更经常被观察。在索引事件不是不平常的现象以后,在一年的吝啬的后续上,死亡率在在六年以内的 TTC 的两 groups.ConclusionsRecurrence 是类似的。万一在恶化阶段的恰好室的参与,它可能与更高的复杂并发症率被联系。TTC 复发应该是在有 TTC 的过去的历史的病人的第一微分诊断。 | Ibrahim El-Battrawy Uzair Ansari Michael Behnes Dennis Hillenbrand Katja Schramm Darius Haghi Ursula Hoffmann Theano Papavassiliu Elif Elmas Christian Fasmer Tobias Becher Stefan Baumann Christina Dosch Felix Heggemann Jurgen Kuschyk Martin Borggrefe Ibrahim Akin | 2016 | Journal of Geriatric Cardiology2016，13，11： | 1 |
| 15 | Biological screening of Euphorbia helioscopia L显示文摘 | M uzair B aloothar Bachoudhary | | 0，，02： | 1 |
| 16 | Green corrosion inhibitors intercalated Mg:Al layered double hydroxide coatings to protect Mg alloy显示文摘Mg alloy was protected with Mg:Al layered double hydroxide(LDH)coating intercalated with three green corrosion inhibitors(sodium benzoate,3-aminopropyltriethoxysilane and 8-hydroxyquinoline).The in-situ hydrothermal approach was adopted to intercalate corrosion inhibitors into Mg:Al LDH coating.The intercalated Mg:Al LDH coating was successfully acquired,and the crystalline structure of Mg:Al LDH coating was verified with X-ray diffraction(XRD).The organic functional groups of corrosion inhibitors were identified with the help of Fourier transform infrared spectroscopy(FTIR)and X-ray photoelectron spectroscopy(XPS).The compact and uniform morphology was confirmed by scanning electron microscopy(SEM).The electrochemical measurement revealed better corrosion resistance of corrosion inhibitorintercalated Mg:Al LDH coatings as compared to that of pristine Mg alloy.The corrosion protection mechanism of corrosion inhibitors was described and unearthed the corrosion inhibitor with the best performance. | Muhammad Junaid Anjum Jing-Mao Zhao Vahdat Zahedi Asl Muhammad Uzair Malik Ghulam Yasin Waheed Qamar Khan | 2021 | Rare Metals2021，40，8： | 1 |
| 17 | Computerized evaluation of water-supply reliability显示文摘 | UZAIR M S | 1990 | IEEB Transaction on Reliability1990，39，1： | 1 |
| 18 | Storm-Water Management Implementation Through Modeling And GIS显示文摘 | Uzair M Shamsi | 1996 | J Water Resottrc Ping And mgmt1996，，2： | 1 |
| 19 | Intermittent Androgen Deprivation: update of cycling characteristics in patients without clinically apparent metastatic prostate cancer 显示文摘 | Grossfeld GD Uzair B Hary C | 2001 | Urology2001，58，： | 1 |
| 20 | Vertical axis wind turbine A review of various configurations and design techniques 显示文摘 | Muhammad Mahmood Aslam Bhutta Nasir Hayat Ahmed Uzair Farooq | 2012 | Renew- able and Sustainable Energy Reviews2012，，16： | 1 |
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