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| 1 | TGF-β signaling in cancer metastasis显示文摘转变生长因素(TGF )- 发信号的事件是众所周知的控制多样的进程和众多的回答例如房间增长,区别, apoptosis,和移植。在癌症的 TGF- 发信号戏上下文依赖者角色:在 pre 恶意的房间, TGF- 首先作为肿瘤 suppressor 工作,当在癌症的以后的阶段发信号的 TGF- 支持侵略和转移时。最近的研究也建议了在 TGF- 发信号和另外的发信号的小径之间的串音例如河马, Wnt, EGFR/RAS,和 PI3K/AKT 小径,可以实质地贡献我们 TGF- 发信号和癌症的当前的理解。由于 TGF- 的广阔效果, TGF- 和它的下游的发信号部件的封锁提供多重治疗学的机会。因此,为为众多的疾病表明治疗的 anti-TGF- 的眼界显得明亮并且将提供珍贵信息并且想在这药上分子的设计。在这评论,我们集中于最近的卓见进在可以贡献新奇指向癌症的治疗的发展的癌症转移发信号的 TGF- 的规定。 | Feng Xie Li Ling Hans van Dam Fangfang Zhou Long Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 36 |
| 2 | ;he regulation of TGF-β/SMAD signaling by protein deubiquitination显示文摘 | Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van Dam Long Zhang Fangfang Zhou | 2014 | Protein & Cell2014，5，7： | 27 |
| 3 | Development and application of functional gene arrays for microbial community analysis显示文摘功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示,简单、人工的微生物引起的社区,改编如此的一种技术分析复杂微生物引起的社区仍然以设计,样品准备,和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音,例如 oligonucleotide 探查设计, nucleic 酸抽取和纯化,数据分析,特性,敏感,和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析,并且连接微生物引起的结构到生态系统工作。 | Z. L. HE J. D. VAN NOSTRAND L.Y. WU J. Z. ZHOU | 2008 | 中国有色金属学会会刊:英文版2008，18，6： | 21 |
| 4 | China’s 1-3-7 surveillance and response strategy for malaria elimination: Is case reporting, investigation and foci response happening according to plan?显示文摘Background:The China’s 1-3-7 strategy was initiated and extensively adopted in different types of counties(geographic regions)for reporting of malaria cases within 1 day,their confirmation and investigation within 3 days,and the appropriate public health response to prevent further transmission within 7 days.Assessing the level of compliance to the 1-3-7 strategy at the county level is a first step towards determining whether the surveillance and response strategy is happening according to plan.This study assessed if the time-bound targets of the 1-3-7 strategy were being sustained over time.Such information would be useful to improve implementation of the 1-3-7 strategy in China.Methods:This cross-sectional study involved country-wide programmatic data for the period January 1st 2013 to June 30th 2014.Data variables were extracted from the national malaria information system and included socio-demographic information,type of county,date of diagnosis,date of reporting,date of case investigation,case classification(indigenous,or imported,or unknown),focus investigation,date of reactive case detection(RACD),and date of indoor residual spraying(IRS).Summary statistics and proportions were used and comparisons between groups were assessed using the chi-square test.Level of significance was set at a P-value≤0.05.Results:Of a total of 5,688 malaria cases from 731 counties,there were 55(1%)indigenous cases(only in Type 1 and Type 2 counties)and 5,633(99%)imported cases from all types of counties.There was no delay in reporting malaria cases by type of county.In terms of case investigation,97.5%cases were investigated within 3 days with the proportion of delays(1.5%)in type 2 counties,being significantly lower than type 1 counties(4.1%).Regarding active foci,96.4%were treated by RACD and/or IRS.Conclusions:The performance of 1-3-7 strategy was encouraging but identified some challenges that if addressed can further improve implementation. | Shui-Sen Zhou Shao-Sen Zhang Li Zhang Aafje ECRietveld Andrew RRamsay Rony Zachariah Karen Bissell Rafael Van den Bergh Zhi-Gui Xia Xiao-Nong Zhou Richard ECibulskis | 2015 | Infectious Diseases of Poverty2015，4，1： | 21 |
| 5 | ZmMs30 Encoding a Novel GDSL Lipase Is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize显示文摘Genic male sterility (GMS) is very useful for hybrid vigor utilization and hybrid seed production. Although a large number of GMS genes have been identified in plants, little is known about the roles of GDSL lipase members in anther and pollen development. Here, we report a maize GMS gene, ZmMs30, which encodes a novel type of GDSL lipase with diverged catalytic residues. Enzyme kinetics and activity assays show that ZmMs30 has lipase activity and prefers to substrates with a short carbon chain. ZmMs30 is specifically expressed in maize anthers during stages 7-9. Loss of ZmMs30 function resulted in defective anther cuticle, irregular foot layer of pollen exine, and complete male sterility. Cytological and lipidomics analyses demonstrate that ZmMs30 is crucial for the aliphatic metabolic pathway required for pollen exine formation and anther cuticle development. Furthermore, we found that male sterility caused by loss of ZmMs30 function was stable in various inbred lines with different genetic background, and that it didn't show any negative effect on maize heterosis and production, suggesting that ZmMs30 is valuable for crossbreeding and hybrid seed production. We then developed a new multi-control sterility system using ZmMs30 and its mutant line, and demonstrated it is feasible for generating desirable GMS lines and valu. able for hybrid maize seed production. Taken together, our study sheds new light on the mechanisms of anther and pollen development, and provides a valuable male-sterility system for hybrid breeding maize. | Xueli An Zhenying Dong Youhui Tian Ke Xie Suowei Wu Taotao Zhu Danfeng Zhang Van Zhou Canfang Niu Biao Ma Quancan Hou Jianxi Bao Simiao Zhang Ziwen Li Yanbo Wang Tingwei Yan Xiaojing Sun Yuwen Zhang Jinping Li Xiangyuan Wan | 2019 | Molecular Plant2019，12，3： | 15 |
| 6 | APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells显示文摘Amyloid beta(Aβ)precursor protein(APP)is a key protein in the pathogenesis of Alzheimer’s disease(AD).Both APP and its paralogue APLP1(amyloid beta precursor-like protein 1)have multiple functions in cell adhesion and proliferation.Previously it was thought that autophagy is a novel beta-amyloid peptide(Aβ)-generating pathway activated in AD.However,the protein proteolysis of APLP1 is still largely unknown.The present study shows that APLP1 is rapidly degraded in neuronal cells in response to stresses,such as proteasome inhibition.Activation of the endoplasmic reticulum(ER)stress by proteasome inhibitors induces autophagy,causing reduction of mature APLP1/APP.Blocking autophagy or JNK stress kinase rescues the protein expression for both APP and APLP1.Therefore,our results suggest that APP/APLP1 is degraded through autophagy and the APLP1 proteolysis is mainly mediated by autophagy-lysosome pathway. | Fangfang Zhou Theo van Laar Huizhe Huang Long Zhang | 2011 | Protein & Cell2011，2，5： | 8 |
| 7 | Effects of dietary supplementation with essential oils and protease on growth performance,antioxidation,inflammation and intestinal function of weaned pigs显示文摘This experiment evaluated the impacts of essential oils(EO)and protease(PRO),independently or in combination,on growth performance,antioxidation,inflammation and intestinal function of weaned pigs.One hundred and sixty weaned pigs(21 d of age,BW of 6.74±0.20 kg)were randomly divided into 4 treatments with 8 replicate pens of 5 pigs per pen.Dietary treatments included the following:1)control diet(CON),2)CON with 300 mg/kg essential oils(EO),3)CON with 500 mg/kg protease(PRO),4)CON with 300 mg/kg essential oil and 500 mg/kg protease(EO + PRO).On d 8,one pig from each penwas selected for sampling.The remaining pigs were fed for an additional week and growth performance was monitored during this period.Dietary treatments had no marked effects(P>0.05)on the growth performance of pigs.However,pigs receiving EO diet had higher(P<0.05)serumglutathione peroxidase(GSH-Px)activity,and tended to decrease(P=0.063)serum concentration of tumor necrosis factor-a(TNF-a).In addition,pigs receiving EO diet had higher(P<0.05)abundances of phylum Actinobacteria,and genera Bifidobacterium,and lower(P<0.05)phylum Bacteroidetes and genera Alloprevotella in colonic digesta.Pigs receiving PRO diet decreased(P<0.05)the serum concentration of malondialdehyde(MDA)and diamine oxidase activity,increased(P<0.05)the villus height and the ratio of villus height to crypt depth in duodenum,increased sucrase activity in jejunal mucosa,and also increased the abundance of phylum Actinobacteria in colonic digesta.Furthermore,the synergistic effects of EO and PROwas observed(P<0.05)for pigs with decreasing serum TNF-a concentration and increasing serum GSH-Px activity.Collectively,the results indicated that dietary supplementation of EO and PRO had no significant effects on growth performance of weaned pigs.EO diet appeared to improve antioxidant activity and intestinal microbiota,while PRO diet improved intestinal morphology and digestive enzyme activity,and there was a synergistic effect of EO and PRO on reducing inflammatory parameters in weaned pigs. | Xie Peng Qiang Zhou Cheng Wu Jian Zhao Quan Tan Ying He Liang Hu Zhengfeng Fang Yan Lin Shengyu Xu Bin Feng Jian Li Yong Zhuo Chris Van Ginneken Xuemei Jiang De Wu Lianqiang Che | 2022 | Animal Nutrition2022，，2： | 8 |
| 8 | Analysis of the meiosis in the F_1 hybrids of Longiflorum × Asiatic(LA) of lilies(Lilium) using genomic in situ hybridization显示文摘Longiflorum and Asiatic lilies of the genus Lilium of the family Liliaceae are two important groups of modern lily cultivars.One of the main trends of lily breeding is to realize introgression between these groups.With cut style pollination and embryo rescue,distant hybrids between the two groups have been obtained.However,the F1 hybrids are highly sterile or some of them could produce a small number of 2n gametes,and their BC1 progenies are usually triploids.Dutch lily breeders have selected many cultivars from these BC1 progenies based on their variation.It is presumably suggested that such variation could be caused by intergenomic recombination and abnormal meiosis during gamete formation in F1 hybrids of Longiflorum × Asiatic(LA) hybrids in Lilium.Therefore,the meiotic process of ten F1 LA hybrids was cytologically investigated using genomic in situ hybridization and traditional cytological methods in the present research.The results showed that:at metaphase I,the homoeologous chromosome pairing among different F1 hybrids ranged from 2.0 to 11.4 bivalents formed by homoeologous chromosomes per pollen mother cell(PMC),and very few multivalents,and even very few bivalents were formed by two chromosomes within one genome rather than homoeologous chromosomes in some PMCs;at anaphase I,all bivalents were disjoined and most univalents were divided.Both the disjoined bivalents(half-bivalents) and the divided univalents(sister chromatids) moved to the opposite poles,and then formed two groups of chromosomes;because the two resulting half-bivalents retained their axes in the cell undisturbed,many crossover types,including single crossovers,three strand double crossovers,four strand double crossovers,four strand triple crossovers,and four strand multiple crossovers between the non-sister chromatids in the tetrads of bivalents,were clearly inferred by analyzing the breakpoints on the disjoined bivalents.The present investigation not only explained the reason for sterility of the F1 LA hybrids and the variation of their BC1 progenies,but also provided a new method to analyze crossover types in other F1 interspecific hybrids as well. | Shujun Zhou Munikote S. Ramanna Richard G.E Visser Jaap M. van Tuyl | 2008 | Journal of Genetics and Genomics2008，35，11： | 8 |
| 9 | Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock"显示文摘 | Wu YH Fischer DF Kalsbcck A Garidou-Boof ML van der Vliet J van Heijningen C Liu RY Zhou JN Swaab DE | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 10 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 11 | A luminescence dating study of open-air Palaeolithic sites in western Epirus, Greece 显示文摘 | Zhou LP van Andel TH Lang A | 2000 | J Archaeol Sci2000，27，： | 4 |
| 12 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 13 | The Cellulose Synthases Are Cargo of the TPLATE Adaptor Complex显示文摘 | Clara Sanchez-Rodriguez Yanyun Shi Christopher Kesten Dongmei Zhang Gloria Sancho-Andres Alexander Ivakov Edwin R. Lampugnani Kamil Sklodowski Masaru Fujimoto Akihiko Nakano Antony Bacic Ian S. Wallace Takashi Ueda Daniel Van Damme Yihua Zhou Staffan Persson | 2018 | Molecular Plant2018，11，2： | 3 |
| 14 | Haplotype-resolved genome assembly and allele- specific gene expression in cultivated ginger显示文摘Ginger(Zingiber officinale)is one of the most valued spice plants worldwide;it is prized for its culinary and folk medicinal applications and is therefore of high economic and cultural importance.Here,we present a haplotype-resolved,chromosome-scale assembly for diploid ginger anchored to 11 pseudochromosome pairs with a total length of 3.1 Gb.Remarkable structural variation was identified between haplotypes,and two inversions larger than 15Mb on chromosome 4 may be associated with ginger infertility.We performed a comprehensive,spatiotemporal,genome-wide analysis of allelic expression patterns,revealing that most alleles are coordinately expressed.The alleles that exhibited the largest differences in expression showed closer proximity to transposable elements,greater coding sequence divergence,more relaxed selection pressure,and more transcription factor binding site differences.We also predicted the transcription factors potentially regulating 6-gingerol biosynthesis.Our allele-aware assembly provides a powerful platform for future functional genomics,molecular breeding,and genome editing in ginger. | Shi-Ping Cheng Kai-Hua Jia Hui Liu Ren-Gang Zhang Zhi-Chao Li Shan-Shan Zhou Tian-Le Shi Ai-Chu Ma Cong-Wen Yu Chan Gao Guang-Lei Cao Wei Zhao Shuai Nie Jing-Fang Guo Si-Qian Jiao Xue-Chan Tian Xue-Mei Yan Yu-Tao Bao Quan-Zheng Yun Xin-Zhu Wang Ilga Porth Yousry AEl-Kassaby Xiao-Ru Wang Zhen Li Yves Van de Peer Jian-Feng Mao | 2021 | Horticulture Research2021，8，1： | 3 |
| 15 | Nontrivial standing wave state in frequency- weighted Kuramoto model显示文摘在有一致频率分布的一个频率加权的 Kuramoto 模型的同步被学习。我们阴谋分叉图并且识别 asymptotic 协调状态。数字模拟证明系统在两个经历二一阶的转变前面、向后的方向。除了小锁阶段的状态,新奇 nonstationary 协调状态,即,一个重要的站波浪状态被观察并且描绘。处于这个状态,因为他们将处于平常的站波浪状态,在协调的簇内的振荡器不是锁频率的。相反,他们的平均频率被锁到一个常数。到重要的站波浪状态的来自支离破碎的状态的批评联合力量能被执行线性稳定性分析获得。理论结果被数字模拟支持。 | Hong-Jie Bi Van Li Li Zhou Shu-Guang Guan | 2017 | Frontiers of physics2017，12，3： | 3 |
| 16 | Taxonomy and pathogenicity of Ceratocystis species on Eucalyptus trees in South China, including C. chinaeucensis sp. nov.显示文摘Commercial plantations of Eucalyptus species have been established in South China,especially during the past 20 years,to meet the needs of a rapidly growing national economy.As part of a survey of fungal diseases affecting Eucalyptus species in South China,Ceratocystis species were collected from Eucalyptus plantations in the GuangDong Province.The aims of this study were to identify these Ceratocystis isolates and to test their pathogenicity to Eucalyptus.The most aggressive isolates were also used to screen different species and clones of Eucalyptus for susceptibility to infection under field conditions.The fungi were identified based on morphology and through comparisons of DNA sequence data of the ITS,partialβ-tubulin and TEF-1αgene regions.Morphological and DNA sequence comparisons showed that isolates collected from Chinese Eucalyptus plantations represent two species,C.acaciivora in the C.fimbriata s.l.species complex and a previously undescribed species belonging to the C.moniliformis s.l.species complex,for which the name C.chinaeucensis sp.nov.is provided.In pathogenicity trials,both C.acaciivora and C.chinaeucensis gave rise to lesions on wounded Eucalyptus trees,and the former fungus was most pathogenic.Differences were also observed in the responses of different Eucalyptus clones to inoculation and this could be useful in reducing disease,if C.acaciivora should emerge as a pathogen in the future. | ShuaiFei Chen Marelize Van Wyk Jolanda Roux Michael J.Wingfield YaoJian Xie XuDong Zhou | 2013 | Fungal Diversity2013，，1： | 2 |
| 17 | 血压变异性加大与认知功能减退相关显示文摘由于预期寿命增加,越来越多的人将面临与增龄相关的认知困难。因此,确定认知障碍的可改变的风险因素非常重要。极短期到中期的血压变异性(blood pressure variability,BPV)可能就是这样一个因素,因为它可能导致脑缺血。 | Zhou TL Kroon AA van Sloten TT van Boxtel MPJ Verhey FRJ Schram MT Kohler S Stehouwer CDA Henry RMA 刘莉(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 18 | A prototype web-based analysis platform for drought monitoring and early warning显示文摘It has long been recognized that an effective drought monitoring and early warning system,which provides functions for real-time condition monitoring and prediction,risk assessment,information dissemination and response recommendation,is very important for the preparedness for and mitigation of drought impacts.In this article,we review the currently existing drought monitor and early warning systems,discuss applicable remote sensing datasets and drought indicators and present the development of a web-based quasi-real-time Global Drought Monitoring&Analysis Platform(Web-GDMAP).The Web-GDMAP is built upon a series of indicators derived from multi-source satellite remote sensing data and various other sources of data.From a technical perspective,the Web-GDMAP system includes a series of components from data storage,model implementation and distribution,to client-side visualization and user intuitive interaction.From a theoretical perspective,the Web-GDMAP system integrates multi-indicators on different aspects of drought,including anomalies in precipitation,anomalies in land surface thermal and vegetation conditions,water deficit of soil and plants,etc.Several case studies on applying the developed Web-GDMAP in the Asian region are demonstrated.Further improvements and perspectives are discussed. | Mattijn van Hoek Jie Zhou Li Jia Jing Lu Chaolei Zheng Guangcheng Hu Massimo Menenti | 2020 | International Journal of Digital Earth2020，13，7： | 2 |
| 19 | Malaria profiles and challenges in artemisinin resistance containment in Myanmar显示文摘Background:This study examined evolving malaria profiles from January,2010 to December,2014 to evaluate achievements and challenges of implementing measures to prevent and control spread of artemisinin resistance in Myanmar.Methods:Using National Malaria Control Programme(NMCP)data,a cross-sectional descriptive study of 52 townships in artemisinin-resistant containment areas in Myanmar was conducted.Annual program data were analysed,and trends over time are graphically presented.Results:In the 52 study townships populated by 8.7 million inhabitants,malaria incidence showed a decreasing trend from 10.54 per 1000 population in 2010 to 2.53 in 2014,and malaria mortalities also decreased from 1.83 per 100000 population in 2010 to 0.17 in 2014.The proportion of confirmed to total tested malaria cases also decreased from 6 to 1%,while identification of cases improved.All cases from all parasites species,including Plasmodium falciparum,decreased.Coverage of LLIN(long-lasting insecticidal net)/ITN(insecticide-treated mosquito nets)and indoor residual spraying(IRS)was high in targeted areas with at-risk persons,even though the total population was not covered.In addition to passive case detection(PCD),active case detection(ACD)was conducted in hard-to-reach areas and worksites where mobile migrant populations were present.ACD improved in most areas from 2012 to 2014,but continues to need to be strengthened.Conclusions:The findings provide useful data on the malaria situation in artemisinin-resistant initiative areas,which may be useful for the NMCP to meet its elimination goal.These profiles could contribute to better planning,implementation,and evaluation of intervention activities. | Thet Wai Nwe Tin Oo Khin Thet Wai Shuisen Zhou Johan van Griensven Palanivel Chinnakali Safieh Shah Aung Thi | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 20 | The role of feed consumption and feed efficiency in copper-stimulated growth显示文摘 | ZHOU W KORNEGAY E T VAN L H | 1994 | J Ainm Sci1994，72，： | 1 |
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