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| 1 | 新型农村合作医疗制度试点对农民卫生服务利用的影响研究显示文摘目的揭示中国新型农村合作医疗制度试点对农民卫生服务利用的影响效果。方法在控制重要混杂因素的情况下采用分组与空白对照的方法进行分析性研究,通过Propensity Score Match的方法进行两组间的匹配后研究效果指标。结果自愿参合人群有一定选择性;参合对促进门诊利用总量增加有限,但对改善应就诊而未就诊的影响较明显;对促进住院服务利用总量增加明显,由于需住院人数和未住院人数的同时增加,对降低未住院率的作用不明显。不同补偿模式发挥作用不同,以补住院和门诊统筹模式的作用更好。结论试点性的新农合制度对农民卫生服务利用有一定的促进作用,作用的发挥与补偿模式紧密相关,仍需加大筹资力度以更好发挥新农合的作用。 | 钱军程 高军 饶克勤 Adam Wagstaff Magnus Lindelow | 2008 | 中国卫生统计2008，25，5： | 11 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 4 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 5 | 扩大圆锭结晶器冷却水出口区显示文摘在过去的几年中,圆锭结晶器已有了几次改进。尽管这些改进主要限于结晶器,但却改善了整个铸造系统的效能。双排喷水孔可增大冷却水的喷射角和喷射速度,减少冲击铸锭后飞溅离开铸锭表面的水量。这些改进提高了二次水冷效果,允许在铸速相同的情况下采用更长的结晶器膛。由于这种结构的结晶器冷却效果提高,故在水温一定的条件下,可减少冷却水的用量。石墨环结构及其材质的改进使铸锭质量提高,结晶器维修工作量减少。这种双排射流结晶器可制成一体式。 | Jeffrey W.Allen,Robert B.Wagstaff,K. Dean Bowles(Wagstaff Co.,Ltd.,3910 North Flora Road Spokane,WA 99216,America) | 1999 | 轻合金加工技术1999，27，1： | 4 |
| 6 | 玩转维基百科显示文摘你可能已经听说过维基百科(Wikipedia),(www.wikipedia.org),如果还没听说,我可要问问你平日是在哪里获取信息的了。维基百科是由无数读者共同创建的百科全书。它是一个条理清晰并不断得到更新和修订的知识库──尽管更新的频率并不固定。由于可被包括非专业人士在内的任何人更新,因此维基百科并非完美无缺, | Jeremy Wagstaff 王玉珍 | 2007 | 英语自学2007，，6： | 3 |
| 7 | The Deformation of Clad Aluminum Sheet Produced By Direct Chill Casting显示文摘 | David J. Lloyd Mark Gallerneault Robert B. Wagstaff | 2010 | Metallurgical and Materials Transactions A2010，，8： | 3 |
| 8 | Direct Chill Casting of CLAD Ingot显示文摘 | Wagstaff Robert B. Lloyd David J. Bischoff Todd F | 2006 | Materials Science Forum . 2006 (519)2006，，： | 2 |
| 9 | Extending health insurance to the rural population: An impact evaluation of China’s new cooperative medical scheme显示文摘 | Adam Wagstaff Magnus Lindelow Gao Jun Xu Ling Qian Juncheng | 2008 | Journal of Health Economics2008，，1： | 2 |
| 10 | Melanoma:Molecular genetics,metastasis,targeted therapies,immunotherapies,and therapeutic resistance显示文摘Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s.For some patients,early diagnosis and surgical removal of melanomas is lifesaving,while other patients typically turn to molecular targeted therapies and immunotherapies as treatment options.Easy sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF,NRAS,and TERT genes,some of which can be therapeutically targeted.Though initially effective,many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory pathways.Immunotherapies represent an alternative to molecular targeted therapies.However,inter-tumoral immune cell populations dictate initial therapeutic response and even tumors that responded to treatment develop resistance in the long term.As the protocol for combination therapies develop,so will our scientific understanding of the many pathways at play in the progression of melanoma.The future direction of the field may be to find a molecule that connects all of the pathways.Meanwhile,noncoding RNAs have been shown to play important roles in melanoma development and progression.Studying noncoding RNAs may help us to understand how resistance e both primary and acquired e develops;ultimately allow us to harness the true potential of current therapies.This review will cover the basic structure of the skin,the mutations and pathways responsible for transforming melanocytes into melanomas,the process by which melanomas metastasize,targeted therapeutics,and the potential that noncoding RNAs have as a prognostic and treatment tool. | William Wagstaff Rimel N.Mwamba Karina Grullon Mikhayla Armstrong Piao Zhao Bryce Hendren-Santiago Kevin H.Qin Alexander J.Li Daniel A.Hu Andrew Youssef Russell R.Reid Hue H.Luu Le Shen Tong-Chuan He Rex C.Haydon | 2022 | Genes & Diseases2022，9，6： | 2 |
| 11 | 高等职业教育的国际化特色与启示——以内蒙古商贸职业学院中英职业教育合作项目为例显示文摘本文在研究分析英国现代职业教育状况及经验的基础上,介绍了内蒙古商贸职业学院中英职业教育合作项目的实施背景及发展情况,通过对中英现代职业教育特点进行比较分析,借鉴高等职业教育发展与改革的思路与方法。 | 徐恒山 李伟 Hsiu Chuan Wagstaff | 2012 | 中国成人教育2012，，15： | 2 |
| 12 | Can insurance increase financial risk? 显示文摘 | Wagstaff A Lindelow M | 2008 | Health Economy2008，，2： | 1 |
| 13 | Wnt3amediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function显示文摘 | Yue Qiaoyun Wagstaff L Yang Xuesong | 2008 | Development2008，135，6： | 1 |
| 14 | Losartan Potassium:Use in hypertension显示文摘 | Wagstaff AJ | 1996 | Drugs1996，820，： | 1 |
| 15 | Lamotrigine:a review of its use in bipolar disorder显示文摘 | Goldsmith DR Wagstaff AJ Ibbotson T | 2003 | Drugs2003，63，19： | 1 |
| 16 | Inhaled iloprost: in primary pulmo- nary hypertension显示文摘 | Goldsmith DR Wagstaff AJ | 2004 | Drugs2004，64，7： | 1 |
| 17 | Statin-associated memory loss:analysis of 60 case reports and review of the literature显示文摘 | Wagstaff LR Mitton MW Arvik BM | 2003 | Pharmacotherapy2003，23，： | 1 |
| 18 | Rosiglitazone:a review of its use in the management of type 2 diabetes mellitus 显示文摘 | Wagstaff A J Goa KL | 2002 | Drugs2002，62，： | 1 |
| 19 | Fexofenadine显示文摘 | Markham A Wagstaff AJ | 1998 | Drugs1998，55，2： | 1 |
| 20 | Catastrophe and impoverish-ment in paying for Health Care: with applications to Vietnam1993- 1998显示文摘 | Wagstaff A Van Doorslaer E | 2003 | Bulletin of the World Health Organization2003，，11： | 1 |
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