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| 1 | Platelets in hemostasis and thrombosis:Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis显示文摘Platelets are small anucleate cells generated from megakaryocytes in the bone marrow.Although platelet generation,maturation,and clearance are still not fully understood,significant progress has been made in the last 1-2 decades.In blood circulation,platelets can quickly adhere and aggregate at sites of vascular injury,forming the platelet plug(i.e.the first wave of hemostasis).Activated platelets can also provide negatively charged phosphatidylserinerich membrane surface that enhances cell-based thrombin generation,which facilitates blood coagulation(i.e.the second wave of hemostasis).Platelets therefore play central roles in hemostasis.However,the same process of hemostasis may also cause thrombosis and vessel occlusion,which are the most common mechanisms leading to heart attack and stroke following ruptured atherosclerotic lesions.In this review,we will introduce the classical mechanisms and newly discovered pathways of platelets in hemostasis and thrombosis,including fibrinogen-independent platelet aggregation and thrombosis,and the plasma fibronectin-mediated 'protein wave' of hemostasis that precedes the classical first wave of hemostasis.Furthermore,we briefly discuss the roles of platelets in inflammation and atherosclerosis and the potential strategies to control atherothrombosis. | Yan Hou Naadiya Carrim Yiming Wang Reid C.Gallant Alexandra Marshall Heyu Ni | 2015 | The Journal of Biomedical Research2015，29，6： | 21 |
| 2 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 3 | Significance of Vibrio species in the marine organic carbon cycle-A review显示文摘The genus Vibrio,belonging to Gammaproteobacteria of the phylum Proteobacteria,is a genetically and ecologically diverse group of heterotrophic bacteria,that are ubiquitous in marine environments,especially in coastal areas.In particular,vibrios dominate,i.e.up to 10%of the readily culturable marine bacteria in these habitats.The distribution of Vibrio spp.is shaped by various environmental parameters,notably temperature,salinity and dissolved organic carbon.Vibriospp.may utilize a wide range of organic carbon compounds,including chitin(this may be metabolized by most Vibrio spp.),alginic acid and agar.Many Vibrio spp.have very short replication times(as short as~10 min),which could facilitate them developing into high biomass content albeit for relatively short durations.Although Vibriospp.usually comprise a minor portion(typically^1%of the total bacterioplankton in coastal waters)of the total microbial population,they have been shown to proliferate explosively in response to various nutrient pulses,e.g.,organic nutrients from algae blooms and iron from Saharan dust.Thus,Vibrio spp.may exert large impacts on marine organic carbon cycling especially in marginal seas.Genomics and related areas of investigation will reveal more about the molecular components and mechanisms involved in Vibrio-mediated biotransformation and remineralization processes. | Xiaohua ZHANG Heyu LIN Xiaolei WANG Brian AUSTIN | 2018 | Science China Earth Sciences2018，61，10： | 5 |
| 4 | Some results on numerical divided difference formulas显示文摘The remainder estimates of numerical divided difference formula are given for the functions of lower and higher smoothness, respectively. Then several divided difference formulas with super-convergence are derived with their remainder expressions. | Wang Xinghua,Wang Heyu & Ming-Jun Lai Department of Mathematics, Zhejiang University, Hangzhou 310028, China Computing Center, Zhejiang University, Hangzhou 310012, China Department of Mathematics, University of Georgia, Athens, GA 30602-7403, USA | 2005 | Science China Mathematics2005，48，11： | 4 |
| 5 | Fish forewarning of comprehensive toxicity in water environment based on Bayesian sequential method显示文摘Environmental impact of pollutants can be analyzed effectively by acquiring fish behavioral signals in water with biological behavior sensors. However, a variety of factors, such as the complexity of biological organisms themselves, the device error and the environmental noise, may compromise the accuracy and timeliness of model predictions. The current methods lack prior knowledge about the fish behavioral signals corresponding to characteristic pollutants, and in the event of a pollutant invasion, the fish behavioral signals are poorly discriminated. Therefore, we propose a novel method based on Bayesian sequential,which utilizes multi-channel prior knowledge to calculate the outlier sequence based on wavelet feature followed by calculating the anomaly probability of observed values. Furthermore, the relationship between the anomaly probability and toxicity is analyzed in order to achieve forewarning effectively. At last, our algorithm for fish toxicity detection is verified by integrating the data on laboratory acceptance of characteristic pollutants. The results show that only one false positive occurred in the six experiments, the present algorithm is effective in suppressing false positives and negatives, which increases the reliability of toxicity detections, and thereby has certain applicability and universality in engineering applications. | Kaifeng Rao Li Tang Xin Zhang Heyu Xiang Liang Tang Yong Liu Wei Wang Jie Jiang Mei Ma Yiping Xu Zijian Wang | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 6 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 7 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 8 | Source apportionment of polycyclic aromatic hydrocarbons(PAHs) in a sediment core from Lake Dagze Co, Tibetan Plateau, China: Comparison of three receptor models显示文摘Receptor models are a useful tool for identifying sources of polycyclic aromatic hydrocarbons(PAHs) in multiple environmental media. In this study, three different receptor models(including the principal component analysis-multiple linear regression(PCA-MLR), positive matrix factorization(PMF), and Unmix models) were used to apportion the sources of 16 priority PAHs in a sediment core of Lake Dagze Co. The ΣPAHs(sum of all 16 measured PAHs) concentrations ranged from 51.89 to 132.82 ng/g with an average of 80.39 ng/g. TheΣ PAHs were dominated by 2-3 ring PAHs, accounting for 80.12% on average, thereby indicating that they mainly originated from biomass and coal combustion and/or from long-range atmospheric transportation. The three models produced consistent source apportionment results. The greatest contributor to ΣPAHs was biomass combustion, followed by coal combustion, vehicle emissions, and petrogenic sources. Moreover, the temporal variation of the common sources was well-correlated among models. The multi-method comparison and evaluation results showed that all three models were useful tools for source apportionment of PAHs, with the PMF model providing better results than the PCA-MLR and Unmix models. The temporal trends of factor contributions were verified by PAHs with different ring numbers. Significant correlations were found between the simulated concentrations of each source factor and the PAHs with different ring numbers(P<0.01), except for the petrogenic source identified by the Unmix model(P>0.05). This study can provide useful information for further investigation of source apportionment of PAHs in the sediment cores. | Yixin Bai Kunlin Shi Heyu Yu Nana Shang Weiyue Hao Chuan Wang Tao Huang Hao Yang Changchun Huang | 2022 | Journal of Environmental Sciences2022，34，11： | 2 |
| 9 | Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia显示文摘 | Shu-qian Xu Chun-yan Wang Xiao-juan Zhu Xiao-yuan Dong Yan Shi Jun Peng Ping Qin Jian-zhi Sun Chengshan Guo Heyu Ni Ming Hou | 2012 | Annals of Hematology2012，，： | 1 |
| 10 | Emission Probabilities and Energy Spectra of Hydrogen Isotopes in Reactions ^(40)Ar+^(112,124)Sn at 30 MeV/u显示文摘Hot nuclei with differentN/Z ratio were produced by using^(40)Ar beam on^(112)Sn and^(124)Sn target,respectively.The energy spectra and the emission probabilities of hydrogen isotopes are analyzed in the 30 MeV/u^940)Ar+^(112,124)Sn reactions.Partial emission probability P_i of a certain species i is defined here | Xiao Zhigang, Jin Genming, Wu Heyu, Wei Zhiyong, Wang Hongwei, Duan Limin Hu Rongjiang, Li Zuyu, Zhang Baoguo, Zhu Yongtai and Wang Sufang | 2001 | IMP & HIRFL Annual Report2001，，1： | 1 |
| 11 | Efficient computation of dendritic growth with r-adaptive finite element methods显示文摘 | Wang Heyu Li Ruo Tang Tao | 2008 | J Comput Phys2008，227，： | 1 |
| 12 | Virtual Strategy QoS routing in satellite networks显示文摘Satellite network users want to unify different satellites to enhance the quality-of-service(Qo S)stability of the satellite networks and select feasible paths through different networks to feed different applications. Unfortunately, the state of affairs is that different applications need to use several different application programming interfaces and to design different protocols on how and when to use a specific network. This is troublesome and error-prone as the application programming interfaces vary a lot. In this paper, we design a Virtual Strategy in satellite network based on which a Qo S routing service scheme is then proposed. We analyze why applications should use and benefit from Virtual Strategy. This Virtual Strategy is a middleware solution that enables seamless usage of services from different satellite network parts. And then, the supporting Qo S routing solution enables the committed Qo S services over Virtual Strategy. Finally, we provide a comparison between the previous satellite networks and our work. The simulation results show that our Virtual Strategy Qo S routing scheme demonstrates dominated performances under complex architecture. | Heyu LIU Fuchun SUN Shaoqing WANG | 2016 | Science China(Information Sciences)2016，59，9： | 1 |
| 13 | Visible light assisted enzyme-photocatalytic cascade degradation of organophosphorus pesticides显示文摘The worldwide application of organophosphorus pesticides(OPs)has promoted agricultural development,but their gradual accumulation in soil and water can seriously affect the central nervous system of humans and other mammals.Organophosphorus hydrolase(OPH)is an effective enzyme that can catalyze the degradation of the residual OPs.However,the degradation products such as p-nitrophenol(p-NP)is still toxic.Thus,it is of great significance to develop a multi-functional support that can be simultaneously used for the immobilization of OPH and the further degradation of p-NP.Herein,a visible light assisted enzyme-photocatalytic integrated catalyst was constructed by immobilizing OPH on hollow structured Au-TiO_(2)(named OPH@H-Au-TiO_(2))for the degradation of OPs.The obtained OPH@H-Au-TiO_(2)can degrade methyl parathion to p-NP by OPH and then degrade p-NP to hydroquinone with low toxicity by using H-Au-TiO_(2)under visible light.OPH molecules were immobilized on HAu-TiO_(2)through adsorption method to prepare OPH@H-Au-TiO_(2).After 2.5 h of reaction,methyl parathion is completely degraded,and about 82.64%of the generated p-NP is further degraded into hydroquinone.After reused for 4 times,the OPH@H-Au-TiO_(2)retains more than 80%of the initial degradation activity.This research presents a new insight in designing and constructing multi-functional biocatalyst,which greatly expands the application scenarios and industrial value of enzyme catalysis. | Ying Zhang Xue Cao Yufeng Yang Sumin Guan Xiaotian Wang Heyu Li Xiaobing Zheng Liya Zhou Yanjun Jiang Jing Gao | 2023 | Green Chemical Engineering2023，4，1： | 1 |
| 14 | Reaction characteristics investigation of CeO_(2)-enhanced CaSO_(4) oxygen carrier with lignite显示文摘Calcium sulfate(CaSO_(4))has been verified as a promising oxygen carrier(OC)in the chemical looping combustion(CLC)for its high oxygen capacity,abundant reserve and low cost,but its low reactivity and deleterious sulfur species emission from the side reactions of CaSO_(4) should be well considered for its wide application in CLC.In order to promote the reactivity of CaSO_(4) and increase its potential to inhibit the gaseous sulfur emission,a CeO_(2)-enhanced CaSO_(4) OC mixed OC of core–shell structure was prepared using the combined template synthesis method.Reaction characteristics of the prepared CaSO_(4)-CeO_(2) mixed OC with a typical lignite was first conducted and systematically investigated,and an improved reactivity of the prepared CaSO_(4)-CeO_(2) mixed OC was demonstrated than its single component CaSO_(4) or CeO_(2) due to the fast transfer and exchange of oxygen from the CaSO_(4) substrate to coal via the doped CeO_(2).Furthermore,the solid products formed from the mixed CaSO_(4)-CeO_(2) OC with the selected coal were collected and analyzed.Especially,evolution and redistribution of the sulfur species of different forms were focused.At the latter reaction stage of YN reaction with the CaSO_(4)-CeO_(2) mixed OC,the SO_(2) emitted from the side reactions of CaSO_(4) was greatly diminished and the doped CeO_(2) was proven effective to directionally fix the SO_(2) released to turn into different solid sulfur compounds,which were determined as Ce_(2)O_(2)S,Ce_(2)S_(3) and Ce_(2)(SO_(4))_(3)·5H_(2)O and formed through the different pathways.In addition,good regeneration of the reduced CaSO_(4)-CeO_(2) mixed OC could be reached in spite of the unavoidable interaction between the included minerals in coal and the reduced mixed OC.Overall,the combined template method-made CaSO_(4)-CeO_(2) mixed OC reported herein was not only endowed with enhanced reactivity for coal conversion,but also owned the potential to directionally fix the gaseous sulfur emission,which is quite applicable as OC for simultaneous decarbonatization and desulfurization in the real CLC process. | Baowen Wang Zhongyuan Cai Heyu Li Yanchen Liang Tao Jiang Ning Ding Haibo Zhao | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 1 |
| 15 | Molecule diffusion behaviours of waterproof sealants into silicone rubber insulation for submarine cable joint based on molecular dynamics simulations显示文摘The repair joints of high-voltage cables play a significant role in the urgent cable main-tenance,by recovering cable conductor,insulation,shielding layer and waterproof layer especially for submarine cables.However,the molecule diffusion and permeation pro-cesses from waterproof sealant into the cable joint insulation occur,leading to the insulation ageing and deterioration.In this article,the molecule diffusion behaviours of six typical molecules from the asphalt-based and polyurethane-based waterproof sealants into silicone rubber insulation are investigated.The results show that the order of diffusion coefficients is as follows,phenanthrene>fluoranthene>pyrene>benzo[k]fluoranthene>indeno[1,2,3-cd]pyrene>polyurethane(PU).The relative molecular mass and binding energy are pivotal factors affecting the diffusion behaviour,while there is a linear relationship between the logarithm of the diffusion coefficient and the ratio of binding energy to relative molecular mass.Besides,the rising ambient temperature in-creases the fraction of free volume of silicone rubber and decreases the binding energy,thus resulting in a higher diffusion coefficient and an enhanced permeation process of the asphalt-based sealant.In summary,the PU-based waterproof sealant,with a much lower permeability than the asphalt-based material,has a potential application in the waterproof layer for high-voltage submarine cable repair joints. | Zhenpeng Zhang Heyu Wang Zhonglei Li Jiankang Zhao Shaohua Wang Wenlin Pan Wenjie Li Te Li Boxue Du | 2021 | High Voltage2021，6，2： | 1 |
| 16 | Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII^(hi) neutrophils显示文摘Breast cancer can metastasize to various organs,including the lungs.The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer.Infection with pathogens such as viruses and bacteria can alter the immune status of the lung.However,the effect of chronic inflammation caused by bacteria on the formation of a premetastatic niche within the lung is unclear,and the contribution of specific immune mediators to tumor metastasis also remains largely undetermined.Here,we used a mouse model revealing that chronic pulmonary bacterial infection augmented breast cancer lung metastasis by recruiting a distinct subtype of tumor-infiltrating MHCII^(hi) neutrophils into the lung,which exhibit cancer-promoting properties.Functionally,MHCII^(hi) neutrophils enhanced the lung metastasis of breast cancer in a cell-intrinsic manner.Furthermore,we identified CCL2 from lung tissues as an important environmental signal to recruit and maintain MHCII^(hi) neutrophils.Our findings clearly link bacterial-immune crosstalk to breast cancer lung metastasis and define MHCII^(hi) neutrophils as the principal mediator between chronic infection and tumor metastasis. | Teng Ma Yu Tang Taolin Wang Yang Yang Yige Zhang Ruihuan Wang Yongxin Zhang Yi Li Mingbo Wu Miao Tang Xueli Hu Chaoyu Zou Yuan Ren Huan Liu Qianhua Zhang Heyue Li Min Wu Jing Li Xikun Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 17 | Segregation of Re at theγ/γ'boundary of Ni-based single crystal superalloys revealed by first-principles calculations based Monte-Carlo simulations显示文摘Nickel-based single crystal superalloys have been widely used in aero-engines and gas turbine engines.To improve the creep resistance,rhenium is often added to the alloys.However,it is not yet fully under-stood how the added Re elements distribute in the alloys and how the microstructure evolves with the addition of Re.Here,we performed extensive first-principles calculations based Monte-Carlo simulated annealing of Ni-Al-Re ternary alloys with different Re concentrations ranging from 0.5 at.%to 6.0 at.%.The results demonstrate that with the decreasing temperature,most of Re atoms stay in theγphase,while a few of Re atoms stay in theγ'phase and tend to occupy the Al positions.At low temperatures,the Re atoms segregate at theγ/γ'boundary,in good agreement with experiment.We find that the disorder-order transition temperature of the Ni-Al-Re ternary alloys increases with the Re concentration due to the Re-enhanced Al-Al ordering tendency.In addition,we observe that at low temperatures the Re segregation at theγ/γ'boundary promotes the formation of Ni 4 Re-or Ni 8 Re-like local structures as the Re concentration is over 2 at.%.The formation of a large amount of these local structures consumes the Re atoms in solid solutions,and thus from the solid-solution strengthening point of view,this would have a negative influence on the creep resistance of the superalloys.This work provides important atomistic insights on the Re distribution and its effects on the stability of superalloys. | Heyu Zhu Jiantao Wang Lei Wang Yongpeng Shi Mingfeng Liu Jiangxu Li Yun Chen Yingche Ma Peitao Liu Xing-Qiu Chen | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 18 | Non-reproducibility of Cross Sections Measured in Dissipative Reaction of ^(19)F+^(27)Al显示文摘The measurement of cross sections of dissipative collision for the reaction system of 119F+27Al has been carried out at China Institute of Atomic Energy, Beijing. In this measurement, the 19F8+ beam was provided by the HI-13 tandem accelerator at incident energy of 114 MeV. Three sets of △E-E telescope were employed to identify the charge number Z of the fragments emitted at +57°, +31°and -29°in laboratory system. | Dong Yuchuan, Wang Qi, Li Songlin, Duan Limin, Xu Hushan, Xu Huagen Chen Ruofu, Wu Heyu and Han Jianlong | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 19 | AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation显示文摘Bone metastasis of cancer cells leads to severe pain by disrupting bone structure and inducing central sensitization.Neuroinflammation in the spinal cord plays a decisive role in the maintenance and development of pain.In the current study,male Sprague-Dawley(SD)rats are used to establish a cancer-induced bone pain(CIBP)model by intratibial injection of MRMT-1 rat breast carcinoma cells.Morphological and behavioral analyses verify the establishment of the CIBP model,which represents bone destruction,spontaneous pain and mechanical hyperalgesia in CIBP rats.Activation of astrocytes marked by upregulated glial fibrillary acidic protein(GFAP)and enhanced production of the proinflammatory cytokine interleukin-1β(IL-1β)are accompanied by increased inflammatory infiltration in the spinal cord of CIBP rats.Furthermore,activation of the NOD-like receptor pyrin domain-containing protein 3(NLRP3)inflammasome is consistent with increased neuroinflammation.Adenosine monophosphateactivated protein kinase(AMPK)activation is involved in attenuating inflammatory pain and neuropathic pain.Intrathecal injection of the AMPK activator AICAR in the lumbar spinal cord reduces dynamin-related protein 1(Drp1)GTPase activity and suppresses NLRP3 inflammasome activation.This effect consequently alleviates pain behaviors in CIBP rats.Cell research on C6 rat glioma cells indicates that AICAR treatment restores IL-1β-induced impairment of mitochondrial membrane potential and elevation of mitochondrial reactive oxygen species(ROS).In summary,our findings indicate that AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation in the spinal cord. | Heyu Yang Yujia Wang Shuqing Zhen Banghua Wang Ming Jiao Ling Liu Dai Li Haili Zhu Min Xie | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 20 | Rotation and Deformation of Dinuclear System Formed in Dissipative Reaction of ^(19)F+^(27)Al显示文摘The measurement of the excitation functions for the reaction products of B, C, N, O, F and Ne produced in the dissipative collisions of 19F+27Al have been carried out at China Institute of Atomic Energy, Beijing. In the measurement, the beam of 19F8+ was provided by the HI-13 tandem accelerator at energies from 110. 25 to 118. 75 MeV in steps of 250 keV. Three sets of△E-E telescope, set at +57°, +31°and -29°,were employed to identify the charge number Z of the fragments. | Han Jianlong, Wang Qi, Dong Yuchuan, Li Songlin, Duan Limin Wu Heyu, Xu Huagen, Chen Ruofu, Xu Hushan and Bai Zhen | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
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