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| 1 | Computed tomography-based radiomics for prediction of neoadjuvant chemotherapy outcomes in locally advanced gastric cancer: A pilot study显示文摘Objective: The standard treatment for patients with locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery. The aim of this study was to investigate the wealth of radiomics for pre-treatment computed tomography(CT) in the prediction of the pathological response of locally advanced gastric cancer with preoperative chemotherapy.Methods: Thirty consecutive patients with CT-staged II/III gastric cancer receiving neoadjuvant chemotherapy were enrolled in this study between December 2014 and March 2017. All patients underwent upper abdominal CT during the unenhanced, late arterial phase(AP) and portal venous phase(PP) before the administration of neoadjuvant chemotherapy. In total, 19,985 radiomics features were extracted in the AP and PP for each patient.Four methods were adopted during feature selection and eight methods were used in the process of building the classifier model. Thirty-two combinations of feature selection and classification methods were examined. Receiver operating characteristic(ROC) curves were used to evaluate the capability of each combination of feature selection and classification method to predict a non-good response(non-GR) based on tumor regression grade(TRG).Results: The mean area under the curve(AUC) ranged from 0.194 to 0.621 in the AP, and from 0.455 to 0.722 in the PP, according to different combinations of feature selection and the classification methods. There was only one cross-combination machine-learning method indicating a relatively higher AUC(>0.600) in the AP, while 12 cross-combination machine-learning methods presented relatively higher AUCs(all >0.600) in the PP. The feature selection method adopted by a filter based on linear discriminant analysis + classifier of random forest achieved a significantly prognostic performance in the PP(AUC, 0.722±0.108; accuracy, 0.793; sensitivity, 0.636; specificity,0.889; Z=2.039; P=0.041).Conclusions: It is possible to predict non-GR after neoadjuvant chemotherapy in locally advanced gastric cancers based on the radiomics of CT. | Zhenhui Li Dafu Zhang Youguo Dai Jian Dong Lin Wu Yajun Li Zixuan Cheng Yingying Ding Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，4： | 18 |
| 2 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 3 | Facile electrodeposition of 3D concentration-gradient Ni-Co hydroxide nanostructures on nickel foam as high performance electrodes for asymmetric supercapacitors显示文摘小说三维(3D ) 集中坡度 Ni 公司氢氧化物 nanostructures (3DCGNC ) 被一个灵巧的逐步的电气化学的免职方法直接在镍泡沫上种了并且强烈地为 supercapacitors 调查同样没有文件夹、没有售票员的电极。基于一种三电极的电气化学的描述技术,获得的 3DCGNC 电极表明了 1,760 F 的一个高特定的电容 ???? | Mingyang Yang Hua Cheng Yingying Gu Zhifang Sun Jing Hu Lujie Cao Fucong Lv Minchan Li Wenxi Wang Zhenyu Wang Shaofei Wu Hongtao Liu Zhouguang Lu | 2015 | Nano Research2015，8，8： | 8 |
| 4 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 5 | Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption显示文摘The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic 'maritime components'. At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture. | ZHENG HongBo ZHOU YouSheng YANG Qing HU ZhuJun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu WU WenXiang | 2018 | Science China Earth Sciences2018，61，2： | 7 |
| 6 | Location patterns of urban industry in Shanghai and implications for sustainability显示文摘瓷器经济经历了快速的转变并且工业重构。术语城市的工业在中国城市经历重构以内描述工业的一种特别类型。给也从城市中心关门了或重定位到城市的穗并且在以外的工业公司的高百分比,突现的全球城市象上海那样,为本地经济、城市的开发正在实现策略,它在城市中心和城市的穗包含城市的工业升级的众多的公司。这研究试图用 2008 微地理的数据在上海城市的区域以内分析七个城市的工业扇区的地点模式。为了避免统一问题(MAUP ) 问题,包括最近的邻居分析的四项基于距离的措施,核密度评价, K 功能和合作地点的可修改的 Areal,商广泛地被使用了分析并且比较在七个部门之间的集中和合作地点。结果揭示也与距离和有趣的合作地点变化的迥异的模式。结果如下:城市中心和城市的穗从城市中心与 20-30 km 有城市的工业公司,而是地区的最高的紧张是为大多数范畴的一个分水岭;集中的度与距离变化,在更短的距离更弱,增加直到 30 km 的最大的距离然后减少直到 50 km;为所有城市的工业,有模式的三种类型,在距离的一个改变的范围的聚类的、随机、分散的分发的混合。因而,这份报纸主张城市的工业的地点模式思考阶段特定的工业重构和空间转变,由可持续性目的调节了。 | CAO Weidong LI Yingying CHENG Jianquan Steven MILLINGTON | 2017 | Journal of Geographical Sciences2017，27，7： | 5 |
| 7 | Gas Sensors Based on Chemi?Resistive Hybrid Functional Nanomaterials显示文摘Chemi-resistive sensors based on hybrid functional materials are promising candidates for gas sensing with high responsivity,good selectivity,fast response/recovery,great stability/repeatability,room-working temperature,low cost,and easy-to-fabricate,for versatile applications.This progress report reviews the advantages and advances of these sensing structures compared with the single constituent,according to five main sensing forms:manipulating/constructing heterojunctions,catalytic reaction,charge transfer,charge carrier transport,molecular binding/sieving,and their combinations.Promises and challenges of the advances of each form are presented and discussed.Critical thinking and ideas regarding the orientation of the development of hybrid material-based gas sensor in the future are discussed. | Yingying Jian Wenwen Hu Zhenhuan Zhao Pengfei Cheng Hossam Haick Mingshui Yao Weiwei Wu | 2020 | Nano-Micro Letters2020，12，6： | 5 |
| 8 | Molecular characterization of transformation and halogenation of natural organic matter during the UV/chlorine AOP using FT-ICR mass spectrometry显示文摘UV/chlorine process,as an emerging advanced oxidation process(AOP),was effective for removing micro-pollutants via various reactive radicals,but it also led to the changes of natural organic matter(NOM)and formation of disinfection byproducts(DBPs).By using negative ion electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry(ESI FT-ICR MS),the transformation of Suwannee River NOM(SRNOM)and the formation of chlorinated DBPs(Cl-DBPs)in the UV/chlorine AOP and subsequent post-chlorination were tracked and compared with dark chlorination.In comparison to dark chlorination,the involvement of Cl O·,Cl·,and HO·in the UV/chlorine AOP promoted the transformation of NOM by removing the compounds owning higher aromaticity(AI mod)value and DBE(double-bond equivalence)/C ratio and causing the decrease in the proportion of aromatic compounds.Meanwhile,more compounds which contained only C,H,O,N atoms(CHON)were observed after the UV/chlorine AOP compared with dark chlorination via photolysis of organic chloramines or radical reactions.A total of 833 compounds contained C,H,O,Cl atoms(CHOCl)were observed after the UV/chlorine AOP,higher than 789 CHOCl compounds in dark chlorination,and one-chlorine-containing components were the dominant species.The different products from chlorine substitution reactions(SR)and addition reactions(AR)suggested that SR often occurred in the precursors owning higher H/C ratio and AR often occurred in the precursors owning higher aromaticity.Post-chlorination further caused the cleavages of NOM structures into small molecular weight compounds,removed CHON compounds and enhanced the formation of Cl-DBPs.The results provide information about NOM transformation and Cl-DBPs formation at molecular levels in the UV/chlorine AOP. | Xiaoxue Ruan Yingying Xiang Chii Shang Shuangshuang Cheng Jingfu Liu Zhineng Hao Xin Yang | 2021 | Journal of Environmental Sciences2021，33，4： | 5 |
| 9 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 10 | High energy batteries based on sulfur cathode显示文摘Lithium-ion batteries(LIBs)have become an indispensable part of our daily life,however,the energy and power capability that LIBs can deliver are lagging far behind the ever-increasing demands of portable electronics and electric vehicles.Metal-sulfur batteries as one of the most promising alternatives to LIBs are receiving rapidly growing research interests due to the extremely high energy density and abundant resources of sulfur.In this short review,we will discuss the state-of-art development of high energy density battery technologies based on sulfur cathode in combination with different metal anodes,with focus on sodium,magnesium and aluminum anodes.We leave lithium-sulfur batteries out of discussion since there are already a large number of nicely organized review papers available.The operation mechanism of various anode materials and the variety of electrolytes used in sulfur batteries will be reviewed.Some perspectives on improving the performances and overcoming the remaining issues in sulfur batteries will be discussed.It is expected that this review will draw more attention to sulfur batteries from both the academic and industrial communities. | Jian Zhu Jianli Zou Hua Cheng Yingying Gu Zhouguang Lu | 2019 | Green Energy & Environment2019，4，4： | 4 |
| 11 | The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy显示文摘Cytokines exert powerful immunomodulatory effects that are critical to physiology and pathology in humans.The application of natural cytokines in clinical studies has not been clearly established,and there are often problems associated with toxicity or lack of efficacy.The key reasons can be attributed to the pleiotropy of cytokine receptors and undesired activation of off-target cells.With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions,artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach.Engineered cytokines are designed to selectively target cells.Herein,the theoretical and experimental evidence of cytokine engineering is reviewed,and the“supercytokines”resulting from structural enhancement and the“immunocytokines”generated by antibody fusion are described.Finally,the“engager cytokines”formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed. | Xiaohu Zheng Yaqi Wu Jiacheng Bi Yingying Huang Ying Cheng Yangyang Li Yuwei Wu Guoshuai Cao Zhigang Tian | 2022 | Cellular & Molecular Immunology2022，19，2： | 4 |
| 12 | Carbon decorated Li_(3)V_(2)(PO_(4))_(3) for high-rate lithium-ion batteries:Electrochemical performance and charge compensation mechanism显示文摘Fast charging and high-power delivering batteries are highly demanded in mobile electronics,electric vehicles and grid energy storage,but there are full of challenges.The star-material Li_(3)V_(2)(PO_(4))_(3) is demonstrated as a promising high-rate cathode material meeting the above requirements.Herein,we report the carbon decorated Li_(3)V_(2)(PO_(4))_(3) (LVP/C) cathode prepared via a facile method,which displays a remarkable high-rate capability and long-term cycling performance.Briefly,the prepared LVP/C delivers a high discharge capacity of 122 mAh g^(-1)(-93% of the theoretical capacity) at a high rate up to 20 C and a superior capacity retention of 87.1% after 1000 cycles.Importantly,by applying a combination of X-ray absorption spectroscopy and full-range mapping of resonant inelastic X-ray scattering,we clearly elucidate the structural and chemical evolutions of LVP upon various potentials and cycle numbers.We show unambiguous spectroscopic evidences that the evolution of the hybridization strength between V and O in LVP/C as a consequence of lithiation/delithiation is highly reversible both in the bulk and on the surface during the discharge-charge processes even over extended cycles,which should be responsible for the remarkable electrochemical performance of LVP/C.Our present study provides not only an effective synthesis strategy but also deeper insights into the surface and bulk electrochemical reaction mechanism of LVP,which should be beneficial for the further design of high-performance LVP electrode materials. | Manling Ding Chen Cheng Qiulong Wei Yue Hu Yingying Yan Kehua Dai Jing Mao Jinghua Guo Liang Zhang Liqiang Maig | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 13 | Efficient production of CYTL1 protein using mouse IgGK signal peptide in the CHO cell expression system显示文摘 | Xiaolin Wang Huihui Liu Wanqiong Yuan Yingying Cheng Wenling Han | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 3 |
| 14 | Exhumation history of the Huangshan granite pluton,southern Anhui Province:New insights from fission-track analysis显示文摘The dating of the uplift onset of the Huangshan pluton in the southern part of Anhui Province associated with the collision between paleo-Pacific Block and the Eurasian Block is a fundamental issue to better understand the uplift mechanisms and the regional tectonic evolution.χ2 values of seven zircon fission track(ZFT) samples collected from the south part of the Huangshan pluton were all<5%.Based on the grain ages of four typical ZFT samples,three thermal overprints ranging in 113-123,72-95 and 49-66 Ma were distinguished respectively using the binomial peak-fitting method in accordance with the tectonic thermal events after south China shifted into circum-Pacific tectonic region.Apatite fission track(AFT) study of the Huangshan pluton shows ages lie between 15±3 and 56±6 Ma with allχ2 values>5%,and all are significantly younger than their host rock formation ages,indicating that the samples have experienced post-formation thermal history.Based on the AFT results and topography characteristics in the Huangshan pluton,three zones with different denudation intensities caused by the differential uplift of the fault blocks were recognized in this paper,indicating that denudation was driven by the increase in elevation significantly.Modeling of the AFT data shows that the earlier cooling phase took place in the early Cenozoic and involved 3.3,3.8 and 6.0°C/Ma of cooling rates equivalent to the exhumation rates of 90,104 and 167 m/Ma in different fault blocks.The last phase of cooling took place from~10 Ma with average cooling rate of~5.6°C/Ma,equivalent to average denudation rates of~156 m/Ma.The fission track results imply that the regional compression field plays an important role for the differential exhumation between individual fault blocks of the Huangshan pluton. | ZHENG Yong YU XinQi YUAN WanMing WANG De'En JIANG GongBing ZHU DeLai WANG Cheng JIA YingYing | 2011 | Science China Earth Sciences2011，54，4： | 3 |
| 15 | Relationship between the parent charge transfer gap and maximum transition temperature in cuprates显示文摘One of the biggest puzzles concerning the cuprate high temperature superconductors is what determines the maximum transition temperature(Tc,max), which varies from less than 30 to above 130 K in different compounds.Despite this dramatic variation, a robust trend is that within each family, the double-layer compound always has higher Tc,maxthan the single-layer counterpart. Here we use scanning tunneling microscopy to investigate the electronic structure of four cuprate parent compounds belonging to two different families. We find that within each family, the double layer compound has a much smaller charge transfer gap size(DCT), indicating a clear anticorrelation between DCTand Tc,max. These results suggest that the charge transfer gap plays a key role in the superconducting physics of cuprates, which shed important new light on the high Tc mechanism from doped Mott insulator perspective. | Wei Ruan Cheng Hu Jianfa Zhao Peng Cai Yingying Peng Cun Ye Runze Yu Xintong Li Zhenqi Hao Changqing Jin Xingjiang Zhou Zheng-Yu Weng Yayu Wang | 2016 | Science Bulletin2016，61，23： | 3 |
| 16 | Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel- evoked neuropathic pain显示文摘 | Yongming Xu Guangxia Cheng Yanrong Zhu Xin Zhang Shaofeng Pu Junzhen Wu Yingying Lv Dongping Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 3 |
| 17 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 18 | Boosting polysulfide redox conversion of Li-S batteries by one-step-synthesized Co-Mo bimetallic nitride显示文摘Lithium-sulfur(Li-S)batteries are considered as one of the most promising next generation energy storage systems due to the high theoretical specific capacity,low cost,and environmental benignity.However,the notorious shuttle effect of polysulfides hinders the practical application of Li-S batteries.Herein,we have rationally designed and synthesized sea urchin-like Co-Mo bimetallic nitride(Co_(3) MO_(3) N)in the absence of additional nitrogen sources with only one step,which was applied as the sulfur host materials for Li-S batteries.The results indicate that Co_(3) Mo_(3) N can efficiently anchor and catalyze the conversion of polysulfides,thus accelerating the electrochemical reaction kinetics and enabling prominent electrochemical properties.As a consequence,the S@Co_(3) Mo_(3) N cathode exhibits a high rate performance of 705 mAh g^(-1) at 3 C rate and an excellent cycling stability with a low capacity fading rate of 0.08%per cycle at 1 C over 600 cycles.Even at a high sulfur loading of 5.4 cmg cm^(-2),it delivers a high initial areal capacity of 4.50 mAh cm^(-2) which is still retained at 3.64 mAh cm^(-2) after 120 cycles.Furthermore,the catalytic mechanism and structural stability of Co_(3) Mo_(3) N during cycling were elucidated by a combination of X-ray photoelectron spectroscopy and X-ray absorption fine structure.This work highlights the strategy of structure-catalysis engineering of bimetallic nitride,which is expected to have a wide application in Li-S batteries. | Yingying Yan Hongtai Li Chen Cheng Tianran Yan Wenping Gao Jing Mao Kehua Dai Liang Zhang | 2021 | Journal of Energy Chemistry2021，30，10： | 3 |
| 19 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 20 | MXene-Derived Defect-Rich TiO2@rGO as High-Rate Anodes for Full Na Ion Batteries and Capacitors显示文摘Sodium ion batteries and capacitors have demonstrated their potential applications for next-generation low-cost energy storage devices.These devices’s rate ability is determined by the fast sodium ion storage behavior in electrode materials.Herein,a defective TiO2@reduced graphene oxide(M-TiO2@rGO)self-supporting foam electrode is constructed via a facile MXene decomposition and graphene oxide self-assembling process.The employment of the MXene parent phase exhibits distinctive advantages,enabling defect engineering,nanoengineering,and fluorine-doped metal oxides.As a result,the M-TiO2@rGO electrode shows a pseudocapacitance-dominated hybrid sodium storage mechanism.The pseudocapacitance-dominated process leads to high capacity,remarkable rate ability,and superior cycling performance.Significantly,an M-TiO2@rGO//Na3 V2(PO4)3 sodium full cell and an M-TiO2@rGO//HPAC sodium ion capacitor are fabricated to demonstrate the promising application of M-TiO2@rGO.The sodium ion battery presents a capacity of 177.1 mAh g-1 at 500 mA g-1 and capacity retention of 74%after 200 cycles.The sodium ion capacitor delivers a maximum energy density of 101.2 Wh kg-1 and a maximum power density of 10,103.7 W kg-1.At 1.0 A g-1,it displays an energy retention of 84.7%after 10,000 cycles. | Yongzheng Fang Yingying Zhang Chenxu Miao Kai Zhu Yong Chen Fei Du Jinling Yin Ke Ye Kui Cheng Jun Yan Guiling Wang Dianxue Cao | 2020 | Nano-Micro Letters2020，12，10： | 2 |
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