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| 1 | Processes of initial collision and suturing between India and Asia显示文摘The initial collision between Indian and Asian continents marked the starting point for transformation of land-sea thermal contrast,uplift of the Tibet-Himalaya orogen,and climate change in Asia.In this paper,we review the published literatures from the past 30 years in order to draw consensus on the processes of initial collision and suturing that took place between the Indian and Asian plates.Following a comparison of the different methods that have been used to constrain the initial timing of collision,we propose that the tectono-sedimentary response in the peripheral foreland basin provides the most sensitive index of this event,and that paleomagnetism presents independent evidence as an alternative,reliable,and quantitative research method.In contrast to previous studies that have suggested collision between India and Asia started in Pakistan between ca.55 Ma and50 Ma and progressively closed eastwards,more recent researches have indicated that this major event first occurred in the center of the Yarlung Tsangpo suture zone(YTSZ) between ca.65 Ma and 63 Ma and then spreading both eastwards and westwards.While continental collision is a complicated process,including the processes of deformation,sedimentation,metamorphism,and magmatism,different researchers have tended to define the nature of this event based on their own understanding,an intuitive bias that has meant that its initial timing has remained controversial for decades.Here,we recommend the use of reconstructions of each geological event within the orogenic evolution sequence as this will allow interpretation of collision timing on the basis of multidisciplinary methods. | DING Lin Satybaev MAKSATBEK CAI FuLong WANG HouQi SONG PeiPing JI WeiQiang XU Qiang ZHANG LiYun Qasim MUHAMMAD Baral UPENDRA | 2017 | Science China Earth Sciences2017，60，4： | 23 |
| 2 | 糖尿病视网膜病变患病率的流行病学调查:在中国6省13473名糖尿病患者中的横断面研究显示文摘目的本研究旨在探究中国糖尿病患者中糖尿病视网膜病变(DR)和视力威胁性糖尿病视网膜病变(STDR)的患病率和严重程度。研究设计、设置与参与者本研究为横断面流行病学调查,研究对象为中国内地地区的糖尿病患者(N=13473)。研究对象为被内科医师诊断为糖尿病,并转诊到筛查门诊的糖尿病患者(其中住院患者占1/3,城市居民占1/3,农村居民占1/3)。研究对象的每只眼睛应用彩色、免散瞳和非立体眼底照相机拍摄2张眼底照片,并根据英国DR分级指南进行分级。主要结果和测量指标DR与STDR的患病率和严重程度。结果在参与本研究的13473例糖尿病患者中,共发现4591例DR和1769例STDR患者,DR的总体患病率为34.08%[95%可信区间(凹)33.28%~34.88%],其中STDR的总体患病率为13.13%(95%C112.56%~13.70%)。在所有研究对象中,12780例参与了眼底照片分级(94.86%)。年龄大于65岁的研究对象患DR或STDR的可能性较低(P〈0.001)。性别对是否患病没有显著影响(P〉0.05)。STDR患者与非STDR患者相比,视力损伤更为严重(P〈0.001)。中国北方DR和STDR的患病率高于南方(P〈0.001)。DR的患病率与糖尿病患病时间f比值比(鲫)2.63;95%C12.42~2.86;P〈0.001]以及糖尿病发病年龄(OR 0.38;95%CI为0.35~0.41;P〈0.001)密切相关。结论DR和STDR在中国内地地区的患病率偏高,并且不同地区患病率存在差异。在DR中,非增殖性DR更常见,但STDR更需要及时的诊断和治疗,特别是在经济欠发达地区。本研究强调了中国内地地区DR筛查和治疗的重要性。 | Liu, Yan Song, Yifan Tao, Liyuan Qiu, Weiqiang Lv, Huibin Jiang, Xiaodan Zhang, Mingzhou Li, Xuemin | 2017 | 英国医学杂志中文版2017，20，11： | 23 |
| 3 | The development and function of follicular helper T cells in immune responses显示文摘小囊的助手 T 房间(Tfh ) 作为提供帮助让 B 房间增殖并且在幼芽的中心经历抗体亲密关系成熟的一个系被提交了。证据支持了那个 Tfh 子集开发象另外的系一样,依赖于一个特别 transcriptional 节目被开始的微型环境。它为 Tfh 房间的开发和函数作为主人管理者被看了那 Bcl-6 和 IL-21 行为。Tfh dysregulation 涉及自体免疫的病理的发展,例如全身的豺狼座 erythematosus,风湿性关节炎和另外的自体免疫的疾病。现在的评论在在他们的开发和函数的 Tfh 房间和焦点的域里加亮最近的进展。 | Maogen Chen Zhiyong Guo Weiqiang Ju Bernhard Ryffel Xiaoshun He Song Guo Zheng | 2012 | Cellular & Molecular Immunology2012，9，5： | 18 |
| 4 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 5 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 6 | Experimental and Numerical Studies of Vitiated Air Effects on Hydrogen-fueled Supersonic Combustor Performance显示文摘This paper deals with the vitiation effects of test air on the scramjet performance in the ground combustion heated facilities. The primary goal is to evaluate the effects of H2O and CO2, the two major vitiated species generated by combustion heater, on hydrogen-fueled supersonic combustor performance with experimental and numerical approaches. The comparative experiments in the clean air and vitiated air are conducted by using the resistance heated direct-connected facility, with the typical Mach 4 flight conditions simulated. The H2O and CO2 species with accurately controlled contents are added to the high enthalpy clean air from resistance heater, to synthesize the vitiated air of a combustion-type heater. Typically, the contents of H2O species can be varied within the range of 3.5%-30% by mole, and 3.0%-10% for CO2 species. The total temperature, total pressure, Mach number and O2 mole fraction at the combustor entrance are well-matched between the clean air and vitiated air. The combustion experiments are completed at the fuel equivalence ratios of 0.53 and 0.42 respectively. Furthermore, three-dimensional (3D) reacting flow simulations of combustor flowpath are performed to provide insight into flow field structures and combustion chemistry details that cannot resolved by experimental instruments available. Finally, the experimental data, combined with computational results, are employed to analyze the effects of H2O and CO2 vitiated air on supersonic combustion characteristics and performance. It is concluded that H2O and CO2 contaminants can significantly inhibit the combustion induced pressure rise measured from combustor wall, and the pressure profile decreases with the increasing H2O and CO2 contents in nonlinear trend; simulation results agree well with experimental data and the overall vitiation effects are captured; direct extrapolation of the results from vitiated air to predict the performance of actual flight conditions could result in over-fueling the combustor, possible inlet un-start and inappropriate combustion mode transition. The detailed analysis and discussion are presented and the research conclusions are summarized. | LUO Feiteng SONG Wenyan ZHANG Zhiqiang LI Weiqiang LI Jianping | 2012 | Chinese Journal of Aeronautics2012，25，2： | 5 |
| 7 | Dynamic analysis of heat extraction rate by supercritical carbon dioxide in fractured rock mass based on a thermal-hydraulic-mechanics coupled model显示文摘Heat production from geothermal reservoirs is a typical heat transfer process involving a cold working fluid contacting a hot rock formation.Compared to the thermal-physical characteristics of water,supercritical CO_(2)(scCO_(2))has a higher heat storage capacity over a wide temperature-pressure range and may be favored as a heat transfer fluid.Singularly characteristic of scCO_(2)-based heat extraction is that the hydraulic-thermal properties of the scCO_(2) vary dramatically and dynamically with the spatial pressure gradient during unsteady-state flow along fracture.This highly nonlinear behavior presents a challenge in the accurate estimation of heat extraction efficiency in scCO_(2)-based EGS.In this paper,a thermal-h ydraulic-mechanical(THM)coupled model is developed by considering deformation of the fractured reservoir,non-Darcy flow and the varying thermal-physical properties of scCO_(2).The proposed model is validated by matching the modeling temperature distribution with published data.The results show that during continuous injection of scCO_(2),the fracture first widens and then narrows,ultimately reopening over the long term.The sequential fracture deformation behaviors are in response to the combined impacts of mechanical compression and thermally-induced deformation.By controlling the injection parameters of the scCO_(2),it is found that the heat extraction rate is positively correlated to its pore pressure or mass flow rate.The heat extraction rate can be significantly enhanced,when the inlet temperature of scCO_(2) is below its critical temperature.As a result,the heat increment recovered per unit mass of scCO_(2) decreases as the hot rock is gradually cooled.Meanwhile,the heat increment recovered per unit mass of scCO_(2) decreases by increasing the inlet temperature of scCO_(2) or its mass flow rate,but increases as the outlet pressure rises.Furthermore,multi-linear regression indicates that controlling the inlet temperature of the scCO_(2) can significantly improve the thermodynamic efficiency of heat extraction. | Chunguang Wang Xingkai Shi Wei Zhang Derek Elsworth Guanglei Cui Shuqing Liu Hongxu Wang Weiqiang Song Songtao Hu Peng Zheng | 2022 | International Journal of Mining Science and Technology2022，32，2： | 3 |
| 8 | An off-line simulation of land surface processes over the northern Tibetan Plateau显示文摘In order to further understand the land surface processes over the northern Tibetan Plateau, this study produced an off-line simulated examination at the Bujiao site on the northern Tibetan Plateau from June 2002 to April 2004, using the Noah Land Surface Model(Noah LSM) and observed data from the CAMP/Tibet experiment. The observed data were necessarily corrected and the number of soil layers in the Noah LSM was changed from 4 to 10 to enable this off-line simulation and analysis. The main conclusions are as follows: the Noah LSM performed well on the northern Tibetan Plateau. The simulated net radiation, upward longwave radiation, and upward shortwave radiation demonstrated the same remarkable annual and seasonal variation as the observed data, especially the upward longwave radiation. The simulated soil temperatures were acceptably close to the observed temperatures, especially in the shallow soil layers. The simulated freezing and melting processes were shown to start from the surface soil layer and spread down to the deep soil layers, but they took longer than the observed processes. However, Noah LSM did not adequately simulate the soil moisture. Therefore, additional high-quality, long-term observations of land surface–atmosphere processes over the Tibetan Plateau will be a key factor in proper adjustments of the model parameters in the future. | MinHong Song YaoMing Ma Yu Zhang WeiQiang Ma SiQiong Luo | 2014 | Research in Cold and Arid Regions2014，6，3： | 2 |
| 9 | Fast screening compositions of PM2.5 by ATR-FTIR: Comparison with results from IC and OC/EC analyzers显示文摘Chemical speciation of fine particles or PM_(2.5) collected on filters is still a costly and timeconsuming task. In this study, filter-based PM_(2.5) samples were collected during November–December 2013 at four sites in Guangzhou, and the major components were fast screened(~7 min per filter sample) by Attenuated Total Reflectance(ATR)-Fourier Transform Infrared Spectroscopic(FTIR) in comparison with that measured by Organic carbon/Element carbon(OC/EC) analyzer and Ion Chromatography(IC). The concentrations of nitrate, ammonium, sulfate,primary organic carbon(POC) and secondary organic carbon(SOC) measured by OC/EC and IC analyzers were better correlated with their infrared absorption peak heights at 1320 cm^(-1) for nitrate, 1435, 3045 and 3215 cm^(-1) for ammonium, 615 cm^(-1) for sulfate, 690, 760 and 890 cm^(-1) for POC and 1640 and 1660 cm^(-1) for SOC respectively, during polluted days(PM_(2.5)> 75 μg/m^3) than during clean days(PM_(2.5)≤ 75 μg/m^3). With the evolution of a haze episode during our field campaign, the concentrations of the major PM_(2.5) components displayed consistent variations with their infrared absorption peak heights, suggesting ATR-FTIR could be a fast and useful technique to characterize filter-based PM_(2.5) compositions particularly during pollution events although cautions should be taken when PM_(2.5) levels are low. Notably, elevated PM_(2.5) mass concentrations occurred with enhanced ratios of [NO_(-3)]/[SO_4^(2-)] and [NH^(+4)]/[SO_4^(2-)], implying that nitrogenous components play vital roles in the PM_(2.5) pollution events in the study region. | Xu Yu Wei Song Qingqing Yu Sheng Li Ming Zhu Yanli Zhang Wei Deng Weiqiang Yang Zhonghui Huang Xinhui Bi Xinming Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 2 |
| 10 | Phosphorylation of tau protein over time in rats subjected to transient brain ischemia显示文摘Transient brain ischemia has been shown to induce hyperphosphorylation of the microtubule-associated protein tau.To further determine the mechanisms underlying these processes,we investigated the interaction between tau,glycogen synthase kinase(GSK)-3βand protein phosphatase 2A.The results confirmed that tau protein was dephosphorylated during brain ischemia;in addition,the activity of GSK-3βwas increased and the activity of protein phosphatase2A was decreased.After reperfusion,tau protein was hyperphosphorylated,the activity of GSK-3βwas decreased and the activity of protein phosphatase 2A remained low.Importantly,the interaction of tau with GSK-3βand protein phosphatase 2A was altered during ischemia and reperfusion Lithium chloride could affect tau phosphorylation by regulating the interaction of tau with GSK-3βand protein phosphatase 2A,and improve learning and memory ability of rats after transient brain ischemia.The present study demonstrated that it was the interaction of tau with GSK-3βand protein phosphatase 2A,rather than their individual activities,that dominates the phosphorylation of tau in transient brain ischemia.Hyperphosphorylated tau protein may play an important role in the evolution of brain injury in ischemic stroke.The neuroprotective effects of lithium chloride partly depend on the inhibition of tau phosphorylation during transient brain ischemia. | Bo Song Qiang Ao Zhen Wang Weiqiang Liu Ying Niu Qin Shen Huancong Zuo Xiufang Zhang Yandao Gong | 2013 | Neural Regeneration Research2013，8，34： | 2 |
| 11 | Characterization of the stress sensitivity of pores for different rank coals by nuclear magnetic resonance显示文摘 | Song Li Dazhen Tang Zhejun Pan Hao Xu Weiqiang Huang | 2013 | Fuel2013，，： | 1 |
| 12 | Urea reactor integrity evaluation based on failure analysis显示文摘 | Song Mingda Wang Weiqiang Zhao Yafang | 2007 | Journal of Pressure Vessel Technology2007，129，4： | 1 |
| 13 | 显示文摘 | Lv Xiaohua Song Weiqiang Ti Yongzhou | 2013 | Carbohydrate Polymers2013，，92： | 1 |
| 14 | Study of the synergistic effect of a triazine-dithiocarbamate derivative with TCP in vegetable oil 显示文摘 | He Zhongyi Song Yuping Zhan Weiqiang | 2005 | Journal of Synthesis Lubrication2005，21，4： | 1 |
| 15 | The Tribological Behaviors of Some Triazine-Dithiocarbamate Derivatives as Additives in Vegetable Oil显示文摘 | Zhan Weiqiang Song Yuping Ren Tianhui | 2004 | Wear2004，，256： | 1 |
| 16 | Gamma Radiation-Induced Grafting of Acrylamide and Dimethyl Diallyl Ammonium Chloride onto Starch显示文摘 | Lü Xiaohua Song Weiqiang Ti Yongzhou | 2013 | Carbohydr Polym2013，92，1： | 1 |
| 17 | The tribological behaviors of some triazine-dithiocarbamate derivatives as additive in vegetable oil显示文摘 | Zhan Weiqiang Song Yuping Ren Tianhui | 2004 | Wear2004，256，23： | 1 |
| 18 | Coupling modelfor carbon dioxide wellbore flow and heat transfer in coiled tubingdrilling显示文摘 | NI Hongjian SONG Weiqiang WANG Ruihe | 2016 | Journal of Natural Gas Science and Engineering2016，30，： | 1 |
| 19 | The tribological behavior of some triazine-dithiocarbamate derivatives as additives in vegetable oil显示文摘 | Weiqiang Zhan Yuping Song Tianhui Ren | 2004 | Wear2004，256，： | 1 |
| 20 | LiMoO 3 (IO 3 ): A new molybdenyl iodate based on WO 3 -type sheets with large SHG response显示文摘 | Xuean Chen Li Zhang Xinan Chang Haiping Xue Hegui Zang Weiqiang Xiao Xuemei Song Hui Yan | 2006 | Journal of Alloys and Compounds2006，，： | 1 |
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