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| 1 | Geochronology and petrogenesis of granitic rocks in Gangdese batholith, southern Tibet显示文摘Based on petrological and geochemical characteristics such as rock assemblage, petrogeochemistry, Sr-Nd isotope, zircon U-Pb age, and Hf isotope, we studied geochronological framework, magma types, source characters, and petrogenesis of different stages of magmatism of the granitic rocks from the Gangdese batholith in southern Tibet. The magmatic activities of the Gangdese batholith can be divided into three stages. The Mesozoic magmatism, induced by northern subduction of Neotethyan slab, was continuously developed, with two peak periods of Late Jurassic and Early Cretaceous. The Paleocene-Eocene magmatism was the most intensive, and resulted from a complex progress of Neotethyan oceanic slab, including subduction, rollback, and subsequent breakoff. And the Oligocene-Miocene magmatism was attributed to the convective removal of thickened lithosphere in an east-west extension setting after India-Asia collision. Isotopically, zircons from these granitic rocks are characterized by positive εHf(t) values, suggesting that the magmatic source of the Gangdese batholith might be an arc terrane, which was accreted to the southern margin of Asia during Late Paleozoic. Therefore, the chronological framework and Hf isotopic characteristics of the Gangdese batholith are distinct from the granitic rocks in adjacent areas, which can be served as a powerful tracer in studying source-to-sink relation of sediments during the uplift and erosion of Tibetan Plateau. | JI WeiQiang WU FuYuan LIU ChuanZhou CHUNG SunLin | 2009 | Science China Earth Sciences2009，52，9： | 89 |
| 2 | Highly fractionated granites:Recognition and research显示文摘Granite is one of the most important components of the continental crust on our Earth; it thus has been an enduring studied subject in geology. According to present knowledge, granite shows a great deal of heterogeneity in terms of its texture,structure, mineral species and geochemical compositions at different scales from small dike to large batholith. However, the reasons for these variations are not well understood although numerous interpretations have been proposed. The key point of this debate is whether granitic magma can be effectively differentiated through fractional crystallization, and, if so, what kind of crystallization occurred during the magmatic evolution. Although granitic magma has high viscosity because of its elevated SiO2 content, we agree that fractional crystallization is effectively processed during its evolution based on the evidence from field investigation,mineral species and its chemical variations, and geochemical compositions. These data indicate that crystal settling by gravitation is not the only mechanism dominating granitic differentiation. On the contrary, flow segregation or dynamic sorting may be more important. Accordingly, granite can be divided into unfractionated, fractionated(including weakly fractionated and highly fractionated) and cumulated types, according to the differentiation degree. Highly fractionated granitic magmas are generally high in primary temperature or high with various volatiles during the later stage, which make the fractional crystallization much easier than the common granitic melts. In addition, effective magmatic differentiation can be also expected when the magma emplaced along a large scale of extensional structure. Highly fractionated granitic magma is easily contaminated by country rocks due to its relatively prolonged crystallization time. Thus, granites do not always reflect the characteristics of the source areas and the physical and chemical conditions of the primary magma. We proposed that highly fractionated granites are an important sign indicating compositional maturity of the continental crust, and they are also closely related to the rare-elemental(metal) mineralization of W,Sn, Nb, Ta, Li, Be, Rb, Cs, REEs, etc. | WU FuYuan LIU XiaoChi JI WeiQiang WANG JiaMin YANG Lei | 2017 | Science China Earth Sciences2017，60，7： | 109 |
| 3 | Zircon SHRIMP Dating for the Weiya Pluton, Eastern Tianshan: Its Geological Implications显示文摘The timing of the emplacement of the Weiya pluton remains controversial due to the absence of systematic and precise dating. This paper reports zircon SHRIMP U-Pb dating of different lithologic phases in the Weiya pluton, and discusses the genesis and tectonic environment. The ages of gabbro, quartz syenite, diorite porphyrite and fine-grained granite are 236?6 Ma, 246?6 Ma, 233?8 Ma and 237?8 Ma, respectively. All these phases were formed in early-middle Indosinian (Triassic) in a post-orogenic environment. In addition to underplating, intraplating of mantle-derived magmas is also a substantial mechanism for magma generation and vertical accretion of the continental crust. Granitoid rocks are important products of vertical continental accretion as underplating evolves gradually to intraplating. The existence of post-orogenic Indosinian granites shows that the middle Tianshan orogenic belt underwent an important tectonic conversion from the Paleo-Asian ocean subduction-collision system to the Paleo-Tethys ocean regime. | ZHANG Zunzhong GU Lianxing WU Changzhi LI Weiqiang XI Aihua WANG Shuo | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 53 |
| 4 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 5 | The 1997-1998 warm event in the South China Sea显示文摘A strong warm event happens during spring 1997 to spring 1999 in the South China Sea. Its intensity and duration show that it is the strongest event on the record over the past decades. It also corresponds with the severe flood over the valley of the Yangtze River and a couple of marine environmental events. This note addressed the evolution process by using several data sets, such as sea surface temperature, height and wind stress in addition to subsurface temperature. The onset of the warm event almost tele-connects with the El Nino event in the tropical Pacific Ocean. Summer monsoon is stronger and winter monsoon is weaker in 1997 so that there are persistent westerly anomalies in the South China Sea. During the development phase, the warm advection caused by southerly anomalies is the major factor while the adjustment of the thermocline is not obvious. Subsequently, the southerly anomalies decay and even northerly anomalies appear in the summer of 1998 resulting from the weaker than normal summer | WANG Dongxiao XIE Qiang DU Yan WANG Weiqiang CHEN Ju | 2002 | Chinese Science Bulletin2002，47，14： | 24 |
| 6 | Abrasion characteristic analyses of solid-liquid two-phase centrifugal pump显示文摘Based on the solid-liquid two-phase mixture transportation test, the renormalization group (RNG) k-e turbulent model was utilized to simulate the solid-liquid two-phase turbulent flow in a centrifugal pump. By comparing the simulated and experimental results, inner flow features were revealed to improve the abrasion characteristic of the solid-liquid two-phase centrifugal pump. The influence of the solid phase on centrifugal pump abrasive performance is small when the particle volume fraction is less than 2.5%. The aggregation degree of the solid particles is enhanced as the particle diameter increases from 0.1 to 1 mm; however, the mixture density on the pressure side is reduced when the particle diameter increases to 1 mm for the impact of inertia. The wear on the hub is most severe for the shear stress on this position; it is also the largest. The wear characteristic is affected greatly by the parameters of the solid phase. The wear chracteristic can be optimized by decreasing the blade outlet angle. In the modified design, the blade angle is different, whereas the other geometric dimensions remain the same. The improved pump is simulated to contrast with the original pump. The results show that the values of mixture density and shear stress both decrease. The wear condition of the blade is improved to a certain extent. | LI Yi ZHU Zuchao HE Zhaohui HE Weiqiang | 2011 | Journal of Thermal Science2011，20，3： | 23 |
| 7 | Processes of initial collision and suturing between India and Asia显示文摘The initial collision between Indian and Asian continents marked the starting point for transformation of land-sea thermal contrast,uplift of the Tibet-Himalaya orogen,and climate change in Asia.In this paper,we review the published literatures from the past 30 years in order to draw consensus on the processes of initial collision and suturing that took place between the Indian and Asian plates.Following a comparison of the different methods that have been used to constrain the initial timing of collision,we propose that the tectono-sedimentary response in the peripheral foreland basin provides the most sensitive index of this event,and that paleomagnetism presents independent evidence as an alternative,reliable,and quantitative research method.In contrast to previous studies that have suggested collision between India and Asia started in Pakistan between ca.55 Ma and50 Ma and progressively closed eastwards,more recent researches have indicated that this major event first occurred in the center of the Yarlung Tsangpo suture zone(YTSZ) between ca.65 Ma and 63 Ma and then spreading both eastwards and westwards.While continental collision is a complicated process,including the processes of deformation,sedimentation,metamorphism,and magmatism,different researchers have tended to define the nature of this event based on their own understanding,an intuitive bias that has meant that its initial timing has remained controversial for decades.Here,we recommend the use of reconstructions of each geological event within the orogenic evolution sequence as this will allow interpretation of collision timing on the basis of multidisciplinary methods. | DING Lin Satybaev MAKSATBEK CAI FuLong WANG HouQi SONG PeiPing JI WeiQiang XU Qiang ZHANG LiYun Qasim MUHAMMAD Baral UPENDRA | 2017 | Science China Earth Sciences2017，60，4： | 23 |
| 8 | 糖尿病视网膜病变患病率的流行病学调查:在中国6省13473名糖尿病患者中的横断面研究显示文摘目的本研究旨在探究中国糖尿病患者中糖尿病视网膜病变(DR)和视力威胁性糖尿病视网膜病变(STDR)的患病率和严重程度。研究设计、设置与参与者本研究为横断面流行病学调查,研究对象为中国内地地区的糖尿病患者(N=13473)。研究对象为被内科医师诊断为糖尿病,并转诊到筛查门诊的糖尿病患者(其中住院患者占1/3,城市居民占1/3,农村居民占1/3)。研究对象的每只眼睛应用彩色、免散瞳和非立体眼底照相机拍摄2张眼底照片,并根据英国DR分级指南进行分级。主要结果和测量指标DR与STDR的患病率和严重程度。结果在参与本研究的13473例糖尿病患者中,共发现4591例DR和1769例STDR患者,DR的总体患病率为34.08%[95%可信区间(凹)33.28%~34.88%],其中STDR的总体患病率为13.13%(95%C112.56%~13.70%)。在所有研究对象中,12780例参与了眼底照片分级(94.86%)。年龄大于65岁的研究对象患DR或STDR的可能性较低(P〈0.001)。性别对是否患病没有显著影响(P〉0.05)。STDR患者与非STDR患者相比,视力损伤更为严重(P〈0.001)。中国北方DR和STDR的患病率高于南方(P〈0.001)。DR的患病率与糖尿病患病时间f比值比(鲫)2.63;95%C12.42~2.86;P〈0.001]以及糖尿病发病年龄(OR 0.38;95%CI为0.35~0.41;P〈0.001)密切相关。结论DR和STDR在中国内地地区的患病率偏高,并且不同地区患病率存在差异。在DR中,非增殖性DR更常见,但STDR更需要及时的诊断和治疗,特别是在经济欠发达地区。本研究强调了中国内地地区DR筛查和治疗的重要性。 | Liu, Yan Song, Yifan Tao, Liyuan Qiu, Weiqiang Lv, Huibin Jiang, Xiaodan Zhang, Mingzhou Li, Xuemin | 2017 | 英国医学杂志中文版2017，20，11： | 23 |
| 9 | The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows显示文摘Probiotics administration can improve host health.This study aims to determine the effects of probiotics(Lactobacillus casei Zhang and Lactobacillus plantarum P-8) administration on milk production,milk functional components,milk composition,and fecal microbiota of dairy cows.Variations in the fecal bacteria microbiota between treatments were assessed based on 16 S rRNA profiles determined by Pac Bio single molecule real-time sequencing technology.The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin G(IgG),lactoferrin(LTF),lysozyme(LYS)and lactoperoxidase(LP),while the somatic cell counts(SCC) significantly decreased(P < 0.01).However,no significant difference was found in the milk fat,protein and lactose contents(P > 0.05).Although the probiotics supplementation did not change the fecal bacteria richness and diversity,significantly more rumen fermentative bacteria(Bacteroides,Roseburia,Ruminococcus,Clostridium,Coprococcus and Dorea) and beneficial bacteria(Faecalibacterium prausnitzii) were found in the probiotics treatment group.Meanwhile,some opportunistic pathogens e.g.Bacillus cereus,Cronobacter sakazakii and Alkaliphilus oremlandii,were suppressed.Additionally,we found some correlations between the milk production,milk components and fecal bacteria.To sum up,our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production. | Haiyan Xu Weiqiang Huang Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun Lee Heping Zhang | 2017 | Science Bulletin2017，62，11： | 21 |
| 10 | The development and function of follicular helper T cells in immune responses显示文摘小囊的助手 T 房间(Tfh ) 作为提供帮助让 B 房间增殖并且在幼芽的中心经历抗体亲密关系成熟的一个系被提交了。证据支持了那个 Tfh 子集开发象另外的系一样,依赖于一个特别 transcriptional 节目被开始的微型环境。它为 Tfh 房间的开发和函数作为主人管理者被看了那 Bcl-6 和 IL-21 行为。Tfh dysregulation 涉及自体免疫的病理的发展,例如全身的豺狼座 erythematosus,风湿性关节炎和另外的自体免疫的疾病。现在的评论在在他们的开发和函数的 Tfh 房间和焦点的域里加亮最近的进展。 | Maogen Chen Zhiyong Guo Weiqiang Ju Bernhard Ryffel Xiaoshun He Song Guo Zheng | 2012 | Cellular & Molecular Immunology2012，9，5： | 18 |
| 11 | Chronology and Geochemistry of Volcanic Rocks in the Cretaceous Suifenhe Formation in Eastern Heilongjiang,China显示文摘摘要:在在东方 Heilongjiang 省的 Suifenhe 形成的暴烈的岩石的锆石 U-Pb 年龄和 geochemical 数据被报导,并且他们的 petrogenesis 在这份报纸被讨论。Suifenhe 形成主要由暗岩,安山岩,和 dacite 组成。从安山岩和 dacite 的锆石是在形状的 euhedral 并且与高 Th/U 比率(0.18-0.57 ) 显示出典型摆动的 zoning,暗示它的 magmatic 起源。诱导地由激光脱离标明日期结果的锆石 U-Pb 联合了血浆团分光计(LA-ICP-MS ) 显示从安山岩的锆石的 206Pb/238U 年龄在 105106 妈以内变化,产出 105.5 | JI Weiqiang XU Wenliang YANG Debin PEI Fuping JIN Ke LIU Xiaoming | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 16 |
| 12 | Optical manipulation from the microscale to the nanoscale: fundamentals, advances and prospects显示文摘Since the invention of optical tweezers,optical manipulation has advanced significantly in scientific areas such as atomic physics,optics and biological science.Especially in the past decade,numerous optical beams and nanoscale devices have been proposed to mechanically act on nanoparticles in increasingly precise,stable and flexible ways.Both the linear and angular momenta of light can be exploited to produce optical tractor beams,tweezers and optical torque from the microscale to the nanoscale.Research on optical forces helps to reveal the nature of light–matter interactions and to resolve the fundamental aspects,which require an appropriate description of momenta and the forces on objects in matter.In this review,starting from basic theories and computational approaches,we highlight the latest optical trapping configurations and their applications in bioscience,as well as recent advances down to the nanoscale.Finally,we discuss the future prospects of nanomanipulation,which has considerable potential applications in a variety of scientific fields and everyday life. | Dongliang Gao Weiqiang Ding Manuel Nieto-Vesperinas Xumin Ding Mahdy Rahman Tianhang Zhang ChweeTeck Lim Cheng-Wei Qiu | 2017 | Light(Science & Applications)2017，6，1： | 16 |
| 13 | Nonintubated uniportal video-assisted thoracoscopic surgery for primary spontaneous pneumothorax显示文摘Objective:The objective of the current study was to evaluate the feasibility and safety of nonintubated uniportal video-assisted thoracoscopic surgery(VATS) for the management of primary spontaneous pneumothorax(PSP).Methods:From November 2011 to June 2013,32 consecutive patients with PSP were treated by nonintubated uniportal thoracoscopic bullectomy using epidural anaesthesia and sedation without endotracheal intubation.An incision 2 cm in length was made at the 6^(th) intercostal space in the median axillary line.The pleural space was entered by blunt dissection for placement of a soft incision protector.Instruments were then inserted through the incision protector to perform thoracoscopic bullectomy.Data were collected within a minimum follow-up period of 10 months.Results:The average time of surgery was 49.0 min(range,33-65 min).No complications were recorded.The postoperative feeding time was 6 h.The mean postoperative chest tube drainage and hospital stay were19.3 h and 41.6 h,respectively.The postoperative pain was mild for 30 patients(93.75%) and moderate for two patients(6.25%).No recurrences of pneumothorax were observed at follow-up.Conclusions:The initial results indicated that nonintubated uniportal video-assisted thoracoscopic operations are not only technically feasible,but may also be a safe and less invasive alternative for select patients in the management of PSP.This is the first report to include the use of a nonintubated uniportal technique in VATS for such a large number of PSP cases.Further work and development of instruments are needed to define the applications and advantages of this technique. | Shuben Li Fei Cui Jun Liu Xin Xu Wenlong Shao Weiqiang Yin Hanzhang Chen Jianxing He | 2015 | Chinese Journal of Cancer Research2015，27，2： | 15 |
| 14 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 15 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 16 | Safety and feasibility of video-assisted thoracoscopic surgery for stage IIIA lung cancer显示文摘Objective: The current study was prospectively designed to explore the application of video-assisted thoracoscopic surgery(VATS) radical treatment for patients with stage IIIA lung cancer, with the primary endpoints being the safety and feasibility of this operation and the second endpoints being the survival and complications after the surgery.Methods: A total of 51 patients with radiologically or mediastinoscopically confirmed stage IIIA lung cancer underwent VATS radical treatment, during which the standard pulmonary lobectomy and mediastinal lymph node dissection were performed after pre-operative assessment. The operative time, intraoperative blood loss/complications, postoperative recovery, postoperative complications, and lymph node dissection were recorded and analyzed. This study was regarded as successful if the surgical success rate reached 90% or higher.Results: A total of 51 patients with non-small cell lung cancer(NSCLC) were enrolled in this study from March 2009 to February 2010. The median post-operative follow-up duration was 50.5 months. Of these 51 patients, 41(80.4%) had N2 lymph node metastases. All patients underwent the thoracoscopic surgeries, among whom 50(98%) received pulmonary lobectomy and mediastinal lymph node dissection completely under the thoracoscope, 6 had their incisions extended to about 6 cm due to larger tumor sizes, and 1 had his surgery performed using a 12 cm small incision for handling the adhesions between lymph nodes and blood vessels. No patient was converted to conventional open thoracotomy. No perioperative death was noted. One patient received a second surgery on the second post-operative day due to large drainage(>1,000 mL), and the postoperative recovery was satisfactory. Up to 45 patients(88.2%) did not suffer from any perioperative complication, and 6(11.8%) experienced one or more complications.Conclusions: VATS radical treatment is a safe and feasible treatment for stage IIIA lung cancer. | Wenlong Shao Jun Liu Wehua Liang Hanzhang Chen Shuben Li Weiqiang Yin Xin Zhang Jianxing He | 2014 | Chinese Journal of Cancer Research2014，26，4： | 12 |
| 17 | Porous LiFePO_(4)/NiP Composite Nanospheres as the Cathode Materials in Rechargeable Lithium Ion Batteries显示文摘We report the synthesis of porous LiFePO4/NiP composite nanospheres and their application in rechargeable lithium-ion batteries.A simple one-step spraying technique was developed to prepare LiFePO_(4)/NiP composite nanospheres with an electrical conductivity 10^(3)-10^(4) times that of bulk particles of LiFePO_(4).Electrochemical measurements show that LiFePO_(4) nanospheres with a uniform loading of 0.86 wt%1.50 wt%NiP exhibit high discharge capacity,good cycling reversibility,and low apparent activation energies.The superior electrode performance of the as-prepared composite nanospheres results from the greatly enhanced electrical conductivity and porous structure of the materials. | Chunsheng Li Shaoyan Zhang Fangyi Cheng Weiqiang Ji Jun Chen | 2008 | Nano Research2008，1，3： | 12 |
| 18 | Numerical Simulation and Experimental Research on the Influence of Solid-phase Characteristics on Centrifugal Pump Performance显示文摘The law governing the movement of particles in the centrifugal pump channel is complicated; thus, it is difficult to examine the solid-liquid two-phase turbulent flow in the pump. Consequently, the solid-liquid two-phase pump is designed based only on the unary theory. However, the obvious variety of centrifugal-pump internal flow appears because of the existence of solid phase, thus changing pump performance. Therefore, it is necessary to establish the flow characteristics of the solid-liquid two-phase pump. In the current paper, two-phase numerical simulation and centrifugal pump performance tests are carried out using different solid-particle diameters and two-phase mixture concentration conditions. Inner flow features are revealed by comparing the simulated and experimental results. The comparing results indicate that the influence of the solid-phase characteristics on centrifugal-pump performance is small when the flow rate is low, specifically when it is less than 2 m3/h. The maximum efficiency declines, and the best efficiency point tends toward the low flow-rate direction along with increasing solid-particle diameter and volume fraction, leading to reduced pump steady efficient range. The variation tendency of the pump head is basically consistent with that of the efficiency. The efficiency and head values of the two-phase mixture transportation are even larger than those of pure-water transportation under smaller particle diameter and volume fraction conditions at the low-flow-rate region. The change of the particle volume fraction has a greater effect on the pump performance than the change in the particle diameter. The experimental values are totally smaller than the simulated values. This research provides the theoretical foundation for the optimal design of centrifugal pump. | LI Yi ZHU Zuchao HE Weiqiang HE Zhaohui | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 11 |
| 19 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 20 | Advances in soliton microcomb generation显示文摘Optical frequency combs,a revolutionary light source characterized by discrete and equally spaced frequencies,are usually regarded as a cornerstone for advanced frequency metrology,precision spectroscopy,high-speed communication,distance ranging,molecule detection,and many others.Due to the rapid development of micro/nanofabrication technology,breakthroughs in the quality factor of microresonators enable ultrahigh energy buildup inside cavities,which gives birth to microcavity-based frequency combs.In particular,the full coherent spectrum of the soliton microcomb(SMC)provides a route to low-noise ultrashort pulses with a repetition rate over two orders of magnitude higher than that of traditional mode-locking approaches.This enables lower power consumption and cost for a wide range of applications.This review summarizes recent achievements in SMCs,including the basic theory and physical model,as well as experimental techniques for single-soliton generation and various extraordinary soliton states(soliton crystals,Stokes solitons,breathers,molecules,cavity solitons,and dark solitons),with a perspective on their potential applications and remaining challenges. | Weiqiang Wang Leiran Wang Wenfu Zhang | 2020 | Advanced Photonics2020，2，3： | 10 |
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