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| 1 | Chitosan conduits combined with nerve growth factor microspheres repair facial nerve defects显示文摘Microspheres containing nerve growth factor for sustained release were prepared by a compound method,and implanted into chitosan conduits to repair 10-mm defects on the right buccal branches of the facial nerve in rabbits.In addition,chitosan conduits combined with nerve growth factor or normal saline,as well as autologous nerve,were used as controls.At 90 days post-surgery,the muscular atrophy on the right upper lip was more evident in the nerve growth factor and normal saline groups than in the nerve growth factor-microspheres and autologous nerve groups.Electrophysiological analysis revealed that the nerve conduction velocity and amplitude were significantly higher in the nerve growth factor-microspheres and autologous nerve groups than in the nerve growth factor and normal saline groups.Moreover,histological observation illustrated that the diameter,number,alignment and myelin sheath thickness of myelinated nerves derived from rabbits were higher in the nerve growth factor-microspheres and autologous nerve groups than in the nerve growth factor and normal saline groups.These findings indicate that chitosan nerve conduits combined with microspheres for sustained release of nerve growth factor can significantly improve facial nerve defect repair in rabbits. | Huawei Liu Weisheng Wen Min Hu Wenting Bi Lijie Chen Sanxia Liu Peng Chen Xinying Tan | 2013 | Neural Regeneration Research2013，8，33： | 22 |
| 2 | Adaptive output feedback control for nonlinear time-delay systems using neural network显示文摘This paper extends the adaptive neural network (NN) control approaches to a class of unknown output feedback nonlinear time-delay systems. An adaptive output feedback NN tracking controller is designed by backstep- ping technique. NNs are used to approximate unknown functions dependent on time delay. Delay-dependent filters are introduced for state estimation. The domination method is used to deal with the smooth time-delay basis functions. The adaptive bounding technique is employed to estimate the upper bound of the NN approximation errors. Based on Lyapunov- Krasovskii functional, the semi-global uniform ultimate boundedness of all the signals in the closed-loop system is proved. The feasibility is investigated by two illustrative simulation examples. | Weisheng CHEN Junmin LI | 2006 | 控制理论与应用(英文版)2006，4，4： | 9 |
| 3 | Analysis of genetic diversity and population structure of Chinese yak breeds (Bos grunniens) using microsatellite markers显示文摘Nine Chinese yak breeds (Maiwa, Tianzhu White, Qinghai Plateau, Sibu, Zhongdian, Pali, Tibetan High Mountain, Jiulong, and Xin-jiang) and Gayal were analyzed by means of 16 microsatellite markers to determine the level of genetic variation within populations, genetic relationship between populations, and population structure for each breed. A total of 206 microsatellite alleles were observed. Mean F-statistics (0.056) for 9 yak breeds indicated that 94.4% of the genetic variation was observed within yak breeds and 5.6% of the genetic variation existed amongst breeds. The Neighbor-Joining phylogenetic tree was constructed based on Nei's standard genetic dis-tances and two clusters were obtained. The Gayal separated from the yaks far away and formed one cluster and 9 yak breeds were grouped together. The analysis of population structure for 9 yak breeds and the Gayal showed that they resulted in four clusters; one clus-ter includes yaks from Tibet Autonomous Region and Qinghai Province, one cluster combines Zhongdian, Maiwa, and Tianzhu White, and Jiulong and Xinjiang come into the third cluster. Pali was mainly in the first cluster (90%), Jiulong was mainly in the second cluster (87.1%), Zhongdian was primarily in the third cluster (83%), and the other yak breeds were distributed in two to three clusters. The Gayal was positively left in the fourth cluster (99.3%). | Guixiang Zhang Weisheng Chen Ming Xue Zhigang Wang Hong Chang Xu Han Xinjun Liao Donglei Wang | 2008 | Journal of Genetics and Genomics2008，35，4： | 8 |
| 4 | Color-tunable Gd-Zn-Cu-ln-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging显示文摘 | Weisheng Guo Weitao Yang Yu Wang Xiaolian Sun Zhongyun Liu Bingbo Zhang Jin Chang Xiaoyuan Chen | 2014 | Nano Research2014，7，11： | 8 |
| 5 | Synthesis of pennogenin utilizing the intact skeleton of diosgenin显示文摘The first synthesis of pennogenin, an aglycone of bioactive components of Chinese traditional medicine named Chonglou(Paris), starting from diosgenin, has been reported, which displays a new strategy of utilizing the resource compounds. According to this new strategy, the full and rational utilization of the intact skeleton and functional groups of starting material has been realized in the conversion of diosgenin to pennogenin. The key step for synthesis of pen-nogenin is the regioselective transformation of cholest-5-en-16,22-dion-3,26-diol to cholest- 5,16-dien-22-on-3,26-diol, which can be used to synthesize other bioactive steroids such as cephalostatin and OSW-1. | TIAN Weisheng XU Qihai CHEN Ling ZHAO Chunfeng | 2004 | Science China Chemistry2004，47，2： | 7 |
| 6 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 7 | Backstepping control of a quadrotor unmanned aerial vehicle based on multi-rate sampling显示文摘Dear editor,An unmanned aerial vehicle(UAV)is a portable power unit,that uses aerodynamic forces for carrying loads.A UAV does not have a human pilot on board;it is controlled remotely or programmed to fly autonomously. | Fakui WANG Weisheng CHEN Hao DAI Jing LI Jinping JIA | 2019 | Science China(Information Sciences)2019，62，1： | 6 |
| 8 | Generation and manipulation of chiral terahertz waves in the three-dimensional topological insulator Bi2Te3显示文摘Arbitrary manipulation of broadband terahertz waves with flexible polarization shaping at the source has great potential in expanding numerous applications,such as imaging,information encryption,and all-optical coherent control of terahertz nonlinear phenomena.Topological insulators featuring unique spinmomentum-locked surface state have already exhibited very promising prospects in terahertz emission,detection,and modulation,which may lay a foundation for future on-chip topological insulator-based terahertz systems.However,polarization-shaped terahertz emitters based on topological insulators with an arbitrarily manipulated temporal evolution of the amplitude and the electric-field vector direction have not yet been explored.We systematically investigated the terahertz radiation from topological insulator Bi2Te3 nanofilms driven by femtosecond laser pulses and successfully realized the generation of efficient chiral terahertz waves with controllable chirality,ellipticity,and principal axis.The convenient engineering of the chiral terahertz waves was interpreted by a photogalvanic effect(PGE)-induced photocurrent,while the linearly polarized terahertz waves originated from linear PGE-induced shift currents.Our work not only provides further understanding of femtosecond coherent control of ultrafast spin currents but also describes an effective way to generate spin-polarized terahertz waves at the source. | Haihui Zhao Xinhou Chen Chen Ouyang Hangtian Wang Deyin Kong Peidi Yang Baolong Zhang Chun Wang Gaoshuai Wei Tianxiao Nie Weisheng Zhao Jungang Miao Yutong Li Li Wang Xiaojun Wu | 2020 | Advanced Photonics2020，2，6： | 6 |
| 9 | Developing individual tree-based models for estimating aboveground biomass of five key coniferous species in China显示文摘Estimating individual tree biomass is critical to forest carbon accounting and ecosystem service modeling.In this study,we developed one-(tree diameter only) and two-variable(tree diameter and height) biomass equations,biomass conversion factor(BCF) models,and an integrated simultaneous equation system(ISES) to estimate the aboveground biomass for five conifer species in China,i.e.,Cunninghamia lanceolata(Lamb.) Hook.,Pinus massoniana Lamb.,P.yunnanensis Faranch,P.tabulaeformis Carr.and P.elliottii Engelm.,based on the field measurement data of aboveground biomass and stem volumes from 1055 destructive sample trees across the country.We found that all three methods,including the one-and two-variable equations,could adequately estimate aboveground biomass with a mean prediction error less than 5%,except for Pinus yunnanensis which yielded an error of about 6%.The BCF method was slightly poorer than the biomass equation and the ISES methods.The average coefficients of determination(R^2) were 0.944,0.938 and 0.943 and the mean prediction errors were 4.26,4.49 and 4.29% for the biomass equation method,the BCF method and the ISES method,respectively.The ISES method was the best approach for estimating aboveground biomass,which not only had high accuracy but also could estimate stocking volumes simultaneously that was compatible with aboveground biomass.In addition,we found that it is possible to develop a species-invariant one-variable allometric model for estimating aboveground biomass of all the five coniferous species.The model had an exponent parameter of 7/3 and the intercept parameter a_0 could be estimated indirectly from stem basic density(a_0= 0.294 q). | Weisheng Zeng Liyong Fu Ming Xu Xuejun Wang Zhenxiong Chen Shunbin Yao | 2018 | Journal of Forestry Research2018，29，5： | 5 |
| 10 | Adaptive neural network tracking control for a class of unknown nonlinear time-delay systems显示文摘For a class of unknown nonlinear time-delay systems, an adaptive neural network (NN) control design approach is proposed. Backstepping, domination and adaptive bounding design technique are combined to construct a robust memoryless adaptive NN tracking controller. Unknown time-delay functions are approximated by NNs, such that the requirement on the nonlinear time-delay functions is relaxed. Based on Lyapunov-Krasoviskii functional, the sem-global uniformly ultimately boundedness (UUB) of all the signals in the closed-loop system is proved. The arbitrary output tracking accuracy is achieved by tuning the design parameters. The feasibility is investigated by an illustrative simulation example. | Chen Weisheng Li Junmin | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 5 |
| 11 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 12 | A potential stratotype for the regional lowermost stage of the continental Paleocene in China显示文摘Phanerozoic chronostratigraphic units can only be defined through their lower boundary stratotypes.The lowermost stage of the Paleocene of China,which mainly consists of terrestrial deposits,can only be defined through its lower boundary stratotype,i.e.the continental Cretaceous/Paleogene boundary stratotype.There is no section yet found which contains continuous terrestrial deposits and biostratigraphic records of the Cretaceous-Paleogene transition in Nanxiong,Guangdong and Jiayin,Heilongjiang,there is no evidence for establishing the continental stratotype of the Cretaceous/Paleogene boundary in either area.Therefore,both the'Shanghuan stage'and'Furaoan stage'are not good candidates for the lowermost stage of the Paleocene of China.From the viewpoint of charophytes,the outcrop section of the Dangyang,Hubei Province(Central China)contains the most continuous,abundant and diverse terrestrial biostratigraphic records of the Cretaceous-Paleogene transition,in particular the early Paleocene,known so far in the world.The biostratigraphic records of ostracods in the transition are also continuous,rich,and diverse.The Dangyang outcrop section is the only section known so far in China that is a possible candidate for a continental stratotype of the Cretaceous/Paleogene boundary in China and the section is the only potential section identified to date for establishing the regional lowermost stage of the Paleocene,Paleogene and Cenozoic in China or stratotype section for the stage. | LI WeiTong LIU GengWu Dennis R.BRAMAN LI YiBin CAO WeiSheng Don BRINKMAN SHEN Jiao CHEN QingBao | 2014 | Science China Earth Sciences2014，57，5： | 3 |
| 13 | Isolation and characterization of emerging subgroup J avian leukosis virus associated with hemangioma in egg-type chickens显示文摘 | Hanzhang Lai Henan Zhang Zhangyong Ning Ruiai Chen Wenyan Zhang Aijian Qing Chaoan Xin Kangzhen Yu Weisheng Cao Ming Liao | 2011 | Veterinary Microbiology2011，，3： | 3 |
| 14 | Adaptive neural control of nonlinear periodic time-varying parameterized mixed-order multi-agent systems with unknown control coefficients显示文摘In this paper, we first consider the adaptive leader-following consensus problem for a class of nonlinear parameterized mixedorder multi-agent systems with unknown control coefficients and time-varying disturbance parameters of the same period. Neural networks and Fourier series expansions are used to describe the unknown nonlinear periodic time-varying parameterized function.A distributed control protocol is designed based on adaptive control, matrix theory, and Nussbaum function. The robustness of the distributed control protocol is analyzed by combining the stability analysis theory of closed-loop systems. On this basis, this paper discusses the case of time-varying disturbance parameters with non-identical periods, expanding the application scope of this control protocol. Finally, the effectiveness of the algorithm is verified by a simulation example. | CHEN JiaXi CHEN WeiSheng LI JunMin ZHANG Shuai | 2022 | Science China(Technological Sciences)2022，65，8： | 2 |
| 15 | Integration of high-performance spin-orbit torque MRAM devices by 200-mm-wafer manufacturing platform显示文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future. | Hongchao Zhang Xiangyue Ma Chuanpeng Jiang Jialiang Yin Shuqin Lyu Shiyang Lu Xiantao Shang Bowen Man Cong Zhang Dandan Li Shuhui Li Wenjing Chen Hongxi Liu Gefei Wang Kaihua Cao Zhaohao Wang Weisheng Zhao | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 16 | Backstepping tracking control for nonlinear time-delay systems显示文摘Two design approaches of state feedback and output feedback tracking controllers are proposed for a class of strict feedback nonlinear time-delay systems by using backstepping technique. When the states of system cannot be observed, the time-delay state observer is designed to estimate the system states. Domination method is used to deal with nonlinear time-delay function under the assumption that the nonlinear time-delay functions of systems satisfy Lipschitz condition. The global asymptotical tracking of the reference signal is achieved and the bound of all signals of the resultant closed-loop system is also guaranteed. By constructing a Lyapunov-Krasoviskii functional, the stability of the closed-loop system is proved. The feasibility of the proposed approach is illustrated by a simulation example. | Chen Weisheng Li Junmin | 2006 | Journal of Systems Engineering and Electronics2006，17，4： | 2 |
| 17 | The characteristics of organic sludge/sawdust derived fuel显示文摘 | Chen Weisheng Chang Fangchih Shen Yunhwei | | 0，，09： | 1 |
| 18 | Globally stable adaptivebackstepping fuzzy control for output-feedback systems withunknown high-frequency gain sign显示文摘 | Chen Weisheng Zhang Zhengqiang | 2010 | Fuzzy Sets andSystens2010，161，： | 1 |
| 19 | Removal of Chloride From Electric Arc Furnace Dust显示文摘 | Chen Weisheng Shen Yunwei Tsai M S | 2011 | Journal of Hazardous Materials2011，190，13： | 1 |
| 20 | Engineered nanoparticles circumvent the adaptive treatment tolerance to immune-checkpoint blockade therapy显示文摘The fight against cancer has witnessed the rapid develop・ment of various therapeutic methodologies,including chemotherapy,surgery,radiotherapy,phototherapy,and the emerging immunotherapy[1].However,malignancies evolve adaptive tolerance under the threatening conditions upon therapies because of some potential biological or genetic mutations,which may cause serious adverse events,compromised therapeutic efficacy and even treatment failure.For instance,following the standard chemotherapy with paclitaxel,primary breast cancer can release exosomes that facilitate the seeding and growth of metastatic cancer cells in distant organs[2].Therefore,the term'adaptive treatment tolerance'(ATT),rather than'drug resistance',has been employed to better describe the dynamic evolution of this phenomenon during/post cancer therapy. | Weisheng Guo Lu Liu Chenyang Xiang Jingqi Chen Xing-Jie Liang | 2019 | Science China Chemistry2019，62，12： | 1 |
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