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| 1 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 2 | Parallel implementation of w-projection wide-field imaging显示文摘w-Projection is a wide-field imaging technique that is widely used in radio synthesis arrays. Processing the wide-field big data generated by the future Square Kilometre Array(SKA) will require significant updates to current methods to significantly reduce the time consumed on data processing. Data loading and gridding are found to be two major time-consuming tasks in w-projection. In this paper, we investigate two parallel methods of accelerating w-projection processing on multiple nodes: the hybrid Message Passing Interface(MPI) and Open Multi-Processing(OpenMP) method based on multicore Central Processing Units(CPUs) and the hybrid MPI and Compute Unified Device Architecture(CUDA)method based on Graphics Processing Units(GPUs). Both methods are successfully employed and operated in various computational environments, confirming their robustness. The experimental results show that the total runtime of both MPI + OpenMP and MPI + CUDA methods is significantly shorter than that of single-thread processing. MPI + CUDA generally shows faster performance when running on multiple nodes than MPI + OpenMP, especially on large numbers of nodes. The single-precision GPU-based processing yields faster computation than the double-precision processing; while the single-and doubleprecision CPU-based processing shows consistent computational performance. The gridding time remarkably increases when the support size of the convolution kernel is larger than 8 and the image size is larger than 2,048 pixels. The present research offers useful guidance for developing SKA imaging pipelines. | Baoqiang Lao Tao An Ang Yu Wenhui Zhang Junyi Wang Quan Guo Shaoguang Guo Xiaocong Wu | 2019 | Science Bulletin2019，64，9： | 2 |
| 3 | Variation on leaching behavior of caustic compounds in bauxite residue during dealkalization process显示文摘Bauxite residue,a byproduct of alumina manufacture,is a serious environmental pollutant due to its high leaching contents of metals and caustic compounds.Four typical anions of CO3^2-,HCO3^-,Al(OH)4^- and OH-(represented caustic compounds) and metal ions(As,B,Mo and V) were selected to assess their leaching behavior under dealkalization process with different conditions including liquid/solid ratio(L/S ratio),temperature and leaching time.The results revealed that washing process could remove the soluble composition in bauxite residue effectively.The leaching concentrations of typical anions in bauxite residue decreased as follows:c(CO3^2-)> c(HCO3^-)> c[Al(OH)4-]> c(OH-).L/S ratio had a more significant effect on leaching behavior of OH-,whilst the leaching concentration of Al(OH)4-varied larger underleaching temperature and time treatment.Under the optimal leaching,the total alkaline,soluble Na concentrations,exchangeable Ca concentrations were 79.52,68.93,and 136.0 mmol/L,respectively,whilst the soluble and exchangeable content of As,B,Mo and V in bauxite residue changed slightly.However,it should be noted that water leaching has released metal ions such as As,B,Mo and V in bauxite residue to the surrounding environment.The semiquantitative analysis of XRD revealed that water leaching increased the content of gismondine from 2.4% to 6.4%.The SEM images demonstrated the dissolution of caustic compounds on bauxite residue surface.The correlation analysis indicated that CO3^2- and HCO3^- could effectively reflect the alkalinity of bauxite residue,and may be regarded as critical de alkalization indicators to evaluate alkalinity removal in bauxite residue. | Yujun Wu Meng Li Feng Zhu William Hartley Jiaxin Liao Wenhui An Shengguo Xue Jun Jiang | 2020 | Journal of Environmental Sciences2020，32，6： | 2 |
| 4 | Hybrid Neural Network Based Gray-Box Approach to Fault Detection of Hybrid Systems 显示文摘 | Wang Wenhui An Dexi Zhou Donghua | 2004 | Springer-Verlag2004，2004，： | 1 |
| 5 | Hybrid neural network based gray-box approach to fault detection of hybrid systems显示文摘 | Wang Wenhui An D Zhou Donghua | 2004 | Lecture Notes in Computer Science2004，，3174： | 1 |
| 6 | Efficient thermal dissipation in wafer-scale heterogeneous integration of single-crystalline��β-Ga_(2)O_(3)thin film on SiC显示文摘The semiconductor,β-Ga_(2)O_(3)is attractive for applications in high power electronic devices with low conduction loss due to its ultra-wide bandgap(∼4.9 eV)and large Baliga’s figure of merit.However,the thermal conductivity of��β-Ga_(2)O_(3)is much lower than that of other wide/ultra-wide bandgap semiconductors,such as SiC and GaN,which results in the deterioration of��β-Ga_(2)O_(3)-based device performance and reliability due to self-heating.To overcome this problem,a scalable thermal management strategy was proposed by heterogeneously integrating wafer-scale single-crystalline��β-Ga_(2)O_(3)thin films on a highly thermally conductive SiC substrate.Characterization of the transferred��β-Ga_(2)O_(3)thin film indicated a uniform thickness to within±2.01%,a smooth surface with a roughness of 0.2 nm,and good crystalline quality with an X-ray rocking curves(XRC)full width at half maximum of 80 arcsec.Transient thermoreflectance measurements were employed to investigate the thermal properties.The thermal performance of the fabricated��β-Ga_(2)O_(3)/SiC heterostructure was effectively improved in comparison with that of the��β-Ga_(2)O_(3)bulk wafer,and the effective thermal boundary resistance could be further reduced to 7.5 m 2 K/GW by a post-annealing process.Schottky barrier diodes(SBDs)were fabricated on both a��β-Ga_(2)O_(3)/SiC heterostructured material and a��β-Ga_(2)O_(3)bulk wafer.Infrared thermal imaging revealed the temperature increase of the SBDs on��β-Ga_(2)O_(3)/SiC to be one quarter that on the��β-Ga_(2)O_(3)bulk wafer with the same applied power,which suggests that the combination of the��-Ga_(2)O_(3)thin film and SiC substrate with high thermal conductivity promotes heat dissipation in��β-Ga_(2)O_(3)-based devices. | Wenhui Xu Tiangui You Yibo Wang Zhenghao Shen Kang Liu Lianghui Zhang Huarui Sun Ruijie Qian Zhenghua An Fengwen Mu Tadatomo Suga Genquan Han Xin Ou Yue Hao Xi Wang | 2021 | Fundamental Research2021，1，6： | 0 |
| 7 | Characteristics of Cloud Water Resource and Precipitation Efficiency of Hydrometeors over Northwest China显示文摘Understanding the characteristics of cloud water resource(CWR)and precipitation efficiency of hydrometeors(PEh)is imperative for the application of CWR in Northwest China.The atmospheric precipitable water(PW)in all four seasons and clouds and PEh in summer were studied with ERA-5 and CloudSat data in this region.The results show that topography,especially in the Tibetan Plateau,exerts significant impacts on the precipitation and PW in summer,since large amounts of clouds are distributed along the mountain ranges.The study region is divided into four typical areas:the monsoon area in eastern Northwest China(NWE),the Qilian Mountains area(QM),the Tianshan Mountains area(TM),and the Source of Three Rivers area(STR).Over the four areas,cloud top height(6.3 km)and cloud base height(3.3 km)over NWE are higher,and precipitating clouds are thicker(7 km)in the single-layer clouds.Liquid water content decreases with increasing altitude,while the ice water content first increases and then decreases.Liquid water path is higher over NWE(0.11 kg m^(−2))than over TM and STR(0.05 kg m^(−2)),and the ice water path is mainly concentrated within the range of 0.025–0.055 kg m^(−2).The PEh values are distributed unevenly and affected evidently by the terrain.Although the PEh values in the four typical areas(0.3–0.6)are higher than those in other regions,the CWR is relatively abundant and has a higher exploitation potential.Therefore,it is well-founded to exploit CWR for alleviating water shortages in these areas of Northwest China in summer. | Zhanyu YAO Lin AN Pei ZHANG Liangshu GAO Shuo JIA Weijian WANG Wenhui ZHAO | 2023 | Journal of Meteorological Research2023，37，3： | 0 |
| 8 | Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents显示文摘Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raised concern about the efficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific B cell response.To this end,a study on a long-term cohort of 208 participants who have recovered from COVID-19 was conducted,and the participants were followed up at 3.3(Visit 1),9.2(Visit 2),and 18.5(Visit 3)months after SARS-CoV-2 infection.They were classified into three groups(no-vaccination(n=54),one-dose(n=62),and two-dose(n=92)groups)on the basis of the administration of inactivated vaccination.The neutralizing antibody(NAb)titers against the wild-type virus continued to decrease in the no-vaccination group,but they rose significantly in the one-dose and two-dose groups,with the highest NAb titers being observed in the two-dose group at Visit 3.The NAb titers against the Delta variant for the no-vaccination,one-dose,and two-dose groups decreased by 3.3,1.9,and 2.3 folds relative to the wild-type virus,respectively,and those against the Omicron variant decreased by 7.0,4.0,and 3.8 folds,respectively.Similarly,the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the second vaccine dose.Results showed that the convalescents benefited from the administration of the inactivated vaccine(one or two doses),which enhanced neutralization against highly mutated SARS-CoV-2 variants and memory B cell responses.Two doses of inactivated vaccine among COVID-19 convalescents are therefore recommended for the prevention of the COVID-19 pandemic,and vaccination guidelines and policies need to be updated. | Hao Wang Yu Yuan Bihao Wu Mingzhong Xiao Zhen Wang Tingyue Diao Rui Zeng Li Chen Yanshou Lei Pinpin Long Yi Guo Xuefeng Lai Yuying Wen Wenhui Li Hao Cai Lulu Song Wei Ni Youyun Zhao Kani Ouyang Jingzhi Wang Qi Wang Li Liu Chaolong Wang An Pan Xiaodong Li Rui Gong Tangchun Wu | 2023 | Frontiers of Medicine2023，17，4： | 0 |
| 9 | Characteristics and health risks of population exposure to phthalates via the use of face towels显示文摘The production of face towels is growing at an annual rate of about 4%in China,reaching 1.13 million tons by 2021.Phthalates(PAEs)are widely used in textiles,and face towels,as an important household textile,may expose people to PAEs via the skin,further leading to health risks.We collected new face towels and analyzed the distribution characterization of PAEs in them.The changes of PAEs were explored in a face towel use experiment and a simulated laundry experiment.Based on the use of face towels by 24 volunteers,we calculated the estimated daily intake(EDI)and comprehensively assessed the hazard quotient(HQ),hazard index(HI),and dermal cancer risk(DCR)of PAEs exposure in the population.PAEs were present in new face towels at total concentrations of | Wenhui Zhang Na Zheng Sujing Wang Siyu Sun Qirui An Xiaoqian Li Zimeng Li Yining Ji Yunyang Li Jiamin Pan | 2023 | Journal of Environmental Sciences2023，，8： | 0 |
| 10 | Brucellosis Outbreak Caused by Brucella melitensis--Jingyang County,Shaanxi Province,China,March–May,2020显示文摘What is already known about this topic?Brucellosis is one of the world’s most overlooked zoonotic diseases,and humans can easily acquire brucellosis from animals and their products.Reemerging brucellosis outbreaks are probably attributable to sociocultural factors and compounded by the lack of adequate control measures in sheep and goat rearing systems.What is added by this report?This is the first identified outbreak caused by Brucella melitensis bv.3 in Jingyang County,Xianyang City,Shaanxi Province.A total of 13 seropositve cases(7 acute patients and 6 asymptomatic persons)were identified from March to May,2020,and the investigation indicated that sheep-to-canine-to-human was the likely transmission route.What are the implications for public health practice?Effective control of sheep brucellosis will significantly reduce the risk of human brucellosis.Priority should be given to building cooperation between all stakeholders,maintaining epidemiological surveillance to detect human brucellosis at medical centers,and making case reporting mandatory for both veterinary and public health services. | Wenhui Chang Yangxin Sun Suoping Fan Cuihong An Shoumin Nie Guozhong Tian Boyan Luo Hongxun Yang Xiaohua Zhai Haiying Tian Jia Zhang Hai Jiang | 2020 | China CDC weekly2020，2，39： | 0 |
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