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| 1 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 3 | Myocardin-related transcription factor A is up-regulated by 17β-estradiol and promotes migration of MCF-7 breast cancer cells via transactivation of MYL9 and CYR61显示文摘证据的许多线建议了雌激素不仅在乳癌的开始和增长,而且在癌症转移起重要作用。然而,后者事件的机械学的基础糟糕被理解。另外,最近的研究建议了那 myocardin 相关的抄写因素 A (MRTF -- 一) 可能与癌症有关转移。然而报告是矛盾的它的角色肯定尚待糊涂。在现在的学习,我们证明过多的 17-estradiol 能支持 MCF-7 乳癌房间和起来调整的迁居 MRTF 的表示 -- 一,肌浆球蛋白规章的轻链 9 (MYL9 ) ,并且充满半胱氨酸的 angiogenic inducer 61 (CYR61 ) 。MRTF 的 Overexpression -- A 显著地在 MYL9 和 CYR61 基因上通过它的 transactivation 效果支持了 MCF-7 房间的移植,当时 RNA 调停干扰 MRTF 击倒 -- A 强烈禁止了目标基因的抄写和表示并且减少了 MCF-7 房间的移植能力。这些结果提供了支持 MRTF 的支持转移的功能的新奇证据 -- 一,并且暗示了那 MRTF -- A 可能是一个开关让雌激素小径在乳癌把它的支持增长的角色变成刺激迁居的角色。 | Chunling Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 3 |
| 4 | Yielding behavior of triplex medium Mn steel alternated with cooling strategies altering martensite/ferrite interfacial feature显示文摘In this paper, we report the influence of cooling processes on the yielding behavior of a medium Mn steel(MMS) with triplex microstructure, i.e. austenite(γ), ferrite(α) and as-quenched martensite(α’). After the intercritical annealing(IA) at both 725℃ and 750℃, the steel was subjected to the two cooling processes, i.e. air cooling(AC) and water quenching(WQ). It exhibits the discontinuous yielding after the AC following the IA at 750℃ while the continuous yielding after the WQ. Compared with WQ process,both the dilatometry and the microstructural examinations show that the AC process leads to lower Ms temperature, larger retained austenite(RA) fraction and less martensite, the latter is always companied with geometry necessary dislocations(GNDs) generated near the α/α’ interfaces. Considering the complexity of nanosized tri-phases in this steel, the presence of martensite with key features in the resultant specimens was systematically examined by atom probe tomography(APT) on the samples prepared by the specific target lift-out method. The APT results directly revealed the C/Mn co-segregation at the α’/αinterfaces in the AC samples but not in WQ samples. The numerical simulation results further suggest that the segregation of C and Mn at the α’/α interfaces may be due to different mechanisms. We conclude that the yielding of triplex MMS is determined by both the quantity of GNDs generated near theα/α’ interfaces, which increases with martensite fraction, and the extent of their immobilization resulting from the interfacial segregation of solute atoms when the presence of martensite is sufficient. WQ tends to suppress the discontinuous yielding of MMS since the rapid cooling may promote more martensite formed with the increasing quantity of GNDs and prevent the interfacial segregation of both C and Mn. | Bin Hu Xiao Shen Qinyi Guo Qinghua Wen Xin Tu Cancan Ding Fanglin Ding Wenwen Song Haiwen Luo | 2022 | Journal of Materials Science & Technology2022，，31： | 2 |
| 5 | Corrigendum to“SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip”[Sci.Bull.(2021)66(8)783-793]显示文摘The authors would like to correct Fig.2g.An annotation error was introduced in the preparation of this figure for publication.The authors declare that this correction does not change the results or conclusions of this paper.The authors sincerely apologize for having this error in the article,and apologize for any inconvenience caused. | Yaqiong Guo Ronghua Luo Yaqing Wang Pengwei Deng Tianzhang Song Min Zhang Peng Wang Xu Zhang Kangli Cui Tingting Tao Zhongyu Li Wenwen Chen Yongtang Zheng Jianhua Qin | 2021 | Science Bulletin2021，66，20： | 2 |
| 6 | Histone acetyltransferase p300 promotes MKLl-mediated transactivation of catechol-O-methyltransferase gene显示文摘以前的研究表明了 histone acetyltransferase p300 被招募到某些心脏、光滑的肌肉的倡导者特定的基因到提高 myocardin 的 transactivation 活动,它是在心血管的区别和开发的一个主人管理者。这里,我们发现编码 catechol-O-methyltransferase (COMT ) 的基因,催化雌激素的变换的重要的新陈代谢的酶,也是 myocardin 相关的抄写因素(MRTF ) 的目标基因。Megakaryoblastic 白血病 1 (MKL1,也命名的 MRTF -- 一) 并且 p300 能 synergistically 扩充 COMT 基因的表示,增加雌激素的新陈代谢的率,并且因此减少雌激素刺激的 MCF-7 乳癌房间的增长。 | Zhipeng Liu Xuegang Luo Lei Liu Wenwen Zhao Shu Guo Yu Guo Nan Wang Hongpeng He XinghuaLiao Wenjian Ma Hao Zhou Tongcun Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 1 |
| 7 | Identification of key taste components in Baccaurea ramiflora Lour.fruit using non-targeted metabolomics显示文摘Among the numerous fruit species of Baccaurea ramiflora Lour.,‘LR’(white flesh)and‘BR’(pink flesh)are two kinds of local strains with high edibility.In order to study the metabolic causes of taste differences,we performed the non-targeted metabonomics analysis of‘LR’and‘BR’using LC-MS/MS.541 metabolites were totally identified,and 45 kinds of metabolites(carbohydrates,fatty acids,flavonoids and terpenoids,etc.)were different between the two strains.The results indicate L-sorbose,D-(+)-glucose,citric acid,L-phenylalanine and oleamide,α-eleostearic acid were the main primary metabolites.The significant difference existed in pathways of unsaturated fatty acids between the studied two strains by pathway enrichment analysis.The results demonstrate that the different in composition,as well as the abundance of primary and secondary metabolites may be the potential causes of taste differences,which provides a new insight into the possible metabolic factors setting off the changing taste of B.ramiflora. | Jie Chen Fengnian Wu Huachen Wang Chunce Guo Wengen Zhang Peisi Luo Jing Zhou Wenwen Hao Guangyao Yang Jianjian Huang | 2023 | Food Science and Human Wellness2023，12，1： | 1 |
| 8 | Effect of different pruning operations on the plant growth,phytohormones and transcriptome profiles of the following spring tea shoots显示文摘Pruning as an important agronomic operation plays a crucial role in the regulation of tea plant growth,development and dry tea quality.The effects of different pruning operations on the plant growth,phytohormones and transcriptome profiles of the following spring tea shoots were studied.Pruning-treated samples had generally increased median of the weight of 100 buds(two leaves and one bud,15.5−20.5 g)and longer stem diameter(1.7−1.8 mm)whereas shorter shoot length(34.6−59.2 mm)at the stage of two leaves and one bud,compared with unpruned samples(14.0 g,1.7 mm,87.4 mm),among which heavy pruning in mid April and early May greatly accelerated the development of the following spring tea shoots.The levels of phytohormones(auxin,gibberellin 1,gibberellin 3,and trans-zeatin)were significantly increased in the spring buds of tea plants heavily pruned in May.The KEGG result indicated that the pathways of plant–pathogen interaction,plant hormone signal transduction and circadian rhythm were regulated by different pruning treatments.Heavy pruning in April or May,without autumn pruning was suitable for producing premium green tea due to the early development and the higher weight of 100 buds.This study provides scientific guidance to regulate the growth of the following spring tea shoots using plant pruning operations. | Lu Lu Wenwen Luo Yanan Zheng Jing Jin Ruyi Liu Yiqing Lv Ying Ye Jianhui Ye | 2022 | Beverage Plant Research2022，2，1： | 1 |
| 9 | A study on quantitative radar rainfall measurements by the method of set-pair analysis 显示文摘 | Luo Peng Song Xingyuan Tian Wenwen | 2009 | Global Congress on Intelligent Systems2009，，2： | 1 |
| 10 | Histone methyltransferase SMYD3 promotes MRTF-Amediated transactivation of MYL9 and migration of MCF-7 breast cancer cells显示文摘 | Luo Xuegang Zhang Chunling Zhao Wenwen | 2014 | Cancer Letters2014，344，1： | 1 |
| 11 | Modelling the effects of soil water potential on growth and quality of cut chrysanthemum ( Chrysanthemum morifolium )显示文摘 | Lu Lin Wenwen Li Jingqing Shao Weihong Luo Jianfeng Dai Xinyou Yin Yanbao Zhou Chunjiang Zhao | 2011 | Scientia Horticulturae2011，，1： | 1 |
| 12 | Histone methyltransferase SMYD3 promotes MRTF-Amediated transactivation of MYL9 and migration of MCF-7 breast cancer cells显示文摘 | Luo Xuegang Zhang Chunling Zhao Wenwen | 2014 | Cancer Letters2014，344，1： | 1 |
| 13 | On the extendability of certain semi-Cayley graphs of finite abelian groups显示文摘 | Xing Gao Wenwen Liu Yanfeng Luo | 2011 | Discrete Mathematics2011，，17： | 1 |
| 14 | Detection of Aspartic Acid in Fermented Cordyceps Powder Using Near Infrared Spectroscopy Based on Variable Selection Algorithms and Multivariate Calibration Methods显示文摘 | Chu Zhang Ning Xu Liubin Luo Fei Liu Wenwen Kong Lei Feng Yong He | 2014 | Food and Bioprocess Technology2014，，2： | 1 |
| 15 | Histopathological and biochemical alternations of the heart induced by acute cadmium exposure in the freshwater crab Sinopotamon yangtsekiense显示文摘 | Wenwen Lei Lan Wang Dongmei Liu Tuan Xu Jixian Luo | 2011 | Chemosphere2011，，5： | 1 |
| 16 | Thermal degradation of the polyimide synthesized from 4,4'-(hexafluoroisopropylidene) diphthalic dianhydride and 4,4'-diaminodiphenylmethane 显示文摘 | Ren Li Fu Wenwen Luo Yuanfang | 2004 | Journal of Applied Polymer Science2004，91，4： | 1 |
| 17 | Expression characteristics of astrocyte elevated gene-1 (AEG-1) in tongue carcinoma and its correlation with poor prognosis显示文摘 | Zun-fu Ke Shanyang He Shuhua Li Dongyuan Luo Chongjin Feng Wenwen Zhou | 2012 | Cancer Epidemiology2012，，： | 1 |
| 18 | Crystal structures of main proteases of SARS-CoV-2 variants bound to a benzothiazole-based inhibitor显示文摘Main protease(Mpro)serves as an indispensable factor in the life cycle of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as well as its constantly emerging variants and is therefore considered an attractive target for antiviral drug development.Benzothiazole-based inhibitors targeting Mpro have recently been investigated by several groups and proven to be promising leads for coronaviral drug development.In the present study,we determine the crystal structures of a benzothiazole-based inhibitor,YH-53,bound to Mpro mutants from SARS-CoV-2 variants of concern(VOCs)or variants of interest(VOIs),including K90R(Beta,B.1.351),G15S(Lambda,C.37),Y54C(Delta,AY.4),M49I(Omicron,BA.5)and P132H(Omicron,B.1.1.529).The structures show that the benzothiazole group in YH-53 forms a C-S covalent bond with the sulfur atom of catalytic residue Cys145 in SARSCoV-2 Mpro mutants.Structural analysis reveals the key molecular determinants necessary for interaction and illustrates the binding mode of YH-53 to these mutant Mpros.In conclusion,structural insights from this study offer more information to develop benzothiazole-based drugs that are broader spectrum,more effective and safer. | Jiqing Luo Weiwei Wang Haihai Jiang Wenwen Li Pei Zeng Jie Wang Xuelan Zhou Xiaofang Zou Shenghui Chen Qisheng Wang Jin Zhang Jian Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 19 | Multiphase-field simulation of austenite reversion in medium-Mn steels显示文摘Medium-Mn steels have attracted immense attention for automotive applications owing to their outstanding combination of high strength and superior ductility.This steel class is generally characterized by an ultrafine-grained duplex microstructure consisting of ferrite and a large amount of austenite.Such a unique microstructure is processed by intercritical annealing,where austenite reversion occurs in a fine martensitic matrix.In the present study,austenite reversion in a medium-Mn alloy was simulated by the multiphase-field approach using the commercial software MICRESS®coupled with the thermodynamic database TCFE8 and the kinetic database MOBFE2.In particular,a faceted anisotropy model was incorporated to replicate the lamellar morphology of reversed austenite.The simulated microstructural morphology and phase transformation kinetics(indicated by the amount of phase)concurred well with experimental observations by scanning electron microscopy and in situ synchrotron high-energy X-ray diffraction,respectively. | Yan Ma Rui Zheng Ziyuan Gao Ulrich Krupp Hai-wen Luo Wenwen Song olfgang Bleck | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，5： | 0 |
| 20 | Corrigendum to “The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs” [Genes & Diseases 5 (2018) 62–74]显示文摘The authors regret having an image assembly error in Figure 5Ca,in which the image for the 'Oh dBiFP-AdRFp'group was erroneously duplicated with an overlapping image from the'36h BiFP dBIFP-AdR-simH19'group.We confirm the error is restricted to the image assembly,and the underlying data and conclusions are correct and unchanged.The authors would like to apologize for any inconvenience caused. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C. Haydon Hue H. Luu Lan Zhou Russell R. Reid Tong-Chuan He Xingye Wu | 2023 | Genes & Diseases2023，10，2： | 0 |
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