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| 1 | Incidence and mortality of laryngeal cancer in China,2008–2012显示文摘Objective:To analyze the incidence and mortality rates of laryngeal cancer in China from 2008 to 2012.Methods:Incident and death cases of laryngeal cancer were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008–2012.The crude incidence and mortality rates of laryngeal cancer were calculated by area(urban/rural),region(eastern,middle,western),gender and age group(0,1–4,5–9,…,85+).China census in 2000 and Segi’s world population were applied for age standardized rates.Join Point(Version 4.5.0.1)model was used for time trend analysis.Results:The crude incidence rate of laryngeal cancer was 1.86/100,000 ranked the 21st in overall cancers.The age-standardized incidence rates by China population(ASIRC)and by World population(ASIRW)were1.22/100,000 and 1.23/100,000,respectively.The crude mortality of laryngeal cancer in China was 1.01/100,000and it was the 21st cause of cancer-related death in overall cancers.Both the age-standardized mortality rates by Chinese standard population(ASMRC)and by world standard population(ASMRW)were 0.63/100,000.Incidence and mortality rates of laryngeal cancer were higher in males than in females and higher in urban areas than in rural areas.Middle areas had the highest incidence and mortality rates followed by eastern and western areas.Incidence and mortality rates of laryngeal cancer retained low level before age of 40 years old but increased greatly after and peaked in age group of 75.Incidence showed significant down trends in recent 10 years by 1.27%annually[95%confidence interval(95%CI):–2.2%,–0.3%].Mortality declined in females sharply by 5.18%per year although stable in males and both sexes combined.Conclusions:Appropriate targeted prevention,early detection and treatment programs should be carried out to control the local burden of laryngeal cancer. | Yuqin Liu Qin Zhao Gaoheng Ding Yitong Zhu Wenying Li Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，3： | 29 |
| 2 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 3 | DNA barcoding of the fungal genus Neonectria and the discovery of two new species显示文摘To determine a suitable DNA barcode for the genus Neonectria,the internal transcribed spacer rDNA,β-tubulin,EF-1α,and RPB2 genes were selected as candidate markers.A total of 205 sequences from 19 species of the genus were analyzed.Intra-and inter-specific divergences and the ease of nucleotide sequence acquisition were treated as criteria to evaluate the feasibility of a DNA barcode.Our results indicated that any single gene among the candidate markers failed to serve as a successful barcode,while the combination of the partial EF-1α and RPB2 genes recognized all species tested.We tentatively propose the combined partial EF-1α and RPB2 genes as a DNA barcode for the genus.During this study,two cryptic species were discovered,based on the combined data of morphology and DNA barcode information.We described and named these two new species N.ditissimopsis and N.microconidia. | ZHAO Peng LUO Jing ZHUANG WenYing LIU XingZhong WU Bing | 2011 | Science China(Life Sciences)2011，54，7： | 15 |
| 4 | Genome-Wide Analysis of Histone Modifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica显示文摘当以前的研究证明了 histone 修正能由调整基因抄写影响工厂生长和开发时,在这些修正和基因表示之间的关系的知识仍然是有限的。这研究使用了高产量的定序跟随的染色质 immunoprecipitation (ChIP-Seq ) ,到调查四 histone 修正的染色体宽的分发:H3K4 (H3K4me2 和 H3K4me3 ) 和在 Oryza sativa L 的 H3K9 和 H3K27 (H3K9ac 和 H3K27ac ) 的 acylation 的 di 和 trimethylation。装饰用的梨树。由分析出版 DNase-Seq 数据,这研究探索了 DNase 过分敏感(DH ) 沿着米饭染色体的地点。histone 标记主要在通用区域出现了并且在基因的抄写开始地点(TSS ) 附近被充实。这分析证明四 histone 修正和 DH 地点都与活跃抄写被联系。而且,四 histone 修正与答应被用来在米饭基因注解预言失踪的基因的特征的抄本 regionsa 是高度并发的。预言被试验性地证实二的抄写预言了失踪的基因进一步验证。而且,顺序主题分析被构造以便识别 DH 地点和许多通常认为的抄写因素绑定地点。 | Zhou Du Hui Li Qiang Wei Xin Zhao Chunchao Wang Qilin Zhu Xin Yi Wenying Xua X. Shirley Liu Weiwei Jin Zhen Su | 2013 | Molecular Plant2013，6，5： | 8 |
| 5 | Isolation and oral immunogenicity assessment of porcine epidemic diarrhea virus NH-TA2020 strain:One of the predominant strains circulating in China from 2017 to 2021显示文摘Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets.Maternal vaccines can effectively enhance the gut-mammary gland-secretory IgA axis to boost lactogenic immunity and passive protection of nursing piglets against PEDV challenge.From 2017 to 2021,we collected 882 diarrhea samples from 303 farms in China to investigate the epidemiology of PEDV.The result showed that about 52.15%(158/303)of the farms were positive for PEDV with an overall detection rate of 63.95%(564/882)of the samples.The S1 fragments of S gene from 104 strains were sequenced for the phylogenetic analysis.A total of 71 PEDV strains(68.27%)sequenced in this study were clustered into the predominant G2c subgroup,while the newly-defined G2d strains(9.62%)were identified in three provinces of China.The NH-TA2020 strain of G2c subgroup was isolated and cultured,and its infection to piglets caused watery diarrhea within 24 h,indicating its strong pathogenicity.Oral administration of NH-TA2020 strain to pregnant gilts stimulated high levels of IgA antibody in colostrum.The piglets fed by the gilts above were challenged with NH-TA2020 strain or CH-HeB-RY-2020 strain from G2d subgroup,and the clinical symptoms and virus shedding were significantly reduced compared to the mock group.Our findings suggest that G2c subgroup is the predominant branch circulating in China from 2017 to 2021.Oral administration of NH-TA2020 enhances maternal IgA and lactogenic immune responses,which confer protection against the homologous and emerging G2d PEDV strains challenges in neonates. | Xiaowen Li Yang Li Jiapei Huang Yali Yao Wenying Zhao Yunjing Zhang Jie Qing Jing Ren Zhong Yan Zewei Wang Xiaofang Hu Duli Kang Hongqiang Liu Zhichun Yan | 2022 | Virologica Sinica2022，37，5： | 6 |
| 6 | Selection of a DNA barcode for Nectriaceae from fungal whole-genomes显示文摘A DNA barcode is a short segment of sequence that is able to distinguish species. A barcode must ideally contain enough variation to distinguish every individual species and be easily obtained. Fungi of Nectriaceae are economically important and show high species diversity. To establish a standard DNA barcode for this group of fungi, the genomes of Neurospora crassa and 30 other filamentous fungi were compared. The expect value was treated as a criterion to recognize homologous sequences. Four candidate markers, Hsp90, AAC, CDC48, and EF3, were tested for their feasibility as barcodes in the identification of 34 well-established species belonging to 13 genera of Nectriaceae. Two hundred and fifteen sequences were analyzed. Intraand inter-specific variations and the success rate of PCR amplification and sequencing were considered as important criteria for estimation of the candidate markers. Ultimately, the partial EF3 gene met the requirements for a good DNA barcode: No overlap was found between the intra-and inter-specific pairwise distances. The smallest inter-specific distance of EF3 gene was 3.19%, while the largest intra-specific distance was 1.79%. In addition, there was a high success rate in PCR and sequencing for this gene (96.3%). CDC48 showed sufficiently high sequence variation among species, but the PCR and sequencing success rate was 84% using a single pair of primers. Although the Hsp90 and AAC genes had higher PCR and sequencing success rates (96.3% and 97.5%, respectively), overlapping occurred between the intraand inter-specific variations, which could lead to misidentification. Therefore, we propose the EF3 gene as a possible DNA barcode for the nectriaceous fungi. | ZENG ZhaoQing ZHAO Peng LUO Jing ZHUANG WenYing YU ZhiHe | 2012 | Science China(Life Sciences)2012，55，1： | 6 |
| 7 | Dual-mode emission of single-layered graphene quantum dots in confined nanospace: Anti-counterfeiting and sensor applications显示文摘为 graphene 量点(GQD ) 的光性质的工程提出二庞大的挑战:1 ) GQD 的 bandgap 被结构的缺点(sp 2 和 sp 3 领域的尺寸,形状,和部分) 主要决定,它导致 non-stoichiometric 自然;2 ) 准备方法限制 GQD 的精确化学结构的成就,在在结构的缺点和 bandgaps 之间的关系上导致许多争论解释。这里,有准确结构的单人赛分层的 GQD 被获得由在原处在分层的双氢氧化物(LDH ) 的限制 nanospace 的设置的先锋的反应。随后,结构性质关系被揭开,表明提高的荧光并且激活同样准备的 GQDs-LDHs 的房间温度磷光,它从 synergistic 效果发源:1 ) 强壮的监禁由 LDH 的 nanospace 提供了;2 ) 源于 LDH 的 GQD 的表面上的富有的包含 O 功能的组催化作用。而且,无色性质和 GQDs-LDHs 的双排放的特征为保护珍贵文件作为伪造反的标记满足前提(钞票,商业发票,等等) 。特别地由于 GQD 和 LDH 的可食的性质的低毒性, GQDs-LDHs/gelatin 囊能是食物和药的地里的潜在的绿伪造反的材料的新一代。 | Liqian Bai Ning Xue Yufei Zhao Xinrui Wang Chao Lu Wenying Shi | 2018 | Nano Research2018，11，4： | 4 |
| 8 | Autophagy as new emerging cellular effect of nanomaterials显示文摘The biosafety issue of nanoscale materials is getting more and more attention with their increasing manufacture and application.In the research of cellular effects and underlying mechanisms related to toxicity of nanomaterials,most emphasis were placed on processes such as apoptosis,metabolic inhibition and oxidative stress.Recent evidence suggests that autophagy is part of the biological effects by nanomaterials and various kinds of nanomaterials are capable of disturbing the autophagic process.This review will highlight the importance of autophagy as an emerging mechanism of nanomaterial toxicity and the implication in the therapy of autophagy-related diseases.We summarize current research status of interaction between nanomaterials and autophagic pathways.It is of note that nanomaterials can either induce or block autophagy,which result in similar phenotype but completely different biological consequence.It is therefore important to perform comprehensive analysis of the whole autophagic flux in the future research. | ZHONG WenYing Lü Min LIU LiYing SUN JinLi ZHONG ZengTao ZHAO Yun SONG HaiYun | 2013 | Chinese Science Bulletin2013，58，33： | 3 |
| 9 | Iron oxide nanoparticles with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy显示文摘Metal-based nanomaterials usually have broad-spectrum antibacterial properties,low biological toxicity and no drug resistance due to their intrinsic enzyme-like catalytic properties and external field(magnetic,thermal,acoustic,optical and electrical)responsiveness.Herein,iron oxide(Fe_(3)O_(4))nanoparticles(IONPs)synthesized by us have good biosafety,excellent photothermal conversion ability and peroxidase-like catalytic activity,which can be used to construct a photothermal-enzymes combined antibacterial treatment platform.IONPs with peroxide-like catalytic activity can induce H_(2)O_(2)to catalyze the production of·OH in a slightly acidic environment,thus achieving certain bactericidal effects and increasing the sensitivity of bacteria to heat.When stimulated by near-infrared light,the photothermal effect could destroy bacterial cell membranes,resulting in cleavage and inactivation of bacterial protein,DNA or RNA.Meanwhile,it can also improve the catalytic activity of peroxidase-like and promote IONPs to catalyze the production of more·OH for killing bacteria.After IONPs synergistic treatment,the antibacterial rate of Escherichia coli and Staphylococcus aureus reached nearly 100%.It also has an obvious killing effect on bacteria in infected wounds of mice and can effectively promote the healing of S.aureusinfected wounds,which has great application potential in clinical anti-infection treatment. | Jiaxin Guo Wenying Wei Yanan Zhao Honglian Dai | 2022 | Regenerative Biomaterials2022，9，1： | 3 |
| 10 | Dynamic Response of Phragmites australis and Suaeda salsa to Climate Change in the Liaohe Delta Wetland显示文摘Because of its unique geographical location and ecological function, the Liaohe Delta Wetland is important in maintaining regional ecological balance and security. Monitoring and evaluating changes in the wetland are therefore of great importance. We used medium-and high-resolution satellite data, meteorological station data, and site measurement data to analyze changes in the area and spatial distribution of Phragmites australis and Suaeda salsa in the Liaohe Delta Wetland from 1998 to 2017, as well as their growth response to the climate change. The results showed that during 1998–2017, the areas of both P. australis and S. salsa wetlands alternated through periods of decreasing,increasing, and then decreasing trends. The annual change in the area and spatial distribution range of S. salsa fluctuated more than that of P. australis. The annual variation of normalized difference vegetation index(NDVI) in P. australis wetland showed an upward trend from 1998 to 2017. The area of P. australis cover that was improved, unchanged, and decreased accounted for 81.8%, 12.3%, and 5.9%, respectively, of the total area;evaporation and wind speed were the main meteorological factors affecting the NDVI;and contribution rates of the climate change and human activities to the NDVI were 73.2% and 26.8%, respectively. The area with vegetation cover being mainly S.salsa that was improved, unchanged, and decreased accounted for 63.3%, 18.3%, and 18.4%, respectively, of the total area;and no meteorological factors significantly affected the NDVI of S. salsa in the region. The interaction between vegetation growth and meteorological factors may help to explain the increasing trend in vegetation cover.The improvement in wetland vegetation also led to carbon sequestration and an increase in sequestration capacity. | Yushu ZHANG Wenying YU Ruipeng JI Yijun ZHAO Rui FENG Qingyu JIA Jinwen WU | 2021 | Journal of Meteorological Research2021，35，1： | 3 |
| 11 | IAP's Solar-Powered Unmanned Surface Vehicle Actively Passes through the Center of typhoon Sinlaku(2020)显示文摘The solar-powered marine unmanned surface vehicle(USV) developed by the USV team of the Institute of Atmospheric Physics is a rugged, long-duration, and autonomous navigation vessel designed for the collection of longrange, continuous, real-time, meteorological and oceanographic measurements, especially under extreme sea conditions(sea state 6–7). These solar-powered USVs completed a long-term continuous navigation observation test over 26 days.During this time, they coordinated double-USV observations and actively navigated into the path of Typhoon Sinlaku(2020) before collecting data very close to its center during the 2020 USV South China Sea Typhoon Observation Experiment. Detailed high temporal resolution(1 min) real-time observations collected by the USV on the typhoon were used for operational typhoon forecasting and warning for the first time. As a mobile meteorological and oceanographic observation station capable of reliable, automated deployment, data collection, and transmission, such solar-powered USVs can replace traditional observation platforms to provide valuable real-time data for research, forecasting, and early warnings for potential marine meteorological disasters. | Hongbin CHEN Jun LI Wenying HE Shuqing MA Yingzhi WEI Jidong PAN Yu ZHAO Xuefen ZHANG Shuzhen HU | 2021 | Advances in Atmospheric Sciences2021，38，4： | 2 |
| 12 | Coal Chemical In-dustry and its Sustainable Development in China显示文摘 | Xie Kechang Li Wenying Zhao Wei | 2009 | Ener-gy2009，，： | 1 |
| 13 | Caspase‐3 Modulates Regenerative Response After Stroke显示文摘 | Wenying Fan Yiqin Dai Haochen Xu Ximin Zhu Ping Cai Lixiang Wang Chungang Sun Changlong Hu Ping Zheng Bing‐Qiao Zhao | 2014 | Stem Cells2014，，2： | 1 |
| 14 | Self-as- sembly of layered double hydroxide nanosheets/Au nanopar- ticles ultrathin films for enzyme-free electrocatalysis of glu- cose显示文摘 | Zhao Jingwen Kong Xianggui Shi Wenying | 2011 | J Mater Chem2011，21，36： | 1 |
| 15 | Coal Chemical Industry and Its Sustainable Development in China显示文摘 | XIE Kechang LI Wenying ZHAO Wei | 2010 | Energy2010，35，11： | 1 |
| 16 | Coal Chemical Industry and Its Sustainable Development in China显示文摘 | Xie Kechang Li Wenying Zhao Wei | 2010 | Energy2010，90，8： | 1 |
| 17 | A novel protein L-cofilin2 identified in Lampetra morii with roles of immune response and cell proliferation promotion显示文摘Cofilin2,an actin-binding protein,is expressed in many eukaryotic cells.It binds to and depolymerizes the actin filaments,and its activity is regulated by phosphorylation,dephosphorylation,and pH[1].Cofilins have been reported to have multiple functions,including cytokinesis,cell locomotion[2],cellular stress responses[3],and pathological situations[4].Under normal conditions,cofilins can regulate the reorganization of actin.Cofilins can also alter the cell function in response to stress conditions through binding with actin.Other functions of cofilins remain to be explored. | Yingying Li Yu Zuo Wenying Zhang Yihua Zhao Qingwei Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 1 |
| 18 | Coal Chemical Industry and Its Sustainable Development in China显示文摘 | Xie Kechang Li Wenying Zhao Wei | 2010 | Energy2010，35，11： | 1 |
| 19 | Coal Chemical Industry and its Sustainable Development in Chinap显示文摘 | Xie Kechang Li Wenying Zhao Wei | 2009 | Energy2009，，： | 1 |
| 20 | Fabrication of aluminum-doped tt-Ni(OH)2 with hierarchical architecture and its largely enhanced electrocatalytic performance显示文摘 | Kong Xianggui Zhao Jingwen Shi Wenying | 2012 | Electrochimica Acta2012，80，2： | 1 |
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