|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neurotherapeutic potential of erythropoietin after ischemic injury of the central nervous system显示文摘Erythropoietin (EPO) is one of the most successful biopharmaceuticals in history and is used for treating anemia of different origins. However, it became clear that EPO could also work in a neuroprotective, antiapoptotic, antioxidative, angiogenetic and neurotropic way. It causes stimulation of cells to delay cell apoptosis, especially in the central nervous system. In rodent models of focal cerebral ischemia, EPO showed an impressive reduction of infarct size by 30% and improvement of neurobehavioral outcome by nearly 40%. A large animal model dealing with ischemia and reperfusion of the spinal cord showed that EPO could reduce the risk of spinal cord injury significantly. In addition, some clinical studies tested whether EPO works in real live clinical settings. One of the most promising studies showed the innocuousness and improvements in follow-up, outcome scales and in infarct size, of EPO-use in humans suffering from ischemic stroke. Another study ended unfortunately in a negative outcome and an increased overall death rate in the EPO group. The most possible reason was the involvement of patients undergoing simultaneously systemic thrombolysis with recombinant tissue plasminogen activator. An experimental study on rats demonstrated that administration of EPO might exacerbate tissue plasminogen activator-induced brain hemorrhage without reducing the ischemic brain damage. This case shows clearly how useful animal models can be to check negative side effects of a treatment before going into clinical trials. Other groups looked in human trials at the effects of EPO on the outcome after ischemic stroke, relation to circulating endothelial progerdtor cells, aneurysmal subarachnoid hemorrhage, traumatic brain injury, hemoglobin transfusion thresholds and elective first-time coronary artery bypass surgery. Most of the results were pos-让ive, but are based mostly on small group sizes. However, some of the most neglected facts when focusing on experimental setups of ischemia of the central nervous system are issues like age and comorbidities. It might be extremely worthy to consider these points for future projects, because EPO might influence all these factors. | Florian Simon Nicolaos Floros Wiebke Ibing Hubert Schelzig Artis Knapsis | 2019 | Neural Regeneration Research2019，14，8： | 15 |
| 2 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 3 | 牙列缺失患者种植体支持的固定和可摘义齿的回顾性研究显示文摘目的:研究十年观察期内种植体支持的固定和可摘义齿修复牙列缺失患者种植体的生存率和影响因素。方法:1995-2006年,227例患者(92例男性,135例女性)平均年龄63.7岁,在Charite’大学口腔颌面外科门诊接受种植和修复治疗。共1652颗种植体种植在牙列缺失上颌骨、下颌骨或双侧颌骨,支持76例(24.68%)固定义齿,232例(75.32%)可摘义齿。观察性别,种植体部位、修复方法对种植体生存率的影响。结果:其中有50例患者73颗种植体丧失,累计种植体生存率94.76%,本研究显示种植体生存率女性(93.93%)略低于男性(95.93%),但没有显著性差异。在上颌骨种植的种植体生存率(95.87%)略高于在下颌骨种植(94.53%),但统计学没有显著性意义。10年累计固定和可摘义齿的种植体生存率分别是98.02%和93.55%,两种修复方法差异有显著性。结论:确认了种植体支持牙列缺失患者修复中长期的成功率,并得出结论种植体生存率与性别,种植部位关系不大,与修复方法有关。种植体支持的固定义齿预后比可摘义齿好。 | 项立新 熊亚茸 Katja Nelson Susanne Heberer Semper Wiebke | 2010 | 口腔颌面修复学杂志2010，11，1： | 8 |
| 4 | Genome Sequence of Helicobacter pylori hpEurope Strain N6显示文摘 | Wiebke Behrens Tobias B?nig Sebastian Suerbaum Christine Josenhans | 2012 | Journal of Bacteriology2012，，14： | 2 |
| 5 | A Margin-Negative R0 Resection Accomplished With Minimal Postoperative Complications Is the Surgeon’s Contribution to Long-Term Survival in Pancreatic Cancer显示文摘 | Thomas J. Howard Joseph E. Krug Jian Yu Nick J. Zyromski C. Max Schmidt Lewis E. Jacobson James A. Madura Eric A. Wiebke Keith D. Lillemoe | 2006 | Journal of Gastrointestinal Surgery2006，，10： | 2 |
| 6 | Porcine Torque teno virus: Determination of viral genomic loads by genogroup-specific multiplex rt-PCR, detection of frequent multiple infections with genogroups 1 or 2, and establishment of viral full-length sequences显示文摘 | Andreas Gallei Stefan Pesch Wiebke Schulze Esking Christoph Keller Volker Fred Ohlinger | 2009 | Veterinary Microbiology2009，，2： | 2 |
| 7 | Pancreatic Fistula Following Pancreaticoduodenectomy: Clinical Predictors and Patient Outcomes显示文摘 | C. Max Schmidt Jennifer Choi Emilie S. Powell Constantin T. Yiannoutsos Nicholas J. Zyromski Attila Nakeeb Henry A. Pitt Eric A. Wiebke James A. Madura Keith D. Lillemoe William Jarnagin | 2009 | HPB Surgery2009，，： | 2 |
| 8 | Dehydroepiandrosterone replacement therapy显示文摘 | Wiebke A Bruno A | 2001 | Curr Opin Endocrinol Diab2001，8，： | 1 |
| 9 | Randomized trial of immune-enbancing enteral nutrition in burn patients 显示文摘 | Saffle JR Wiebke G Jenniogs K | 1997 | J Trauma1997，42，： | 1 |
| 10 | Chemoenymatically induced copolymerization of phenolics with acrylate compounds显示文摘 | Carsten Mai Wiebke Schormann Aloys Hiittermann | 1996 | Enzyme Micrb Technol1996，37，5： | 1 |
| 11 | Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): Occupational Health and Safety Aspects显示文摘 | Wiebke Sola? Urs Giger-Pabst Jürgen Zieren Marc A. Reymond | 2013 | Annals of Surgical Oncology2013，，： | 1 |
| 12 | Porcine Torque teno virus:Determination of viral genomie loads by geno-group-specic multiplex rt-PCR detection of frequent mul- tiple infections with geno groups 1 or 2, and establish- ment of viral full-length sequences 显示文摘 | Andreas G Stefan P Wiebke S E | 2010 | Vet Microbiol2010，143，24： | 1 |
| 13 | Riociguat for the treatment of pulmonary hypertension显示文摘 | Ralph T Schermuly Wiebke Janssen Norbert Weissmann Johannes-Peter Stasch Friedrich Grimminger Hossein Ardeschir Ghofrani | 2011 | Expert Opinion on Investigational Drugs2011，，4： | 1 |
| 14 | Classification and treatment of local septic complications in acute pancreatitis 显示文摘 | HOWARD TJ WIEBKE EA MOGAVER OG | 1995 | Am J Surg1995，170，： | 1 |
| 15 | GABA in the insula - a predictor of the neural response to interoceptive awareness显示文摘 | Wiebking C Duncan NW Tiret B | 2014 | Neuroimage2014，86，： | 1 |
| 16 | Wireless Local Positionin显示文摘 | Vossiek M Wiebking L Gulden P | 2003 | IEEE Microwave magazine2003，，： | 1 |
| 17 | Present status and perspectives of cell-based therapies for liver diseases显示文摘 | Andreas Nussler Sarah Konig Michael Ott Etienne Sokal Bruno Christ Wolfgang Thasler Marc Brulport Geredn Gabelein Wiebke Schormann Maren Schulze Ewa Ellis Matthias Kraemer Frank Nocken Wolfgang Fleig Michael Manns Steven C. Strom Jan G. Hengstler | 2006 | Journal of Hepatology2006，，1： | 1 |
| 18 | Spinal anaesthesia for obstetrics显示文摘 | Wiebke Gogarten | 2003 | Best Practice & Research Clinical Anaesthesiology2003，，3： | 1 |
| 19 | Characterization of aqueous carboxymethylcellulose solutions in terms of their molecular structure and its influence on rhoalogical behaviour显示文摘 | Werner-Michael Kulicke Arne Henning Kull Wiebke Kull | 1996 | Polymer1996，37，13： | 1 |
| 20 | Precipitation of Nanometre-sized Uniform Ceramic Particles inEmulsions显示文摘 | Wiebke Sager | 1993 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1993，79，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员