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| 1 | Mercury adsorption characteristics of HBr-modified fly ash in an entrained-flow reactor显示文摘In this study, the mercury adsorption characteristics of HBr-modified fly ash in an entrained-flow reactor were investigated through thermal decomposition methods. The results show that the mercury adsorption performance of the HBr-modified fly ash was enhanced significantly. The mercury species adsorbed by unmodified fly ash were Hg Cl2,Hg S and Hg O. The mercury adsorbed by HBr-modified fly ash, in the entrained-flow reactor,existed in two forms, Hg Br2 and Hg O, and the HBr was the dominant factor promoting oxidation of elemental mercury in the entrained-flow reactor. In the current study, the concentration of Hg Br2 and Hg O in ash from the fine ash vessel was 4.6 times greater than for ash from the coarse ash vessel. The fine ash had better mercury adsorption performance than coarse ash, which is most likely due to the higher specific surface area and longer residence time. | Yongsheng Zhang Lilin Zhao Ruitao Guo Na Song Jiawei Wang Yan Cao William Orndorff Wei-ping Pan | 2015 | Journal of Environmental Sciences2015，27，7： | 9 |
| 2 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 3 | Temporal pattern of resolution/recurrence of choroidal neovascularization during bevacizumab therapy for wet age-related macular degeneration显示文摘AIM:To characterize temporal pattern of resolution and recurrence of naive choroidal neovascularization(CNV) secondary to wet age-related macular degeneration(AMD) treated with intravitreal bevacizumab on as needed regimen,and to analyze baseline risk factors for CNV resolution or recurrence.METHODS:Ninety-one eyes of 80 patients with newly diagnosed wet AMD were retrospectively studied.All eyes were treated with a round of three monthly intravitreal bevacizumab injections,followed by one additional 'bonus' injection after resolution of CNV activity.During follow-up,eyes were monitored with fluorescein angiography,optical coherence tomography,and best-corrected visual acuity(BCVA).In case of recurrences of CNV activity,eyes were retreated with other rounds of bevacizumab injections following the same treatment protocol.RESULTS:Over a median follow-up of 532d,the median resolution time of CNV activity in the first,second,and third treatment round was 98d,126d,and 111d,respectively.The median recurrence time for the three rounds was 154d,126d,and 151d,respectively.No significant difference in resolution time(P=0.09) or in recurrence time(P=0.11) was detected among treatment rounds.Age(P=0.0082) and lens status(P=0.035) were found to be associated with CNV resolution;for every 1-year increase in age there was 4% greater chance of CNV resolution;Phakic eyes demonstrated a 33% better chance to experience CNV resolution than pseudophakic eyes.For CNV recurrence,lens status(P=0.0009) and gender(P=0.0446) were found to be predictive;pseudophakic eyes had a 3.69-fold greater risk to experience recurrence of CNV activity compared to phakic eyes;males had a 2.19-fold greater risk to experience recurrence of CNV activity than females.No significant BCVA changes among three treatment rounds were noted(P=0.56).CONCLUSION:Resolution time and recurrence time of CNV activity were not significantly different among treatment rounds,suggesting absence of tachyphylaxis to bevacizumab.A cautious decision should be made upon discontinuing treatment in wet AMD eyes of younger or pseudophakic patients,which showed slower response to bevacizumab.In addition,wet AMD eyes of male or pseudophakic patients should be evaluated more carefully after stopping the treatment,because they may have early reactivation of the CNV.BCVA was preserved by bevacizumab treatment despite multiple recurrences. | Haiyan Wang Giulio Barteselli William R.Freeman Su Na Lee Jay Chhablani Sharif El-Emam Lingyun Cheng | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 5 |
| 4 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 5 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 6 | Evalu- ation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with es- sential fatty acids on calcification显示文摘 | BURGESS NA REYNOLDS TM WILLIAMS N | 1995 | Urol Res1995，23，4： | 1 |
| 7 | Escherichia coli enterotoxin B subunit triggers apoptosis of CD8 + cells by activating transcription factor c-myc显示文摘 | SORIANI M WILLIAMS NA HIRST TR | 2001 | Infect Immun2001，69，8： | 1 |
| 8 | Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechano- sensitive arteriolar constriction显示文摘 | Flavahan NA Bailey SR William A | 2005 | Am J Physiol Heart Circ Physiol2005，288，2： | 1 |
| 9 | Estimation of the Nb-Ti-Ta phase diagram 显示文摘 | Li Na William H Warnes | 2001 | IEEE Trans Applied Superconductivity2001，11，1： | 1 |
| 10 | Successful management of external duodenal fistula in a specialized unit显示文摘 | Williams NM Scott NA Irving MH | 1997 | Am J Surg1997，173，： | 1 |
| 11 | Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia显示文摘 | Parvathi Ranganathan Xueyan Yu Caroline Na Ramasamy Santhanam Sharon Shacham Michael Kauffman Alison Walker Rebecca Klisovic William Blum Michael Caligiuri Carlo M. Croce Guido Marcucci Ramiro Garzon | 2012 | Blood2012，，9： | 1 |
| 12 | Incidence and nmnagement of catheter-related sepsis in patients receiving home parenteral nutrition显示文摘 | Williams N Carlson GL Scott NA | 1994 | Br J Surg1994，81，3： | 1 |
| 13 | Systemic inflammatory response exacerbates the neuropsychol-ogical effects of induced hyperammonemia in cirrhosis显示文摘 | Shawcross DL Davies NA Williams R | 2004 | J Hepatol2004，40，2： | 1 |
| 14 | CD4+T cells inhibit growth of Epstein-Barr virus-transformed B cells through CD95-CD95ligand-mediated apoptosis显示文摘 | Wilson AD Redchenko I Williams NA | 1998 | Int Immunol1998，10，： | 1 |
| 15 | ProtocadherinX/Y,a candidate gene-pair for schizophrenia and schizoaffective disorder:a DHPLC investigation of genomic sequence显示文摘 | Giouzeli M Williams NA Lonie LJ | 2004 | Am J Med Genet B Neuropsychiatr Genet2004，129，1： | 1 |
| 16 | CD4+ T cells inhibit growth of Epstein-Barr virus-transformed B cells through CD95-CD9s ligand-mediated apoptosis显示文摘 | Wilson AD Irina R Williams NA | 1998 | Int Immunol1998，10，8： | 1 |
| 17 | CD4 + T cells inhibit growth of Epstein-Barr virus-transformed B cells through CD95-CD95 ligand mediated apoptosis显示文摘 | WILSON AD IRINA R WILLIAMS NA | 1998 | Int Immunol1998，10，8： | 1 |
| 18 | Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis显示文摘 | Shwcross DL Davies NA Williams R | 2004 | Journal of Hepatology2004，40，： | 1 |
| 19 | Successful management of enteralduodenal fistula in a specialized unit显示文摘 | Williams NM Scoff NA Irving MH | 1997 | Am J Surg1997，173，3： | 1 |
| 20 | Trefoil factor family domain peptides显示文摘 | WILLIAMS GR WRIGHT NA | | 0，，： | 1 |
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