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| 1 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017，27，1： | 40 |
| 2 | Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要)显示文摘 | Gao, Y Yao, A Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 25 |
| 3 | Seismological method for prediction of areal rockbursts in deep mine with seismic source mechanism and unstable failure theory显示文摘The research on the rock burst prediction was made on the basis of seismology,rock mechanics and the data from Dongguashan Copper Mine(DCM) ,the deepest metal mine in China.The seismic responses to mining in DCM were investigated through the analyses of the spatio-temporal distribution of hypocenters,apparent stress and displacement of seismic events,and the process of the generation of hazardous seismicity in DCM was studied in the framework of the theory of asperity in the seismic source mechanism.A method of locating areas with hazardous seismicity and a conceptual model of hazardous seismic nucleation in DCM were proposed.A criterion of rockburst prediction was analyzed theoretically in the framework of unstable failure theories,and consequently,the rate of change in the ratio of the seismic stiffness of rock in a seismic nucleation area to that in surrounding area,dS/dt,is defined as an index of the rockburst prediction.The possibility of a rockburst will increase if dS/dt>0,and the possibility of rock burst will decrease if dS/dt<0.The correctness of these methods is demonstrated by analyses of rock failure cases in DCM. | 唐礼忠 XIA K W | 2010 | Journal of Central South University2010，17，5： | 23 |
| 4 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 5 | 二甲双胍通过沉默MATE1表达富集在细胞内选择性抑制KRAS突变转移性结肠癌显示文摘结肠癌(CRC)是常见癌症之一,转移是导致死亡的主要原因。近期研究发现一线化疗药物伊立替康或奥沙利铂联合表皮生长因子受体(EGFR)靶向药物可将转移性结直肠癌(mCRC)患者中位总体生存期提高2年以上。然而,KRAS突变的结肠癌患者(约30%~50%)表现对EGFR靶向药物的耐药性。因此,EGFR靶向药物不能用于KRAS突变的mCRC患者治疗。前期多项研究指出二甲双胍具有抗肿瘤作用,且服用二甲双胍与患者良好预后密切相关。然而,多项回顾性研究发现二甲双胍与癌症患者预后不相关,关于二甲双胍对肿瘤的治疗作用及分子机制尚存在诸多问题和分歧。 | 安华英(编译) Xie J Xia L Xiang W | 2020 | 中华医学杂志2020，100，32： | 5 |
| 6 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 7 | CALCULATION OF 3-D TRANSIENT TEMPERATURE FIELD DURING LASER TRANSFORMATION HARDENING PROCESS显示文摘A three-dimensional transient heat transfer model for laser transformation hardening process has been developed in this paper. The finite size of the laser treated sample, the surface heat loss of the sample, the latent heat of phase transformation and the temperature dependence of thermal properties of materials were considered. The heat source was considered as a moving Gaussian heat flux with a constant velocity. Three-dimension unequally spatial grid explicit finite difference equations, alternating direction implicit finite difference equations and implicit finite difference equations were deduced respectively. Three programs to calculate the temperature field were developed using Fortran language. The transient temperature fields of C22, 42CrMo, C60 steel samples during laser transformation hardening process were calculated using these programs, and the widths and depths of laser transformation hardening zones were also predicted. C22, 42CrMo, C60 steel samples were treated by CO2 laser,the widths and depths of laser transformation hardening zones of these samples were also measured experimentally. The calculated widths and depths of laser transformation hardening zones are in good agreement with the experimental results. | L. W Zhang, R.S. Wang, J. Th.M.De Hosson, Y.L. Xia and F. G. Wang 1) The State Key Lab. for Materials Modification by Laser, Ion and Electron Beams, Dalian University of Technology, Dalian 116023, China 2) Department of Applied Physics, University of Gro | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 4 |
| 8 | Regnase-1, a rapid response ribonuclease regulating nflammation and stress responses显示文摘 | Renfang Mao Riyun Yang Xia Chen Edward W Harhaj Xiaoying Wang Yihui Fan | 2017 | Cellular & Molecular Immunology2017，14，5： | 3 |
| 9 | Projection of the Zhujiang(Pearl) River Delta's potential submerged area due to sea level rise during the 21st century based on CMIP5 simulations显示文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level(GMSL) change and the Zhujiang(Pearl) River Delta(PRD)sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m(uncertainty interval from1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios(representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006–2100. By around the year 2050, the PRD sea level will rise 0.29(0.21 to 0.40) m under RCP2.6, 0.31(0.22 to 0.42) m under RCP4.5, and 0.34(0.25 to 0.46) m under RCP8.5, respectively.By 2100, it will rise 0.59(0.36 to 0.88) m, 0.71(0.47 to 1.02) m, and 1.0(0.68 to 1.41) m, respectively. In addition,considering the extreme value of relative sea level due to land subsidence(i.e., 0.20 m) and that obtained from intermonthly variability(i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5scenario with the upper uncertainty level(i.e., 1.41 m). Accordingly, the potential submerged area is 8.57×103 km2 for the PRD, about 1.3 times its present area. | XIA Jiangjiang YAN Zhongwei ZHOU Wen FONG Soi Kun LEONG Ka Cheng TANG Iu Man CHANG S W LEONG W K JIN Shaofei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
| 10 | 不同MELD评分患者术前临床特征及MELD评分对肝移植术中循环调控的影响显示文摘目的探讨不同MELD评分患者术前的临床特征及MELD评分对终末期肝病病人肝移植手术中循环调控的影响.方法124例2004年1月至12月在加州大学洛杉矶分校医疗中心行肝移植手术病人,根据术前患者MELD评分分为2组,MELD≤30为低MELD评分组,MELD>30为高MELD评分组,比较两组患者术前临床资料、实验室生化指标和术中输血量及升压药使用情况.结果术前凝血酶原时间国际标准化比值(INR)、血清肌酐、血球压积和纤维蛋白原两组间差异有显著性,高MELD评分组术前气管插管机械通气及使用升压药更常见,术中输血量及升压药使用率明显增加.结论高MELD评分患者术前病情较重,术中有较多的并发症,需更严密的麻醉监测和管理. | 杜斌 王晓薇 Victor W Xia 黄青青 何晓峰 | 2009 | 昆明医学院学报2009，30，4： | 2 |
| 11 | Natural Convective Boiling in Vertical Rectangular Narrow Channels 显示文摘 | Xia C Hu W Guo Z Y | 1996 | Experimental Thermal and Fluid Science1996，12，： | 2 |
| 12 | Chimeric calcium/calmodulin-dependent protein kinase in tobacco: differential regulation by calmodulin isoforms显示文摘 | LIU Z XIA M POOVAIAH B W | 1998 | Plant Molecular Biology1998，38，： | 1 |
| 13 | Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo显示文摘 | Xia Q Sung J Chowdhury W | 2006 | Cancer Res2006，66，14： | 1 |
| 14 | Efficient estimation for semivarying-coefficient models显示文摘 | Zhang W Y Tong H | 2004 | Biometrika2004，91，： | 1 |
| 15 | Visible gold in arsenian pyrite at the Shuiyindong Carlin -type gold deposit,Guizhou,China implications for the environment and processes of ore fonnation显示文摘 | Su W C Xia B Zhang H T Zhang X C | 2008 | Ore Geology Reviews2008，33，： | 1 |
| 16 | Identification and characteriza- tion of mouse metastasis-suppressor KISS1 and its G-protein- coupled receptor显示文摘 | Stafford L J Xia C Ma W | 2002 | Cancer Res2002，62，9： | 1 |
| 17 | Mechanical analysis and study on structural parameter of partially earth-anchored cable-stayed bridge part one: mechanical analysis 显示文摘 | Zhang L W Xiao R C Xia R J | 2011 | Applied Mechanics and Materials2011，4447，： | 1 |
| 18 | Single-index volatility models and estimation显示文摘 | Xia Y C Tong H Li W K | 2002 | Statistica Sinica2002，12，3： | 1 |
| 19 | New trends of HCV in-fection in China revealed by genetic analysis of viral se-quences determined from first-time volunteer blood donors显示文摘 | FU Y WANG Y XIA W | 2010 | J Viral Hepat2010，18，1： | 1 |
| 20 | The heavy ion cooler-storage-ring project (HIRFL- CSR) at Lanzhou显示文摘 | XIA J W ZHAN W L WEN B W | 2002 | Nucl Instrum Methods Phys Res A2002，488，12： | 1 |
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