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| 1 | Improvement of wheat drought and salt tolerance by expression of a stress- inducible transcription factorGmDREB of soybean (Glycinemax)显示文摘Under stress conditions such as droughthigh-salinity and low-temperature, the transcription factorof DREB (dehydration responsive element binding proteins)improved efficiently stress resistance by regulating the ex-pression of its downstream genes with various environmentastress resistance in plants. GmDREB gene (GenBank Acces-sion No. AF514908) encoding a stress-inducible transcriptionfactor was cloned by screening a cDNA library of Glycinemax cv. Jinong 27 with yeast one-hybrid method. GmDREBgene was 910 bp in length and encoded 174 amino acids con-taining a conserved AP2/EREBP DNA-binding domain of 58amino acids. Two conserved functional amino acids, valineand glutamic acid, were located on the 14th and the 19thamino acid residues in the conserved structural domain. Analkaline amino acid region (KKR) related to a nuclear local-ization signal was at the N-terminal, while an acidic aminoacid region (DDD) related to trans-activation was at theC-terminal. Plant expression vectors were constructed andtransformed into wheat by bombardment. In total, 13 trans-genic plants with Ubi::GmDREB and 11 transgenic plantswith rd29A::GmDREB were identified from 103 regenerationplants by molecular analysis. The drought and salt tolerancesof T1 transgenic lines with Ubi::GmDREB orrd29A::GmDREB were demonstrated to be improved ascompared to wild type. The result also suggested that bothUbiquitin and rd29A promoters could effectively drive theexpression of the GmDREB gene and enhance drought andsalt tolerance of T1 plants. | GAO Shiqing XU Huijun CHENG Xianguo CHEN Ming XU Zhaoshi LI Liancheng YE Xingguo DU Lipu HAO Xiaoyan MA Youzhi | 2005 | Chinese Science Bulletin2005，50，23： | 30 |
| 2 | Effect of treatment course of comprehensive intervention with Traditional Chinese Medicine on mortality of acquired immunodeficiency syndrome patients treated with combined antiretroviral therapy显示文摘OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with combined antiretroviral therapy(c ART).METHODS:AIDS patients who had taken c ART in a national TCM human immunodeficiency virus treatment trial program(NTCMTP) before 2009 were enrolled in this study and followed for 36 months from November 2009.Patients enrolled in the NTCMTP in 2004 were taken as the first group,those enrolled in 2006 as the second group,and those enrolled in 2009 as the third group.Cumulative survival rates were calculated by the life table method.Survival curves for subgroups were compared by the log-rank test.Hazard ratios were calculated with a Cox proportional hazards model.RESULTS:A total of 1443 AIDS patients were followed for 3 years(4198 person-years).During this period,91(6.3%) patients died and 13(0.9%) were lost to follow-up.The total mortality rate was 2.17/100 person-years.The mortality rate of patients enrolled in the NTCMTP in 2004 was 1.49/100 person-years,which was lower than that of patients enrolled in 2006(2.23/100 person-years) and 2009(3.48/100 person-years).After adjusting for other factors,a shorter time of treatment with TCM,male sex,older age,lower CD4 + T-cell counts,and long-term treatment with c ART were risk factors of mortality.CONCLUSION:Long-term treatment with TCM decreased the mortality risk of AIDS patients.Factors such as being male,older age,CD4+ T-cell counts,and time of treatment with TCM and c ART were correlated with mortality. | Guo Huijun Wang Jian Li Zhengwei Jiang Ziqiang Xu Qianlei Xu Liran | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 3 | Survival of people living with HIV after treatment with Traditional Chinese Medicine in Henan province of China: a retrospective cohortstudy显示文摘OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating PLHIV.METHODS: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard models.RESULTS:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+T-cellcounts.CONCLUSION: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results. | Yantao Jin Zhibin Liu Xiumin Chen Xin Wang Dan Wang Ziqiang Jiang Ying Liu Jian Wang Wen Zou Huijun Guo Liran Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 8 |
| 4 | Differences in acquired immune deficiency syndrome treatment and evaluation strategies between Chinese and Western Medicine显示文摘Complementary and alternative medicine, including Chinese medicine(CM), has been used to treat acquired immune deficiency syndrome(AIDS) for almost 30 years. We aimed to compare the main differences between AIDS treatment and evaluation strategies between CM and Western Medicine(WM), and analyze advantages and disadvantages.The characteristics of integrative medicine(IM),based on CM and WM, include a patient-centered mode of medicine based on evidence. IM focuses on complex intervention and management with systemic and individual treatment. The evaluation indexes of IM might consist of objective indicators and subjective indexes. IM might be a more valuable method for treating AIDS in the future instead of WM or CM alone. | Liu Zhibin Li Xia Yang Jiping Xu Liran Guo Huijun | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 8 |
| 5 | Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2显示文摘Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals. | Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu Ningyi Jin Chengyu Jiang | 2019 | Science Bulletin2019，64，3： | 6 |
| 6 | Comment on the intervention of Traditional Chinese Medicine on survival rates of patients living with human immunodeficiency virus and acquired immune deficiency syndrome显示文摘Despite many differences between Traditional Chinese Medicine(TCM) and conventional medicine,the use of TCM in the treatment of human immunodeficiency virus and acquired immune deficiency syndrome(HIV/AIDS) is increasingly recognized and accepted by patients. Recent research findings on the benefits of Chinese herbal medicine on long-term survival in patients with HIV/AIDS are encouraging and hopeful, but inconclusive. More research is needed. | Li Qiang Liu Zhibin Yang Jiping Guo Huijun Xu Liran | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 5 |
| 7 | Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China显示文摘OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART. | Yuan Jun Xu Qianlei Chen Xiumin Meng Pengfei Li Qingya Xu Liran Meng Xiangle Jin Yantao Guo Huijun | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 5 |
| 8 | TiO_2/Schwertmannite nanocomposites as superior co-catalysts in heterogeneous photo-Fenton process显示文摘The heterogeneous photo-Fenton reaction is an effective technique in combating organic contaminants for both soil and water remediation,and extensive studies have focused on enhancing its efficiency and reducing its costs.In this work,we developed novel photoFenton catalysts by simply milling commercially available TiO_2(P25)with Schwertmannite(Sh),a natural iron-oxyhydroxysulfate nanomineral.We expect that the photo-generated electrons from TiO_2could continuously migrate to Sh,which then could enhance the separation of electron-hole pairs on TiO_2and accelerate the reduction of Fe(III)to Fe(II)on Sh,leading to high degradation efficiency of the target organic contaminants.SEM and TEM results showed the distribution of TiO_2on Sh surface for the nanocomposites(TiO_2/Sh).Under simulated sunlight irradiation,the much higher content of Fe(II)was determined on TiO_2/Sh than on Sh via a common method in the iron ore,and the consumption of H_2O_2and the production of·OH were more significant in the TiO_2/Sh system than those in the TiO_2and Sh systems.These results well support our hypothesis that the photo-generated electrons could migrate from TiO_2to Sh on the composites,and can also explain the much higher degradation efficiency of Rhodamine B(RhB)in the TiO_2/Sh system.Besides,TiO_2/Sh had lower Fe dissolution as compared with Sh,and retained high catalytic stability after four repeated cycles.Above merits of the TiO_2/Sh composites,in combining with their simple synthesis method and low-cost property,indicated that they should have promising applications as heterogeneous photo-Fenton catalysts. | Yanping Zhu Chun Zeng Runliang Zhu Yin Xu Xingyan Wang Huijun Zhou Jianxi Zhu Hongping He | 2019 | Journal of Environmental Sciences2019，31，6： | 5 |
| 9 | Surface modification of PGP for a neutrophil–nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein显示文摘Exploiting cells as vehicles combined with nanoparticles combined with therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem cells have been used for tumor immunotherapy, tissue regeneration and inflammatory disorders, and it is known that neutrophils can accumulate in brain lesions in many brain diseases including depression. N-Acetyl Pro–Gly–Pro(PGP) peptide shows high specific binding affinity to neutrophils through the CXCR2 receptor. In this study, PGP was used to modify baicalein-loaded solid lipid nanoparticles(PGP-SLNs) to facilitate binding to neutrophils in vivo. Brain-targeted delivery to the basolateral amygdala(BLA) was demonstrated by enhanced concentration of baicalein in the BLA. An enhanced anti-depressant effect was observed in vitro and in vivo. The mechanism involved inhibition of apoptosis and a decrease in lactate dehydrogenase release. Behavioral evaluation carried out with rats demonstrated that anti-depression outcomes were achieved. The results indicate that PGP-SLNs decrease immobility time, increase swimming time and climbing time and attenuate locomotion in olfactory-bulbectomized(OB) rats. In conclusion, PGP modification is a strategy for targeting the brain with a cell–nanoparticle delivery system for depression therapy. | Baoyu Chen Man Luo Jianming Liang Chun Zhang Caifang Gao Jue Wang Jianxin Wang Yongji Li Desheng Xu Lina Liu Ning Zhang Huijun Chen Jing Qin | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 4 |
| 10 | The effect of different deformation mechanisms on the chemical structure of anthracite coals显示文摘To study the effect of different deformation mechanisms on the chemical structure of anthracite coals and further understand the correlation between changed chemical structures and coal and gas outburst, ten groups of sub-high-temperature and sub-high-pressure deformation experiments were performed. All samples maintained primary structure, which were collected from the Qudi Mine in the southern Qinshui Basin of China. The samples were analyzed by ultimate analysis, Vitrinite Reflection(VR), Fourier Transform Infrared spectroscopy(FTIR), and Raman spectroscopy both before and after deformation experiments for contrasting. The results showed that the VR values of all samples after experiments were significantly higher than before experiments, which suggested that the metamorphism degree of anthracite coals was increased by deformation. The results also indicated that both temperature and strain rate had significant effects on the chemical structure of anthracite coals. At a high strain rate of 4×10?5 s?1, the deformation of the samples was mainly brittle in which the mechanical energy was transformed mainly into frictional energy. In this situation, all samples developed several distinct fractured surfaces and the change of chemical structures was not obvious. On the contrary, with the decrease of the strain rates, the ductile deformation was dominated and the mechanical energy was mainly transformed into strain energy, resulting in the accumulation of deformation energy confessed by increasing quantity of dislocation and creep in the coal's interior nucleus. The absorption in the aromatic ring groups increased; otherwise the absorption in the aliphatic structures and ether oxygen groups decreased rapidly. During these experiments, CO was collected from two experimental samples. The number of aromatic rings and the structure defects within the two generated gas samples increased and the degree of molecular structure orders decreased. | XU RongTing LI HuiJun HOU QuanLin LI XiaoShi YU LiYe | 2015 | Science China Earth Sciences2015，58，4： | 4 |
| 11 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 12 | Asymptomatic stage of human immunodeficiency virus infection is the optimal timing for its management with Traditional Chinese Medicine显示文摘Acquired immune deficiency syndrome(AIDS) is a worldwide public health problem and an incurable disease.The roles of Traditional Chinese Medicine(TCM) on AIDS had been recognized and accepted by more and more people.Being a relatively long period,to initiate combination antiretroviral therapy(cART) for the asymptomatic human immunodeficiency virus(HIV) infection patient is not consensus.According to TCM theory,not only the imbalance of Yin and Yang but also the disharmony of internal body function and external natural environment had occurred in the body of the patient,the imbalance and the disharmony should be adjusted by the means of the treatment based on the patters identified among the symptoms in terms of TCM.We aimed to analyze the feature of patients with asymptomatic infection,and compare the advantages and disadvantages of the usage of cART for asymptomatic infection,explored the possible mechanism underlying TCM treatment of the asymptomatic infection,by reviewing the TCM treatment progress on asymptomatic HIV infection. | Chen Xiumin Yuan Qingting Liu Zhibin Yang Jiping Xu Liran Guo Huijun | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 3 |
| 13 | RNA-seq profiling reveals differentially expressed genes as potential markers for vital reaction in skin contusion: a pilot study显示文摘Detection of the vitality of wounds is essential in forensic practice.The present study used Illumina RNA-seq technology to determine gene expression profiles in contused mouse skin.In obtained high quality sequencing reads,the reads were mapped onto a reference transcriptome (Mus_musculus.GRCm38.83).The results revealed that there were 659 upregulated and 996 down-regulated differentially expressed genes (DEGs) in contused mouse skin.The DEGs were further analyzed using the Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes databases.Genes from different functional categories and signalling pathways were enriched,including the immune system process,immune response,defense response,cytokine-cytokine receptor interaction,complement and coagulation cascades and chemokine signalling pathway.Expression patterns of 11 DEGs were verified by RT-qPCR in mice skins.In addition,alterations of five DEGs were also analyzed in postmortem human wound samples.The results were in concordance with the results of RNA-seq.These findings suggest that RNA-seq is a powerful tool to reveal DEGs as potential markers for vital reaction in terms of forensic practices. | Jingtao Xu Rui Zhao Ye Xue Huanqin Xiao Yanliang Sheng Dong Zhao Jietao He Hongyan Huang Qi Wang Huijun Wang | 2018 | Forensic Sciences Research2018，3，2： | 3 |
| 14 | Effect of electropulsing treatment on static recrystallization behavior of cold-rolled magnesium alloy ZK60 with different reductions显示文摘Effect of electropulsing treatment(EPT) on recrystallization behavior of cold-rolled Mg alloy ZK60 strips was investigated. It was found that EPT significantly improved nucleation rate and migration ability of grain boundaries, leading to accelerated recrystallization of the deformed metals at relatively low temperature. After the recrystallization induced by EPT, the average grain size of 20% rolling reduction samples decreased from 113 um to around 10 um, meanwhile the typical basal-type texture of the coldrolled sample was weakened. EPT was normally accompanied with a thermal and an athermal effects. The athermal effect played a dominated role in increasing nucleation rate, while the thermal effect promoted grain growth. A fewer recrystallized grains originated along the grain boundaries in the 10% reduction samples, while most of the recrystallization took place inside the twins in the 20% reduction samples. | Huijun Guo Xun Zeng Jianfeng Fan Hua Zhang Qiang Zhang Weiguo Li Hongbiao Dong Bingshe Xu | 2019 | Journal of Materials Science & Technology2019，35，6： | 2 |
| 15 | Morphological and microscopic characterization of five commonly-used testacean traditional Chinese medicines显示文摘Testacean traditional Chinese medicine(TTCM), derived from the outer shell of sea or freshwater mollusks, is a special and important category of Chinese medicinal materials. To ensure the effective use of TTCM, a comparative identification study was performed on five commonly-used testacean drugs, including Haliotidis Concha, Arcae Concha, Meretricis Concha, Ostreae Concha and Margaritifera Concha(Shijueming, Walengzi, Geqiao, Muli and Zhenzhumu in Chinese, respectively).Typical morphological photographs of the crude drugs were acquired, and the key microscopic characteristics of the derived powders under normal light microscope and polarized light microscope were summarized. The major results can be concluded as follows:(1) the original species involved in the five TTCMs could be distinguished by their respective interspecies morphological characteristics;(2) the key identification characteristics of the five powdered crude drugs were mainly crystal fragments, with the fragment features under both normal light and polarized light microscope providing powerful points for differentiating the five commonly-used testacean drugs. This study demonstrated that it is feasible to provide authentication for these five kinds of TTCMs by the combination of morphology with microscopy. | Ying Xu Wei Song Ping Zhou Ping Li Huijun Li | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 2 |
| 16 | Prevalence trend and risk factors for anemia among patients with human immunodeficiency virus infection receiving antiretroviral therapy in rural China显示文摘OBJECTIVE: To estimate the prevalence trend and risk factors for anemia in patients with human immunodeficiency virus(HIV) infection receiving antiretroviral therapy(ART) in rural China.METHODS: We conducted cross-sectional studies among the same population in 2010, 2012, and2014, based on data from standard medical record registers. Factors associated with anemia were evaluated using a logistic regression model.RESULTS: The number of patients with HIV infec-tion included in each cross-sectional study was1456 in 2010, 1531 in 2012, and 1567 in 2014, and the prevalence of anemia was 44.3%, 34.7%, and27.6%, respectively. The prevalence of anemia was lower in female patients in 2010 [odds ratio(OR)0.68; 95% confidence interval(CI) 0.55-0.85]; however, there was no difference by sex in 2012(OR0.90; 95% CI 0.72-1.11) and 2014(OR 1.05; 95% CI0.84-1.32). Patients with a higher level of education had a lower risk of anemia in 2014(OR 0.72; 95% CI0.56-0.92), but there was no difference in 2010(OR1.00; 95% CI 0.79-1.25) and 2012(OR 0.99; 95% CI0.79-1.24). Patients who had received a longer duration of ART had a higher risk of anemia in 2014(OR1.74; 95% CI 1.15-2.64), but there was no difference in 2010 and 2012(P > 0.05). Patients receiving Traditional Chinese Medicine(TCM) therapy had a lower risk of anemia.CONCLUSION: The prevalence of anemia among patients with HIV infection receiving ART decreased between 2010 and 2014 in Henan Province but was still higher than the prevalence in the general population of China. TCM therapy can potentially decrease the risk of anemia among patients with HIV infection. | Jin Yantao Liu Sa Yuan Jun Meng Xiangle Guo Huijun Xu Liran Xu Qianlei | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 2 |
| 17 | Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells显示文摘在染色体 10 上删除的生长 4 的禁止者(ING4 )(PTEN ) 和磷酸酶和 tensin 相当或相同的事物作为是的肿瘤 suppressors 众所周知仔细与肿瘤出现和前进有关。ING4 和 PTEN 在鼻咽的癌房间显示出 synergistic antitumor 活动,这被报导。二肿瘤 suppressors 在生长抑制和 apoptosis 激活上表明了 synergistic 效果。在这研究,我们在 hepatocellular 癌调查了他们的治疗学的潜力 ?(HCC ) 房间。Recombinant 侵入人体气管粘膜的病菌共同表示 ING4 和 PTEN (Ad-ING4-PTEN ) 被构造,并且 SMMC-7721 和 HepG2 HCC 房间上的 antitumor 效果被评估。Ad-ING4-PTEN 合作地禁止了房间生长,刺激了 apoptosis,并且压制了在 HCC 房间,和在 SMMC-7721 的调整房间周期的侵略。进一步的研究证明由 Ad-ING4-PTEN 的 ING4 和 PTEN 的联合合作地提高了房间的表示的改变周期相关的蛋白质( p53 , p21 ,和 cyclin D1 )和 apoptotic 因素(坏, Bcl-2 , Bcl-XL ,和 Bax ),它涉及房间周期的规定和 apoptotic 小径的激活,导致 synergistic antitumor 效果。这些结果显示 ING4 和 PTEN 的联合可以为 HCC 提供有效治疗学的策略。 | Nargis Rakshit Sijun Yang Wei Zhou Yi Xu Chenghui Deng Jiecheng Yang Huijun Yu Wenxiang Wei | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 2 |
| 18 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 19 | Springtime Convective Quasi-Biweekly Oscillation and Interannual Variation of Its Intensity over the South China Sea and Western North Pacific显示文摘This study investigates characteristics of the convective quasi-biweekly oscillation(QBWO) over the South China Sea(SCS) and western North Pacific(WNP) in spring, and the interannual variation of its intensity. Convective QBWO over the WNP and SCS shows both similarities and differences. Convective QBWO over the WNP originates mainly from southeast of the Philippine Sea and propagates northwestward. In contrast, convective QBWO over the SCS can be traced mainly to east of the Philippines and features a westward propagation. Such a westward or northwestward propagation is probably related to n = 1 equatorial Rossby waves. During the evolution of convective QBWO over the WNP and SCS, the vertical motion and specific humidity exhibit a barotropic structure and the vertical relative vorticity shows a baroclinic structure in the troposphere. The dominant mode of interannual variation of convective QBWO intensity over the SCS–WNP region in spring is homogeneous. Its positive phase indicates enhanced convective QBWO intensity accompanied by local enhanced QBWO intensity of vertical motion throughout the troposphere as well as local enhanced(weakened) QBWO intensity of kinetic energy, vertical relative vorticity,and wind in the lower(upper) troposphere. The positive phase usually results from local increases of the background moisture and anomalous vertical shear of easterlies. The latter contributes to the relationship between the dominant mode and QBWO intensities of kinetic energy, vertical relative vorticity, and wind. Finally, a connection between the dominant mode and the sea surface temperature anomalies in the tropical Pacific Ocean is demonstrated. | Zhiqing XU Ke FAN Huijun WANG | 2019 | Journal of Meteorological Research2019，33，2： | 2 |
| 20 | New insights in pre-replication complex formation with single-molecule visualization显示文摘Precise genomic DNA replication is critical for faithful transferring of genetic information to the next generation.Genomic DNA replication consists of three different stages:initiation,elongation and termination.In eukaryotic cells,DNA replication initiates from multiple | Huijun Xue Xin Xu Yu V. Fu | 2015 | Science Bulletin2015，60，12： | 2 |
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