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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Methodologic research on TIMP-1,TIMP-2 detection as a new diagnostic index for hepatic fibrosis and its significance显示文摘AIM: To set up a new method to detect tissue inhibitors ofmetalloproteinase1 and -2(TIMP-1 and TIMP-2) in sero ofpatients with hepatic cirrhosis, and to investigate theexpression and location of TIMP-1 and TIMP-2 in liver tissueof patients with hepatic cirrhosis, and the correlationbetween TIMPs in liver and those in sera so as to discusswhether TIMPs can be used ss a diagnosis index of hepaticfibrosisMETHODS: The monoclonal antibodies (McAbs) of TIMP-1and TIMP-2 were used to sensitize erythrocytes, and solid-phase absorption to sensitized erythrocytes (SPASE) wasused to detect TIMP-1 and TIMP-2 in the sera of patients withhepatic cirrhosis. Meanwhile, with the method of in situhybridization and immunohistochemistry, we studied themRNA expression and antigen location of TIMP-1 and TIMP-2in the livers of 40 hepatic cirrhosis patients with pathologicdiagnosis.RESULTS: With SPASE, they were 16.4 % higher in theacute hepatitis group, 33.3 % higher in the chronic hepatitisgroup, and the positive rates were 73.6 % and 61. 2 %respectively in sero of hepatic cirrhosis patients, which wereremarkably higher than those in chronic hepatitis and acutehepatitis group ( P < 0. 001 ). In 40 samples of hepaticcirrhosis tissues, all of them showed positive expression ofTIMP-1 and TIMP-2 mRNA detected withimmunohistochemistry or in situ hybridization (positive ratewas 100 % ). Expression of TIMPs in different degrees couldbe found in liver tissue with cirrhosis. TIMPs were located incytoplasm of liver cells of patients with hepatic cirrhosis.There was a significant correlation between serum TIMPslevel and liver TIMPs level.CONCLUSION: SPASE is a useful method to detect the TIMP-1 and TIMP-2 in sera of patients with hepatic cirrhosis, andTIMP-1 and TIMP-2 can be considered as a useful diagnosticindex of hepatic fibrosis, especially TIMP-1. | Oing-He Nie Yong-Oian Cheng Yu-Mei Xie Yong-Xing Zhou Bai-Xian Guang Yi-Zhan Cao,The Centre of Diagnosis and Treatment for Infectious Disease of Chinese PLA,Tangdu Hospital,Fourth Military Medical University,Xi’an 710038,Shanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 51 |
| 3 | Expression of regulating apoptosis gene and apoptosis index in primary liver cancer显示文摘INTRODUCTIONProgramed cell death plays an important role in thegenesis of cancer.Certain cancer genes canregulate apoptosis.Recently,several proteins thatare structurally related to Bcl-2,an inhibitor ofapoptosis,have been identified.Therefore,novel strategies and agents that target specificmolecular pathways,as well as triggering a | Hong Yu Xu You Lin Yang Xi Li Guan Guang Song Ai Min Jiang Li Jun Shi | 2000 | World Journal of Gastroenterology2000，6，5： | 21 |
| 4 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 5 | Effect of various crop rotations on rice yield and nitrogen use efficiency in paddy–upland systems in southeastern China显示文摘To evaluate the effects of various rotation systems on rice grain yield and N use efficiency, a paddy–upland cropping experiment(2013–2016) was conducted in southeastern China. The experiment was designed using six different rice––winter crop rotations: rice–fallow(RF),rice–wheat(RW), rice–potato with rice straw mulch(RP), rice–green manure(Chinese milk vetch; RC–G), rice–oilseed rape(RO), and rice–green manure crop(oilseed rape with fresh straw incorporated into soil at flowering; RO–G) and three N rates, N0(0 kg N ha-1), N1(142.5 kg N ha-1), and N2(202.5 kg N ha-1). Average rice yields in the RF(5.93 t ha-1) rotation were significantly lower than those in the rotations with winter crops(7.20–7.48 t ha-1)under the N0 treatment, suggesting that incorporation of straw might be more effective for increasing soil N than winter fallow. The rice yield differences among the rotations varied by year with the N input. In general, the grain yields in the RP and RO–G rotations –were respectively 11.6–28.5% and 14.80–37.19% higher than those in the RF in plots with N applied. Increasing the N rate may have tended to minimize the average yield gap between the RF and the other rotations; the yield gaps were 18.55%, 4.14%, and 0.23% in N0, N1, and N2, respectively. However, the N recovery efficiency in the RF was significantly lower than that in other rotations, except for 2015 under both N1 and N2 rates, a finding that implies a large amount of chemical N loss. No significant differences in nitrogen agronomic efficiency(NAE) and physiological efficiency(NPE) were found between the rotations with legume(RC–G) and non–legume(RO and RW) winter crops, a result that may be due partly to straw incorporation. For this reason, we concluded that the return of straw could reduce differences in N use efficiency between rotations with and without legume crops. The degree of synchrony between the crop N demand and the N supply was evaluated by comparison of nitrogen balance degree(NBD) values. The NBD values in the RP and RW were significantly lower than those in the other rotations under both N1 and N2 rates. Thus,in view of the higher grain yield in the RP compared to the RW under the N1 rate, the RP rotation might be a promising practice with comparable grain yield and greater N use efficiency under reduced N input relative to the other rotations. The primary yield components of the RF and RP were identified as number of panicles m-2 and numbers of kernels panicle-1, respectively. The NAE and NPE were positively correlated with harvest index, possibly providing a useful indicator for evaluating N use efficiency. | Song Chen Shaowen Liu Xi Zheng Min Yin Guang Chu Chunmei Xu Jinxiang Yan Liping Chen Danying Wang Xiufu Zhang | 2018 | The Crop Journal2018，6，6： | 13 |
| 6 | Comparison of Xpert MTB/RIF, Real Amp, and CPA Tests in Detecting Mycobacterium tuberculosis显示文摘Today, tuberculosis (TB) remains a global public health threat associated with significantly high rates of morbidity and mortality. The World Health Organization's (WHO) Global Tuberculosis Report 2018[1] has reported that in 2017, 10.0 million people across the world had developed TB diseases that resulted in an estimated 1.6 million deaths, and 889, 000 people developed TB in China that led to 39, 000 TB-related deaths. Therefore, rapid and accurate detection of Mycobacterium tuberculosis (MTB) is important for initiating early treatment and reducing mortality. Traditional diagnostic methods for pulmonary TB incorporate chest radiography and sputum smear microscopy;however, several cases of tuberculosis go undiagnosed because of the low sensitivity of smear microscopy[2]. | OU Xi Chao LI Hui LIU Dong Xin XIA Hui MA Xiao Guang WANG Shao Hua WANG Sheng Fen ZHU Yan Kun ZHAO Bing ZHAO Yan Lin | 2019 | Biomedical and Environmental Sciences2019，32，3： | 9 |
| 7 | Unsteady flow structures in the tip region for a centrifugal compressor impeller before rotating stall显示文摘To get an insight into the occurrence and the mechanism of flow unsteadiness in the tip region of centrifugal compressor impellers, the flow in Krain’s impeller is investigated by using both steady and unsteady RANS solver techniques. It is found that the flow unsteadiness on the pressure side is much stronger than that on the suction side. The periodical frequency of the unsteady flow is around half of the blade passing frequency. The originating mechanism of the flow unsteadiness is illustrated with the time-dependent tip leakage flow and blade loading at the tip region. Due to the blockage caused by the joint effects of broken-downed tip leakage vortex, separated fluids and tip leakage flow at downstream, a low pressure region is formed on the pressure side, consequently the blade loadings is altered. In turn, the changed blade loadings will alter the intensity of tip leakage flow. Such alternative behavior finally results in the periodic process. By comparing the calculated flow field in the cases of single-passage and four-passage models, it is confirmed that the investigated flow unsteadiness is confined in each single passage, as no phase differences are found in the model of four passages. This is different from the situation in axial compressor when the rotating instability is encountered. The flow unsteadiness only occurs at the working conditions with small mass flow rates, and the oscillation intensity will be enhanced with the decrease of mass flow rate. When the mass flow rate is too small, the flow unsteadiness in a single passage may trigger rotating stall, as the disturbance propagates in the circumferential direction. | ZHAO HuiJing WANG ZhiHeng XI Guang | 2017 | Science China(Technological Sciences)2017，60，6： | 9 |
| 8 | Influences of cavity leakage on the design of low flow coefficient centrifugal impeller显示文摘The low flow coefficient centrifugal impeller(LFCCI)gives a relatively low efficiency and a special treatment is required for the design of this kind of impeller.This paper investigates the influences of cavity leakage on the performance prediction and design of LFCCI based on Computational Fluid Dynamics(CFD)techniques.The results show that,the reduction in the effi-ciency of impeller due to the introduction of cavity leakage varies with the blade shape of impeller in a wide range since there is a strong and complex interaction of main flow and leakage flow in the LFCCI.To get a credible optimization result,the backside and foreside cavities should be considered in the CFD-based design of LFCCI. | WANG ZhiHeng XI Guang | 2011 | Science China(Technological Sciences)2011，54，2： | 6 |
| 9 | DYNAMIC BEHAVIOR OF A CRACKED FLEXIBLE ROTOR SUPPORTED ON JOURNAL BEARINGS显示文摘The dynamic behavior of a cracked flexible rotor supported on three kinds ofjournal bearings is presented. Numerical experiments show that nonsynchronous responseswill happen due to the rotor crack, and the amplitudes of the nonsynchronous componentsbecome larger with the increase of crack. On the other hand, the fluid forces of journalbearings can suppress the nonsynchronous response. The (1/2) × or (3/2) × harmoniccomponent rarely appears for small crack near the rotating speed ratio Ω = 2Ωc or Ω =(2/3)Ωc. In the case of supercritical rotating speed, the additional 0× harmonic component is increased as the crack increases. The bearing parameters affect greatly the occur-rence of the nonsynchronous responses by means of exerting innuence on the critical spedand the stabi1ity of the system. | Zheng Jibing Meng Guang(Institute of Vibratian Engineering, Northwestern PolytechnicalUniversity, Xi’an, China, 710072) | 1997 | Chinese Journal of Aeronautics1997，10，1： | 6 |
| 10 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 11 | Investigation of the spike-stall warning method using the blade passing signal显示文摘The vaned-diffuser usually brings compressor instability problems under the small flow rate, for instance the spike-type rotating stall phenomenon which restricts the operation range and may cause the trouble of blade fatigue. Since it is difficult to mathematically predict the spike-type stall for its randomness, finding out a practical method to warning this stall precursor appears to be meaningful. The paper explains the relationship between the spike-type precursor and the blade passing irregularity coefficient to analyze whether this coefficient is appropriate for the spike-stall warning inside a centrifugal compressor with the vaned-diffuser. The advanced wireless measurements were conducted on a 1.5 stages test centrifugal compressor to capture the unsteady behavior progressing from the design to stall inception within the region between the impeller trailing edge(TE) and diffuser leading edge(LE). The circumferential distribution of the blade passing irregularity has been quantitatively revealed.The steep increase of the blade passing irregularity at some 'special locations', which is responsible for the onset of the spiketype precursor, is highlighted. Also, to further understand the spike precursor inside the diffuser passage corresponding to the circumferential 'special location' with maximum irregularity, the high-response transient measurement within this passage is presented. With the help of full-annulus computational fluid dynamics(CFD) simulation and the mathematical model, it is proved that the blade passing irregularity precisely reflects the flow characteristics during the spike precursor, which presents the guidance for this stall warning method. | ZHAO JiaYi XI Guang WANG ZhiHeng ZHAO Yang | 2018 | Science China(Technological Sciences)2018，61，6： | 5 |
| 12 | Atomically Smooth Ultrathin Films of Topological Insulator Sb_(2)Te_(3)显示文摘The growth and characterization of single-crystalline thin films of topological insulators(TIs)is an important step towards their possible applications.Using in situ scanning tunneling microscopy(STM)and angle-resolved photoemission spectroscopy(ARPES),we show that moderately thick Sb_(2)Te_(3)films grown layer-by-layer by molecular beam epitaxy(MBE)on Si(111)are atomically smooth,single-crystalline,and intrinsically insulating.Furthermore,these films were found to exhibit a robust TI electronic structure with their Fermi energy lying within the energy gap of the bulk that intersects only the Dirac cone of the surface states.Depositing Cs in situ moves the Fermi energy of the Sb_(2)Te_(3)films without changing the electronic band structure,as predicted by theory.We found that the TI behavior is preserved in Sb_(2)Te_(3)films down to five quintuple layers(QLs). | Guang Wang Xiegang Zhu Jing Wen Xi Chen Ke He Lili Wang Xucun Ma Ying Liu Xi Dai Zhong Fang Jinfeng Jia Qikun Xue | 2010 | Nano Research2010，3，12： | 5 |
| 13 | Effects of Structural Changes in Subchondral Bone on Articular Cartilage in a Beagle Dog Model显示文摘Objective Using MR T2-mapping and histopathologic score for articular cartilage to evaluate the effect of structural changes in subchondral bone on articular cartilage. Methods Twenty-four male Beagle dogs were randomly divided into a subchondral bone defect group(n = 12) and a bone cement group(n = 12). Models of subchondral bone defectin the medial tibial plateau and subchondral bone filled with bone cement were constructed. In all dogs, the left knee joint was used as the experimental sideand the right knee as the sham side. The T2 value for articular cartilage at the medial tibial plateau was measured at postoperative weeks 4, 8, 16, and 24. The articular cartilage specimens were stained with hematoxylin and eosin, and evaluated using the Mankin score. Results There was a statistically significant difference(P < 0.05) in Mankin score between the bone defect group and the cement group at postoperative weeks 16 and 24. There was a statistically significant difference in the T2 values between the bone defect group and its sham group(P < 0.05) from week 8, and between the cement group and its sham group(P < 0.05) from week 16. There was significant difference in T2 values between the two experimental groups at postoperative week 24(P < 0.01). The T2 value for articular cartilage was positively correlated with the Mankin score(ρ = 0.758, P < 0.01). Conclusion Structural changes in subchondral bone can lead to degeneration of the adjacent articular cartilage. Defects in subchondral bone cause more severe degeneration of cartilage than subchondral bone filled with cement. The T2 value for articular cartilage increases with the extent of degeneration. MR T2-mapping images and the T2 value for articular cartilage can indicate earlycartilage degeneration. | YAN Dong LIU Tong Xi LIU Bao Yue WANG Ling QIAN Zhan Hua CHENG Xiao Guang LI Kun Cheng | 2017 | Biomedical and Environmental Sciences2017，30，3： | 4 |
| 14 | A New Method for Blood NT-proBNP Determination Based on a Near-infrared Point of Care Testing Device with High Sensitivity and Wide Scope显示文摘Objective To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic(POCT) device with wide scope. Methods The lateral flow assay(LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device. Serial dilutions of serum samples were prepared using NT-proBNP-free serum series. The prepared test strips, combined with a near-infrared POCT device, were validated by known concentrations of clinical samples. The POCT device gave the output of the ratio of the intensity of the fluorescence signal of the detection line to that of the quality control line. The relationship between the ratio value and the concentration of the specimen was plotted as a work curve. The results of 62 clinical specimens obtained from our method were compared in parallel with those obtained from the Roche E411 kit. Results Based on the log-log plot, the new method demonstrated that there was a good linear relationship between the ratio value and NT-proBNP concentrations ranging from 20 pg/mL to 10 ng/mL. The results of the 62 clinical specimens measured by our method showed a good linear correlation with those measured by the Roche E411 kit. Conclusion The new LFA detection method of NT-proBNP levels based on the near-infrared POCT device was rapid and highly sensitive with wide scope and was thus suitable for rapid and early clinical diagnosis of cardiac impairment. | ZHANG Xiao Guang SHU Yao Gen GAO Ju WANG Xuan LIU Li Peng WANG Meng CAO Yu Xi ZENG Yi | 2017 | Biomedical and Environmental Sciences2017，30，6： | 4 |
| 15 | Numerical Investigation of the Aerodynamic Performance Affected by Spiral Inlet and Outlet in a Positive Displacement Blower显示文摘The flow in the positive displacement blower is very complex.The existing two-dimensional numerical simulation cannot provide the detailed flow information,especially flow characteristics along the axial direction,which is unfavorable to improve the performance of positive displacement blower.To investigate the effects of spiral inlet and outlet on the aerodynamic performance of positive displacement blower,three-dimensional unsteady flow characteristics in a three-lobe positive displacement blower with and without the spiral inlet and outlet are simulated by solving Navier-Stokes equations coupled with RNG k-ε turbulent model.In the numerical simulation,the dynamic mesh technique and overset mesh updating method are used.The computational results are compared with the experimental measurements on the variation of flow rate with the outlet pressure to verify the validity of the numerical method presented.The results show that the mass flow rate with the change of pressure is slightly affected by the application of spiral inlet and outlet,but the internal flow state is largely affected.In the exhaust region,the fluctuations of pressure,velocity and temperature as well as the average values of velocity are significantly reduced.This illustrates that the spiral outlet can effectively suppress the fluctuations of pressure,thus reducing reflux shock and energy dissipation.In the intake area,the average value of pressure,velocity and temperature are slightly declined,but the fluctuations of them are significantly reduced,indicating that the spiral inlet plays the role in making the flow more stable.The numerical results obtained reveal the three-dimensional flow characteristics of the positive displacement blower with spiral inlet and outlet,and provide useful reference to improve performance and empirical correction in the noise-reduction design of the positive displacement blowers. | LIU Xiaomin LU Jun GAO Renheng XI Guang | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 4 |
| 16 | Diagnosis and surgical treatment of multiple endocrine neoplasia显示文摘背景多重内分泌的瘤形成(人) 是相对稀罕的。但是更多的病人能被详细检查发现。我们讨论诊断和人的外科的治疗。95 个人盒子的临床的数据回顾地被分析的方法。有包括从 6 个家庭的 19 个盒子的 MEN1 的 30 个盒子。MEN1 基因变化在在 1997 以后承认的 81.48% 盒子中被检测。有主要甲状腺机能过盛(PHPT ) 的 22 个盒子,包括 insulinoma 的 9 个盒子的 enteropanceatic 肿瘤的 10 个盒子,垂体腺瘤的 15 个盒子,肾的腺瘤的 9 个盒子, thymic 的 2 个盒子良性肿瘤。二个病人把 4 腺深奥, 3 个病人把 3 腺深奥, 16 个病人把 2 腺深奥,并且 6 个病人把仅仅一腺深奥。三个病人有既不临床的症状也不生物化学的变化,并且被 MEN1 基因变化诊断。与 nephrolithasis 介绍的六个病人和 6 个病人损害了胰腺的内分泌的功能。有 MEN2a 的 60 个盒子和 MEN2b 的 5 个盒子。MEN2a 的 58 个盒子属于 19 个家族。所有 MEN2a 病人但是介绍的沤在 codon 的基因变化 634,并且所有 MEN2b 盒子在 codon 有变化 918。MEN2a 的 48 个盒子与提高的 calcitonin 层次有甲状腺群众。27 个病人包括多重 loci 和 5 恶意的 12 个盒子有 pheochromocytoma。与甲状腺机能过盛介绍的 13 个病人。5 个 MEN2b 病人与 Marfanoid 有髓的甲状腺癌和 mucosal ganglioneuromatosis。在他们之中, 3 个病人有双边的 pheochromocytoma。在 MEN1 的结果,小计 parathyroidectomy 与 PHPT 在 12 个病人被执行,一个病人收到了甲状旁腺的腺瘤 enucleation。Insulinomas 是在 4 个病人的 enucleated。二个病人经历了胸腺肿瘤根除。有地区性的淋巴节点的双边的解剖的全部的甲状腺切除与 MEN2a 在 16 个病人被执行,小瘤 enucleation 在 9 个病人被执行。22 个 MEN2a 病人在 10 种情况中包括双边的肾的切除术经历了 pheochromocytoma enucleation。5 个 MEN2b 病人与双边的淋巴节点解剖经历了全部的甲状腺切除。在他们之中, 3 个盒子经历了双边的肾的操作。结论人在症状变化。Germline 变化测试在建立诊断是有用的。外科的管理应该在 MEN2 在胎儿的肿瘤的 MEN1 和预防针对生活质量的改进。 | ZHOU Guang-wen WEI Yao CHEN Xi JIANG Xiao-hua LI Xiao-ying NING Guang LI Hong-wei | 2009 | Chinese Medical Journal2009，，13： | 4 |
| 17 | RecQ Helicase-catalyzed DNA Unwinding Detected by Fluorescence Resonance Energy Transfer显示文摘fluorometric 试金被用来学习摊开 Escherichia 关口 i RecQ helicase 导致的动力学的脱氧核糖核酸。这试金基于荧光回声精力转移并且在站流动,放松的脱氧核糖核酸被荧光黄源于催化 helicase 的脱氧核糖核酸放松的荧光排放改进在监视上执行了。由这个方法,我们决定了在不同的酶集中摊开 RecQ 的率的脱氧核糖核酸。我们也学习了在镁离子集中上摊开大小和率的脱氧核糖核酸的依赖。我们证明这个方法能被用来决定脱氧核糖核酸放松的极性。这试金应该极大地为催化 RecQ 的脱氧核糖核酸放松便于机制的进一步的学习。 | Xing-Dong ZHANG Shuo-Xing DOU Ping XIE Peng-Ye WANG Xu Guang XI | 2005 | Acta Biochimica et Biophysica Sinica2005，37，9： | 3 |
| 18 | A new prenylated arylbenzofuran derivative from Morus alba L.显示文摘2-[3,5-Di-O-β-D-glucosyl-4-(3-methylbut-2-enyl)phenyl]benzofuran-6-ol,a new prenylated arylbenzofuran derivative was isolated from Morus alba L.Its structure was elucidated by various spectroscopic methods including MS,~1H NMR,^(13)C NMR,DEPT,~1H-~1HCOSY,HMQC and HMBC. | Tian, Hai Ying He, Xi Zeng, Guang Yao Tan, Jian Bin Shuang, Fu Liu, Guo Ru Tan, Gui Shan Zhou, Ying Jun | 2010 | Chinese Chemical Letters2010，21，3： | 3 |
| 19 | Solar radiation-use characteristics of indica/japonica hybrid rice (Oryza sativa L.) in the late season in southeast China显示文摘New indica and japonica hybrid rice cultivars,such as the Yongyou series,provide farmers with very high yield potential.However,information on their canopy light capture and solar radiation use efficiency in the late season is limited.Field experiments were performed to compare the radiation-use parameters of four rice types:indica rice(IR),inbred japonica rice(IJR),hybrid japonica rice(HJR),and hybrid indica/japonica rice(HIJR),from 2016 to 2018 during the late season in Hangzhou,China.The grain yield,aboveground biomass,intercepted solar radiation(SI),and radiation-use efficiency(RUE)of the HIJR were on average respectively 13.4%–53.4%,14.3%–30.6%,7.6%–21.4%,and 8.2%–14.9%higher than those of the HJR,IJR,and IR.The leaf area index(LAI)of the HIJR was 18.2%–57.0%greater than that of the IJR and HJR at four growth stages,resulting in respectively 17.8%–38.5%and 10.7%–42.8%greater canopy light interception rates(LIR)and amount of intercepted solar radiation during the vegetative stage.The prolonged grain-filling stage also led to respectively 33.9%–52.6%and 30.5%–51.4%increases in amounts of incident and intercepted radiation for the HIJR relative to the IR during grain filling.These results indicate that the SI superiority of the HIJR was caused by canopy closure as rapid as that of the IR during the vegetative stage(greater LAI and canopy LIR during the growing season)and a grain-filling stage as long as that of the HJR.For grain-filling stage,differences in leaf Pn between HIJR,IR,and IJR were not significant,suggesting that the greater RUE of the HIJR(12.7%–52.8%higher)than that of the other rice types resulted from improved canopy architecture after flowering(FL).Principal components analysis(PCA)revealed that the superiority of the HIJR in terms of solar radiation use resulted from the greater canopy light capture capability of IR and the prolonged growth period(especially during grain filling)of japonica rice in the late growing season. | Min Yin Shaowen Liu Xi Zheng Guang Chu Chunmei Xu Xiufu Zhang Dangying Wang Song Chen | 2021 | The Crop Journal2021，9，2： | 3 |
| 20 | Nuclear pseudogenes of mitochondrial DNA as a variable part of the human genome显示文摘INTRODUCTIONNuclearpseudogenesofmitochondrial(mt)DNAwereinitiallydiscoveredintheearly80's[1--6].However,mechanismsforthegenerationofmtDNApseudogenesarestillnotclearandmayvaryindifferentcases.BothRNA--[7--8]andDNAmediated[9--11]processeshavebeensugges... | YUAN JIN DUO JIN XIU SHI GUANG XUNMENG LI GUO AN GENG XI HU( Shanghai Institute of Cell Biology and the ShanghaiLife Science Center, Chinese Academy of Sciences,320 Yue Yang Road, Shanghai 200031, China)( Department of Biology, Shandong Normal Univers | 1999 | Cell Research1999，9，4： | 3 |
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