|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mapping of qGL7-2, a grain length QTL on chromosome 7 of rice显示文摘剩余在米饭染色体上带在二 SSR loci RM11 和 RM134 之间的一个异质接合的片断的异质接合的线(RHL ) 7 从一套 recombinant 被选择从生气 D50 (javanica )/HB277 (indica ) 的生来的线。以前的父母比后者生产长得多的谷物。这种选择的 Selfed 子孙 genotypically 被分析(SSR ) 并且 phenotypically (谷物长度) 。谷物长度在印射的人口是不连续地可变的,允许在 4.8 厘米间隔以内的这 QTL qGL7-2 的放置由 RM351 和 RM234 定义。在这个区域以内的一套新标记被开发,它把 QTL 缩小了到标记 Indel1 和 RM21945 定义的 278 kb 区域。这个区域包含 49 预言的基因。结果也建议为谷物长度的新奇等位基因将被用于标记的应用程序为谷物长度的改进的帮助选择。 | Gaoneng Shao Shaoqing Tang Ju Luo Guiai Jiao Xiangjin Wei Ao Tang Jianli Wu Jieyun Zhuang Peisong Hu | 2010 | Journal of Genetics and Genomics2010，37，8： | 28 |
| 2 | GRAIN INCOMPLETE FILLING 2 regulates grain filling and starch synthesis during rice caryopsis development显示文摘Rice grain filling determines grain weight,final yield and grain quality.Here,a rice defective grain filling mutant,gif2,was identified.Grains of gif2 showed a slower filling rate and a significant lower final grain weight and yield compared to wild-type.The starch content in gif2 was noticeably decreased and its physicochemical properties were also altered.Moreover,gif2 endosperm cells showed obvious defects in compound granule formation.Positional cloning identified GIF2 to encode an ADP-glucose pyrophosphorylase(AGP) large subunit,AGPL2;consequently,AGP enzyme activity in gif2 endosperms was remarkably decreased.GIF2 is mainly expressed in developing grains and the coded protein localizes in the cytosol.Yeast two hybrid assay showed that GIF2 interacted with AGP small subunits Os AGPS1,Os AGPS2a and Os AGPS2 b.Transcript levels for granule-bound starch synthase,starch synthase,starch branching enzyme and starch debranching enzyme were distinctly elevated in gif2 grains.In addition,the level of nucleotide diversity of the GIF2 locus was extremely low in both cultivated and wild rice.All of these results suggest that GIF2 plays important roles in the regulation of grain filling and starch biosynthesis during caryopsis development,and that it has been preserved during selection throughout domestication of modern rice. | Xiangjin Wei Guiai Jiao Haiyan Lin Zhonghua Sheng Gaoneng Shao Lihong Xie Shaoqing Tang Qingguo Xu Peisong Hu | 2017 | Journal of Integrative Plant Biology2017，59，2： | 20 |
| 3 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 4 | GBSS-BINDING PROTEIN,encoding a CBM48 domain-containing protein,affects rice quality and yield^∞显示文摘The percentage of amylose in the endosperm of rice(Oryza sativa)largely determines grain cooking and eating qualities.Granule-bound starch synthase I(GBSSI)and GBSSII are responsible for amylose biosynthesis in the endosperm and leaf,respectively.Here,we identified OsGBP,a rice GBSS-binding protein that interacted with GBSSI and GBSSII in vitro and in vivo.The total starch and amylose contents in osgbp mutants were significantly lower than those of wild type in leaves and grains,resulting in reduced grain weight and quality.The carbohydrate-binding module 48(CBM48)domain present in the C-terminus of OsGBP is crucial for OsGBP binding to starch.In the osgbp mutant,the extent of GBSSI and GBSSII binding to starch in the leaf and endospermwas significantly lower than wild type.Our data suggest that OsGBP plays an important role in leaf and endosperm starch biosynthesis by mediating the binding of GBSS proteins to developing starch granules.This elucidation of the function of OsGBP enhances our understanding of the molecular basis of starch biosyn-thesis in rice and contributes information that can be potentially used for the genetic improvement of yield and grain quality. | Wei Wang Xiangjin Wei Guiai Jiao Wenqiang Chen Yawen Wu Zhonghua Sheng Shikai Hu Lihong Xie Jiayu Wang Shaoqing Tang Peisong Hu | 2020 | Journal of Integrative Plant Biology2020，62，7： | 12 |
| 5 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 6 | Targeted mutagenesis of POLYAMINE OXIDASE 5 that negatively regulates mesocotyl elongation enables the generation of direct-seeding rice with improved grain yield显示文摘Under conditions of labor or resource scarcity,direct seeding,rather than transplantation,is the preferred mode of rice(Oryza sativa)cultivation.This approach requires varieties that exhibit uniform seedling emergence.Mesocotyl elongation(ME),the main driver of rapid emergence of rice seedlings from soil,is enhanced by darkness and inhibited by light.Plant polyamine oxidases(PAOs)oxidize polyamines(PAs)and release H2O2,Here,we established that OsPAO5 expression in rice seedlings is increased in the presence of light and inhibited by darkness.To determine its role in ME,we created OsPAO5 mutants using CRISPR/Cas9.Compared with the wild type,pao5 mutants had longer mesocotyls,released less H2O2,and synthesized more ethylene.The mutant seedlings emerged at a higher and more uniform rate,indicating their potential for use in direct seeding.Nucleotide polymorphism analysis revealed that an SNP(PAO5-578G/A)located 578 bp upstream of the OsPAO5 start codon alters its expression,and was selected during rice mesocotyl domestication.The PAO5-578G genotype conferring a long mesocotyl mainly exists in wild rice,most Aus accessions,and some Geng(Japonica)accessions.Intriguingly,knocking out OsPAO5 can remarkably increase the grain weight,grain number,and yield potential.In summary,we developed a novel strategy to obtain elite rice with higher emergence vigor and yield potential,which can be conveniently and widely used to breed varieties of direct-seeding rice. | Yusong Lv Gaoneng Shao Guiai Jiao Zhonghua Sheng Lihong Xie Shikai Hu Shaoqing Tang Xiangjin Wei Peisong Hu | 2021 | Molecular Plant2021，14，2： | 12 |
| 7 | Editing of Rice Isoamylase Gene ISA1 Provides Insights into Its Function in Starch Formation显示文摘Isoamylase 1(ISA1) is an isoamylase-type debranching enzyme which plays a predominant role in amylopectin synthesis. In this study, the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated endonuclease 9(CRISPR/Cas9) system was used to edit ISA1 gene in rice via Agrobacterium-mediated transformation. We identified 36 genetic edited lines from 55 T_0 transgenic events, and classified the mutation forms into 7 types. Of those, two homozygous mutants, cr-isa1-1(type 1, with an adenine insertion) and cr-isa1-2(type 3, with a cytosine deletion) were selected for further analysis. Seed sizes of both cr-isa1-1 and cr-isa1-2 were affected, and the two mutants also displayed a shrunken endosperm with significantly lower grain weight. Electron microscopy analysis showed that abnormal starch granules and amyloplasts were found in cr-isa1-1 and cr-isa1-2 endosperm cells. The contents of total starch, amylose and amylopectin in the endosperm of the cr-isa1 mutants were significantly reduced, whereas sugar content and starch gel consistency were observably increased compared to the wild-type. The gelatinization temperature and starch chain length distributions of the cr-isa1 mutants were also altered. Moreover, transcript levels of most starch synthesis-related genes were significantly lower in cr-isa1 mutants. In conclusion, the results indicated that gene edition of ISA1 affected starch synthesis and endosperm development, and brought potential implications for rice quality breeding. | CHAO Shufen CAI Yicong FENG Baobing JIAO Guiai SHENG Zhonghua LUO Ju TANG Shaoqing WANG Jianlong HU Peisong WEI Xiangjin | 2019 | Rice science2019，26，2： | 10 |
| 8 | Long-term trends in fog and boundary layer characteristics in Tianjin,China显示文摘Long-term trends in fog episodes,vertical variations of atmospheric boundary structure,and air pollutant concentrations during two different heavy fog events in the Tianjin area were analyzed.The total amount of fog has increased since 1980 due to the stability of the boundary layer and an increase of pollutant emissions.The variation in the characteristics of the boundary layer and air pollutant concentrations were significantly different between the two fog processes(fog 1 and fog II).The onset of fog I was accompanied by a temperature inversion in the low atmosphere,and the average kinetic energy showed a clear diurnal trend and vertical variation,which increased with height.The dissipation of fog I was mainly due to turbulence.However,the atmospheric stratification was not stable in the lower layer before the onset of fog II.The diurnal and vertical changes in kinetic energy were very small,in which turbulent momentum at each measurement height tended to be zero.In the dissipation process of fog II,wind speed increased significantly.Surface PM_(2.)5 concentrations decreased,but the ratio of PM_(2.5) to PM_(10)increased from 0.66 to 0.82 until fog I dissipated.However,the concentration of PM2.5 did not decrease at the early stage of fog II,but the ratio of PM_(2.5) to PM_(10) PM_(2.5)/PM_(10) decreased to 0.21 when fog II dissipated.This study showed that there was a clear difference in the evolution of pollutant concentration for different pollutants and in different developing stages during the fog events.PM2.5 concentration accumulated faster than those of SO_2 and NO_x,and the PM_(2.5) cumulative rate was greater in the mid-term of the fog process. | Suqin Han Ziying Cai Yufen Zhang Jiao Wang Qing Yao Peiyan Li Xiangjin Li | 2015 | Particuology2015，13，3： | 7 |
| 9 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 10 | OsVP1 activates Sdr4 expression to control rice seed dormancy via the ABA signaling pathway显示文摘Pre-harvest sprouting(PHS)is a disadvantageous trait in cereal production worldwide,causing large economic losses each year.Its regulation mechanism is still unclear.We generated the Oryza sativa Viviparous1(OsVP1)mutant using gene editing technique,which shows increased PHS compared with that of the wild type Nipponbare.OsVP1 is localized mainly in the nucleus and expressed in various tissues and organs.Expression of Seed dormancy 4(Sdr4),a key gene controlling PHS,was sharply reduced in OsVP1 mutants.OsVP1 bound to the specific motif CACCTG in the promoter of Sdr4 and activated its expression in rice protoplasts.Overexpression of Sdr4 reduced the high seed germination rate of OsVP1 mutant cr-osvp1-1,showing that Sdr4 acts as a downstream target of OsVP1.Both OsVP1 and Sdr4 loss-of-function mutants were insensitive to exogenous ABA and employed the ABA signaling pathway in regulating seed dormancy.These findings shed light on the control of seed dormancy aimed at preventing PHS in rice. | Wenqiang Chen Wei Wang Yusong Lyu Yawen Wu Pingliang Huang Shikai Hu Xiangjin Wei Guiai Jiao Zhonghua Sheng Shaoqing Tang Gaoneng Shao Ju Luo | 2021 | The Crop Journal2021，9，1： | 5 |
| 11 | The OsNAC23-Tre6P-SnRK1 a feed-forward loop regulates sugar homeostasis and grain yield in rice显示文摘Tre6P(trehalose-6-phosphate)mediates sensing of carbon availability to maintain sugar homeostasis in plants,which underpins crop yield and resilience.However,how Tre6P responds to fluctuations in sugar levels and regulates the utilization of sugars for growth remains to be addressed.Here,we report that the sugar-inducible rice NAC transcription factor OsNAC23 directly represses the transcription of the Tre6P phosphatase gene TPP1 to simultaneously elevate Tre6P and repress trehalose levels,thus facilitating carbon partitioning from source to sink organs.Meanwhile,OsNAC23 and Tre6P suppress the transcription and enzyme activity of SnRK1a,a low-carbon sensor and antagonist of OsNAC23,to prevent the SnRK1a-mediated phosphorylation and degradation of OsNAC23.Thus,OsNAC23,Tre6P,and SnRK1a form a feed-forward loop to sense sugar and maintain sugar homeostasis by transporting sugars to sink organs.Importantly,plants over-expressing OsNAC23 exhibited an elevated photosynthetic rate,sugar transport,and sink organ size,which consistently increased rice yields by 13%–17%in three elite-variety backgrounds and two locations,suggesting that manipulation of OsNAC23 expression has great potential for rice improvement.Collectively,these findings enhance our understanding of Tre6P-mediated sugar signaling and homeostasis,and provide a new strategy for genetic improvement of rice and possibly also other crops. | Zhiyong Li Xiangjin Wei Xiaohong Tong Juan Zhao Xixi Liu Huimei Wang Liqun Tang Yazhou Shu Guanghao Li Yifeng Wang Jiezheng Ying Guiai Jiao Honghong Hu Peisong Hu Jian Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 12 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 13 | Late Paleozoic to Mesozoic Intrusions Distribution in the North Sanjiang Orogenic Belt,Southwest China:Evidence from Zircon U-Pb Dating and Geochemistry显示文摘A mosaic of terranes or blocks and associated Late Paleozoic to Mesozoic sutures are characteristics of the north Sanjiang orogenic belt(NSOB).A detailed field study and sampling across the three magmatic belts in north Sanjiang orogenic belt,which are the Jomda-Weixi magmatic belt,the Yidun magmatic belt and the Northeast Lhasa magmatic belt,yield abundant data that demonstrate multiphase magmatism took place during the late Paleozoic to early Mesozoic.9 new zircon LA-ICP-MS U-Pb ages and 160 published geochronological data have identified five continuous episodes of magma activities in the NSOB from the Late Paleozoic to Mesozoic:the Late Permian to Early Triassic(c.261-230 Ma);the Middle to Late Triassic(c.229-210 Ma);the Early to Middle Jurassic(c.206-165 Ma);the Early Cretaceous(c.138-110 Ma) and the Late Cretaceous(c.103-75 Ma).105 new and 830 published geochemical data reveal that the intrusive rocks in different episodes have distinct geochemical compositions.The Late Permian to Early Triassic intrusive rocks are all distributed in the Jomda-Weixi magmatic belt,showing arc-like characteristics;the Middle to Late Triassic intrusive rocks widely distributed in both Jomda-Weixi and Yidun magmatic belts,also demonstrating volcanic-arc granite features;the Early to Middle Jurassic intrusive rocks are mostly exposed in the easternmost Yidun magmatic belt and scattered in the westernmost Yangtza Block along the Garze-Litang suture,showing the properties of syn-collisional granite;nearly all the Early Cretaceous intrusive rocks distributed in the NE Lhasa magmatic belt along Bangong suture,exhibiting both arc-like and syn-collision-like characteristics;and the Late Cretaceous intrusive rocks mainly exposed in the westernmost Yidun magmatic belt,with A-type granite features.These suggest that the co-collision related magmatism in Indosinian period developed in the central and eastern parts of NSOB while the Yanshan period co-collision related magmatism mainly occurred in the west area.In detail,the earliest magmatism developed in late Permian to Triassic and formed the Jomda-Wei magmatic belt,then magmatic activity migrated eastwards and westwards,forming the Yidun magmatic bellt,the magmatism weakend at the end of late Triassic,until the explosure of the magmatic activity occurred in early Cretaceous in the west NSOB,forming the NE Lhasa magmatic belt.Then the magmatism migrated eastwards and made an impact on the within-plate magmatism in Yidun magmatic belt in late Cretaceous. | GONG Xuejing YANG Zhusen MENG Xiangjin PAN Xiaofei WANG Qian ZHANG Lejun | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 4 |
| 14 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 15 | Ganglioside GD3 synthase(GD3S),a novel cancer drug target显示文摘Gangliosides are a class of important glycosphingolipids containing sialic acid that are widely distributed on the outer surface of cells and are abundantly distributed in brain tissue. Disialoganglioside with three glycosyl groups(GD3) and disialoganglioside with two glycosyl groups(GD2) are markedly increased in pathological conditions such as cancers and neurodegenerative diseases. GD3 and GD2 were found to play important roles in cancers by mediating cell proliferation, migration, invasion, adhesion,angiogenesis and in preventing immunosuppression of tumors. GD3 synthase(GD3S) is the regulatory enzyme of GD3 and GD2 synthesis, and is important in tumorigenesis and the development of cancers.The study of GD3S as a drug target may be of great significance for the discovery of new drugs for cancer treatment. This review will describe the gangliosides and their roles in physiological and pathological conditions; the roles of GD3 and GD2 in cancers; the expression, functions and mechanisms of GD3S,and its potential as a drug target in cancers. | Jinyi Liu Xiangjin Zheng Xiaocong Pang Li Li Jinhua Wang Cui Yang Guanhua Du | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 4 |
| 16 | Aboveground biomass and its spatial distribution pattern of herbaceous marsh vegetation in China显示文摘Herbaceous marsh is the most widely distributed type of marsh wetland ecosystem,and has important ecological functions such as water conservation,climate regulation,carbon storage and fixation,and sheltering rare species.The carbon sequestration function of herbaceous marsh plays a key role in slowing climate warming and maintaining regional environmental stability.Vegetation biomass is an important index reflecting the carbon sequestration capacity of wetlands.Investigating the biomass of marsh vegetation can provide a scientific basis for estimating the carbon storage and carbon sequestration capacity of marshes.Based on field survey data of aboveground biomass of herbaceous marsh vegetation and the distribution data set of marsh in China,we analyzed the aboveground biomass and its spatial distribution pattern of herbaceous marsh on a national scale for the first time.The results showed that in China the total area of herbaceous marsh was 9.7×10^(4) km^(2),the average density of aboveground biomass of herbaceous marsh vegetation was 227.5±23.0 g C m-2(95%confidence interval,the same below),and the total aboveground biomass was 22.2±2.2 Tg C(1 Tg=1012 g).The aboveground biomass density of herbaceous marsh vegetation is generally low in Northeast China and the Tibetan Plateau,and high in central North China and coastal regions in China.In different marsh distribution regions of China,the average biomass density of herbaceous marsh vegetation from small to large was as follows:temperate humid and semi-humid marsh region(182.3±49.3 g C m^(-2)) | Xiangjin SHEN Ming JIANG Xianguo LU Xingtu LIU Bo LIU Jiaqi ZHANG Xianwei WANG Shouzheng TONG Guangchun LEI Shengzhong WANG Chuan TONG Hangqing FAN Kun TIAN Xiaolong WANG Yuanman HU Yonghong XIE Muyuan MA Shuwen ZHANG Chunxiang CAO Zhichen WANG | 2021 | Science China Earth Sciences2021，64，7： | 4 |
| 17 | Effect of glycyrrhizin on traumatic brain injury in rats and its mechanism显示文摘ObjectiveTo 在创伤的大脑损害(TBI ) MethodsMale Sprague-Dawley 老鼠随机被划分成三个组以后,在老鼠在高活动性的组盒子 1 的表示(HMGB1 ) 上象它的效果一样调查 glycyrrhizin (Gly ) 的 neuroprotective 效果:假冒的组 TBI 组和 TBI + Gly 组(n = 36 每组) 。老鼠 TBI 模型被使用修改 Feeney’s 方法做。在 TBI + Gly 组 Gly 在 10 的剂量静脉内地被管理; mg/kg 30 在 TBI 以后的 min。在 24 在 TBI 马达功能和大脑水内容以后的 h 被评估。同时包括像使用费的受体的 HMGB1/HMGB1 受体 4 (TLR4 ) 并且为先进 glycation 结束产品(愤怒) 的受体 /nuclear 因素 -- 在受伤大脑纸巾表明小径和煽动性的 cytokines 的 B (NF- B ) 用量的即时聚合酶链反应被检测西方的污点 electrophoretic 活动性移动试金和连接酶的 immunosorbent 试金。而且 HMGB1 愤怒和 TLR4 immunohistochemistry 和 apoptosis 是走表演缺陷和大脑浮肿的 analyzedResultsBeam 显著地在 TBI 被减少; + Gly 组与 TBI 相比组;同时, HMGB1/HMGB1 受体(TLR4 和愤怒) 的在表示上 /NF-B DNA 有约束力的活动和煽动性的 cytokines 被禁止。 HMGB1 ,愤怒和TLR4积极的房间和 apoptotic 房间的百分比是分别地58.37% ; ± ;5.06%,54.15% ; ± ;4.65%,65.50% ; ± ;4.83%,52.02% ; ± ;4.63%在 TBI 组和39.99% ; ± ;4.99%,34.87% ; ± ;5.02%,43.33% ; ± ;4.54%,37.84% ; ± ;5.16%在 TBI ;+ ; Gly 组(所有 P ;< ; 0.01 与 TBI 相比组织)能 .ConclusionGly | Gu Xiangjin Xu Jin Ma Banyou Chen Gong Gu Peiyuan Wei Dong Hu Weixing | 2014 | Chinese Journal of Traumatology2014，17，1： | 4 |
| 18 | Tumorigenic bacteria in colorectal cancer:mechanisms and treatments显示文摘Colorectal cancer(CRC)is the third most common and the second most fatal cancer.In recent years,more attention has been directed toward the role of gut microbiota in the initiation and development of CRC.Some bacterial species,such as Fusobacterium nucleatum,Escherichia coli,Bacteroides fragilis,Enterococcus faecalis,and Salmonella sp.have been associated with CRC,based upon sequencing studies in CRC patients and functional studies in cell culture and animal models.These bacteria can cause host DNA damage by genotoxic substances,including colibactin secreted by pks+Escherichia coli,B.fragilis toxin(BFT)produced by Bacteroides fragilis,and typhoid toxin(TT)from Salmonella.These bacteria can also indirectly promote CRC by influencing host-signaling pathways,such as E-cadherin/β-catenin,TLR4/MYD88/NF-κB,and SMO/RAS/p38 MAPK.Moreover,some of these bacteria can contribute to CRC progression by helping tumor cells to evade the immune response by suppressing immune cell function,creating a proinflammatory environment,or influencing the autophagy process.Treatments with the classical antibacterial drugs,metronidazole or erythromycin,the antibacterial active ingredients,M13@Ag(electrostatically assembled from inorganic silver nanoparticles and the protein capsid of bacteriophage M13),berberine,and zerumbone,were found to inhibit tumorigenic bacteria to different degrees.In this review,we described progress in elucidating the tumorigenic mechanisms of several CRC-associated bacteria,as well as progress in developing effective antibacterial therapies.Specific bacteria have been shown to be active in the oncogenesis and progression of CRC,and some antibacterial compounds have shown therapeutic potential in bacteria-induced CRC.These bacteria may be useful as biomarkers or therapeutic targets for CRC. | Sha Li Jinyi Liu Xiangjin Zheng Liwen Ren Yihui Yang Wan Li Weiqi Fu Jinhua Wang Guanhua Du | 2022 | Cancer Biology & Medicine2022，19，2： | 3 |
| 19 | Alanine aminotransferase(OsAlaAT1)modulates nitrogen utilization,grain yield,and quality in rice显示文摘Widespread use of inorganic nitrogen fertilizers has increased yields of many grains, including rice (Oryza sativa L.);however, fertilizers are costly for farmers and cause serious environmental problems, such as soil acidification and water eutrophication (Guo et al., 2010, 2021;Liu et al., 2021). Improving nitrogen use efficiency(NUE) in rice offers a practical way to enhance grain yield and alleviate the environmental problems caused by overuse of nitrogen fertilizer. Identifying and characterizing genes involved in NUE provides crucial information for this aim. | Liangbing Fang Liuyang Ma Shaolu Zhao Ruijie Cao Guiai Jiao Peisong Hu Xiangjin Wei | 2022 | Journal of Genetics and Genomics2022，49，5： | 3 |
| 20 | MELK is an oncogenic kinase essential for metastasis,mitotic progression,and programmed death in lung carcinoma显示文摘Lung cancer is the fastest growth rate of morbidity and mortality in nearly a decade,and remains difficult to treat.Furthermore,the molecular mechanisms underlying its development are still unclear.In this study,bioinformatics analysis showed that MELK was highly expressed in lung cancer and negatively correlated to the survival of lung adenocarcinoma(LUAD).Immunohistochemistry analysis of LUAD patient tissues revealed there were a high level of MELK expression in LUAD.Knockdown of MELK expression inhibits the migration and invasion of LUAD cells,which may be mediated by Twist1,Slug,MMP7,and N-catenin.Overexpression of MELK promoted the growth of LUAD cells in medium,3D Matrigel,and nude mice.Inhibition of MELK by OTSSP167 arrested cycle of LUAD cells at G2/M phase via PLK1-CDC25C-CDK1 pathway,and triggered apoptosis-mediated pyroptosis.Together,these data indicate that MELK is critical for metastasis,mitotic progression,and programmed death of LUAD and may be a promising therapeutic target for LUAD. | Qin Tang Wan Li Xiangjin Zheng Liwen Ren Jinyi Liu Sha Li Jinhua Wang Guanhua Du | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员