|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Assessment of gas and dust explosion in coal mines by means of fuzzy fault tree analysis显示文摘During the past decade, coal dust and gas explosions have been the most two serious types of disasters in China, threatening the lives of miners and causing significant losses in terms of national property. In this paper, an evaluation model of coal dust and gas explosions was constructed based on a fuzzy fault tree by taking the Xingli Coal Mine as a research site to identify the risk factors of coal dust and gas explosions.Furthermore, the hazards associated with such explosions were evaluated for this particular coal mine.After completing an on-site investigation, the fuzzy probabilities of basic events were obtained through expert scoring, and these expert opinions were then aggregated as trapezoidal fuzzy numbers to calculate the degrees of importance of all basic events. Finally, these degrees of importance were sorted. According to the resulting order, the basic events with higher probabilities were determined to identify key hazards in the daily safety management of this particular coal mine. Moreover, effective measures for preventing gas and coal dust explosions were derived. The fuzzy fault tree analysis method is of high significance in the analysis of accidental coal mine explosions and provides theoretical guidance for improving the efficiency of coal mine safety management in a scientific and feasible manner. | Shulei Shi Bingyou Jiang Xiangrui Meng | 2018 | International Journal of Mining Science and Technology2018，28，6： | 9 |
| 3 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 4 | Key technologies and engineering practices for soft-rock protective seam mining显示文摘Severe gas disasters in deep mining areas are increasing,and traditional protective coal seam mining is facing significant challenges.This paper proposes an innovative technology using soft rock as the protective seam in the absence of an appropriate coal seam.Based on the geological engineering conditions of the new horizontal first mining area of Luling Coal Mine in Huaibei,China,the impacts of different mining parameters of the soft-rock protective seam on the pressure-relief effect of the protected coal seam were analyzed through numerical simulation.The unit stress of the protected coal seam,which was less than half of the primary rock stress,was used as the mining stress pressure-relief index.The optimized interlayer space was found to be 59 m for the first soft-rock working face,with a 2 m mining thickness and 105 m face length.The physicochemical characteristics of the orebody were analyzed,and a device selection framework for the soft-rock protective seam was developed.Optimal equipment for the working face was selected,including the fully-mechanized hydraulic support and coal cutter.A production technology that combined fully-mechanized and blasting-assisted soft-rock mining was developed.Engineering practices demonstrated that normal circulation operation can be achieved on the working face of the soft-rock protective seam,with an average advancement rate of 1.64 m/d.The maximum residual gas pressure and content,which were measured at the cut hole position of the protected coal seams(Nos.8 and 9),decreased to 0.35 MPa and 4.87 m^3/t,respectively.The results suggested that soft-rock protective seam mining can produce a significant gas-control effect. | Xiang Cheng Guangming Zhao Yingming Li Xiangrui Meng Qingyi Tu | 2020 | International Journal of Mining Science and Technology2020，30，6： | 7 |
| 5 | miR-10a inhibits cell proliferation and promotes cell apoptosis by targeting BCL6 in diffuse large B-cell lymphoma显示文摘BCL6 (B 房间淋巴瘤 6 ) 基因是经常在弥漫的大 B 房间淋巴瘤(DLBCL ) 被表示的 proto-oncogene。功能的 BCL6 损失能杀死 DLBCL 房间,证明 BCL6 为 DLBCL 房间的幸存是必要的并且能是一个治疗学的目标。在这研究,我们发现那 BCL6 蛋白质层次,建议那是一致地在 DLBCL 纸巾的 upregulated 而它的 mRNA 层次在纸巾随机变化了, post-transcriptional 机制涉及 BCL6 规定。我们使用了生物信息学分析寻找 miRNAs,它潜在地指向 BCL6,并且在 BCL6 的 3-untranslated 区域(3-UTR ) 为 miR-10a 识别了特定的指向的地点。我们进一步鉴别在 miR-10a 层次和 BCL6 蛋白质层次之间的反的关联,然而并非 mRNA 铺平,在 DLBCL 肿瘤织物样品。由 overexpressing 或在 DLBCL 房间将 miR-10a 击倒,我们试验性地直接验证了那 miR-10a 认出 BCL6 抄本和调整 BCL6 表示的 3-UTR。而且,我们证明否定地由 miR-10a 调整 BCL6 压制了增长并且支持了 DLBCL 房间的 apoptosis。 | Qian Fan Xiangrui Meng Hongwei Liang Huilai Zhang Xianming Liu Lanfang Li Wei Li Wu Sun Haiyang Zhang Ke Zen Chen-Yu Zhang Zhen Zhou Xi Chen Yi Ba | 2016 | Protein & Cell2016，7，12： | 5 |
| 6 | A ROBUST FINITE ELEMENT METHOD FOR A 3-D ELLIPTIC SINGULAR PERTURBATION PROBLEM显示文摘这篇论文为一个三维的第四顺序的椭圆形的单个不安问题建议一个柔韧的有限元素方法。方法使用三维的莫利元素并且在相应于秒顺序的双线性的形式的部分代替有限元素功能由合适的近似的微分操作员。给如此的近似,为秒顺序问题的一个会聚的非一致的元素被构造。方法在不安参数一致地收敛,这被显示出。 | Ming Wang Xiangrui Meng | 2007 | Journal of Computational Mathematics2007，25，6： | 4 |
| 7 | Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer显示文摘Objective:The oncoprotein,hepatitis B X-interacting protein(HBXIP),has been reported to play an important role in human malignancies.However,its functions in non-small cell lung cancer(NSCLC)are poorly understood.The goal of the present study was to identify the role of HBXIP in the regulation of NSCLC development.Methods:The level of HBXIP expression in NSCLC tissue was assessed by immunohistochemical and Western blot analyses,and its relationships with clinicopathological features and outcomes were statistically evaluated.The effects of HBXIP on NSCLC cell progression were assessed through cell viability,colony formation,and flow cytometry analyses in vitro.The mechanism by which HBXIP regulated the MAPK pathway was studied by Western blot,immunofluorescence,and immunoprecipitation assays.In addition,in vivo experiments were performed to evaluate the progression of NSCLC and ERK signaling pathway activation after HBXIP knockdown.Results:HBXIP was overexpressed in human NSCLC and was correlated with the invasiveness of NSCLC.The high expression of HBXIP in NSCLC was significantly correlated with gender(P=0.033),N stage(P=0.002),and tumor-node-metastasis stage(P=0.008).In vitro experiments using an NSCLC cell line revealed that HBXIP knockdown resulted in the suppression of cell proliferation and colony formation,which was consistent with the enhanced cell cycle arrest in G1 phase.The results of a mechanistic investigation suggested that binding of HBXIP to MEK1 protein promoted MAPK/ERK signaling pathway activation in NSCLC by preventing the proteasome-mediated degradation of MEK1.In addition,the results obtained using in vivo subcutaneous tumor xenografts confirmed that HBXIP deficiency decreased MEK1 protein levels and NSCLC tumor growth.Conclusions:Taken together,our results showed that the HBXIP-MEK interaction promoted oncogenesis via the MAPK/ERK pathway,which may serve as a novel therapeutic target for cancers in which MAPK/ERK signaling is a dominant feature. | Jun Zhang Bei Sun Xianhui Ruan Xiukun Hou Jingtai Zhi Xiangrui Meng Xiangqian Zheng Ming Gao | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 8 | A damage-based constitutive model for rock under impacting load显示文摘Using the Splitting Hopkinson Pressure Bar(SHPB) experimental system, investigations were made into the dynamic mechanical performances of underground soft rocks. The experiments proved that the measured stress–strain curves display the characteristics of plastic deformation. By making use of a revised overstress constitutive formula for the stress model and by taking into account that the strain rate and strain are a function of 1 E(t)/E0, a revised overstress constitutive formula for the stress model was simplified by applying dimensional analysis and consequently, a simplified overstress formula was obtained for the stress model. Then, by taking into consideration the effects of damage under a dynamic load on the dynamic loading strength of the rock, the continuous damage theory and the statistical strength theory were introduced into the development of the simplified overstress constitutive formula for the stress model. Hence, a damage-based constitutive formula for an overstress model, which can be appropriately applied to the analysis of full dynamic stress–strain curves, was developed. By using the simplified damage-based constitutive formula for an overstress model, the actually measured curves are fitted, indicating that the fitting curves and those actually measured are in good agreement. | Guangming Zhao Lixiang Xie Xiangrui Meng | 2014 | International Journal of Mining Science and Technology2014，24，4： | 3 |
| 9 | Influence of frequency on the surface discharge characteristics of PEEK under positive repetitive square voltage显示文摘In this study, the surface discharge current pulses of polyetheretherketone (PEEK) material under positive repetitive square voltage in a nitrogen atmosphere are measured. The influences of different voltage amplitudes and frequencies on the detail parameters of forward discharge and backward discharge current pulses are statistically analysed. The results show that as the square voltage amplitude increases, the current pulse amplitude, fall time and pulse width of both forward and backward discharge current increase, and the rise time does not change significantly. As the voltage frequency increases, current pulse amplitude, fall time and pulse width of both forward and backward discharge current decrease, and the rise time does not change significantly. Due to the independence of the discharge at different repetitive cycles, the specific discharge process in one cycle is analysed in detail to explain the influence mechanism of the voltage amplitude and frequency on the discharge current. By mean of the Richardson-Schottky and the Cavallini relaxation model, the relationship between discharge voltage ratio and surface charge, and the decay process of surface discharge are analysed. Furthermore, the influences of amplitude and frequency of the positive repetitive square voltage on the PEEK surface current pulses are explained qualitatively. | Zhuodong Yang Xuebao Li Xiangrui Meng Zhibin Zhao Pengyu Fu Bin Zhai Xiang Cui | 2020 | High Voltage2020，5，6： | 2 |
| 10 | Dynamic study of steam generation from low-grade waste heat in a zeolite–water adsorption heat pump显示文摘 | Bing Xue Xiangrui Meng Xinli Wei Koichi Nakaso Jun Fukai | 2014 | Applied Thermal Engineering2014，，： | 1 |
| 11 | Microstructures and properties of superlight Mg–Li–Al–Zn wrought alloys显示文摘 | Xiangrui Meng Ruizhi Wu Milin Zhang Libin Wu Chongliang Cui | 2009 | Journal of Alloys and Compounds2009，，1： | 1 |
| 12 | Research and development of Chinese anti-COVID-19 drugs显示文摘The outbreak and spread of coronavirus disease 2019(COVID-19)highlighted the importance and urgency of the research and development of therapeutic drugs.Very early into the COVID-19 pandemic,China has begun developing drugs,with some notable progress.Herein,we summarizes the anti-COVID-19 drugs and promising drug candidates originally developed and researched in China.Furthermore,we discussed the developmental prospects,mechanisms of action,and advantages and disadvantages of the anti-COVID-19 drugs in development,with the aim to contribute to the rational use of drugs in COVID-19 treatment and more effective development of new drugs against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the variants.Neutralizing antibody is an effective approach to overcome COVID-19.However,drug resistance induced by rapid virus mutation will likely to challenge neutralizing antibodies.Taking into account current epidemic trends,small molecule drugs have a crucial role in fighting COVID-19 due to their significant advantage of convenient administration and affordable and broad-spectrum.Traditional Chinese medicines,including natural products and traditional Chinese medicine prescriptions,contribute to the treatment of COVID-19 due to their unique mechanism of action.Currently,the research and development of Chinese anti-COVID-19 drugs have led to some promising achievements,thus prompting us to expect even more rapidly available solutions. | Xiwei Ji Xiangrui Meng Xiao Zhu Qingfeng He Yimin Cui | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 1 |
| 13 | Microstructures and properties of superlight Mg-Li-Al-Zn wrought alloys 显示文摘 | Meng Xiangrui Wu Ruizhi Zhang Milin | 2009 | Journal of Alloys and Compounds2009，486，112： | 1 |
| 14 | Evaluation and empirical research on the energy efficiency of 20 mining cities in Eastern and Central China显示文摘The gap of energy efficiency of eastern and central mining cities in China continues to expand, getting more attention from relevant departments. In this work, 20 mining cities in Eastern and Central China from 2010 to 2014 have been selected as research samples using data envelopment analysis(DEA).Research results show that the level of energy efficiency in mining cities is still low. China is in an extensive economic growth mode with high input, high consumption, low output and low efficiency. Mining cities in China have a huge potential to conserve energy and reduce emissions. China should optimize industrial structures, strengthen scientific and technological input and innovation, as well as implement energy-saving emissions reductions, and increase investment in environmental protection and ideological propaganda. | Liu Xiaomeng Meng Xiangrui | 2018 | International Journal of Mining Science and Technology2018，28，3： | 1 |
| 15 | Structural limiting factors of mixed-valent tin oxides in photoelectrochemical application:A comparative exploration显示文摘Photoelectrocatalytic(PEC)materials for harvesting solar energy can be discovered from existing photocatalytic semiconductors.Nonetheless,mixed valence tin oxides,a group of widely reported visible light active photocatalysts,can hardly be developed into efficient PEC photoelectrodes.To overcome this difficulty by clarifying its origin,two typical mixed valence tin oxides,Sn^(2+):SnO_(2) microrods and porous Sn_(3)O_(4) particles were deliberately prepared as the models.Sn^(2+):SnO_(2) microrods of less porosity exhibited a photocurrent over ten times higher than Sn_(3)O_(4) particles.Photo-electrochemical impedance spectroscopy revealed this was due to their charge kinetics difference,specifically the internal transport/-transfer responding to the morphology.Moreover,hydroxyl residuals from synthesis were found to be very inhibitive for the PEC efficiency as well,which was in coherence with our TGA and Raman spectroscopic study.These finding experimentally proved the necessity of reconsidering the surface area,crystallinity,and defects when developing photocatalysts into efficient PEC structures. | Yalong Zou Deyu Liu Xiangrui Meng Qitao Liu Yang Zhou Jianming Li Zhiying Zhao Ding Chen Yongbo Kuang | 2021 | Journal of Energy Chemistry2021，30，5： | 0 |
| 16 | Collision Dynamics of an Energetic Carbon Ion Impinging on the Stone-Wales Defect in a Single-walled Carbon Nanotube显示文摘 | ZHANG Chao MAO Fei MENG Xiangrui PAN Chengling SHENG Shaoding | 2016 | Chemical Research in Chinese Universities2016，32，5： | 0 |
| 17 | Time-domain and Frequency-domain Analyses of PETT Oscillation in Press Pack IGBTs显示文摘Plasma extraction transit time(PETT)oscillation might appear in IGBT devices,which is harmful to the electromagnetic compatibility(EMC)of a renewable energy system.To eliminate this oscillation,its frequency-domain characteristics in wire-bonded IGBT devices have been extensively studied.However,the time-domain analysis of PETT oscillation,especially in Press Pack IGBT(PPI)devices,has not attracted enough attention yet.In this paper,PETT oscillations with multi-chips in PPI devices are systematically investigated by experiments.It is first reported there are multiple resonant oscillations at the tail period when multi-chips turn off.Oscillations overlap in the time domain waveforms,which lead PETT oscillation to be more serious in multi-chips.Then,PETT oscillation is divided into three different feedback states for the first time.For the IGBT chip in the PETT oscillation,its physical based model and behavior model are proposed,which further form the equivalent circuit as the two-port network.Moreover,it is indicated that only parallel resonances can lead to PETT oscillation,which is consistent with experiment results. | Jiayu Fan Xiang Cui Xinling Tang Cheng Peng Zhibin Zhao Xiangrui Meng Xuebao Li Zhong Chen | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 0 |
| 18 | Quantification of emission variability for off-road equipment in China based on real-world measurements显示文摘The objective of this paper is to quantify the variability in emissions of off-road equipment using a portable emission measurement system.A total of 53 commonly used equipment for agriculture,base construction,paving construction,and material handling were selected.Time-based and fuel-based emissions were quantified by different duty and engine modes.Three duty modes(idling,moving,and working)were used.Ten engine modes were defined based on normalized engine revolutions-per-minute and manifold absolute pressure,respectively.Composite emission factors taking into account both duty modes and its corresponding time percentage during a typical duty cycle were estimated.Results showed that there existed a large off-road equipment variability in emissions.Depending on duty and engine modes,time-based NO emissions ranged from 3.1 to 237.9,29.1‒1475.6,83.2‒681.6,and 3.2‒385.2 g/h for agriculture,base construction,paving construction and material handling equipment,respectively while for fuel-based NO emissions these ranges were 5.3‒52.0,11.7‒69.0,4.8‒30.8,and 11.0‒54.6 g/kg,respectively.Furthermore,emission factors derived from this study exhibited a much larger variability compared to those used in NONROAD by US EPA and National Guideline for Off-road Equipment of China.This implied that localized measurements of emissions are needed for improvement of accuracy of emission inventory.Furthermore,both equipment types and operations should be considered for development of emission inventory and control strategy. | Kaili Pang Kaishan Zhang Shuai Ma Xiangrui Meng | 2022 | Frontiers of Environmental Science & Engineering2022，16，2： | 0 |
| 19 | Experimental study on failure characteristics of single-sided unloading rock under different intermediate principal stress conditions显示文摘Investigation of unloading rock failure under differentσ_(2)facilitates the control mechanism of excavation surrounding rock.This study focused on single-sided unloading tests of granite specimens under true triaxial conditions.The strength and failure characteristics were studied with micro-camera and acoustic emission(AE)monitoring.Furthermore,the choice of test path and the effect ofσ_(2)on fracture of unloading rock were discussed.Results show that the increasedσ_(2)can strengthen the stability of single-sided unloading rock.After unloading,the rock’s free surface underwent five phases,namely,inoculation,particle ejection,buckling rupture,stable failure,and unstable rockburst phases.Moreover,atσ_(2)≤30 MPa,the b value shows the following variation tendency:rising,dropping,significant fluctuation,and dropping,with dispersed damages signal.Atσ_(2)≥40 MPa,the tendency shows:a rise,a decrease,a slight fluctuation,and final drop,with concentrated damages signal.After unloading,AE energy is mainly concentrated in the micro-energy range.With the increasedσ_(2),the micro-energy ratio rises.In contrast,low,medium and large energy ratios drop gradually.The increased tensile fractures and decreased shear fractures indicate that the failure mode of the unloading rock gradually changes from tensile-shear mode to tensile-split one.The fractional dimension of the rock fragments first increases and then decreases with an inflection point at 20 MPa.The distribution of SIF on the planes changes asσ_(2)increases,resulting in strengthening and then weakening of the rock bearing capacity. | Chongyan Liu Guangming Zhao Wensong Xu Xiangrui Meng Zhixi Liu Xiang Cheng Gang Lin | 2023 | International Journal of Mining Science and Technology2023，33，3： | 0 |
| 20 | High-power microwaves response characteristics of silicon and GaAs solar cells显示文摘The high-power microwave(HPM)effect heats solar cells,which is an important component of a satellite.This creates a serious reliability problem and affects the normal operation of a satellite.In this paper,the different HPM response characteristics of two kinds of solar cells are comparatively researched by simulation.The results show that there are similarities and differences in hot spot distribution and damage mechanisms between both kinds of solar cell,which are related to the amplitude of HPM.In addition,the duty cycle of repetition frequency contributes more to the temperature accumulation of the solar cells than the carrier frequency.These results will help future research of damage assessment technology,reliability enhancement and the selection of materials for solar cells. | Xiangrui Meng Changchun Chai Fuxing Li Yi Sun Yintang Yang | 2022 | Journal of Semiconductors2022，43，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员