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| 1 | Preparation of calcium sulfate whiskers from FGD gypsum via hydrothermal crystallization in the H_2SO_4-NaCl-H_2O system显示文摘Little attention has thus far been paid to the potential effect of solution composition on the hydrothermal crystallization of calcium sulfate whiskers prepared from flue-gas desulfurization(FGD) gypsum.When purified FGD gypsum was used as raw material,the morphology and phase structure of the hydrothermal products grown in pure water,H_2SO_4-H_2O,NaCl-H_2O,and H_2SO_4-NaCl-H_2O solutions as well as the solubility of purified FGD gypsum in these solutions were investigated.The results indicate that calcium sulfate whiskers grow favorably in the H_2SO_4-NaCl-H_2O system.When prepared using 10-70 g NaCl/kg gypsum-0.01 M H_2SO_4-H_2O at 130 ℃ for 60 min,the obtained calcium sulfate whiskers had diameters ranging from 3 to 5 |xm and lengths from 200 to 600 |xm,and their phase structure was calcium sulfate hemihydrate(HH).Opposing effects of sulfuric acid and sodium chloride on the solubility of the purified FGD gypsum were observed.With the co-presence of sulfuric acid and sodium chloride in the reaction solution,the concentrations of Ca^(2+) and SO_4^(2-) can be kept relatively stable,which implies that the crystallization of the hydrothermal products can be controlled by changing the concentrations of sulfuric acid and sodium chloride. | Xiao Wang Liushuan Yang Xinfeng Zhu Jiakuan Yang | 2014 | Particuology2014，12，6： | 34 |
| 2 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 3 | Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein显示文摘Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein. | Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang Lin Li Shibo Jiang Wei Xu Gengfu Xiao Shuwen Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | The autocorrelation distribution of balanced Boolean function显示文摘 | Yu ZHOU Weiguo ZHANG Juan LI Xinfeng DONG Guozhen XIAO | 2013 | Frontiers of Computer Science2013，7，2： | 4 |
| 5 | Liquid biopsy for esophageal cancer: Is detection of circulating cell-free DNA as a biomarker feasible?显示文摘Esophageal cancer(EC)is a common cancer and is histopathologically classified into esophageal squamous cell carcinoma and esophageal adenocarcinoma.EC is a worldwide public health issue because of late diagnosis and lack of effective therapy.In contrast to standard tumor biopsies,liquid biopsies are emerging as a tool which is minimally invasive that can complement or even substitute more classical approaches.Specifically,cell-free DNA(cfDNA)has shown promise in cancer-related clinical applications.Indeed,cfDNA has been shown to be an effective circulating biomarker for non-invasive cancer diagnosis and monitoring of cancer patients.Although the clinical application of cfDNA has been reported on other cancers,few studies have evaluated its use in EC.Here,we review this relevant literature and discuss limitations and advantages of its application in the diagnosis and monitoring of EC. | Zuyang Yuan Xinfeng Wang Xiao Geng Yin Li Juwei Mu Fengwei Tan Qi Xue Shugeng Gao Jie He | 2021 | Cancer Communications2021，41，1： | 4 |
| 6 | Preliminary Analysis of Diesel-Degrading Bacteria Immobilized on Organic Carriers in Seawater显示文摘Oil pollution in marine environment is becoming increasingly serious. Oil bioremediation by immobilization technology has been widely studied. However, the effect of bacteria immobilization was limited because of lack of nutrients. In this paper, the organic materials(corn straw, corn cob and corn leaf) were used as carriers. The diesel removal rate achieved by the immobilized bacteria was studied, and the effects of nutrients(e.g. nitrogen and phosphorus) released from organic carriers to the immobilized bacteria were analyzed. Test results indicated that a certain amount of nutrients was released from organic carriers. Additionally, the diesel removal rates achieved by different immobilized bacteria were all higher than those achieved by free bacteria. And, the diesel removal rates achieved by bacteria decreased in the following order: bacteria immobilized on corn straw(79%), bacteria immobilized on corn leaf(70%) and bacteria immobilized on corn cob(43%). These findings indicated two aspects, viz.: the carriers porous structure and the nutrients, which were favorable to biodegradation. Finally, the changes in nitrogen and phosphorus contents that were released from different carriers during biodegradation were studied. The results showed that the rate of diesel biodegradation was fast in the initial phase because of the sufficient nutrients released from carriers. Meanwhile, in the final phase, the rate of diesel biodegradation was relatively slow because of few nutrients released from carriers. | Liu Zhixiu Xue Jianliang Wu Yanan Li Menglu Sun Xiyu Cui Hao Cheng Lijie Gao Yu Xiao Xinfeng | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 4 |
| 7 | Surface molecular imprinting on g-C3N4 photooxidative nanozyme for improved colorimetric biosensing显示文摘Graphitic carbon nitride(g-C3 N4),as a visible-light-active organic semiconductor,has attracted growing attentions in photocatalysis and photoluminescence-based biosensing.Here,we demonstrated the intrinsic photooxidase activity of g-C3 N4 and then surface molecular imprinting on g-C3 N4 nanozymes was achieved for improved biosensing.Upon blue LED irradiation,the g-C3 N4 exhibited superior enzymatic activity for oxidation of chromogenic substrate like 3,3’,5,5’-tetramethylbenzidine(TMB)without destructive H2 O2.The oxidation was mainly ascribed to ·O2^-that was generated during light irradiation.The surface molecular imprinting on g-C3 N4 can lead to an over 1000-fold alleviation in matrix-interference from serum samples,4-fold improved enzymatic activity as well as enhanced substrate specificity comparing with bare g-C3 N4 during colorimetric sensing.Also,the MIP-g-C3 N4 possesses a high affinity to TMB with a Km value of only 22 μmol/L,much lower than other comment nanozymes like AuNPs,Fe3 O4 NPs,etc.It was successfully applied for detection of cysteine in serum sample with satisfactory recoveries. | Yuanheng Wu Qiang Chen Shuang Liu Hua Xiao Menglin Zhang Xinfeng Zhang | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 8 | Analysis and Optimisation of Halomonas Growth Factors Based on PCA and RSM显示文摘The biomass of petroleum-degrading bacteria, such as Halomonas spp., is crucial to the alleviation of severe oil spills through bioremediation. In this paper, the bacterium(HDMP1) was isolated and identified. Growth factors were analysed and optimised through the single-factor experiments, the factor analysis(FA), the principal component analysis(PCA), and the response surface methodology(RSM). Results indicated that HDMP1 was identified as genus Halomonas. In the single-factor experiments, the range of suitable growth conditions for HDMP1 covered: a salt concentration of 2%-4%, a medium pH value of approximately 9, an inoculum concentration of 1.0%, a substrate concentration of 1.0%-1.4%, and a rotation rate of 140 r/min. The evaluation by FA and PCA indicated that three significant growth factors were the salt concentration, the pH value, and the rotation rate. A maximum biomass of HDMP1 was obtained under the conditions covering a salt concentration of 3.5%, a medium pH of 8, and a rotation rate of 151 r/min by optimization. | Shi Ke Huang Guofu Xu Huachun Xue Jianliang Sun Jingkuan Xiao Xinfeng Li Lin | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 1 |
| 9 | Microalgae cultivation and culture medium recycling by a two-stage cultivation system显示文摘Nutrients and water play an important role in microalgae cultivation.Using wastewater as a culture medium is a promising alternative to recycle nutrients and water,and for further developing microalgae-based products.In the present study,two species of microalgae,Chlorella sp.(high ammonia nitrogen tolerance)and Spirulinaplatensis (S.platensis,high growth rate),were cultured by using poultry wastewater through a two-stage cultivation system for algal biomass production.Ultrafiltration (UF)or centrifuge was used to harvest Chlorella-sp.from the first cultivation stage and to recycle culture medium for S.platensis growth in the second cultivation stage.Results showed the two-stage cultiyation system produced high microalgae biomass including 0.39g·L^-1 Chlorella sp.and 3.45g·L^-1 S.platensis in the first-stage and second-stage,respectively.In addition,the removal efficiencies of NH4+reached 19% and almost 100% in the first and the second stage,respectively. Total phosphorus (TP)removal reached 17% and 83%,and total organic carbon (TOC)removal reached 55% and 72% in the first and the second stage,respectively.UF and centrifuge can reeycle 96.8% and 100% water,respectively.This study provides a new method for the combined of pure microalgae cultivation and wastewater treatment with eulture medium recycling. | Xinfeng Wang Lu Lin Haifeng Lu Zhidan Liu Na Duan Taili Dong Hua Xiao Baoming Li Pei Xu | 2018 | Frontiers of Environmental Science & Engineering2018，12，6： | 1 |
| 10 | Effects of Different Plant Hormones for Microbial Degradation of PASHs and Diesel under Aerobic Conditions显示文摘The effects of plant hormones for biodegradation of polycyclic aromatic sulfur heterocycles(PASHs)and diesel fuel were studied.Indole butyric acid(IBA)and gibberellin were found to promote biodegradation of DBT and diesel,respectively.Concentrations of plant hormones,pH,temperature,soil moisture and substrate concentrations were optimized in microbial metabolic processes.Two main factors including temperature and IBA concentration were determined by factor analysis in DBT biodegradation.And soil moisture and diesel concentration were important factors in diesel biodegradation.Binding sites between cell surface and DBT or diesel components were performed by molecular operating environment(MOE).This study suggested that plant hormones could be applied to effectively remove pollutants in environment. | Shang Xiufang Li Lin Xiao Xinfeng Xue Jianliang Gao Yu Gao Hongge Hu Shugang | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 1 |
| 11 | Exploring drug–protein interactions using the relationship between injection volume and capacity factor显示文摘 | Xinfeng Zhao Qian Li Jiejun Chen Chaoni Xiao Liujiao Bian Jianbin Zheng Xiaohui Zheng Zijian Li Youyi Zhang | 2014 | Journal of Chromatography A2014，，： | 1 |
| 12 | Active control of friction realized by vibrational excitation:Numerical simulation based on the Prandtl-Tomlinson model and molecular dynamics显示文摘Superlubricity and active friction control have been extensively researched in order to reduce the consumption of fossil energy,the failure of moving parts,and the waste of materials.The vibration-induced superlubricity(VIS)presents a promising solution for friction reduction since it does not require high-standard environment.However,the mechanism underlying the VIS remains unclear since the atomic-scale information in a buried interface is unavailable to experimental methods.In this paper,the mechanism of VIS was examined via numerical calculation based on the Prandtl-Tomlinson(PT)model and molecular dynamics(MD)simulations.The results revealed that the pushing effect of stick-slip is one of the direct sources of friction reduction ability under vibrational excitation,which was affected by the response amplitude,frequency,and the trace of the tip.Moreover,the proportion of this pushing effect could be modulated by changing the phase difference when applying coupled vibrational excitation in x-and z-axis.This results in a significant change in friction reduction ability with phase.By this way,active friction control from the stick-slip to superlubricity can be achieved conveniently. | Xiao MA Xinfeng TAN Dan GUO Shizhu WEN | 2023 | Friction2023，11，7： | 0 |
| 13 | Investigation of charge transfer between donor and acceptor for small-molecule organic solar cells by scanning tunneling microscopy and ultrafast transient absorption spectroscopy显示文摘Small-molecule organic solar cell is a category of clean energy potential device since charge transfers between donor and acceptor.The morphologies,co-assembly behavior,interaction sites,and charge transfer of BTID-nF(n=1,2)/PC71BM donor-acceptor system in the active layer of organic solar cell have been studied employing scanning tunneling microscopy(STM),scanning tunneling spectroscopy(STS),density functional theory(DFT)calculations,and transient absorption(TA)spectroscopy.The results show that BTID-1F and BTID-2F form bright strip structures,whereas BTID-nF(n=1,2)/PC71BM form ridge-like structures with each complex composed of one BTID-nF(n=1,2)molecule and four PC71BM molecules which adsorbed around the BTID-nF(n=1,2)molecule by S···πinteraction.With the assistance of S···πinteraction between BTID-nF(n=1,2)and PC71BM,BTID-nF(n=1,2)/PC71BM co-assembled ridge-like structures are more stable than the BTID-nF(n=1,2)ridge structures.To investigate the charge transfer of BTID-nF(n=1,2)/PC71BM system,STS measurements,DFT calculation,and TA spectroscopy are further performed.The results show that charge transfer occurs in BTID-nF(n=1,2)/PC71BM system with the electron transferring from BTID-nF(n=1,2)molecules to PC71BM. | Yuchuan Xiao Linxiu Cheng Xinyu Sui Qi Wang Jie Chen Dan Deng Jianqi Zhang Xuan Peng Xiaokang Li Xunwen Xiao Ke Deng Xinfeng Liu Zhixiang Wei Qingdao Zeng | 2022 | Nano Research2022，15，9： | 0 |
| 14 | Systematic review on the adverse reactions of oral administration of Indigo Naturalis and its preparations显示文摘Objective:This article systematically analyses the effects of adverse drug events/adverse drug reactions(ADEs/ADRs)of oral Indigo Naturalis(Qingdai)preparations in order to provide references for its rational clinical application.Methods:All clinical studies reporting ADE/ADR related to the oral administration of Qingdai preparations were searched through electronic databases,including PubMed,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),China Biology Medicine disc(CBM),VIP Information Chinese Journal Service Platform(VIP),and Wanfang database,from inception to September 27,2020.Information were extracted from these literatures,including primary disease,type of adverse reactions,dose,treatment,outcomes and so on.Incidence of ADE/ADR was estimated,as well as distribution of primary diseases and victim organs and systems were analyzed.Results:A total of 682 articles were included,with 651 clinical population studies and 31 case reports.Among them,604 detailed ADR/AE involving 33459 patients using oral Qingdai preparations,and a total of 5061 cases were found to present adverse events,including 2827 cases of digestive system(abdominal pain,diarrhea,etc.),469 cases of blood system damage(thrombocytopenia,leukopenia,anemia,etc.),313 cases of liver damage(abnormal liver function,liver toxicity,elevated liver enzymes,etc.),327 cases of nervous system reactions(headache,dizziness,poor sleep,etc.)and 1186 cases of other systems and organs.Severe adverse events(SAEs)mainly were liver damage,and could be relived after symptomatic treatment.Conclusion:From the systematic information retrieval and analysis,it is found that oral Qingdai preparations application may clinically cause ADEs/ADRs in terms of gastrointestinal tract and liver damage.Therefore,when using oral Qingdai preparations,liver and stomach protection should be done.At the same time,pay close attention to various biochemical indicators and the patient's drug response during the treatment process,and,if necessary,deal with it in time so as not to deteriorate the condition.Moreover,active surveillance system should be conducted to monitor ADE/ADR,so as to establish a clearer causal relationship between the drug and the adverse event. | Xueyi Deng Rui Lan Qianwen Xie Jingmin Xiao Jiaqi Lai Jing Chen Yihan He Shaonan Liu Lihong Yang Xinfeng Guo | 2021 | TMR Modern Herbal Medicine2021，4，1： | 0 |
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