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| 1 | Effect of Na_2CO_3 on Energy Consumption of Micro-arc Oxidation of Magnesium Alloy显示文摘Micro-arc oxidation(MAO)coatings were fabricated on AZ31 magnesium alloy and the effect of Na2CO3 on the energy consumption was studied.The results show that the concentration of Na2CO3 has a critical effect on the discharge behavior of MAO process.With increasing the Na2CO3 concentration in the electrolyte,the arcing voltage and working voltage decrease.A proper concentration is needed to achieve the highest growth rate of the coatings and the lowest energy consumption per unit coating volume.The addition of Na2CO3 decreases the arcing and working voltage of MAO discharge.It is attributed to that the Na2CO3 leads to much more micropores due to the decomposition of MgCO3 to produce more gas. | Wang Xiaobo,Tian Xiubo,Gong Chunzhi,Yang Shiqin State Key Laboratory of Advanced Welding and Joining,Harbin Institute of Technology,Harbin 150001,China | 2012 | 稀有金属材料与工程2012，41，S1： | 3 |
| 2 | M0S_(2) nanoparticles grown on carbon nanomaterials for lubricating oil additives显示文摘In this study,the nanocomposites of MoS_(2) nanoparticles(NPs)grown on carbon nanotubes(MoS_(2)@CNT),graphene(MoS_(2)@Gr),and fullerene C60(MoS_(2)@C60)were synthesized,characterized,and evaluated for potential use as lubricant additives.By using the benefit of the synergistic effect between MoS_(2) and carbon nanomaterials(CNMs),these nanocomposites can be well dispersed in polyalkylene glycol(PAG)base oil and show superior stability compared with pure MoS_(2) NPs.Moreover,the dispersions of MoS_(2)@CNT,MoS_(2)@Gr,and MoS_(2)@C60 added in PAG have noticeably improved friction reducing and antiwear(AW)behaviors at elevated temperature for comparison with that of PAG and PAG containing CNT,Gr,C60,and M0S2 NPs,respectively.The enhanced lubricating properties of these nanocomposites were also elucidated by exploring the tribofilm formed on the disc. | Kuiliang GONG Wenjing LOU Gaiqing ZHAO Xinhu WU Xiaobo WANG | 2021 | Friction2021，9，4： | 3 |
| 3 | Oct-1 Mediates ACTH-Induced Proliferation of Vascular Smooth Muscle Cells显示文摘Adrenocorticotrophic hormone(ACTH),a 39-amino acid peptide hormone,has been reported in the appreciation of the proliferation of vascular smooth muscle cells(VSMCs),however,the mechanism in molecular scale supporting the appreciation remains to be elucidated.In this study,we observed that the protein expression levels of ACTH at 24 h after exposure to 15%cyclic stretch were significantly higher than that after 5%cyclic stretch.When VSMCs were treated with 1000 nM ACTH directly,Oct-1 and lamin B1 expression were both up-regulated associating with each other,and the presence of Oct-1 was found shuttling between the cytosol and nucleus.When we silenced Oct-1 expression with RNA interference,the proliferation of VSMCs decreases significantly,which also validates a dominant contribution of Oct-1 in ACTH-induced VSMC proliferation.We further screened the target molecules of Oct-1 related to the proliferation with ingenuity pathway analysis(IPA),and found that superoxide dismutase 1(SOD1)was significantly induced by ACTH stimulation yet suppressed by Oct-1 interference.All these findings in the present study highlight a new molecular mechanism that ACTH up-regulates Oct-1 expression and activates the protein expression of downstream target SOD1,finally induces the VSMC proliferation.The present work proved Octamer transcription factor-1(Oct-1)as a key transcription factor in the mechanical regulation of VSMC proliferation,which in turn,provide a new target for the treatment of hypertension. | Qian Xiao Xia Tang Yuanxiu Chen Han Bao Lizhi Gao Xiaobo Gong Ping Zhang | 2019 | Molecular & Cellular Biomechanics2019，16，3： | 3 |
| 4 | Numerical study of clathrin-mediated endocytosis of nanoparticles by cells under tension显示文摘In this study, a three-dimensional mathematical model was used to study the contribution of clathrins during the process of cellular uptake of spherical nanoparticles under different membrane tensions. The clathrin-coated pit (CCP) that forms around the inward budding of the cell membrane was modeled as a vesicle with bending rigidity. An optimization algorithm was proposed for minimizing the total energy of the system, which comprises the deforming nanoparticle, receptor-ligand bonds, cell membrane, and CCP, in which way, the profile of the system is acquired. The results showed that the CCP enable full wrapping of the nanoparticles at various membrane tensions. When the cell membrane tension increases, the total deformation energy also increases, but the ratio of CCP bending to the minimum value of the total energy of the system decreases. The results also showed that the diameter of the endocytic vesicles determined by the competition between the stretching of the cell membrane and confinement of the coated pits are much larger than the nanoparticles, which is quit different as the results in passive endocytosis that is not facilitated by the CCPs. The present results indicate that variations of tension on cell membranes constitutes a biophysical marker for understanding the size distribution of CCPs observed in experiments. The present results also suggest that the early abortion of endocytosis is related to that the receptor-ligand bonds cannot generate adequate force to wrap the nanoparticles into the cell membrane before the clathrins respond to support the endocytic vesicles. Correspondingly, late abortion may relate to the inability of CCPs to confine the nanoparticles until the occurrence of the necking stage of endocytosis. | Xinyue Liu Hongwei Yang Yunqiao Liu Xiaobo Gong Huaxiong Huang | 2019 | Acta Mechanica Sinica2019，35，3： | 2 |
| 5 | A numerical study of mass transfer of ozone dissolution in bubble plumes with an Euler-Lagrange method 显示文摘 | Xiaobo Gong and Shu Takagi | 2007 | Chemical Engineering Sci- ence2007，62，： | 1 |
| 6 | Memory access integrity:detecting fine-grained memory access errors in binary code显示文摘As one of the most notorious programming errors,memory access errors still hurt modern software security.Particularly,they are hidden deeply in important software systems written in memory unsafe languages like C/C++.Plenty of work have been proposed to detect bugs leading to memory access errors.However,all existing works lack the ability to handle two challenges.First,they are not able to tackle fine-grained memory access errors,e.g.,data overflow inside one data structure.These errors are usually overlooked for a long time since they happen inside one memory block and do not lead to program crash.Second,most existing works rely on source code or debugging information to recover memory boundary information,so they cannot be directly applied to detection of memory access errors in binary code.However,searching memory access errors in binary code is a very common scenario in software vulnerability detection and exploitation.In order to overcome these challenges,we propose Memory Access Integrity(MAI),a dynamic method to detect finegrained memory access errors in off-the-shelf binary executables.The core idea is to recover fine-grained accessing policy between memory access behaviors and memory ranges,and then detect memory access errors based on the policy.The key insight in our work is that memory accessing patterns reveal information for recovering the boundary of memory objects and the accessing policy.Based on these recovered information,our method maintains a new memory model to simulate the life cycle of memory objects and report errors when any accessing policy is violated.We evaluate our tool on popular CTF datasets and real world softwares.Compared with the state of the art detection tool,the evaluation result demonstrates that our tool can detect fine-grained memory access errors effectively and efficiently.As the practical impact,our tool has detected three 0-day memory access errors in an audio decoder. | Wenjie Li Dongpeng Xu WeiWu Xiaorui Gong Xiaobo Xiang Yan Wang Fangming gu Qianxiang Zeng | 2019 | Cybersecurity2019，2，1： | 1 |
| 7 | A Numerical Study of Passive Receptor-Mediated Endocytosis of Nanoparticles:The Effect of Mechanical Properties显示文摘In this work,a three-dimensional axisymmetric model with nanoparticle,receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparticles in drug delivery.The minimization of the system energy function was carried out numerically,and the deformations of nanoparticle,receptor-ligand bonds and cell membrane were predicted.Results show that passive endocytosis may fail due to the rupture of receptor-ligand bonds during the wrapping process,and the size and rigidity of nanoparticles affect the total deformation energy and the terminal wrapping stage.Our results suggest that,in addition to the energy requirement,the success of passive endocytosis also depends on the maximum strength of the receptor-ligand bonds. | Xinyue Liu Yunqiao Liu Xiaobo Gong Huaxiong Huang | 2018 | Computer Modeling in Engineering & Sciences2018，，8： | 1 |
| 8 | NLFM Interference Suppressing Based on Time-Varying AR Modeling and Adaptive IIR Notch Filter显示文摘 | FENG Jining YANG Xiaobo DIAO Zhejun GONG Wenfei WU Siliang | 2011 | Chinese Journal of Electronics2011，20，4： | 1 |
| 9 | Dependence of femtosecond time-resolved magneto-optical Kerr rotation on the direction of polarization of the probe beam显示文摘We demonstrate that the femtosecond time-resolved magneto-optical Kerr rotation oscillates with the direction of polarization of the probe beam when a sample of Al0.25Ga0.75As/GaAs multi-quantum wells is excited by a circularly polarized pump and detected by a linearly polarized probe at wavelengths from 800 to 830 nm. Analytical expressions are derived to explain the mechanism, which is in good agreement with the numerical computation and the experimental data. The results suggest that the Kerr signal can be enhanced by choosing an optimal direction of polarization, which is of benefit to the measurement of the weak Kerr rotation. | FENG XiaoBo LI Yan QIN Yi XIAO YunFeng YANG Hong GONG QiHuang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，8： | 1 |
| 10 | Quantitative analysis of micro structural and conductivity evolution of Ni-YSZ anodes during thermal cycling based on nano-computed tomography显示文摘 | Yong Guan Yunhui Gong Wenjie Li Jeff Gelb Lei Zhang Gang Liu Xiaobo Zhang Xiangxia Song Changrong Xia Ying Xiong Haiqian Wang Ziyu Wu Yangchao Tian | 2011 | Journal of Power Sources2011，，24： | 1 |
| 11 | Safety evaluation of zinc threoninate chelate显示文摘 | HU Xiaobo GONG Yi LI Lei | 2010 | International Journal of Toxicology2010，29，4： | 1 |
| 12 | Experimental exploration of five-qubit quantum error-correcting code with superconducting qubits显示文摘Quantum error correction is an essential ingredient for universal quantum computing.D espite tremendous experimental efforts in the study of quantum error correction,to date,there has been no demonstration in the realis ation of universal quantum error-correcting code,with the subsequent verification of all key features including the identification of an arbitrary physical error,the capability for transversal manipulation of the logical state and state decoding.To address this challenge,we experimentally realise the [5,1,3]code,the so-called smallest perfect code that permits corrections of generic single-qubit errors.In the experiment,having optimised the encoding circuit,we employ an array of superconducting qubits to realise the [5,1,3] code for several typical logical states including the magic state,an indispensable resource for realising non-Clifford gates.The encoded states are prepared with an average fidelity of 57.1(3)% while with a high fidelity of 98.6(1)% in the code space.Then,the arbitrary single-qubit errors introduced manually are identified by measuring the stabilisers.We further implement logical Pauli operations with a fidelity of 97.2(2)% within the code space.Finally,we realise the decoding circuit and recover the input state with an overall fidelity of 74.5(6)%,in total with 92 gates.Our work demonstrates each key aspect of the [5,1,3] code and verifies the viability of experimental realisation of quantum error-correcting codes with superconducting qubits. | Ming Gong Xiao Yuan Shiyu Wang Yulin Wu Youwei Zhao Chen Zha Shaowei Li Zhen Zhang Qi Zhao Yunchao Liu Futian Liang Jin Lin Yu Xu Hui Deng Hao Rong He Lu Simon C.Benjamin Cheng-Zhi Peng Xiongfeng Ma Yu-Ao Chen Xiaobo Zhu Jian-Wei Pan | 2022 | National Science Review2022，9，1： | 1 |
| 13 | A numerical study of mass transfer of ozone dissolution in bubble plumes with an Euler–Lagrange method显示文摘 | Xiaobo Gong Shu Takagi Huaxiong Huang Yoichiro Matsumoto | 2006 | Chemical Engineering Science2006，，4： | 1 |
| 14 | A Full Eulerian Fluid-Membrane Coupling Method with a Smoothed Volume-of-Fluid Approach显示文摘A novel full Eulerian fluid-elastic membrane coupling method on the fixed Cartesian coordinate mesh is proposed within the framework of the volume-of-fluid approach.The present method is based on a full Eulerian fluid-(bulk)structure coupling solver(Sugiyama et al.,J.Comput.Phys.,230(2011)596–627),with the bulk structure replaced by elastic membranes.In this study,a closed membrane is considered,and it is described by a volume-of-fluid or volume-fraction information generally called VOF function.A smoothed indicator(or characteristic)function is introduced as a phase indicator which results in a smoothed VOF function.This smoothed VOF function uses a smoothed delta function,and it enables a membrane singular force to be incorporated into a mixture momentum equation.In order to deal with a membrane deformation on the Eulerian mesh,a deformation tensor is introduced and updated within a compactly supported region near the interface.Both the neo-Hookean and the Skalak models are employed in the numerical simulations.A smoothed(and less dissipative)interface capturing method is employed for the advection of the VOF function and the quantities defined on the membrane.The stability restriction due to membrane stiffness is relaxed by using a quasi-implicit approach.The present method is validated by using the spherical membrane deformation problems,and is applied to a pressure-driven flow with the biconcave membrane capsules(red blood cells). | Satoshi Ii Xiaobo Gong Kazuyasu Sugiyama Jinbiao Wu Huaxiong Huang Shu Takagi | 2012 | Communications in Computational Physics2012，12，7： | 1 |
| 15 | Characterizing the Mechanical Variations of Human Femoropopliteal Artery During Aging Process显示文摘Vascular diseases during aging process are closely correlated to the age-related changes of mechanical stimuli for resident cells.Characterizing the variations of mechanical environments in vessel walls with advancing age is crucial for a better understanding of vascular remodeling and pathological changes.In this study,the mechanical stress,strain,and wall stiffness of the femoropopliteal arteries(FPAs)were compared among four different age groups from adolescent to young,middle-aged,and aged subjects.The material parameters and geometries adopted in the FPA models were obtained from published experimental results.It is found that high mechanical stress appears at different layers in young and old FPA walls respectively.The characteristics of the middle-aged FPA wall suggests that it is the most capable of resisting high blood pressures and maintaining a mechanical homeostasis during the entire life span.It is demonstrated that the variations of stress and strain rather than that of wall stiffness can be used as an indicator to illustrate the profile of FPA aging.Our results could serve as an age-specific mechanical reference for vascular mechanobiological studies,and allow further exploration of cellular dysfunctions in vessel walls during aging process. | Shaoxiong Yang Yingxin Qi Zonglai Jiang Xiaobo Gong | 2019 | Molecular & Cellular Biomechanics2019，16，1： | 1 |
| 16 | Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)显示文摘The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic burdens.Abnormal metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβantibodies.Nonetheless,the cognitive benefits of the current treatments are limited.The etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive impairment.Hence,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve cognition.To attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients.The Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat AD.The aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline. | Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang | 2023 | Neuroprotection2023，1，2： | 0 |
| 17 | AppChainer:investigating the chainability among payloads in android applications显示文摘Statistics show that more than 80 applications are installed on each android smartphone.Vulnerability research on Android applications is of critical importance.Recently,academic researchers mainly focus on single bug patterns,while few of them investigate the relations between multiple bugs.Industrial researchers proposed a series of logic exploit chains leveraging multiple logic bugs.However,there is no general model to evaluate the chaining abilities between bugs.This paper presents a formal model to elucidate the relations between multiple bugs in Android applications.To prove the effectiveness of the model,we design and implement a prototype system named AppChainer.AppChainer automatically identifies attack surfaces of Android applications and investigates whether the payloads entering these attack surfaces are“chainable”.Experimental results on 2138 popular Android applications show that AppChainer is effective in identifying and chaining attacker-controllable payloads.It identifies 14467 chainable payloads and constructs 5458 chains both inside a single application and among various applications.The time cost and resource consumption of AppChainer are also acceptable.For each application,the average analysis time is 317 s,and the average memory consumed is 2368 MB.Compared with the most relevant work Jandroid,the experiment results on our custom DroidChainBench show that AppChainer outperforms Jandroid at the precision rate and performs equally with Jandroid at the recall rate. | Xiaobo Xiang Yue Jiang Qingli Guo Xiu Zhang Xiaorui Gong Baoxu Liu | 2023 | Cybersecurity2023，6，4： | 0 |
| 18 | SeHed,a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect显示文摘Dear Editor,The moderate level of reactive oxygen species(ROS)contributes to cellular functions such as proliferation,differentiation,and infection resistance,but the excessive level of ROS causes oxidative damage which underlies the basic mechanism for aging and geriatric diseases.1 Therefore,precisely managing cellular ROS levels,meaning to keep redox homeostasis properly,stands as an aim for health and longevity.Actually,this aim is challenging,as it asks not only to restrain excessive ROS accumulation at the right time and right place but also to guarantee proper ROS levels for fitting physiological requirements.Traditional ways for eliminating ROS put more attention on the efficiency and identified a variety of drugs and enzymes with antioxidant properties,known as enzymatic and non-enzymatic ROS scavengers,respectively.However,how to accurately manage the integrative effect of ROS scavengers in vivo remains a problem.Actually,the effectiveness of non-enzymatic antioxidants in vivo is controversial,explained mostly by the uncertainty to reach a given organ with the appropriate concentration or to work there persistently.2 As to enzymatic ROS scavengers,although their overexpression in a given place can be achieved,this mode is often unwieldy or harmful to intrinsic physiologic functions in cases.3 For this reason,we attempt to develop new ways for in vivo antioxidation,for establishing a high-quality balance between efficiency and safety.As the consequence,we innovated a gene expression system that can limit the excessive ROS accumulation but keep the physiological level of ROS. | Ning Huang Honghan Chen Hui Gong Haoran Tai Xiaojuan Han Xiaobo Wang Chuhui Gong Tingting Zhao Yu Yang Hengyi Xiao | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 19 | Quenched Galaxies are Important Host Candidates of Binary Black Hole and Binary Neutron Star Mergers显示文摘In this work,we present the probabilities of mergers of binary black holes(BBHs)and binary neutron stars(BNSs)as functions of stellar mass,metallicity,specific star formation rate(sSFR),and age for galaxies with redshift z≤0.1.Using the binary-star evolution(BSE)code and some fitting formulae,we construct a phenomenological model of cosmic gravitational wave(GW)merger events.By using the Bayesian analysis method and the observations from Advanced LIGO and Virgo,we obtain the relevant parameters of the phenomenological model(such as the maximum black hole mass is 93_(-22)^(+73)M_(⊙)).Combining the above model results with the galaxy catalog given by the EMERGE empirical galaxy model,we find the normalized probability of occurrence of a merger event varying with log10 sSFR yr(-1)for galaxies with z≤0.1 is different from that in previous studies,that is,two peaks exist in this work while there is only one peak(log_(10)(sSFR/yr^(−1))=−10)in the previous work.The sSFR value corresponding to the new peak is log_(10)(sSFR/yr^(−1))=−12 and in line with the value(log_(10)(sSFR yr^-1)=-12.65_(-0.66)^(+0.44)of NGC 4493,the host galaxy of BNS merger event GW170817.The new peak is caused by today’s quenched galaxies,which give a large contribution to the total SFR at high redshift in the EMERGE empirical galaxy model.Moreover,we find that the BNS mergers are most likely detected in galaxies with age∼11 Gyr,which is greater than previous results(6−8Gyr)and close to the age of NGC 4993,13.2_(-0.9)^(+0.5)Gyr. | Xiaobo Gong Feng-Hui Zhang Xiaoyu Kang Lifang Li | 2023 | Research in Astronomy and Astrophysics2023，23，9： | 0 |
| 20 | Memory access integrity:detecting fine-grained memory access errors in binary code显示文摘As one of the most notorious programming errors,memory access errors still hurt modern software security.Particularly,they are hidden deeply in important software systems written in memory unsafe languages like C/C++.Plenty of work have been proposed to detect bugs leading to memory access errors.However,all existing works lack the ability to handle two challenges.First,they are not able to tackle fine-grained memory access errors,e.g.,data overflow inside one data structure.These errors are usually overlooked for a long time since they happen inside one memory block and do not lead to program crash.Second,most existing works rely on source code or debugging information to recover memory boundary information,so they cannot be directly applied to detection of memory access errors in binary code.However,searching memory access errors in binary code is a very common scenario in software vulnerability detection and exploitation.In order to overcome these challenges,we propose Memory Access Integrity(MAI),a dynamic method to detect finegrained memory access errors in off-the-shelf binary executables.The core idea is to recover fine-grained accessing policy between memory access behaviors and memory ranges,and then detect memory access errors based on the policy.The key insight in our work is that memory accessing patterns reveal information for recovering the boundary of memory objects and the accessing policy.Based on these recovered information,our method maintains a new memory model to simulate the life cycle of memory objects and report errors when any accessing policy is violated.We evaluate our tool on popular CTF datasets and real world softwares.Compared with the state of the art detection tool,the evaluation result demonstrates that our tool can detect fine-grained memory access errors effectively and efficiently.As the practical impact,our tool has detected three 0-day memory access errors in an audio decoder. | Wenjie Li Dongpeng Xu WeiWu Xiaorui Gong Xiaobo Xiang YanWang Fangming gu Qianxiang Zeng | 2018 | Cybersecurity2018，1，1： | 0 |
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