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| 1 | Preoperative Corticosteroid Usage and Hypoalbuminemia Increase Occurrence of Short-term Postoperative Complications in Chinese Patients with Ulcerative Colitis显示文摘 | Ji Li Hong Lyu Hong Yang Yue Li Bei Tan Ming-Ming Wei Xi-Yu Sun Jing-Nan Li Bin Wu Jia-Ming Qian | 2016 | Chinese Medical Journal2016，，4： | 14 |
| 2 | Recent developments of large diameter X80 UOE line pipes显示文摘High-strength pipeline steel and large diameter line pipes are often used to increase the capacity of transportation and reduce the cost associated with the construction and operation of long-distance gas pipeline projects. China's initiatives to construct long-distance natural gas pipelines has brought in new opportunities for the development of X80 line pipes. Baosteel has designed the optimum chemical composition of X80 with high niobium and low molybdenum content. In addition,a welding experimental platform and a finite element model(FEM) have supported the development of X80 UOE pipes in an efficient and economical way. The application and recent development of X80 UOE pipes were introduced in this paper. To comply with the requirements of the Second West-East Gas Pipeline Project(2ndWEPP),X80 pipeline steel with low carbon bainite microstructure was developed by utilizing the optimized composition and TMCP process. The matching welding material,welding procedure and UOE forming processes for 1219mm outside diameter X80 UOE pipes were also developed. More than 340000 t of X80 UOE pipes were produced and applied in the 2ndWEPP. Furthermore,to meet the prospective demand for long-distance gas pipelines with an annual transportation capacity of over 40 billion m3,larger size X80UOE pipes with 1 422 mm OD × 30. 8 mm WT were trial produced recently. DWTT performance,the main technical challenge for heavier wall pipes,was improved by using optimized microstructural design. The newly developed X80 pipes can be potentially used for larger transportation capacity pipelines in China. | ZHANG Chuanguo ZHENG Lei XIE Shiqiang ZHANG Bei HAN Jianzeng QIAN Weifang | 2014 | Baosteel Technical Research2014，8，2： | 9 |
| 3 | Polyaspartic acid as a corrosion inhibitor for WE43 magnesium alloy显示文摘The inhibition behavior of polyaspartic acid(PASP)as an environment-friendly corrosion inhibitor for WE43 magnesium alloy was investigated in 3.5 wt.%NaCl solution by means for EIS measurement,potentiodynamic polarization curve,and scanning electron microscopy.The results show that PASP can inhibit the corrosion of WE43 magnesium alloy.The maximum inhibition efficiency is achieved when PASP concentration is 400 ppm in this study. | Lihui Yang Yantao Li Bei Qian Baorong Hou | 2015 | Journal of Magnesium and Alloys2015，3，1： | 8 |
| 4 | Comparative study of model tests on automatically formed roadway and gob-side entry driving in deep coal mines显示文摘Automatically formed roadway(AFR)by roof cutting with bolt grouting(RCBG)is a new deep coal mining technology.By using this technology,the broken roadway roof is strengthened,and roof cutting is applied to cut off stress transfer between the roadway and gob to ensure the collapse of the overlying strata.The roadway is automatically formed owing to the broken expansion characteristics of the collapsed strata and mining pressure.Taking the Suncun Coal Mine as the engineering background,the control effect of this new technology on roadways was studied.To compare the law of stress evolution and the surrounding rock control mechanisms between AFR and traditional gob-side entry driving,a comparative study of geomechanical model tests on the above methods was carried out.The results showed that the new technology of AFR by RCBG effectively reduced the stress concentration of the roadway compared with gob-side entry driving.The side abutment pressure peak of the solid coal side was reduced by 24.3%,which showed an obvious pressure-releasing effect.Moreover,the position of the side abutment pressure peak was far from the solid coal side,making it more beneficial for roadway stability.The deformation of AFR surrounding rock was also smaller than the deformation of the gob-side entry driving by the overload test.The former was more beneficial for roadway stability than the latter under higher stress conditions.Field application tests showed that the new technology can effectively control roadway deformation.Moreover,the technology reduced roadway excavation and avoided resource waste caused by reserved coal pillars. | Qi Wang Manchao He Shucai Li Zhenhua Jiang Yue Wang Qian Qin Bei Jiang | 2021 | International Journal of Mining Science and Technology2021，31，4： | 8 |
| 5 | Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome显示文摘 | Yan Qiao Bei Wang Jiao-Jiao Yang Yan-Feng Fan Qian GUO Zhan-Jun Dou Ya-Qiong Huang Ting-Ting Feng Shu-Juan Wang Dong-Dong An Xiao-Ling Gao | 2018 | Chinese Medical Journal2018，，16： | 7 |
| 6 | A Facile Strategy for Non-fluorinated Intrinsic Low-k and Low-loss Dielectric Polymers: Valid Exploitation of Secondary Relaxation Behaviors显示文摘High-performance low-k and low-loss circuit materials are urgently needed in the field of microelectronics due to the upcoming FifthGeneration Mobile Communications Technology(5 G Technology).Herein,a facile design strategy for non-fluorinated intrinsic low-k and low-loss polyimides is reported by fully considering the secondary relaxation behaviors of the polymer chains.A new amorphous non-fluorinated polymer(TmBPPA)with a k value of 2.23 and a loss tangent lower than 3.94×10^-3 at 104 Hz has been designed and synthesized,which to the best of our knowledge is the lowest value amongst the non-fluorinated and non-porous polymers reported in literature.Meanwhile,TmBPPA exhibits excellent overall properties,such as excellent thermostability,good mechanical properties,low moisture absorption,and high bonding strength.As high-performance flexible circuit materials,all these characteristics are highly expected to meet the present and future demands for high density,high speed,and high frequency electronic circuit used in 5 G wireless networks. | Chao Qian Zhen-Guo Fan Wei-Wen Zheng Run-Xin Bei Tian-Wen Zhu Si-Wei Liu Zhen-Guo Chi Matthew P.Aldred Xu-Dong Chen Yi Zhang Jia-Rui Xu | 2020 | Chinese Journal of Polymer Science2020，38，3： | 7 |
| 7 | Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention:study design and protocol for the randomized controlled trial显示文摘Previous studies have shown that nicorandil has a protective effect on cardiomyocytes.However,there is no study to investigate whether perioperative intravenous nicorandil can further reduce the myocardial infarct size in patients with ST-segment elevation myocardial infarction(STEMI)compared to the current standard of percutaneous coronary intervention(PCI)regimen.The CHANGE(China-Administration of Nicorandil Group)study is a multicenter,prospective,randomized,double-blind and parallel-controlled clinical study of STEMI patients undergoing primary PCI in China,aiming to evaluate the efficacy and safety of intravenous nicorandil in ameliorating the myocardial infarct size in STEMI patients undergoing primary PCI and provide evidence-based support for myocardial protection strategies of STEMI patients. | Xiao-Si JIANG Li-Chao TIAN Zi-Chao JIANG Yu-Ting ZOU Ping LI Xin-Chun YANG Xi SU Jin-Wen TIAN Bei SHI Zong-Zhuang LI Yong-Jun LI Ren-Qiang YANG Geng QIAN Yun-Dai CHEN | 2020 | Journal of Geriatric Cardiology2020，17，8： | 7 |
| 8 | Easily manageable prognostic factors in 152 Chinese elderly acute myeloid leukemia patients:a single-center retrospective study显示文摘We retrospectively investigated the prognostic factors of acute myeloid leukemia(AML) in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital.Log-rank test showed that 6 parameters including older age,higher white blood cell(WBC) counts,lactate dehydrogenase(LDH)and bone marrow(BM) blasts at diagnosis,unfavorable risk cytogenetics,and non-mutated CEBPα were significant adverse prognostic factors of overall survival(OS) for elderly AML patients(P = 0.0013,0.0358,0.0132,0.0242,0.0236 and 0.0130,respectively).Moreover,older age and higher LDH were significant adverse predictors for relapse-free survival(RFS)(P = 0.0447 and 0.0470,respectively).Univariate analysis revealed similar results for OS to those of the log-rank test and only higher LDH at diagnosis was a significant adverse predictor for RFS(P = 0.028,HR:1.979,95%CI:1.075-3.644).In multivariate analysis,we identified 2 trends towards independent prognostic factors for OS,including BM blasts at diagnosis(P = 0.057,HR:1.676,95%CI:0.984-2.854)and mutation status of CEBPα(P = 0.064,HR:4.173,95%CI:0.918-18.966).Our data indicated that older age,gender and a previous history of hematologic diseases resulted in lower complete remission rate(P = 0.012,0.051 and 0.086,respectively).We further developed an easy scoring system for predicting prognosis and response to induction therapy in older AML patients.Patients who had lower scores showed significantly longer OS and RFS(P = 0.0006 and 0.1001,respectively) and higher CR rate(P = 0.014).Our research is limited by its retrospective nature and the results from our study need to be further validated by prospective randomized clinical trials. | Jiadai Xu Tingmei Chen Yun Liu Huayuan Zhu Wei Wu WenYi Shen Bei Xu Sixuan Qian Jianyong Li Peng Liu | 2014 | The Journal of Biomedical Research2014，28，5： | 7 |
| 9 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 10 | Observation and modeling on irregular purple soil water infiltration process显示文摘The infiltration process is a critical link between surface water and groundwater. In this research, a specific device to observe infiltration processes in homogeneous and heterogeneous soils with triangular and inverted triangular profiles was designed, and the Green-Ampt model was employed for the process simulation. The results indicate that(1) the wetting front in coarse texture soils transports faster than in fine texture soils;(2) for the homogeneous case, the wetting front in triangularshaped soils transports faster than the inverted triangular type, but the triangular-shaped soils show a lower infiltration rate;(3) in the initial step, the wetting front in triangular-shaped soils shows higher transport speed, but depicts lower speed with increase in the time;(4) both the wetting front and infiltration rate show a significant exponential relation with the time. From these findings, an empirical model was developed which agrees well with the observed data and provides a useful method for this field of soil research. | CHENG Dong-bing DONG Lin-yao QIAN Feng SUN Bei | 2017 | Journal of Mountain Science2017，14，6： | 6 |
| 11 | Origin of strong solid solution strengthening in the CrCoNi-W medium entropy alloy显示文摘Solid solution strengthening is one of the most conventional strategies for optimizing alloys strength,while the corresponding mechanisms can be more complicated than we traditionally thought specifically as heterogeneity of microstructure is involved.In this work,by comparing the change of chemical distribution,dislocation behaviors and mechanical properties after doping equivalent amount of tungsten(W)atoms in CrCoNi alloy and pure Ni,respectively,it is found that the alloying element W in CrCoNi alloy resulted in much stronger strengthening effect due to the significant increase of heterogeneity in chemical distribution after doping trace amount of W.The large atomic scale concentration fluctuation of all elements in CrCoNi-3W causes dislocation motion via strong nanoscale segment detrapping and severe dislocation pile up which is not the case in Ni-3W.The results revealed the high sensitivity of elements distribution in multi-principle element alloys to composition and the significant consequent influence in tuning the mechanical properties,giving insight for complex alloy design. | Yujie Chen Yan Fang Xiaoqian Fu Yiping Lu Sijing Chen Hongbin Bei Qian Yu | 2021 | Journal of Materials Science & Technology2021，，14： | 5 |
| 12 | Comparison study of slag corrosion resistance of MgO–MgAl_(2)O_(4),MgO–CaO and MgO–C refractories under electromagnetic field显示文摘To illuminate the corrosion behavior of MgO-based refractories under electromagnetic field(EMF),herein,the slag corrosion and penetration resistance of MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories were investigated using the rotary immersion slag resistance test at 1873 K for 1 h.The results showed that the order of the good slag resistance of as-tested refractories was MgO–C>MgO–CaO>MgO–MgAl_(2)O_(4).The EMF accelerated the corrosion and penetration of slag to the refractories,which caused the molten slag to be easier into the refractories by natural convection and Marangoni effect.In addition,the MgO–C refractories did not show an overwhelming advantage in slag resistance because EMF impeded the formation of the dense protection layer.Consequently,in view of the present results,the MgO–C refractories are still the most promising slag line material for refining furnace among MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories. | Xin‑ming Ren Bei‑yue Ma Shi‑ming Li Hong‑xia Li Guo‑qi Liu Wen‑gang Yang Fan Qian Shi‑xian Zhao Jing‑kun Yu | 2021 | Journal of Iron and Steel Research(International)2021，28，1： | 4 |
| 13 | Geochronology and Geochemistry of the Granites from the Longtoushan Hydrothermal Gold Deposit in the Dayaoshan Area,Guangxi:Implication for Petrogenesis and Mineralization显示文摘The gold mineralization in the Longtoushan hydrothermal gold deposit is concentrated within the contact zone of the granitic complex. Whole rock geochemistry and in-situ U-Pb and Hf isotopic data were used to constrain the genesis and age of the granites and related Cu-Au mineralization in the Longtoushan Deposit. The granites mainly consist of the granite porphyry, rhyolite porphyry, porphyritic granite and quartz porphyry. LA-ICP-MS U-Pb dating of zircons from the granite porphyry, rhyolite porphyry and quartz porphyry indicates that they intruded from ca. 94 to 97 Ma. These intrusions exhibit similar trace element characteristics, i.e., right-dipping REE patterns, depletion of Ba, Sr, P and Ti, and enrichment of Th, U, Nd, Zr and Hf. The εHf(t) values of zircons from the granite porphyry, rhyolite porphyry and quartz porphyry range from-26.81 to-8.19,-8.12 to-5.33, and-8.99 to-5.83, respectively, suggesting that they were mainly derived from the partial melting of the Proterozoic crust. The Cu-Au mineralization is mainly related to the rhyolite porphyry and porphyritic granite, respectively. The Longtoushan granites were most likely formed in a post-collisional extensional environment, and the deposit is a part of the Late Yanshanian magmatism related mineralization in the Dayaoshan area and its adjacent areas. | Lihua Qian Jianqing Lai Lifang Hu Rong Cao Shilong Tao Bei You | 2019 | Journal of Earth Science2019，30，2： | 4 |
| 14 | 假肥大型肌营养不良症(DMD/BMD)遗传学诊断及剪接突变的致病性分析(英文)显示文摘目的:针对100例无亲缘关系的假肥大型肌营养不良症(DMD/BMD)患者,联合应用多种检测技术进行遗传学诊断,并且建立个体化产前诊断及胚胎植入前遗传学诊断方案,以最大限度地降低DMD/BMD患儿的出生。创新点:通过minigene剪接实验分析DMD:c.1149+1G>A和c.1150-2A>G突变是否导致剪接异常,并确定剪接方式。方法:收集100例无亲缘关系DMD/BMD患者的临床资料,应用多重连接依赖式探针扩增技术(MLPA)、第二代测序(NGS)、minigene剪接实验(HMSA)进行遗传学诊断,并通过单体型分析及性别鉴定进行胚胎植入前遗传学诊断。结论:联合应用多种检测技术可以尽早地对患者进行遗传学诊断,为临床遗传咨询和产前诊断及胚胎植入前遗传学诊断提供了科学依据。 | Yan-mei YANG Kai YAN Bei LIU Min CHEN Li-ya WANG Ying-zhi HUANG Ye-qing QIAN Yi-xi SUN Hong-ge LI Min-yue DONG | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，9： | 3 |
| 15 | Clinical significance of serum biochemistry changes in mice with targeted disruption of βB2-crystallin gene显示文摘AIM: To explore the pathogenesis, influencing factors, ways of medical intervention and evaluation indicators of cataract by observing changes in serum biochemical indices in mice with targeted disruption of βB2-crystallin. · METHODS: Nine 6-week-old male mice with targeted knockout of βB2-crystallin were used as the study group, and nine age- and sex-matched normal wild-type mice as the control group. The genetype of the modeled mice was identified by PCR technique. Tropicamide and phenylephrine eye drops were used as the cycloplegic agents to observe changes in lens opacity with a slit-lamp. The lens was then removed and blood was collected for biochemical evaluation in the serum. · RESULTS: Two genotypes were successfully identified by PCR technique. Slit-lamp observation showed that the lens cortex was opaque and GSH level in the lens cortex was remarkably decreased in mice with βB2-crystallin deficiency compared with the control group (P <0.01). Serum Na+, Cl-, Ca2+, Mg2+ and Fe2+ levels, ALT and AST activities, and TP, ALP, Cr, TC, GLU content were decreased significantly compared with the control group (P <0.05). There was no difference in LDH, P, Cu2+, K+ levels between the two groups (P >0.05). · CONCLUSION: Compared with the wild-type mice, serum biochemical indices underwent significant changes in mice with targeted disruption of βB2-crystallin gene, especially with abnormal distribution of Na+&Ca2+, which induced the formation of cataract. | Fen-Fen Xiang, Wen-Jie Li | 2012 | International Journal of Ophthalmology(English edition)2012，5，1： | 3 |
| 16 | Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer:Results from 24 hospitals in China显示文摘BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of debate.AIM To investigate whether RL can improve the prognosis of patients with T1b GBC.METHODS We studied a multicenter cohort of patients with T1b GBC who underwent surgery between 2008 and 2016 at 24 hospitals in 13 provinces in China.The logrank test and Cox proportional hazards model were used to compare the overall survival(OS)of patients who underwent cholecystectomy(Ch)+RL and those who underwent Ch only.To investigate whether combined hepatectomy(Hep)improved OS in T1b patients,we studied patients who underwent Ch+RL to compare the OS of patients who underwent combined Hep and patients who did not.RESULTS Of the 121 patients(aged 61.9±10.1 years),77(63.6%)underwent Ch+RL,and 44(36.4%)underwent Ch only.Seven(9.1%)patients in the Ch+RL group had lymph node metastasis.The 5-year OS rate was significantly higher in the Ch+RL group than in the Ch group(76.3%vs 56.8%,P=0.036).Multivariate analysis showed that Ch+RL was significantly associated with improved OS(hazard ratio:0.51;95%confidence interval:0.26-0.99).Among the 77 patients who underwent Ch+RL,no survival improvement was found in patients who underwent combined Hep(5-year OS rate:79.5%for combined Hep and 76.1%for no Hep;P=0.50).CONCLUSION T1b GBC patients who underwent Ch+RL had a better prognosis than those who underwent Ch.Hep+Ch showed no improvement in prognosis in T1b GBC patients.Although recommended by both the National Comprehensive Cancer Network and Chinese Medical Association guidelines,RL was only performed in 63.6%of T1b GBC patients.Routine Ch+RL should be advised in T1b GBC. | Tai Ren Yong-Sheng Li Xue-Yi Dang Yang Li Zi-Yu Shao Run-Fa Bao Yi-Jun Shu Xu-An Wang Wen-Guang Wu Xiang-Song Wu Mao-Lan Li Hong Cao Kun-Hua Wang Hong-Yu Cai Chong Jin Hui-Han Jin Bo Yang Xiao-Qing Jiang Jian-Feng Gu Yun-Fu Cui Zai-Yang Zhang Chun-Fu Zhu Bei Sun Chao-Liu Dai Lin-Hui Zheng Jing-Yu Cao Zhe-Wei Fei Chang-Jun Liu Bing Li Jun Liu Ye-Ben Qian Yi Wang Ya-Wei Hua Xi Zhang Chang Liu Wan-Yee Lau Ying-Bin Liu | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 3 |
| 17 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 18 | Disturbed Th17/Treg balance in patients with rheumatoid arthritis显示文摘 | Qian Niu Bei Cai Zhuo-chun Huang Yun-ying Shi Lan-lan Wang | 2012 | Rheumatology International2012，，9： | 2 |
| 19 | An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair显示文摘Myocardial infarction(MI)leads to massive cardiomyocyte death and deposition of collagen fibers.This fibrous tissue disrupts electrical signaling in the myocardium,leading to cardiac systolic and diastolic dysfunction,as well as arrhythmias.Conductive hydrogels are a promising therapeutic strategy for MI.Here,we prepared a highly water-soluble conductive material(GP)by grafting polypyrrole(PPy)onto non-conductive gelatin.This component was added to the gel system formed by the Schiff base reaction between oxidized xanthan gum(OXG)and gelatin to construct an injectable conductive hydrogel.The prepared self-healing OGGP3(3 wt%GP)hydrogel had good biocompatibility,elastic modulus,and electrical conductivity that matched the natural heart.The prepared biomaterials were injected into the rat myocardial scar tissue 2 days after MI.We found that the cardiac function of the rats treated with OGGP3 was improved,making it more difficult to induce arrhythmias.The electrical resistivity of myocardial fibrous tissue was reduced,and the conduction velocity of myocardial tissue was increased.Histological analysis showed reduced infarct size,increased left ventricular wall thickness,increased vessel density,and decreased inflammatory response in the infarcted area.Our findings clearly demonstrate that the OGGP3 hydrogel attenuates ventricular remodeling and inhibits infarct dilation,thus showing its potential for the treatment of MI. | Linghong Zhang Tao Li Yan Yu Kun Shi Zhongwu Bei Yongjun Qian Zhiyong Qian | 2023 | Bioactive Materials2023，，2： | 2 |
| 20 | Jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice through down-regulating the YY1/TGF-β1 signaling pathway显示文摘Diabetic nephropathy(DN)is one of the most common complications of diabetes mellitus,which is characterized in renal tubulointerstitial fibrosis(TIF).The current study was designed to investigate the protective effect of Jujuboside A(Ju A)on TIF in type 2 diabetes(T2DM)mice,and explore its underlying anti-fibrosis mechanism.A mouse T2DM model was established using high fat diet(HFD)feeding combined with intraperitoneal injection of streptozotocin(STZ).Then,diabetic mice were treated with Ju A(10,20 and 40 mg·kg^(−1)·d^(−1),i.g.)for 12 weeks.Results showed that administration of Ju A not only down-regulated fasting blood glucose(FBG)levels,but also improved hyperlipidemia and renal function in diabetic mice.Moreover,the reduced ECM accumulation was observed in the renal cortex of Ju A treated diabetic mice,while the TIF progression was also attenuated by Ju A through blocking the epithelial-to-mesenchymal transition(EMT)of renal tubular epithelial cells(RTECs).Further mechanism studies showed that Ju A treatment effectively down-regulated the protein expression and subsequent nuclear translocation of Yin Yang 1(YY1)in the renal cortex of diabetic mice,and reduced the levels of transforming growth factor-β1(TGF-β1)in the serum and renal cortex of Ju A treated mice.According to in vitro studies,the up-regulated YY1/TGF-β1 signaling pathway was restored by Ju A in high glucose(HG)cultured HK-2 cells.Taken together,these findings demonstrated that Ju A can ameliorate the TIF of DN through down-regulating the YY1/TGF-β1 signaling pathway. | LIU Yang-Yang LI Lin JI Bei HAO Shi-Long KUANG Xiao-Feng CAO Xin-Yun YUAN Jia-Yu JIANG Zhen-Zhou QIAN Si-Tong WEI Chu-Jing XU Jing YIN Xiao-Xing LU Qian YANG Ting-Ting | 2022 | Chinese Journal of Natural Medicines2022，20，9： | 2 |
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