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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 3 | Progress in the Study of False Smut Disease in Rice显示文摘 | Xiaoyi Guo Yan Li Jing Fan Liang Li Fu Huang Wenming Wang | 2012 | Journal of Agricultural Science and Technology(A)2012，2，11： | 15 |
| 4 | JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients显示文摘以前的研究揭示了那根骨头从病人们早展出了的全身的豺狼座 erythematosus (SLE ) 的髓间充质的干细胞(BM-MSCs ) 老朽签名,它可以参予 SLE 的发展。然而,关于这现象的分子的机制充分没被阐明。在当前的学习,我们试图调查表明发信号的抄写(STAT ) 的变换器和使活跃之物的 Janus kinase (JAK ) 是否调停了从 SLE 病人的 BM-MSCs 的老朽。12 个女 SLE 病人和健康题目在学习被注册。所有 BM-MSCs 被密度坡度 centrifugation 孤立。西方的污点分析被用来测试表明分子的 JAK-STAT 的表示。我们由流动 cytometry 观察了房间,由染色的 F 肌动朊的细胞骨架结构的变化,和房间周期的分发的女郎的活动。从 SLE 病人的 BM-MSCs 显示出表明 transduction, phosphorylated JAK2 的高水平,和 STAT3 的 JAK-STAT 的老朽,和反常激活的突出的特征。在在正常 MSC 的 IFN- 的刺激以后,发信号的 JAK-STAT 被激活。房间体积和联系老朽的牛乳糖的数字(SA -- 女郎) 在 SLE BM-MSCs 积极被增加。细胞骨架的组织是将近混乱的。房间增长的率被减少。AG490, JAK2 的禁止者,并且在 BM-MSCs 的 STAT3 击倒,能显著地颠倒老朽。在摘要,我们的学习显示 JAK-STAT 发信号小径可以在 SLE BM-MSCs 的老朽起一个关键作用。 | Juan Ji Yeqing Wu Yan Meng Lijuan Zhang Guijuan Feng Yunfei Xia Wenrong Xue Shuyang Zhao Zhifeng Gu Xiaoyi Shao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 8 |
| 5 | Drug release property of a pH-responsive double-hydrophilic hyperbranched graft copolymer显示文摘In this paper, we report the synthesis and self-assembly of double-hydrophilic hyperbranched graft copolymers of HPG-g-PDMAEMA, which consist of a hyperbranched polyglycerol (HPG) core and several grafted poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) arms. HPG was synthesized by cationic polymerization. Then HPG-Br macroinitiator was obtained by esterification of HPG with 2-bromoisobutyryl bromide, which was subsequently used in the preparation of HPG-g-PDMAEMA graft copolymers through atom transfer radical polymerization (ATRP) of DMAEMA monomers. The molecular structures were studied by 1H NMR and GPC. The pyrene-based fluorescent probe method, 1H NMR and DLS were used to study the self-assembly behavior of HPG-g-PDMAEMA. The drug loading and pH-responsive release properties of HPG-g-PDMAEMA were also investigated by using coumarin 102 as a model drug. The results show that the HPG-g-PDMAEMA micelles can continuously release and re-encapsulate coumarin 102 as the pH continuously changes from 11.5 to 2.5; however, this process is not totally reversible. | SUN XiaoYi ZHOU YongFeng YAN DeYue | 2009 | Science China Chemistry2009，52，10： | 7 |
| 6 | Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plkl to centrosomes显示文摘中心体主要被安排微导管动力学并且便于 G1/S 和 G2/M 转变为有效房间周期前进要求。然而,在 S 阶段前进的中心体的角色大部分是未知的。这里,我们报导 FOR20 (20 kDa 的蠢人相关的蛋白质) 的那弄空,保存 centrosomal 蛋白质,禁止 S 阶段前进并且阻止 Plk1 指向(像马球的 kinase 1 ) 到中心体,在 FOR20 与 Plk1 交往的地方。Plk1 的脱离显著地也导致 S 阶段缺点,它被没能本地化到中心体的 Plk1,甚至 kinase 死了的异种,然而并非异种的宫外的表示颠倒。拴住中心体的 Plk1 的外长的表示,然而并非野类型的 Plk1,撤销 FOR20 导致弄空的 S 阶段独立于它的 kinase 活动背叛。因此,这些数据显示到由 FOR20 的中心体的 Plk1 的招募可以充当一个信号准许 S 阶段的有效前进。这代表一迄今在房间周期规定的中心体的 uncharacterized 角色。 | Minhong Shen Yuqi Cai YuehongYang Xiaoyi Yan Xiaoqi Liu Tianhua Zhou | 2013 | Cell Research2013，23，11： | 6 |
| 7 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 8 | Supramolecular self-assembly and controllable drug release of thermosensitive hyperbranched multiarm copolymers显示文摘A novel temperature-responsive hyperbranched multiarm copolymer with a hydrophobic hyperbranched poly(3-ethyl-3-(hydroxymethyl)oxetane)(HBPO) core and thermosensitive poly(N-isopropylacrylamide)(PNIPAM) arms was synthesized via the atom transfer radical polymerization(ATRP) of NIPAM monomers from a hyperbranched HBPO macroinitiator.It was found that HBPO-star-PNIPAM self-assembled into multimolecular micelles(around 60 nm) in water at room temperature according to pyrene probe fluorescence spectrometry,1H NMR,TEM,and DLS measurements.The micelle solution showed a reversible thermosensitive phase transition at a lower critical solution temperature(LCST)(around 32°C) observed by variable temperature optical absorbance measurements.Variable temperature NMR and DLS analyses demonstrated that the LCST transition originated from the secondary aggregation of the micelles driven by increasing hydrophobic interaction due to the dehydration of PNIPAM shells upon heating.The drug loading and release properties of HBPO-star-PNIPAM micelles were also investigated using prednisone acetate as a model drug.The micelles showed a much improved drug encapsulation efficiency and temperature-dependent sustainable release behavior due to the special micellar structure.The micelles exhibited no apparent cytotoxicity against human HeLa cells. | GUO Bo,SUN XiaoYi,ZHOU YongFeng & YAN DeYue College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China | 2010 | Science China Chemistry2010，53，3： | 5 |
| 9 | Synthesis and photocatalytic performance of ZnO with flower-like structure from zinc oxide ore显示文摘Employing zinc sulfate solution obtained from zinc oxide ore as raw material,sodium hydroxide as precipitant and PEG20000 as dispersant,ultrafine ZnO powders with different morphologies were successfully synthesized through hydrothermal method.The influences of the dosage of PEG20000 solution,molar ratio of OH-/Zn2+,reaction temperature,reaction time and Zn2+concentration on the structures and morphologies of the ZnO powders were discussed in detail.The reaction conditions of synthesizing ZnO powders with flower-like structure were obtained as below:dosage of PEG20000 with 10%mass fraction 5 mL,molar ratio of OH-to Zn2+5,reaction temperature 150℃,reaction time 8 h at Zn2+concentration1 mol L-1.The growth mechanism of ZnO particles with different morphologies was proposed.The ZnO powder with flower-like structure are composed of multiple micro-rods with hexagon morphology and has good photocatalytic degradation ability to degrade Rh B.20 mL Rh B solution with 15 mgL-1 could be completely degraded over flower-like ZnO powder 300 mg within 3 h. | Xiaoyi Shen Hongmei Shao Yan Liu Yuchun Zhai | 2020 | Journal of Materials Science & Technology2020，47，16： | 5 |
| 10 | NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1显示文摘新兴的数据显示肌动朊动力学与 ciliogenesis 被联系。然而,内在的机制仍然保持不清楚。这里,我们发现那原子分发基因 C (NudC ) , Hsp90 合作女伴,为肌动朊组织和动力学被要求。NudC 的弄空支持睫延伸并且增加 ciliated 房间的百分比。进一步的结果证明那 NudC 绑在并且稳定 cofilin 1,肌动朊动力学的一个关键管理者。cofilin 击倒 1 也便于 ciliogenesis。而且, 1 在 zebrafish,包括的弄弯的身体,心囊的浮肿和有缺陷者引起类似的睫的缺点的 NudC 或 cofilin 的弄空左右的不对称现象。显型在有教养的房间和 zebrafish 由 NudC 弄空导致了的 1 显著地颠倒的 cofilin 的宫外的表示。因此,我们的数据建议 NudC 由稳定 cofilin 调整肌动朊细胞骨架和 ciliogenesis 1。 | Cheng Zhang Wen Zhang Yi Lu Xiaoyi Yan Xiumin Yan Xueliang Zhu Wei Liu YuehongYang Tianhua Zhou | 2016 | Cell Research2016，26，2： | 5 |
| 11 | Unveiling the roles of interspecific competition and local adaptation in phenotypic differentiation of parapatric frogs显示文摘Understanding how ecological processes affect phenotypic evolution has been and continues to be an important goal of ecology and evolutionary biology. Interspecific competition for resources can be a selective force driving phenotypic differentiation that reduces competition among sympatric species (character divergence), enabling closely-related species to coexist. However, although patterns of character divergence are well documented in both empirical and theoretical researches, how local adaptation to abiotic environment affects trait evolution in the face of interspecific competition is less known. Here, we investigate how patterns in morphological traits of 2 parapatric frog species, Feirana quadranus and F. taihangnica, vary among allopatric and sympatric regions using range-wide data derived from extensive field surveys. Feirana quadranus was overall larger than F. taihangnica in body size (i.e., snout-vent length [SVL]), and the difference between SVL of both species in sympatry was larger than that in allopatry. From allopatry to sympatry, the 2 species diverged in foot and hand traits, but converged in eye size and interorbital span, even when we controlled for the effects of geographic gradients. Sympatric divergence in SVL, hand and foot traits is likely acting as a case of evolutionary shift caused by interspecific competition. In contrast, sympatric convergence of eye-related traits may derive at least partly from adaptation to local environments. These results imply the relative roles of interspecific competition and local adaptation in shaping phenotypic diversification. Our findings illustrate how traits evolve in parapatric species pair due to sympatric divergent and convergent evolution. It thus provides insights into understanding underlying evolutionary processes of parapatric species, that is, competition and local adaptation. | Yan HUANG Xiaoyi Wang Xin Yang Jianping Jiang Junhua Hua | 2020 | Current Zoology2020，66，4： | 2 |
| 12 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 13 | Jasmonate perception: Ligand-receptor interaction, regulation, and evolution显示文摘Phytohormones integrate external environmental and developmental signals with internal cellular responses for plant survival and multiplication in changing surroundings.Jasmonate(JA),which might originate from prokaryotes and benefit plant terrestrial adaptation,is a vital phytohormone that regulates diverse developmental processes and defense responses against various environmental stresses.In this review,we first provide an overview of ligand-receptor binding techniques used for the characterization of phytohormone-receptor interactions,then introduce the identification of the receptor COI1 and active JA molecules,and finally summarize recent advances on the regulation of JA perception and its evolution. | Shuai Hu Kaiming Yu Jianbin Yan Xiaoyi Shan Daoxin Xie | 2023 | Molecular Plant2023，16，1： | 1 |
| 14 | The influence of body mass index on Life quality and clinical improvement after total hip arthroplasty显示文摘 | Zhang Ziji Zhao Xiaoyi Kang Yan | 2012 | J Orthop Sci2012，17，3： | 1 |
| 15 | An Improved 3D SPIHT Coding for Hyper Spectral Imagery Data Compression 显示文摘 | Yan Jingwen Shen Guiming Hu Xiaoyi | 2002 | Chinese Journal of Lasers2002，11，4： | 1 |
| 16 | Quasi-Spherical Brookite TiO_2 Nanostructures Synthesized Using Solvothermal Method in the Presence of Oxalic Acid显示文摘Brookite TiO_2,the latest TiO_2 photocatalyst,promises to be an interesting candidate for photocatalytic applications because of its unique physical and chemical properties. In this study,pure-phase brookite TiO_2 with a quasi-spherical nanostructure was successfully synthesized via a solvothermal method using tetrabutyl titanate(Ti(OC_4H_9)_4,TBOT) as the Ti source in the presence of oxalic acid. NaOH was used to regulate the pH of solution. The structure and morphology of the samples were then analyzed using multiple methods,such as X-ray diff raction(XRD),Raman spectroscopy,scanning electron microscopy(SEM),transmission electron microscopy(TEM),Brunauer–Emmett–Teller(BET) measurements and ultraviolet–visible diff use spectroscopy(UV–Vis). Photocatalytic activities of the as-synthesized brookite TiO_2 were evaluated by degrading aqueous methylene blue solution under UV light irradiation. The effect of thermal treatment temperature on photocatalytic activity of the samples was also investigated. The produced brookite TiO_2 nanopowders calcined at 500 °C for 2 h showed the highest photocatalytic activity,and the corresponding degradation rate of methylene blue(10 mg/L) reached 96.7% after 90 min of illumination. In addition,the formation mechanism of pure-phase brookite TiO_2 was investigated. It was found that the formation of pure-phase brookite TiO_2 in this study was ascribed to the combined action of oxalic acid and sodium hydroxide. | Yifei Wang Yunling Zou Qianqian Shang Xin Tan Tao Yu Xianshou Huang Wenxin Shi Yao Xie Gao Yan Xiaoyi Wang | 2018 | Transactions of Tianjin University2018，24，4： | 1 |
| 17 | Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer显示文摘 | Xiaoyi Huang Tiezheng Yuan Meihua Liang Meijun Du Shu Xia Rachel Dittmar Dian Wang William See Brian A. Costello Fernando Quevedo Winston Tan Debashis Nandy Graham H. Bevan Sherri Longenbach Zhifu Sun Yan Lu Tao Wang Stephen N. Thibodeau Lisa Boardman Man | 2014 | European Urology2014，，： | 1 |
| 18 | Cyanidin-3-O-beta-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity显示文摘 | WEI Xiaoyi WANG Dongliang YANG Yan | 2011 | J Sci Food Agric2011，91，6： | 1 |
| 19 | The protective role of hydrogen sulfide in myocardial ischemia–reperfusion-induced injury in diabetic rats显示文摘 | Yan Gao Xiaoyi Yao Yina Zhang Weimin Li Kai Kang Liang Sun Xueying Sun | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 20 | Medical humanity: how do we learn it?显示文摘Medical humanity,as ambiguous and inclusive as the concept seems at first glance,is broadly defined as an interdisciplinary field in humanities,social science and the arts,involving such extensive fields as ethics,history,religion,cultural studies,sociology,psychology,literature,etc.,and their application to medical education and practice.1 In the United States,Europe and Canada,many medical universities have integrated the learning of medical humanities in their curricula,which many scholars claim may help medical students to build up a humane and holistic orientation in the future. | Chang Yifan Zhou Xiaoyi Zhang Yan | 2014 | Chinese Medical Journal2014，，24： | 1 |
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