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| 1 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 2 | Mechanically reprogrammable Pancharatnam-Berry metasurface for microwaves显示文摘Metasurfaces have enabled the realization of several optical functionalities over an ultrathin platform,fostering the exciting field of flat optics.Traditional metasurfaces are achieved by arranging a layout of static meta-atoms to imprint a desired operation on the impinging wavefront,but their functionality cannot be altered.Reconfigurability and programmability of metasurfaces are the next important step to broaden their impact,adding customized on-demand functionality in which each meta-atom can be individually reprogrammed.We demonstrate a mechanical metasurface platform with controllable rotation at the meta-atom level,which can implement continuous Pancharatnam–Berry phase control of circularly polarized microwaves.As the proof-of-concept experiments,we demonstrate metalensing,focused vortex beam generation,and holographic imaging in the same metasurface template,exhibiting versatility and superior performance.Such dynamic control of electromagnetic waves using a single,low-cost metasurface paves an avenue towards practical applications,driving the field of reprogrammable intelligent metasurfaces for a variety of applications. | Quan Xu Xiaoqiang Su Xueqian Zhang Lijuan Dong Lifeng Liu Yunlong Shi Qiu Wang Ming Kang Andrea Alù Shuang Zhang Jiaguang Han Weili Zhang | 2022 | Advanced Photonics2022，4，1： | 5 |
| 3 | Geomagnetic paleointensity dating of South China Sea sediments for the last 130 kyr显示文摘 | Yang Xiaoqiang Friedrich Heller Wu Nengyou Yang Jie Su Zhihua | 2009 | Earth and Planetary Science Letters2009，，1： | 1 |
| 4 | The Analysis of Influencing Factors on Customer's Purchasing Decision-making显示文摘 | Yu Su Bo Wang Xiaoqiang Li | 2005 | China-USA Business Review2005，4，1： | 1 |
| 5 | Effect of Dzyaloshinskii-Moriya anisotropic antisymmetric interaction and intrinsic decoherence on entanglement teleportation显示文摘 | Qiu Liang Wang Anmin Su Xiaoqiang | 2008 | Physica A2008，387，26： | 1 |
| 6 | Intrinsic in-plane nodal chain and generalized quaternion charge protected nodal link in photonics显示文摘Nodal lines are degeneracies formed by crossing bands in three-dimensional momentum space.Interestingly,these degenerate lines can chain together via touching points and manifest as nodal chains.These nodal chains are usually embedded in two orthogonal planes and protected by the corresponding mirror symmetries.Here,we propose and demonstrate an in-plane nodal chain in photonics,where all chained nodal lines coexist in a single mirror plane instead of two orthogonal ones.Nodal lines are degeneracies formed by crossing bands in three-dimensional momentum space.Interestingly,these degenerate lines can chain together via touching points and manifest as nodal chains.These nodal chains are usually embedded in two orthogonal planes and protected by the corresponding mirror symmetries.Here,we propose and demonstrate an in-plane nodal chain in photonics,where all chained nodal lines coexist in a single mirror plane instead of two orthogonal ones.The chain point is stabilized by the intrinsic symmetry that is specific to electromagnetic waves at theГpoint of zero frequency.By adding another mirror plane,we find a nodal ring that is constructed by two higher bands and links with the in-plane nodal chain.The nodal link in momentum space exhibits non-Abelian characteristics on a C_(2)T-invariant plane,where admissible transitions of the nodal link structure are determined by generalized quaternion charges.Through near-field scanning measurements of bi-anisotropic metamaterials,we experimentally mapped out the in-plane nodal chain and nodal link in such systems.The chain point is stabilized by the intrinsic symmetry that is specific to electromagnetic waves at the r point of zero frequency.By adding another mirror plane,we find a nodal ring that is constructed by two higher bands and links with the in-plane nodal chain.The nodal link in momentum space exhibits non-Abelian characteristics on a C2T-invariant plane,where admissible transitions of the nodal link structure are determined by generalized quaternion charges.Through near-field scanning measurements of bi-anisotropic metamaterials,we experimentally mapped out the in-plane nodal chain and nodal link in such systems. | Dongyang Wang Biao Yang Qinghua Guo Ruo-Yang Zhang Lingbo Xia Xiaoqiang Su Wen-Jie Chen Jiaguang Han Shuang Zhang C.T.Chan | 2021 | Light(Science & Applications)2021，10，5： | 0 |
| 7 | Allometry-based estimation of forest aboveground biomass combining LiDAR canopy height attributes and optical spectral indexes显示文摘Accurate estimates of forest aboveground biomass(AGB)are essential for global carbon cycle studies and have widely relied on approaches using spectral and structural information of forest canopies extracted from various remote sensing datasets.However,combining the advantages of active and passive data sources to improve estimation accuracy remains challenging.Here,we proposed a new approach for forest AGB modeling based on allometric relationships and using the form of power-law to integrate structural and spectral information.Over 60 km^(2) of drone light detection and ranging(LiDAR)data and 1,370 field plot measurements,covering the four major forest types of China(coniferous forest,sub-tropical broadleaf forest,coniferous and broadleaf-leaved mixed forest,and tropical broadleaf forest),were collected together with Sentinel-2 images to evaluate the proposed approach.The results show that the most universally useful structural and spectral metrics are the average values of canopy height and spectral index rather than their maximum values.Compared with structural attributes used alone,combining structural and spectral information can improve the estimation accuracy of AGB,increasing R^(2) by about 10%and reducing the root mean square error by about 22%;the accuracy of the proposed approach can yield a R^(2) of 0.7 in different forests types.The proposed approach performs the best in coniferous forest,followed by sub-tropical broadleaf forest,coniferous and broadleaf-leaved mixed forest,and then tropical broadleaf forest.Furthermore,the simple linear regression used in the proposed method is less sensitive to sample size and outperforms statistically multivariate machine learning-based regression models such as stepwise multiple regression,artificial neural networks,and Random Forest.The proposed approach may provide an alternative solution to map large-scale forest biomass using space-borne LiDAR and optical images with high accuracy. | Qiuli Yang Yanjun Su Tianyu Hu Shichao Jin Xiaoqiang Liu Chunyue Niu Zhonghua Liu Maggi Kelly Jianxin Wei Qinghua Guo | 2022 | Forest Ecosystems2022，9，5： | 0 |
| 8 | μ-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway:a comprehensive study including randomized controlled trial显示文摘Background:μ-opioid receptor agonists(MORAs)are indispensable for analgesia in bladder cancer(BC)patients,both during surgery and for chronic pain treatment.Whether MORAs affect BC progression and metastasis remains largely unknown.This study focused on the effects of MORAs on the formation of circulating tumor cells(CTCs)in BC and aimed to provide potential therapeutic targets,which would retain the pain-relieving effects of MORAs in BC patients without sacrificing their long-term prognosis.Methods:Different preclinical models were used to identify the effects of MORAs on the progression of BC.A novel immunocapture microfluidic chip was utilized to analyze whether MORAs affected the number of CTCs in mouse models and clinical BC patients.Bioinformatic analyses,total transcriptome sequencing,and molecular biology methods were then used to investigate the underlying mechanisms in these models and in BC cell lines.Results:Mouse models of hematogenous metastasis and in situ BC demonstrated that tumor metastasis was significantly increased after MORA treatment.A significant increase in the number of mesenchymal and/or epithelial CTCs was detected after MORA treatment in both the mouse models and clinical trial patients.Mechanistically,MORAs facilitated the formation of CTCs by activating the MOR/PI3K/AKT/Slug signaling pathway,hereby promoting the epithelialmesenchymal transition(EMT)of BC cells,as knockdown of MOR,Slug or blockade of PI3K inhibited the EMT process and CTC formation.Conclusion:MORAs promoted BC metastasis by facilitating CTC formation.The EMT-CTC axis could be targeted for preventive measures during MORA treatment to inhibit the associated tumormetastasis or recurrence in BC patients. | Xiaoqiang Wang Song Zhang Di Jin Jiamei Luo Yumiao Shi Yiqi Zhang Lingling Wu Yanling Song Diansan Su Zhiying Pan Haige Chen Ming Cao Chaoyong Yang Weifeng Yu Jie Tian | 2023 | Cancer Communications2023，43，3： | 0 |
| 9 | Moiré-driven electromagnetic responses and magic angles in a sandwiched hyperbolic metasurface显示文摘Recent moiréconfigurations provide a new platform for tunable and sensitive photonic responses,as their enhanced light–matter interactions originate from the relative displacement or rotation angle in a stacking bilayer or multilayer periodic array.However,previous findings are mostly focused on atomically thin condensed matter,with limitations on the fabrication of multilayer structures and the control of rotation angles.Structured microwave moiréconfigurations are still difficult to realize.Here,we design a novel moiréstructure,which presents unprecedented capability in the manipulation of light–matter interactions.Based on the effective medium theory and S-parameter retrieval process,the rotation matrix is introduced into the dispersion relation to analyze the underlying physical mechanism,where the permittivity tensor transforms from a diagonal matrix to a fully populated one,whereas the permeability tensor evolves from a unit matrix to a diagonal one and finally becomes fully filled,so that the electromagnetic responses change drastically as a result of stacking and rotation.Besides,the experiment and simulation results reveal hybridization of eigenmodes,drastic manipulation of surface states,and magic angle properties by controlling the mutual rotation angles between two isolated layers.Here,not only a more precisely controllable bilayer hyperbolic metasurface is introduced to moiréphysics,the findings also open up a new avenue to realize flat bands at arbitrary frequencies,which shows great potential in active engineering of surface waves and designing multifunctional plasmonic devices. | YI LIU CHUNMEI OUYANG QUAN XU XIAOQIANG SU QUANLONG YANG JIAJUN MA YANFENG LI ZHEN TIAN JIANQIANG GU LIYUAN LIU JIAGUANG HAN YUNLONG SHI WEILI ZHANG | 2022 | Photonics Research2022，10，9： | 0 |
| 10 | Canopy structure:An intermediate factor regulating grassland diversity-function relationships under human disturbances显示文摘Grasslands are one of the largest coupled human-nature terrestrial ecosystems on Earth,and severe anthropogenic-induced grassland ecosystem function declines have been reported recently.Understanding factors influencing grassland ecosystem functions is critical for making sustainable management policies.Canopy structure is an important factor influencing plant growth through mediating within-canopy microclimate(e.g.,light,water,and wind),and it is found coordinating tightly with plant species diversity to influence forest ecosystem functions.However,the role of canopy structure in regulating grassland ecosystem functions along with plant species diversity has been rarely investigated.Here,we investigated this problem by collecting field data from 170 field plots distributed along an over 2000 km transect across the northern agro-pastoral ecotone of China.Aboveground net primary productivity(ANPP)and resilience,two indicators of grassland ecosystem functions,were measured from field data and satellite remote sensing data.Terrestrial laser scanning data were collected to measure canopy structure(represented by mean height and canopy cover).Our results showed that plant species diversity was positively correlated to canopy structural traits,and negatively correlated to human activity intensity.Canopy structure was a significant indicator for ANPP and resilience,but their correlations were inconsistent under different human activity intensity levels.Compared to plant species diversity,canopy structural traits were better indicators for grassland ecosystem functions,especially for ANPP.Through structure equation modeling analyses,we found that plant species diversity did not have a direct influence on ANPP under human disturbances.Instead,it had a strong indirect effect on ANPP by altering canopy structural traits.As to resilience,plant species diversity had both a direct positive contribution and an indirect contribution through mediating canopy cover.This study highlights that canopy structure is an important intermediate factor regulating grassland diversity-function relationships under human disturbances,which should be included in future grassland monitoring and management. | Xiaoxia Zhao Yuhao Feng Kexin Xu Mengqi Cao Shuya Hu Qiuli Yang Xiaoqiang Liu Qin Ma Tianyu Hu Maggi Kelly Qinghua Guo Yanjun Su | 2023 | Fundamental Research2023，3，2： | 0 |
| 11 | Nonscalability of Fractal Dimension to Quantify Canopy Structural Complexity from Individual Trees to Forest Stands显示文摘Canopy structural complexity is a critical emergent forest attribute,and light detection and ranging(lidar)-based fractal dimension has been recognized as its powerful measure at the individual tree level.However,the current lidar-based estimation method is highly sensitive to data characteristics,and its scalability from individual trees to forest stands remains unclear.This study proposed an improved method to estimate fractal dimension from lidar data by considering Shannon entropy,and evaluated its scalability from individual trees to forest stands through mathematical derivations.Moreover,a total of 280 forest stand scenes simulated from the terrestrial lidar data of 115 trees spanning large variability in canopy structural complexity were used to evaluate the robustness of the proposed method and the scalability of fractal dimension.The results show that the proposed method can significantly improve the robustness of lidar-derived fractal dimensions.Both mathematical derivations and experimental analyses demonstrate that the fractal dimension of a forest stand is equal to that of the tree with the largest fractal dimension in it,manifesting its nonscalability from individual trees to forest stands.The nonscalability of fractal dimension reveals its limited capability in canopy structural complexity quantification and indicates that the power-law scaling theory of a forest stand underlying fractal geometry is determined by its dominant tree instead of the entire community.Nevertheless,we believe that fractal dimension is still a useful indicator of canopy structural complexity at the individual tree level and might be used along with other stand-level indexes to reflect the“tree-to-stand”correlation of canopy structural complexity. | Xiaoqiang Liu Qin Ma Xiaoyong Wu Tianyu Hu Guanhua Dai Jin Wu Shengli Tao Shaopeng Wang Lingli Liu Qinghua Guo Yanjun Su | 2022 | Journal of Remote Sensing2022，，1： | 0 |
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