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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 3 | Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease显示文摘Accelerated forgetting has been identified as a feature of Alzheimer's disease(AD),but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models.Ras-re-lated C3 botulinum toxin substrate 1(Rac1),a small GTPase,has been shown to regulate active forgetting in Drosophila and mice?Here,we showed that Rac1 activity is aberrantly elevated in the hippocampal tissues of AD patients and AD animal models.Moreover,amyloid-beta 42 could induce Rac1 activation in cultured cells.The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice,but also significantly contributed to severe memory loss in aged APP/PS1 mice.A similar age-dependent Rac1 activity-based memory loss was also observed in an AD fly model.Moreover,inhibition of Rac1 activity could ameliorate cognitive defects and synaptic plasticity in AD animal models.Finally,two novel compounds,identified through behavioral screening of a randomly selected pool of brain permeable small molecules for their positive effect in rescuing memory loss in both fly and mouse models,were found to be capable of inhibiting Rac1 activity.Thus,multiple lines of evidence corroborate in supporting the idea that inhibition of Rac1 activity is effective for treating AD-related memory loss. | Wenjuan Wu Shuwen Du Wei Shi Yunlong Liu Ying Hu Zuolei Xie Xinsheng Yao Zhenyu Liu Weiwei Ma Lin Xu Chao Ma Yi Zhong | 2019 | Protein & Cell2019，10，10： | 10 |
| 4 | Mechanically reprogrammable Pancharatnam-Berry metasurface for microwaves显示文摘Metasurfaces have enabled the realization of several optical functionalities over an ultrathin platform,fostering the exciting field of flat optics.Traditional metasurfaces are achieved by arranging a layout of static meta-atoms to imprint a desired operation on the impinging wavefront,but their functionality cannot be altered.Reconfigurability and programmability of metasurfaces are the next important step to broaden their impact,adding customized on-demand functionality in which each meta-atom can be individually reprogrammed.We demonstrate a mechanical metasurface platform with controllable rotation at the meta-atom level,which can implement continuous Pancharatnam–Berry phase control of circularly polarized microwaves.As the proof-of-concept experiments,we demonstrate metalensing,focused vortex beam generation,and holographic imaging in the same metasurface template,exhibiting versatility and superior performance.Such dynamic control of electromagnetic waves using a single,low-cost metasurface paves an avenue towards practical applications,driving the field of reprogrammable intelligent metasurfaces for a variety of applications. | Quan Xu Xiaoqiang Su Xueqian Zhang Lijuan Dong Lifeng Liu Yunlong Shi Qiu Wang Ming Kang Andrea Alù Shuang Zhang Jiaguang Han Weili Zhang | 2022 | Advanced Photonics2022，4，1： | 5 |
| 5 | Discrete element modelling of railway ballast performance considering particle shape and rolling resistance显示文摘To simulate ballast performance accurately and efficiently,the input in discrete element models should be carefully selected,including the contact model and applied particle shape.To study the effects of the contact model and applied particle shape on the ballast performance(shear strength and deformation),the direct shear test(DST)model and the large-scale process simulation test(LPST)model were developed on the basis of two types of contact models,namely the rolling resistance linear(RRL)model and the linear contact(LC)model.Particle shapes are differentiated by clumps.A clump is a sphere assembly for one ballast particle.The results show that compared with the typical LC model,the RRL method is more efficient and realistic to predict shear strength results of ballast assemblies in DSTs.In addition,the RRL contact model can also provide accurate vertical and lateral ballast deformation under the cyclic loading in LPSTs. | Yunlong Guo Chunfa Zhao Valeri Markine Can Shi Guoqing Jing Wanming Zhai | 2020 | Railway Engineering Science2020，28，4： | 4 |
| 6 | Equality Testing for Soil Grid Unit Resolutions to Polygon Unit Scales with DNDC Modeling of Regional SOC Pools显示文摘Matching soil grid unit resolutions with polygon unit map scales is important to minimize the uncertainty of regional soil organic carbon(SOC) pool simulation due to their strong influences on the modeling.A series of soil grid units at varying cell sizes was derived from soil polygon units at six map scales,namely,1:50 000(C5),1:200 000(D2),1:500 000(P5),1:1 000 000(N1),1:4 000 000(N4) and 1:14 000 000(N14),in the Taihu Region of China.Both soil unit formats were used for regional SOC pool simulation with a De Nitrification-DeC omposition(DNDC) process-based model,which spans the time period from 1982 to 2000 at the six map scales.Four indices,namely,soil type number(STN),area(AREA),average SOC density(ASOCD) and total SOC stocks(SOCS) of surface paddy soils that were simulated by the DNDC,were distinguished from all these soil polygon and grid units.Subjecting to the four index values(IV) from the parent polygon units,the variations in an index value(VIV,%) from the grid units were used to assess its dataset accuracy and redundancy,which reflects the uncertainty in the simulation of SOC pools.Optimal soil grid unit resolutions were generated and suggested for the DNDC simulation of regional SOC pools,matching their respective soil polygon unit map scales.With these optimal raster resolutions,the soil grid units datasets can have the same accuracy as their parent polygon units datasets without any redundancy,when VIV < 1% was assumed to be a criterion for all four indices.A quadratic curve regression model,namely,y = – 0.80 × 10^(–6)x^2 + 0.0228 x + 0.0211(R^2 = 0.9994,P < 0.05),and a power function model R? = 10.394?^(0.2153)(R^2 = 0.9759,P < 0.05) were revealed,which describe the relationship between the optimal soil grid unit resolution(y,km) and soil polygon unit map scale(1:10 000x),the ratio(R?,%) of the optimal soil grid size to average polygon patch size(?,km^2) and the ?,with the highest R^2 among different mathematical regressions,respectively.This knowledge may facilitate the grid partitioning of regions during the investigation and simulation of SOC pool dynamics at a certain map scale,and be referenced to other landscape polygon patches' mesh partition. | YU Dongsheng PAN Yue ZHANG Haidong WANG Xiyang NI Yunlong ZHANG Liming SHI Xue-zheng | 2017 | Chinese Geographical Science2017，27，4： | 2 |
| 7 | Towards Practical Application of Li-S Battery with High Sulfur Loading and Lean Electrolyte:Will Carbon-Based Hosts Win This Race?显示文摘As the need for high-energy–density batteries continues to grow, lithium-sulfur(Li–S) batteries have become a highly promising next-generation energy solution due to their low cost and exceptional energy density compared to commercially available Li-ion batteries. Research into carbon-based sulfur hosts for Li–S batteries has been ongoing for over two decades, leading to a significant number of publications and patents.However, the commercialization of Li–S batteries has yet to be realized. This can be attributed, in part, to the instability of the Li metal anode. However, even when considering just the cathode side, there is still no consensus on whether carbon-based hosts will prove to be the best sulfur hosts for the industrialization of Li–S batteries. Recently, there has been controversy surrounding the use of carbon-based materials as the ideal sulfur hosts for practical applications of Li–S batteries under high sulfur loading and lean electrolyte conditions. To address this question, it is important to review the results of research into carbon-based hosts, assess their strengths and weaknesses, and provide a clear perspective. This review systematically evaluates the merits and mechanisms of various strategies for developing carbon-based host materials for high sulfur loading and lean electrolyte conditions. The review covers structural design and functional optimization strategies in detail, providing a comprehensive understanding of the development of sulfur hosts. The review also describes the use of efficient machine learning methods for investigating Li–S batteries. Finally, the outlook section lists and discusses current trends, challenges, and uncertainties surrounding carbon-based hosts, and concludes by presenting our standpoint and perspective on the subject. | Yi Gong Jing Li Kai Yang Shaoyin Li Ming Xu Guangpeng Zhang Yan Shi Qiong Cai Huanxin Li Yunlong Zhao | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 8 | Correlates of Sexual Lifestyles Among Older Adults Living With HIV in China: Findings From the Sexual Well-being (SWELL) Study显示文摘Sexual lifestyles are closely related to overall human health and well-being.Few studies have focused on sexual lifestyles among older adults living with HIV(OALHIV),especially in low-and middle-income countries.This study is a part of the sexual well-being among older adults in China(SWELL)study,which is a multicenter cross-sectional study focused on sexual health among older adults aged 50 years and older.Participants were 680 OALHIV(≥50 years old)from the SWELL study conducted from June 2020 to December 2022.Data were collected through one-on-one interviews.We used logistic regression to assess the correlates of sexual activity and sexual satis-faction.Among all participants,37.1%were sexually active.Being older,male,in a steady relationship and employed were associated with being sexually active.The prevalence of sexual satisfaction was 69.8%among sexually active OALHIV.Being homosexual and reporting a better general health status were associated with sexual satisfaction.The OALHIV who have depressive symptoms were less likely to report sexual satisfaction.To support holistic healthy aging among OALHIV,it is important for healthcare providers to be educated about the importance of enquiring about sexual activity,satisfaction and problems and addressing concerns while conveying sex-positive attitudes during clinical reviews,as these are still critical aspects of their health and well-being. | Bingyi Wang Xin Peng Leiwen Fu Xinyi Li Tongxin Shi Bowen Liang Tian Tian Thomas Fitzpatrick Zhen Lu Weijie Zhang JunyeBian Xin Xiao YingWang Yunlong Ao Lin Ouyang YongCai Maohe Yu Guohui Wu Linghua Li Xiaojun Meng Huachun Zou | 2023 | Infectious Microbes & Diseases2023，5，3： | 1 |
| 9 | Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors显示文摘Background:Tumors possess incessant growth features,and expansion of their masses demands sufficient oxygen supply by red blood cells(RBCs).In adult mammals,the bone marrow(BM)is the main organ regulating hematopoiesis with dedicated manners.Other than BM,extramedullary hematopoiesis is discovered in various pathophysiological settings.However,whether tumors can contribute to hematopoiesis is completely unknown.Accumulating evidence shows that,in the tumor microenvironment(TME),perivascular localized cells retain progenitor cell properties and can differentiate into other cells.Here,we sought to better understand whether and how perivascular localized pericytes in tumors manipulate hematopoiesis.Methods:To test if vascular cells can differentiate into RBCs,genome-wide expression profiling was performed using mouse-derived pericytes.Genetic tracing of perivascular localized cells employing NG2-CreERT2:R26R-tdTomato mouse strain was used to validate the findings in vivo.Fluorescence-activated cell sorting(FACS),single-cell sequencing,and colony formation assays were applied for biological studies.The production of erythroid differentiationspecific cytokine,erythropoietin(EPO),in TME was checked using quantitative polymerase chain reaction(qPCR),enzyme-linked immunosorbent assay(ELISA,magnetic-activated cell sorting and immunohistochemistry.To investigate BM function in tumor erythropoiesis,BM transplantation mouse models were employed.Results:Genome-wide expression profiling showed that in response to plateletderived growth factor subunit B(PDGF-B),neural/glial antigen 2(NG2)+perivascular localized cells exhibited hematopoietic stem and progenitor-like features and underwent differentiation towards the erythroid lineage.PDGF-B simultaneously targeted cancer-associated fibroblasts to produce high levels of EPO,a crucial hormone that necessitates erythropoiesis.FACS analysis using genetic tracing of NG2+cells in tumors defined the perivascular localized cell-derived subpopulation of hematopoietic cells.Single-cell sequencing and colony formation assays validated the fact that,upon PDGF-B stimulation,NG2+cells isolated from tumors acted as erythroblast progenitor cells,which were distinctive from the canonical BM hematopoietic stem cells.Conclusions:Our data provide a new concept of hematopoiesis within tumor tissues and novel mechanistic insights into perivascular localized cell-derived erythroid cells within TME.Targeting tumor hematopoiesis is a novel therapeutic concept for treating various cancers that may have profound impacts on cancer therapy. | Kayoko Hosaka Chenchen Wang Shiyue Zhang Xue Lv Takahiro Seki Yin Zhang Xu Jing Jieyu Wu Qiqiao Du Xingkang He Yulong Fan Xuan Li Makoto Kondo Masahito Yoshihara Hong Qian Lihong Shi Ping Zhu Yuanfu Xu Yunlong Yang Tao Cheng Yihai Cao | 2023 | Cancer Communications2023，43，6： | 1 |
| 10 | 海马Rac1蛋白的激活调节新物体识别记忆的遗忘过程显示文摘在神经生物学的研究当中,遗忘过程普遍被认为属于被动过程即记忆不能够形成和维持,因而大部分的研究集中在记忆形成和维持的分子机制上,而忽略了遗忘本身的分子机制,即记忆形成过程中生物体通过激活自身的分子信号途径介导主动遗忘过程。 | Yunlong Liu Shuwen Du Li Lv Bo Lei Wei Shi Yikai Tang Lianzhang Wang 钟毅 | 2017 | 科学新闻2017，19，4： | 1 |
| 11 | Skeleton Keypoints Extraction Method Combined with Object Detection显示文摘Big data is a comprehensive result of the development of the Internet of Things and information systems.Computer vision requires a lot of data as the basis for research.Because skeleton data can adapt well to dynamic environment and complex background,it is used in action recognition tasks.In recent years,skeleton-based action recognition has received more and more attention in the field of computer vision.Therefore,the keypoints of human skeletons are essential for describing the pose estimation of human and predicting the action recognition of the human.This paper proposes a skeleton point extraction method combined with object detection,which can focus on the extraction of skeleton keypoints.After a large number of experiments,our model can be combined with object detection for skeleton points extraction,and the detection efficiency is improved. | Jiabao Shi Zhao Qiu Tao Chen Jiale Lin Hancheng Huang Yunlong He d Yu Yang | 2022 | Journal of New Media2022，4，2： | 0 |
| 12 | ^(18)F-FDG PET/MR Imaging for Evaluating of Obstructive Jaundice:Chinese Expert Consensus显示文摘The cause of obstructive jaundice is usually complex which renders its differential diagnosis and lesion localization challenging in clinical practice.Integrated Positron Emission tomography/Magnetic Resonance(PET/MR)offers complementary information from PET and MR in the diagnosis of obstructive jaundice and is becoming widely adopted in clinical setting.While preserving its diagnostic accuracy,it is important to standardize and streamline the clinical scan protocol of PET/MR in evaluating obstructive jaundice.Based on literature review and experience of large number of clinical cases from the author group,this article reports an expert consensus on imaging protocol optimization and case interpretation template standardization. | Lifang PANG Yushen GU Zhi YANG Zhifang WU Wei FAN Xiaohua ZHU Jun ZHAO Changjiu ZHAO Xuemei WANG Yongju GAO Li HUO Yi MO Meiyun WANG Jie LU Lingzhi HU Zheng ZHANG Feng WANG Xuemei DU Yue CHEN Jianjun LIU Zhaoping CHENG Yunlong LOU Shuzhan YAO Rong XU Sijin LI Hongcheng SHI | 2022 | Clinical Cancer Bulletin2022，1，2： | 0 |
| 13 | Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat显示文摘Neural stem progenitor cell(NSPC)transplantation has been regarded as a promising therapeutic method for spinal cord injury(SCI)repair.However,different NSPCs may have different therapeutic effects,and it is therefore important to identify the optimal NSPC type.In our study,we compared the transcriptomes of human fetal brain-derived NSPCs(BNSPCs),spinal cord-derived NSPCs(SCNSPCs)and H9 embryonic stem-cell derived NSPCs(H9-NSPCs)in vitro and subsequently we transplanted each NSPC type on a collagen scaffold into a T8-9 complete SCI rat model in vivo.In vitro data showed that SCNSPCs had more highly expressed genes involved in nerve-related functions than the other two cell types.In vivo,compared with BNSPCs and H9-NSPCs,SCNSPCs exhibited the best therapeutic effects;in fact,SCNSPCs facilitated electrophysiological and hindlimb functional recovery.This study demonstrates that SCNSPCs may be an appropriate candidate cell type for SCI repair,which is of great clinical significance. | Bai Xu Man Yin Yaming Yang Yunlong Zou Wenbin Liu Lianyong Qiao Jixiang Zhang Zhan Wang Yayu Wu He Shen Minghan Sun Weiyuan Liu Weiwei Xue Yongheng Fan Qi Zhang Bing Chen Xianming Wu Ya Shi Falong Lu Yannan Zhao Zhifeng Xiao Jianwu Dai | 2023 | Bioactive Materials2023，，5： | 0 |
| 14 | Moiré-driven electromagnetic responses and magic angles in a sandwiched hyperbolic metasurface显示文摘Recent moiréconfigurations provide a new platform for tunable and sensitive photonic responses,as their enhanced light–matter interactions originate from the relative displacement or rotation angle in a stacking bilayer or multilayer periodic array.However,previous findings are mostly focused on atomically thin condensed matter,with limitations on the fabrication of multilayer structures and the control of rotation angles.Structured microwave moiréconfigurations are still difficult to realize.Here,we design a novel moiréstructure,which presents unprecedented capability in the manipulation of light–matter interactions.Based on the effective medium theory and S-parameter retrieval process,the rotation matrix is introduced into the dispersion relation to analyze the underlying physical mechanism,where the permittivity tensor transforms from a diagonal matrix to a fully populated one,whereas the permeability tensor evolves from a unit matrix to a diagonal one and finally becomes fully filled,so that the electromagnetic responses change drastically as a result of stacking and rotation.Besides,the experiment and simulation results reveal hybridization of eigenmodes,drastic manipulation of surface states,and magic angle properties by controlling the mutual rotation angles between two isolated layers.Here,not only a more precisely controllable bilayer hyperbolic metasurface is introduced to moiréphysics,the findings also open up a new avenue to realize flat bands at arbitrary frequencies,which shows great potential in active engineering of surface waves and designing multifunctional plasmonic devices. | YI LIU CHUNMEI OUYANG QUAN XU XIAOQIANG SU QUANLONG YANG JIAJUN MA YANFENG LI ZHEN TIAN JIANQIANG GU LIYUAN LIU JIAGUANG HAN YUNLONG SHI WEILI ZHANG | 2022 | Photonics Research2022，10，9： | 0 |
| 15 | High-throughput first-principle prediction of collinear magnetic topological materials显示文摘The success of topological band theory and symmetry-based topological classification significantly advances our understanding of the Berry phase.Based on the critical concept of topological obstruction,efficient theoretical frameworks,including topological quantum chemistry and symmetry indicator theory,were developed,making a massive characterization of real materials possible.However,the classification of magnetic materials often involves the complexity of their unknown magnetic structures,which are often hard to know from experiments,thus,hindering the topological classification.In this paper,we design a high-throughput workflow to classify magnetic topological materials by automating the search for collinear magnetic structures and the characterization of their topological natures.We computed 1049 chosen transition-metal compounds(TMCs)without oxygen and identified 64 topological insulators and 53 semimetals,which become 73 and 26 when U correction is further considered.Due to the lack of magnetic structure information from experiments,our high-throughput predictions provide insightful reference results and make the step toward a complete diagnosis of magnetic topological materials. | Yunlong Su Jiayu Hu Xiaochan Cai Wujun Shi Yunyouyou Xia Yuanfeng Xu Xuguang Xu Yulin Chen Gang Li | 2022 | npj Computational Materials2022，，1： | 0 |
| 16 | A nonchlorinated solvent-processed polymer semiconductor for high-performance ambipolar transistors显示文摘Ambipolar polymer semiconductors are potentially serviceable for logic circuits,light-emitting field-effect transistors(LFETs)and polymer solar cells(PSCs).Although several high-performance ambipolar polymers have been developed,their optoelectronic devices are generally processed from toxic chlorinated solvents.To achieve the commercial applications of organic FETs(OFETs),the polymers should be processed from nonchlorinated solvents,instead of chlorinated solvents.However,most conjugated polymers show poor solubility in nonchlorinated solvents.It is of great importance to develop ambipolar polymers that can be processed from nonchlorinated solvents.Here,we develop a nonchlorinated solvent processed polymer named poly[7-fluoro-N,N′-di(4-decyltetradecyl)-7′-azaisoindigo-6′,6′′-(thieno[3,2-b]thiophene-2,5-diyl)-7′′′-fluoro-N′′,N′′′-di(4-decyltetradecyl)-7′′-azaisoindigo-6,6′′′-([2,2′′-bithiophene]-5,5′′-diyl)](PITTI-BT)by designing a monomer with a large molar mass.The polymer displays good solubility in p-xylene(PX).Well-aligned films of PITTI-BT are achieved by an off-center spin-coating(SC)method.Based on the high-quality films,the OFETs fabricated from PX solution achieve record ambipolar performance with hole and electron mobilities of 3.06 and2.81 cm^(2)V^(-1)s^(-1),respectively.The combination of nonchlorinated solvents and good alignment process offers an effective and eco-friendly approach to obtain high-performance ambipolar transistors. | Jie Yang Yaqian Jiang Zhiyuan Zhao Xueli Yang Zheye Zhang Jinyang Chen Junyu Li Wei Shi Shuai Wang Yunlong Guo Yunqi Liu | 2022 | National Science Review2022，9，4： | 0 |
| 17 | Liquid-liquid phase separation in DNA double-strand break repair显示文摘DNA repair factors function through spatiotemporal condensation and dissolution at DNA double-strand breaks(DSBs).Recent advances have indicated that some DSB repair factors undergo liquid-liquid phase separation(LLPS)and show droplet-like properties,as well as dynamic material exchange.Importantly,LLPS regulates various biological processes,and aberrant LLPS is involved in the pathologic progression of various diseases. | Jia Chen Jie Shi Jian Zheng Yunlong Wang Xiangbo Wan | 2023 | Cancer Biology & Medicine2023，20，9： | 0 |
| 18 | Numerical study on interaction between eddies and the Kuroshio Current east of Taiwan,China显示文摘We investigated the interaction between mesoscale eddies and the Kuroshio Current east of Taiwan,China,using a fine-resolution regional general circulation model.Mesoscale eddies are injected into a region east of Taiwan,China,according to the quasi-geostrophic theory of stratified fluids.Modeled eddies propagated westward at the velocity of the first baroclinic mode Rossby wave.When eddies collide with the Kuroshio Current east of Taiwan,China,the spatial structure and volume transport of the Kuroshio Current shows a significant variation.The upper 600 m of the anticyclonic eddy cannot cross the Kuroshio Current to reach the region west of the Kuroshio Current;rather,these waters flow northward along the eastern side of the Kuroshio Current.The upper water carried by the anticyclonic eddies cannot reach the shelf of the East China Sea(ECS).In contrast,the waters in the upper layer of the cyclonic eddy reach the western side of the Kuroshio Current and then flow northward.The dynamic mechanism analysis shows that the interaction between the Kuroshio Current and the cyclonic(anticyclonic)eddy decrease(increase)the horizontal potential vorticity(PV)gradient,or PV barrier,whereby the cyclonic(anticyclonic)eddy can(cannot)cross the Kuroshio Current.This study implies that the continental shelf could potentially be influenced by cyclonic eddies in the open ocean,which can transport heat and material from the upper open ocean across the Kuroshio Current to the shelf waters. | Yunlong SHI Dezhou YANG Yijun HE | 2021 | Journal of Oceanology and Limnology2021，39，2： | 0 |
| 19 | Integrated'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome显示文摘OBJECTIVE:To observe the efficacy of moxibustion in the treatment of chronic fatigue syndrome(CFS)and explore the effects on gut microbiota and metabolic profiles.METHODS:Forty-eight male Sprague-Dawley rats were randomly assigned to control group(Con),CFS model group(Mod,established by multiple chronic stress for 35 d),MoxA group(CFS model with moxibustion Shenque(CV8)and Guanyuan(CV4),10 min/d,28 d)and MoxB group(CFS model with moxibustion Zusanli(ST36),10 min/d,28 d).Open-field test(OFT)and Morris-water-maze test(MWMT)were determined for assessment the CFS model and the therapeutic effects of moxibustion.16S rRNA gene sequencing analysis based gut microbiota integrated untargeted liquid chromatograph-mass spectrometer(LC-MS)based fecal metabolomics were executed,as well as Spearman correlation analysis,was utilized to uncover the functional relevance between the potential metabolites and gut microbiota.RESULTS:The results of our behavioral tests showed that moxibustion improved the performance of CFS rats in the OFT and the MWMT.Microbiome profiling analysis revealed that the gut microbiomes of CFS rats were less diverse with altered composition,including increases in pro-inflammatory species(such as Proteobacteria)and decreases in anti-inflammatory species(such as Bacteroides,Lactobacillus,Ruminococcus,and Prevotella).Moxibustion partially normalized these changes in the gut microbiota.Furthermore,CFS was associated with metabolic disorders,which were effectively ameliorated by moxibustion.This was demonstrated by the normalization of 33 microbiota-related metabolites,including mannose(P=0.001),aspartic acid(P=0.009),alanine(P=0.007),serine(P=0.000),threonine(P=0.027),methionine(P=0.023),5-hydroxytryptamine(P=0.008),alpha-linolenic acid(P=0.003),eicosapentaenoic acid(P=0.006),hypoxanthine(P=0.000),vitamin B6(P=0.000),cholic acid(P=0.013),and taurocholate(P=0.002).Correlation analysis showed a significant association between the perturbed fecal microbiota and metabolite levels,with a notable negative relationship between LCA and Bacteroides.CONCLUSIONS:In this study,we demonstrated that moxibustion has an antifatigue-like effect.The results from the 16S rRNA gene sequencing and metabolomics analysis suggest that the therapeutic effects of moxibustion on CFS are related to the regulation of gut microorganisms and their metabolites.The increase in Bacteroides and decrease in LCA may be key targets for the moxibustion treatment of CFS. | LI Chaoran YANG Yan FENG Chuwen LI Heng QU Yuanyuan WANG Yulin WANG Delong WANG Qingyong GUO Jing SHI Tianyu SUN Xiaowei WANG Xue HOU Yunlong SUN Zhongren YANG Tiansong | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 20 | Development and Commercial Application of Supported Palladium Catalyst for Isomerization of C_5/C_6 Hydrocarbons显示文摘1 Introduction
China has enforced a new gasoline standard starting 2003 to limit the olefins, aromatics and benzene contents in gasoline.The isomerate is the cleanest gasoline component because it does not contain the above-mentioned components, and is also an excellent gasoline blending component because of its higher RON and MON ratings. | Han Song Hu Yaoliang Xu Zhengge Wu Zhengtai Shi Li Ding Yunlong | 2005 | China Petroleum Processing & Petrochemical Technology2005，7，4： | 0 |
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