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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 3 | Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery显示文摘 | Miao Guo Chailu Que Chenhong Wang Xiaozhou Liu Husheng Yan Keliang Liu | 2010 | Biomaterials2010，，1： | 1 |
| 4 | Morphology Change of Metastable Regrown Graphite with Boron Additive under HPHT显示文摘By temperature gradient method under high pressure and high temperature(HPHT),with NiMnCo alloy as the solvent metal,at diamond-stable region of about 5.4 GPa and 1500 K,metastable regrown graphite crystals of different morphology were synthesized.With B as an additive incorporated into the NiMnCo-C system,metastable regrown graphite crystals of sphere-like shape were firstly obtained under HPHT.If the growth system does not contain B,sheet-like regrown graphite crystals,most with regular hexagonal morphology,are grown upwards and standing vertically in the metal solvent.When B additive of 1.0 wt pct was added into carbon source(graphite powder),all metastable regrown graphite crystals took on the habit of regular sphere-like morphology,and were grown by a spiral layer growth mechanism. | Chuanyi Zang Xiaozhou Chen Qiang Hu Wei Guo Guofeng Huang Xiaopeng Jia | 2009 | Journal of Materials Science & Technology2009，25，4： | 0 |
| 5 | Problem and Improvement of Kissinger Method──New Method on Measuring Crystallization Activation Energy of Amorphous Alloy显示文摘ProblemandImprovementofKissingerMethod──NewMethodonMeasuringCrystallizationActivationEnergyofAmorphousAlloyCaoXingguo;CheXiao... | Cao Xingguo Che Xiaozhou Liu Ping Guo Zechen | 1996 | Journal of Iron and Steel Research(International)1996，3，2： | 0 |
| 6 | A new method to reduce end effect of linear induction motor显示文摘A new method to compensate the end effect of a linear induction motor (LIM) in low-speed maglev vehicles is proposed. With this method, the motors are close to each other so that the front motor's exit-end magnetic field extends into the next motor's entry zone. As a result, the motor's magnetic field traveling wave become continuous and the end effect of short primary LIMs is greatly weakened. In the analysis of the air-gap magnetic field distribution, the LIM is assumedly divided into two identical motors with the distances of 20, 40, 60, and 80 mm. The results show that the air-gap magnetic field is still continuous within these distances due to LIM's end effect. As the distance between two motors increases, the distortion of the air-gap magnetic field becomes more severe. Then, we investigate the relationship between the secondary speed and the thrust in three cases, i.e., a single LIM, two motors divided with 72 mm with pole pitch corrected, and two motors divided with 60 mm without the pole pitch being corrected. We find that the thrust has a small decrease when the speed increases, which means that the magnetic field is already continuous and its amplitude is approximately a constant. Furthermore, the thrust loss of case 3 is more than that of case 2, which indicates that the pole pitch correction is effective. | Xiaozhou GUO Bin ZHOU Jisan LIAN | 2012 | Journal of Modern Transportation2012，20，2： | 0 |
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