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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 3 | 3D printing of Mg-substituted wollastonite reinforcing diopside porous bioceramics with enhanced mechanical and biological performances显示文摘Mechanical strength and its long-term stability of bioceramic scaffolds is still a problem to treat the osteonecrosis of the femoral head.Considering the long-term stability of diopside(DIO)ceramic but poor mechanical strength,we developed the DIO-based porous bioceramic composites via dilute magnesium substituted wollastonite reinforcing and three-dimensional(3D)printing.The experimental results showed that the secondary phase(i.e.10%magnesium substituting calcium silicate;CSM10)could readily improve the sintering property of the bioceramic composites(DIO/CSM10-x,x=0-30)with increasing the CSM10 content from 0%to 30%,and the presence of the CSM10 also improved the biomimetic apatite mineralization ability in the pore struts of the scaffolds.Furthermore,the flexible strength(12.5 -30 MPa)and compressive strength(14-37 MPa)of the 3D printed porous bioceramics remarkably increased with increasing CSM10 content,and the compressive strength of DIO/CSM10-30 showed a limited decay(from 37 MPa to 29 MPa)in the Tris buffer solution for a long time stage(8 weeks).These findings suggest that the new CSM10-reinforced diopside porous constructs possess excellent mechanical properties and can potentially be used to the clinic,especially for the treatment of osteonecrosis of the femoral head work as a bioceramic rod. | Dongshuang He Chen Zhuang Sanzhong Xu Xiurong Ke Xianyan Yang Lei Zhang Guojing Yang Xiaoyi Chen Xiaozhou Mou An Liu Zhongru Gou | 2016 | Bioactive Materials2016，1，1： | 5 |
| 4 | The numerical simulation of interface crack propagation without re-meshing显示文摘Based on the framework of the extended finite element method (XFEM), the enriched exponent discontinuous function is modified properly by introducing the rigidity ratio of two sides materials of interface crack, and the portion integral scheme is adopted for interface elements containing two materials. To embody the singularity of the crack tip, the triangle function is introduced directly. What’s more, the maximum loop stress fracture criterion is adopted to determine the extension direction in extended material domains, and the true extension distance for each load step is determined by reducing or increasing half the current trial extension distance until the equivalent stress intensity factor reaches the type I fracture toughness of material. Finally, with the improved XFEM, the interface crack propagation in a cantilever deep beam and concrete gravity dam are simulated without re-meshing respectively and their failure modes are also analyzed. | XIA XiaoZhou ZHANG Qing WANG Hong YANG Shuai | 2011 | Science China(Technological Sciences)2011，54，7： | 4 |
| 5 | Two-dimensional Riemann problems of simplified Euler equation显示文摘The two-dimensional Riemann problem of simplifed Euler equation is discussed, in which initial value contains two different constant states that are separated by a smooth curve. This problem is a natural description of realistic phenomena, but it is hard to study by conventional idea. So a new approach is proposed. Some new properties about two-dimensional rarefaction wave, shock wave and intermediate state of solutions are disclosed. | YANG Xiaozhou 1,2 and HUANG Feimin+1 1. Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing 100080, China 2. Department of Mathematics, Shantou University, Guangdong 515063, China | 1998 | Chinese Science Bulletin1998，43，6： | 3 |
| 6 | Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake显示文摘LRP6,a co-receptor for the morphogen Wnt,aids endocytosis of anthrax complexes.Here we report that Dickkopf1(DKK1)protein,a secreted LRP6 ligand and antagonist,is also a modulator of anthrax toxin sensitivity.shRNA-mediated gene silencing or TALEN-mediated gene knockout of DKK1 reduced sensitivity of cells to PA-dependent hybrid toxins.However,unlike the solely inhibitory effect on Wnt signaling,the effects of DKK1 overexpression on anthrax toxicity were bidirectional,depending on its endogenous expression and cell context.Fluorescence microscopy and biochemical analyses showed that DKK1 facilitates internalization of anthrax toxins and their receptors,an event mediated by DKK1-LRP6-Kremen2 complex.Monoclonal antibodies against DKK1 provided dose-dependent protection to macrophages from killing by anthrax lethal toxin(LT).Our discovery that DKK1 forms ternary structure with LRP6 and Kremen2 in promoting PA-mediated toxin internalization provides a paradigm for bacterial exploitation of mechanisms that host cells use to internalize signaling proteins. | QIAN LiLi CAI ChangZu YUAN PengFei JEONG Sun-Young YANG XiaoZhou DEALMEIDA Venita ERNST James COSTA Michael COHEN Stanley N. WEI WenSheng | 2014 | Science China(Life Sciences)2014，57，5： | 2 |
| 7 | Climate-induced Changes in Spring Maize Water Requirement in Xiliaohe River Watershed显示文摘Xiliaohe River watershed plays an important role in regional and national grain security.With the development of society and economy,water consumption that increased dramatically causes water shortages.Crop water requirement can provide quantitative basis for making regional irrigation scheme.In this study,spring maize water requirement is calculated by using PenmanMonteith formula and spring maize coefficient from May to September at 10 meteorological stations in Xiliaohe River watershed from 1951 to 2005.The variation trend of the spring maize water requirement during the whole growing stage,water requirement in every month,and meteorological influencing factors are obtained by using Mann-Kendall method,and the degree of grey incidence between the water requirement and meteorological influencing factors are shown.The results are the spring maize water requirement during the whole growing stages increases at half of the stations in Xiliaohe River watershed,and are remarkably affected by the water requirement in May.The monthly mean,maximum and minimum air temperature form May to September show an increasing trend in Xiliaohe River watershed in recent 55 years.The monthly mean and minimum air temperature increases notably.The relative humidity,precipitation,wind speed and sunshine show a decreasing trend with variety for different months.The monthly maximum air temperature,wind speed,sunshine and monthly mean air temperature have the highest correlation degree with spring maize water requirement from May to September. | Sun Xiaozhou Feng Zhiming Yang Yanzhao Zhang Weike | 2009 | Chinese Journal of Population,Resources and Environment2009，7，4： | 1 |
| 8 | Improving the sensitivity for DNA sensing based on doubleanchored DNA modified gold nanoparticles显示文摘DNA modified nanoparticles(Au NPs) are an established and widely used type of nucleotide sensor. We sought to improve the design by applying short rigid DNA duplexes near the surface of the Au NPs forming a so called double-anchored Au NP sensor, and compared it with other conventional DNA modified Au NPs. The improved design exhibited higher assembly efficiency, and consequently increased its sensitivity to target DNA. | Xiaozhou Ma Miao Wang Chun Chen Mark Antonin Isbell Rui Wang Dongsheng Liu Zhongqiang Yang | 2016 | Science China Chemistry2016，59，6： | 1 |
| 9 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 10 | Genomic Surveillance for SARS-CoV-2—China,September 26,2022 to January 29,2023显示文摘Introduction:The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has generated 2,431 variants over the course of its global transmission over the past 3 years.To better evaluate the genomic variation of SARS-CoV-2 before and after the optimization of coronavirus disease 2019(COVID-19)prevention and control strategies,we analyzed the genetic evolution branch composition and genomic variation of SARS-CoV-2 in both domestic and imported cases in China(the data from Hong Kong and Macao Special Administrative Regions and Taiwan,China were not included)from September 26,2022 to January 29,2023.Methods:Analysis of the number of genome sequences,sampling time,dynamic changes of evolutionary branches,origin,and clinical typing of SARS-CoV-2 variants submitted by 31 provincial-level administrative divisions(PLADs)and Xinjiang Production and Construction Corps(XPCC)was conducted to assess the accuracy and timeliness of SARS-CoV-2 variant surveillance.Results:From September 26,2022 to January 29,2023,20,013 valid genome sequences of domestic cases were reported in China,with 72 evolutionary branches.Additionally,1,978 valid genome sequences of imported cases were reported,with 169 evolutionary branches.The prevalence of the Omicron variants of SARS-CoV-2 in both domestic and imported cases was consistent with that of international epidemic variants.Conclusions:This study provides an overview of the prevalence of Omicron variants of SARS-CoV-2 in China.After optimizing COVID-19 prevention and control strategies,no novel Omicron variants of SARSCoV-2 with altered biological characteristics or public health significance have been identified since December 1,2022. | Shiwen Wang Peihua Niu Qiudong Su Xiaozhou He Jing Tang Ji Wang Yenan Feng Cao Chen Xiang Zhao Zhixiao Chen Wenling Wang Zeyuan Yin Yuchao Wu Changcheng Wu Lili Li Aili Cui Yan Zhang Caiyun Long Xiaoyu Yang Zhongxian Zhang Hong Bo Wenbo Xu SARS-CoV-Genome Working Group | 2023 | China CDC weekly2023，5，7： | 1 |
| 11 | Effects of live rock on removal of dissolved inorganic nitrogen in coral aquaria显示文摘Maintaining stable water quality is one of the key processes for recirculating coral aquaculture. Traditional aquarium systems which mainly utilized a nitrification of nitrifying bacteria attached to the surface of massive artificial filter material are difficult to maintain the oligotrophic conditions necessary for coral aquaculture. This study investigated the removal effects of dissolved inorganic nitrogen(ammonia and nitrate) by live rock(LR), a key component in the 'Berlin system' coral aquarium. The expression levels of bacterial functional genes, AOA3,amo A and nos Z, were measured on the exterior and interior of LR. The nitrifying and denitrifying bacterial abundance on LR was quantified and the nitrogen nutrient regulatory effects of LR were evaluated. The results demonstrated that LR mainly removed ammonium(NH_4^+) from the water with a mean efficiency of 0.141 mg/(kg·h), while the removal of nitrate(NO_3~–) was not significant. Bacterial diversity analysis showed that ammonia-oxidizing bacteria(AOB) were the most common bacteria on LR, which accounted for 0.5%–1.4% of the total bacterial population, followed by denitrifying bacteria, which accounted for 0.2% of the total population, and the ammonia-oxidizing archaea(AOA) were the least common type(<0.01%). The low abundance of denitrifying bacteria may be responsible for the poor nitrate(NO_3~–) removal of LR. Thus, other biological filtration methods are needed in coral aquaria to control nitrates generated from nitrification or biological metabolism. | LI Yan ZHENG Xinqing YANG Xiaozhou OU Dangyun LIN Rongcheng LIU Xinming | 2017 | Acta Oceanologica Sinica2017，36，12： | 1 |
| 12 | Vertical multiple-layer structure of temperature and turbulent diffusivity in the South China Sea显示文摘We report field measurements of vertical profiles of the turbulent diffusivity and temperature at different stations in the South China Sea(SCS).Our study shows that the measured turbulent diffusivity follows a power-law distribution with a varying exponent in water layers.Similar multiple-layer scaling regimes were also observed from the temperature fluctuations.Combining turbulent diffusivity and temperature fluctuations,the vertical structure of temperature was revealed.Furthermore,we discussed the temperature profiles in each layer.A constant function of a dimensionless temperature profile was found in water layers that have identical turbulence conditions.Our results reveal the multiple-layer structure of temperature in the SCS.This study contributes to the understanding of the vertical structure of multiple layers in the SCS and provides clues for exploring the physical mechanism for maintaining the temperature structure. | Xin He Changrong Liang Yang Yang Guiying Chen Xiaodong Shang Xiaozhou He Penger Tong | 2022 | Acta Oceanologica Sinica2022，41，10： | 1 |
| 13 | Bond-associated non-ordinary state-based peridynamic model for multiple spalling simulation of concrete显示文摘The non-ordinary state-based peridynamic(NOSB PD)model has the capability of incorporating existing constitutive relationships in the classical continuum mechanics.In the present work,we first develop an NOSB PD model corresponding to the Johnson–Holmquist II(JH-2)constitutive damage model,which can describe the severe damage of concrete under intense impact compression.Besides,the numerical oscillation problem of the NOSB PD caused by zero-energy mode is analyzed and hence a bond-associated non-ordinary state-based peridynamic(BA-NOSB PD)model is adopted to remove the oscillation.Then,the elastic deformation of a three-dimensional bar is analyzed to verify the capability of BA-NOSB PD in eliminating the numerical oscillation.Furthermore,concrete spalling caused by the interaction of incident compression wave and reflected tension wave is simulated.The dynamic tensile fracture process of concrete multiple spalling is accurately reproduced for several examples according to the spalling number and spalling thickness analysis,illustrating the approach can well simulate and analyze the concrete spalling discontinuities. | Siyang Yang Xin Gu Qing Zhang Xiaozhou Xia | 2021 | Acta Mechanica Sinica2021，37，7： | 0 |
| 14 | The influences of large earthquake signals on the recovery of surface waves from ambient noise cross-correlation functions显示文摘Ambient noise tomography(ANT)has been widely used to image crust and upmost mantle structures.ANT assumes that sources of ambient noise are diffuse and evenly distributed in space and the energy of different modes is equipartitioned.At present,the sources of the primary and the secondary microseisms are well studied,but there are only a few on the studies of long-period ambient noise sources.In this study,we study the effects of large earthquake signals on the recovery of surface waves from seismic ambient noise data recorded by seismic stations from the US permanent networks and Global Seismographic Network(GSN).Our results show that large earthquake signals play an important role on the recovery of long-period surface waves from ambient noise cross-correlation functions.Our results are consistent with previous studies that suggest the contribution of earthquake signals to the recovery of surface waves from cross-correlations of ambient noise is dominant at periods larger than 20–40 s. | Huayi Zhu Xiaojin Xie Xiaozhou Yang Yinhe Luo | 2020 | Earthquake Science2020，33，5： | 0 |
| 15 | A Layout Method of Space-Based Pseudolite System Based on GDOP Geometry显示文摘The pseudolite system can be used to provide positioning and timing service for users in a specific area.In order to provide better positioning and timing service,a good geometric configuration needs to be formed for the pseudolite system.For the problem of pseudolite system deployment,the average and mean square values of geometric dilution of precision(GDOP)are optimized in this paper for users in a target area.We proposed a space-based pseudolite deployment method based on GDOP geometry,starting from the minimum GDOP value for users in the central area.From the simulation results,it can be seen that,compared with the empirical method and the NSGA-II method,the method in this paper has the smallest average GDOP,a better robustness,and a higher positioning accuracy in the target area,through which a pseudolite deployment proposal can be quickly obtained. | YANG Xin WANG Feixue LIU Wenxiang XIAO Wei YE Xiaozhou | 2023 | Chinese Journal of Electronics2023，32，5： | 0 |
| 16 | Temporal evolution of scour at bridge abutments in compound channels显示文摘Bridge abutment-induced sediment scour in compound river channels is time-sensitive during floods,and,thus,estimating the scour rate has significance in design.In the current study,large-scale laboratory experiments were done to examine the influence of multiple factors on scour evolution,including channel geometry,bed mobility(clear-water or live-bed),and lateral(embankment intrusion)and vertical(deck submergence)flow contractions.A new method is applied for scour measurement and determination of characteristic scour trends.Results show that the nondimensional time scale is related to flow intensity and may peak before reaching the clear-water scour threshold;the corresponding equations also are derived.It is found that the use of scour countermeasures has a significant impact on the scour rate,and the existing equations for unprotected abutments have limitations.Under clear-water conditions,the scour rate is closely related to the overall flow contraction,which can be better reflected by the ratio of the approaching unit discharge to that at the bridge section.Specifically,the effect of vertical flow contraction on scour rate is more dominant than other factors.Two scour rate curves are derived to suit different structural and flow contraction types for clear-water scour.In contrast,the live-bed scour rate data are generally consistent and fall in a narrow band,showing less dependence on other factors.Finally,a new design approach is established to estimate the time scale and scour rate using the new equations proposed in this paper. | Yifan Yang Bruce WMelville Xiaozhou Xiong Lu Wang | 2022 | International Journal of Sediment Research2022，37，5： | 0 |
| 17 | BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy显示文摘Cisplatin(CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence rate.Synergy therapy has been proven as a potent approach to minimize recurrence and achieve enhanced treatment effects.Herein,chemotherapy drug CDDP is assembled with the photothermal-Fenton agent of bovine serum albumin(BSA)stabilized gallic acid-functionalized iron nanoparticles(GA-Fe NPs)to achieve chemo/chemodynamic synergistic cascade oncotherapy.The Pt-GA-Fe NPs can be utilized to generate H_(2)O_(2) via the activation of nicotinamide adenine dinucleotide phosphate(NADPH)oxidases(NOXs)in the tumor microenvironment(TME),which would then greatly boost H2O2-depending chemodynamic therapy(CDT).The generated cytotoxic reactive oxygen species(hydroxyl radicals,·OH)and the depletion of glutathione(GSH)would further promote CDDP-induced DNA damage.Moreover,benefiting from the absorption in the near-infrared(NIR)region,Pt-GA-Fe NPs exhibit excellent photothermal conversion efficiency(η=45.5%)and allow photoacoustic imaging(PAI)guided photothermal therapy(PTT).In vitro and in vivo experiments show that synergy therapy can effectively kill cancer cells and successfully cure cancer without systemic toxicity.The work highlights a new type of therapeutic agent based on CDDP with the ability of H_(2)O_(2) self-generation,thermal responsiveness,and enhanced CDT effects for applications in cancer therapy. | Nan Yang Tian Zhang Changyu Cao Genxiang Mao Jinjun Shao Xuejiao Song Wenjun Wang Xiaozhou Mou Xiaochen Dong | 2022 | Nano Research2022，15，3： | 0 |
| 18 | Interplay of transcription factors and microRNAs during embryonic hematopoiesis显示文摘Hematopoietic stem cells (HSCs), which are localized in the bone marrow of adult mammals, come from hematopoietic endothelium during embryonic stages. Although the basic processes of HSC generation and differentiation have been described in the past, the epigenetic regulation of embryonic hematopoiesis remains to be fully described. Here, by utilizing an in vitro differentiation system of mouse embryonic stem cells (ESCs), we identified more than 20 microRNAs that were highly enriched in embryonic hematopoietic cells, including some (e.g. miR-10b, miR-15b, and miR-27a) with previously unknown functions in blood formation. Luciferase and gene expression assays further revealed combinational binding and regulation of these microRNAs by key transcription factors in blood cells. Finally, bioinformatics and functional analyses supported an interactive regulatory control between transcription factors and microRNAs in hematopoiesis. | Xueping Gong Ruihua Chao Pengxiang Wang Xiaoli Huang Jingjing Zhang Xiaozhou Zhu Yanyang Zhang Xue Yang Chao Hou Xiangjun Ji Tieliu Shi Yuan Wang | 2017 | Science China(Life Sciences)2017，60，2： | 0 |
| 19 | Unveiling the grain boundary-related effects on the incipient plasticity and dislocation behavior in nanocrystalline CrCoNi medium-entropy alloy显示文摘The incipient plasticity and dislocation behavior in a nanocrystalline(NC)CrCoNi medium-entropy alloy were systematically investigated in terms of pop-in events during instrumental nano-indentation tests.Quantitative statistical analysis and molecular dynamic simulations were performed to reveal the effects of grain boundaries(GBs)on initial stages of plastic deformation.Multiple pop-in events appeared during loading on the NC CrCoNi.The first pop-in that represents the initial yielding was identified to be controlled by dislocation nucleation,which is in sharp contrast to the continuous elastic-plastic transition mediated by GB mechanisms in NC pure metals.This can be attributed to the sluggish kinetics of the chemically complex GBs(CCGBs)in the NC CrCoNi that hinders diffusive GB activities but facilitates dislocation nucleation.Subsequent pop-ins were also found to be closely related to the extra dragging effects imposed by the CCGBs on dislocation propagation in the NC alloy.Moreover,the extremely small grain sizes and the consequent high-volume fraction of GBs in the NC alloy severely restrict the lengths of dislocation source and the radii of dislocation loop,giving rise to a higher critical stress,smaller activation volume and lower pop-in width as compared with its coarse-grained counterpart.These results provide new insights into the onset of nano-plasticity in concentrated multi-principal element alloys. | Shuo Sun Yang Yang Chenxu Han Guixun Sun Yan Chen Hongxiang Zong Jiangjiang Hu Shuang Han Xiaozhou Liao Xiangdong Ding Jianshe Lian | 2022 | Journal of Materials Science & Technology2022，，32： | 0 |
| 20 | Detached eddy simulation on the structure of swirling jet flow field显示文摘The improved delayed detached eddy simulation method with shear stress transport model was used to analyze the evolution of vortex structure,velocity and pressure fields of swirling jet.The influence of nozzle pressure drop on vortex structure development and turbulence pulsation was investigated.The development of vortex structure could be divided into three stages:Kelvin-Helmholtz(K-H)instability,transition stage and swirling flow instability.Swirling flow could significantly enhance radial turbulence pulsation and increase diffusion angle.At the downstream of the jet flow,turbulence pulsation dissipation was the main reason for jet velocity attenuation.With the increase of pressure drop,the jet velocity,pulsation amplitude and the symmetry of velocity distribution increased correspondingly.Meanwhile the pressure pulsation along with the axis and vortex transport intensity also increased significantly.When the jet distance exceeded about 9 times the dimensionless jet distance,the impact distance of swirling jet could not be improved effectively by increasing the pressure drop.However,it could effectively increase the swirl intensity and jet diffusion angle.The swirling jet is more suitable for radial horizontal drilling with large hole size,coalbed methane horizontal well cavity completion and roadway drilling and pressure relief,etc. | CHEN Jianxiang YANG Ruiyue HUANG Zhongwei LI Gensheng QIN Xiaozhou LI Jingbin WU Xiaoguang | 2022 | Petroleum Exploration and Development2022，49，4： | 0 |
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