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| 1 | Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome显示文摘 | HE Quan-ying FENG Jing ZHANG Xilong LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun WANG Bei LIN Qi-chang ZHANG Jin-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2012 | Chinese Medical Journal2012，，10： | 15 |
| 2 | The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity显示文摘Ribosomal proteins(RPs), the essential components of the ribosome, are a family of RNA-binding proteins, which play prime roles in ribosome biogenesis and protein translation. Recent studies revealed that RPs have additional extra-ribosomal functions, independent of protein biosynthesis, in regulation of diverse cellular processes. Here, we review recent advances in our understanding of how RPs regulate apoptosis, cell cycle arrest, cell proliferation, neoplastic transformation, cell migration and invasion, and tumorigenesis through both MDM2/p53-dependent and p53-independent mechanisms. We also discuss the roles of RPs in the maintenance of genome integrity via modulating DNA damage response and repair. We further discuss mutations or deletions at the somatic or germline levels of some RPs in human cancers as well as in patients of Diamond-Blackfan anemia and 5q- syndrome with high susceptibility to cancer development. Moreover, we discuss the potential clinical application, based upon abnormal levels of RPs, in biomarker development for early diagnosis and/or prognosis of certain human cancers. Finally, we discuss the pressing issues in the field as future perspectives for better understanding the roles of RPs in human cancers to eventually benefit human health. | Xilong Xu Xiufang Xiong Yi Sun | 2016 | Science China(Life Sciences)2016，59，7： | 13 |
| 3 | Selection of leading industries for coal resource cities based on coupling coordination of industry's technological innovation显示文摘Taking the city of Qitaihe is as an example in order to provide practical methods for the selection of leading industries for coal resource cities, this paper establishes the specific operation scheme for selection of leading industries according to the actual situation of coal resource cities based on the theory of coupling coordination together with the coupling coordination for technological innovation. The results show that the degree for coupling coordination of the technological innovation for each alternative industry differentiates with the development of coal resource cities. For example, the average degree of food processing industry from agricultural produce is 0.9. Therefore, coal resource cities should develop some industries related to coal industry, such as coking industry, some chemical and medicines industry and non-metallic mineral products manufacturing, in the near future, however, some industries with greater market and influence potentials and low carbon emissions should be attached much importance to in the future. | Du Jiming Yu Bo Yao Xilong | 2012 | International Journal of Mining Science and Technology2012，22，3： | 9 |
| 4 | Reviews of Metallurgical Technology to Recovery Platinum Group Metals from Secondary Resource in China显示文摘China is extremely poor in mineral resources of Platinum Group Metals (PGMs), productive output of PGMs from mineral resource is 2.5 tons per year. At the same time, China is the biggest PGMs consumption country in the world, the mineral resource of PGMs is critical shortage, it shows the importance of recycling the secondary resource of PGMs. Sino-Platinum Metals Resource (Yimen) Co., Ltd. is the leader in recycling of PGMs from secondary resource, and has made outstanding contributions to China PGMs secondary resources recycling. This article elucidates the current situation of secondary resources recovery and development of metallurgical technology for PGMs. | GUO Junmei HE Xiaotang WANG Huan WU Xilong ZHAO Yu LI Yong LI Kun HAN Shouli | 2012 | 贵金属2012，33，A01： | 9 |
| 5 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 6 | Study on the Recovery of Rhodium from Spent Organic Rhodium Catalysts of Acetic Acid Industry Using Pyrometallurgical Process显示文摘A new process recycling rhodium from organic waste containing rhodium in acetic acid industry is developed. Use the special affinity of base metal sulfides (FeS, Ni2S3 , CuS, etc.) on platinum group metals, adopting high nickel matte trapping-aluminothermic activation method to recovery rhodium from incinerator residue of organic rhodium waste. The method is shorter process, lower equipment requirement, and the higher activity of rhodium black. In pyrometallurgy enrichment process,the recovery rate of rhodium reached 94.65%, the full flow of rhodium recovery rate was 92.04%. | HE Xiaotang WANG Huan WU Xilong LI Yong ZHAO Yu HAN Shouli LI Kun GUO Junmei | 2012 | 贵金属2012，33，A01： | 7 |
| 7 | Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells显示文摘动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素,它是否能调整 LPL 的表示,仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇,免费胆固醇,和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物,例如 interleukin-6 (IL-6 ) , interleukin-1 (IL-1 ) 和肿瘤坏死 factor-alpha (TNF-) 。apelin-13 禁止了由西方的污点和即时 PCR 分析揭示了的 LPL 的表示,这也被发现。生物信息学分析和双酶的记者试金直接显示了那 miR-361-5p downregulated 由指向 LPL 的 3UTR 的 LPL 的表示。另外, apelin-13 + miR-361-5p 显著地模仿 downregulated 在房间的 LPL 的表示。最后,我们表明了那 apelin-13 downregulated 通过激活 PKC 的活动的 LPL 的表示。一起拿,我们的结果显示出那 apelin-13 downregulated 经由激活在 THP-1 导出巨噬细胞的泡沫房间表明小径的 APJ/PKC/miR-361-5p 的 LPL 的表示,导致类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制。因此,我们的研究由 apelin-13 提供重要新卓见进类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制,并且在动脉粥样硬化作为一个有希望的治疗学的目标加亮 apelin-13。 | Xin Zhang Qiong Ye Duo Gong Yuan Lv Haipeng Cheng Chong Huang Lingyan Chen Zhenwang Zhao Liang Li Xie Wei Min Zhang Xiaodan Xia Xiaohua Yu Xilong Zheng Shuzhi Wang Zongbao Wang Chaoke Tang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 6 |
| 8 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 9 | Amino acids 89-96 of Salmonella typhimunum Tlagell=n represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response显示文摘 | Lei Zhang Zhiming Pan Xilong Kang Yun Yang Heekap Kang Na Zhang James M Rosati Xinan Jiao | 2015 | Cellular & Molecular Immunology2015，12，5： | 6 |
| 10 | Health risks of heavy metals to the general public in Tianjin, China via consumption of vegetables and fish显示文摘 | Xilong Wang T. Sato Baoshan Xing S. Tao | 2004 | Science of the Total Environment2004，，1： | 4 |
| 11 | Enhanced Efficiency of Milk Utilization for Growth in Surviving Low-Birth-Weight Piglets显示文摘This study determined effects of birth weights (0.70 to 1.09, 1.10 to 1.49, 1.50 to 1.89, and≥1.90 kg) on the efficiency of milk utilization for growth in sow-reared piglets. One-hundred-sixty piglets from 18 multiparous sows (Landrace×Large White) were individually weighed immediately after birth (day 0) and at 7-day intervals for 35 days. Milk consumption of piglets was determined weekly using the weigh-suckle-weigh method. Deaths of piglets were recorded daily. Piglets with the lightest birth weight had the highest incidence of mortality. Birth weights between 0.70 and 1.89 kg were positively associated with average daily gains (ADG, g/day) during the suckling period (P<0.01). Compared with piglets having birth weights of 1.50 to 1.89 kg, birth weights≥1.90 kg did not confer any additional benefit on preweaning survival or ADG. Colostrum or milk consumption per kilogram of body weight among low-, normal-, and large-birth-weight piglets did not differ in the first week. At days 14 to 35, milk consumption of piglets (g/kg BW/day) increased (P<0.01) but the ratio of gain to milk consumption decreased (P<0.01) progressively, as their birth weights increased from 0.70 to ≥1.90 kg. Additionally, surviving low-birth-weight piglets had a higher relative growth rate (%/day) than normal-and large-birth-weight piglets. Based on these novel findings, it is imperative that great efforts be made to improve the survival of low-birth-weight piglets so as to increase the efficiency of nutrient utilization by both lactating sows and suckling piglets. | Reza Rezaei Darrell A. Knabe Xilong Li Shuo Feng Guoyao Wu | 2011 | Journal of Animal Science and Biotechnology2011，2，2： | 4 |
| 12 | Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein显示文摘Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis(AS).The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood.In this study,we investigated the effect of macrophage sortilin on ATP-binding cassette transporter A1(ABCA1)expression,ABCA1-mediated cholesterol efflux,and aortic AS.Macrophage sortilin expression was upregulated by oxidized low-density lipoproteins(ox-LDLs)in both concentration-and time-dependent manners.Its expression reached the peak level when cells were incubated with 50μg/ml ox-LDL for 24 h.Overexpression of sortilin in macrophage reduced cholesterol efflux,leading to an increase in intracellular total cholesterol,free cholesterol,and cholesterol ester.Sortilin was found to bind with ABCA1 protein and suppress macrophage ABCA1 expression,resulting in a decrease in cholesterol efflux from macrophages.The inhibitory effect of sortilin in cholesterol efflux was partially reversed by treatment with chloroquine,a lysosomal inhibitor.On the contrary,the ABCA1 protein level and ABCA1-mediated cholesterol efflux is increased by sortilin short hairpin RNA transfection.The fecal and biliary cholesterol 3H-sterol from cholesterol-laden mouse peritoneal macrophage was reduced by sortilin overexpression through lentivirus vector(LV)-sortilin in low-density lipoprotein receptor knockout mice,which was prevented by co-treatment with chloroquine.Treatment with LV-sortilin reduced plasma high-density lipoprotein and increased plasma ox-LDL levels.Accordingly,aortic lipid deposition and plaque area were exacerbated,and ABCA1 expression was reduced in mice in response to infection with LV-sortilin alone.These effects of LV-sortilin were partially reversed by chloroquine.Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages,leading to foam cell formation and AS development. | Yuncheng Lv Jing Yang Anbo Gao Sha Sun Xilong Zheng Xi Chen Wei Wan Chaoke Tang Wei Xie Suyun Li Dongming Guo Tianhong Peng Guojun Zhao Liyuan Zhong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 4 |
| 13 | Application of non-invasive ventilation in China over 20 years显示文摘Over the last 20 years,the application of non-invasive ventilation (NIV) in China has progressively increased both in the hospital and extrahospital setting.The history of the NIV and its increasing spread in the clinical practice over China are one of the most important results of the cooperation between medicine and non-invasive mechanic technology. | Wang Chen Zhang Xilong | 2014 | Chinese Medical Journal2014，，24： | 3 |
| 14 | HDL impairs osteoclastogenesis and induces osteoclast apoptosis via upregulation of ABCG1 expression显示文摘 | Xinyun Huang Yuan Lv Panpan He Zongbao Wang Fang Xiong Linhao He Xilong Zheng Dawei Zhang Qi Cao Chaoke Tang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 15 | Autonomous Domain Correlation-Based Cross-domain Network View Caching Method for SDN Distributed Controller显示文摘Software-defined networks(SDN) maintain a global view of the network, thus improving the intelligence of forwarding decisions. With the expansion of the network scale, distributed controllers are used in a variety of large-scale networks in which subnetworks managed by controller instance are called autonomous domains. We analyze statistic frequency of communication across the autonomous domain. We calculate the autonomous domain correlations for controller instances using acquired statistical information. We cache network views to highly correlated controller instances. Distributed controllers are capable of considering both the average response time and overall storage. An experiment shows that our method can fully take advantage of these two performance indicators. | FU Tao HU Liang CHAI Sheng CHE Xilong | 2016 | Chinese Journal of Electronics2016，25，6： | 3 |
| 16 | Amino acids 89–96 of Salmonella flagellin: a key site for its adjuvant effect independent of the TLR5 signaling pathway显示文摘Flagellin,the main component of bacterial flagella,is a well-known pathogen-associated molecular pattern(PAMP)that can be recognized by the cell surface-localized Toll-like receptor 5(TLR5)and the cytosolic NOD-like receptor protein 4(NLRC4)inflammasome receptor NAIP5/6.1 Hosts can detect flagellated bacteria using the dual sensors,TLR5 and NAIP5/6,to recognize flagellin,and these sensors then initiate innate immune responses to protect the host from bacterial infection.Recognition by extracellular TLR5 can trigger the MyD88-dependent signaling pathway and activate nuclear factorκB,leading to the upregulation of several proinflammatory cytokines. | Xilong Kang Zhiming Pan Xinan Jiao | 2017 | Cellular & Molecular Immunology2017，14，12： | 3 |
| 17 | Spatial resolved temperature measurement based on absorption spectroscopy using a single tunable diode laser显示文摘基于为不一致的流动地的波长多路的 line-of-sight 吸收和侧面试穿,测量被报导的一个新奇方法。扫描梳激光温度和当前的调整 WMS 计划的波长被用来实现 wavelength-multiplexed-profile 试穿方法。八 H2O 的第二个泛音(2f ) 信号在 7,170 厘米附近转移特征 ? 1 用单个悦耳的二极管激光在一个时期被测量。在一个 CH4/air premixed 公寓火焰炉子之上的空间解决的温度分发被获得。结果借助于 WMS-2f TDLAS 为不一致的流动领域诊断验证策略的可行性。关键词 WMS-2f TDLAS - 侧面试穿 - 空间解决 - 温度测量工程被中国(10772188 ) 的国家自然科学基础支持。 | Xilong Yu Fei Li Lihong Chen Xinyu Zhang | 2010 | Acta Mechanica Sinica2010，26，1： | 3 |
| 18 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 19 | Oxidation of KCNB1 K^+ channels in central nervous system and beyond显示文摘KCNB1, a voltage-gated potassium(K+) channel that conducts a major delayed rectifier current in the brain, pancreas and cardiovascular system is a key player in apoptotic programs associated with oxidative stress. As a result, this protein represents a bona fide drug target for limiting the toxic effects of oxygen radicals. Until recently the consensus view was that reactive oxygen species trigger a pro-apoptotic surge in KCNB1 current via phosphorylation and SNARE-dependent incorpora-tion of KCNB1 channels into the plasma membrane. However, new evidence shows that KCNB1 can be modified by oxidants and that oxidized KCNB1 channels can directly activate pro-apoptotic signaling pathways. Hence, a more articulated picture of the pro-apoptotic role of KCNB1 is emerging in which the protein induces cell's death through distinct molecular mechanisms and activation of multiple pathways. In this review article we discuss the diverse functional, toxic and protective roles that KCNB1 channels play in the major organs where they are expressed. | Federico Sesti Xilong Wu Shuang Liu | 2014 | World Journal of Biological Chemistry2014，5，2： | 3 |
| 20 | Research on the Necessity of Building National-level Grape and Cherry Germplasm Resources Bank in Shandong Province显示文摘At present,the grape and cherry industries in Shandong are in the leading position in China and have driven the development of related high-end manufacturing industries such as wine,brandy,preserved fruit processing,fruit juice processing and health products. Therefore,vigorously developing the grape and cherry industries in Shandong Province and carrying out development and innovation are important parts of Shandong Province in responding to the strategy of national new and old kinetic energy conversion. However,currently the germplasm resources preserved in the fruit tree resources banks in China are only 45% of those in the US and 27. 2% of those in the EU. Moreover,the development of fruit trees resources banks in Shandong is relatively backward in China,and there is still no banks related with grape and cherry germplasm resources in Shandong. Therefore,importance can be attached to the agriculture,forestry,and animal husbandry to build germplasm resources banks for grape and cherry industries in Shandong Province. Building the national-level grape and cherry germplasm resources bank in Shandong Province can also promote the utilization of wild and farm germplasm resources in the future; advance the research on the genes related to disease resistance,stress resistance and quality of grapes and cherries; push forward the construction and development of cherry and grape mutants banks. It is conducive to the research on the agronomic traits of grapes and cherries,and can provide the parents resources for planting innovation and improving the quality of grapes and cherries,as well as promote the development and application of molecular markers of grapes and cherries,including the identification of lines and crossbreeding. Thereby,it cannot only promote the industry development,but also achieve the development of cultivation,breeding and basic research in an all-round way and the development of ' production,study and research' going side by side. | Pengfei WANG Fengshan REN Yongmei WANG Xinying WU Xilong JIANG Yingchun CHEN Shan WANG Qian MU Liying YANG Wanjun CHEN | 2018 | Agricultural Biotechnology2018，7，2： | 3 |
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