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| 1 | Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma显示文摘The blood–brain barrier(BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme(GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel(PTX) by improving the stability and targeting efficiency of PTX/albumin nanoparticles(NPs). Here we characterize PTX-loaded human serum albumin(HSA) NPs stabilized with intramolecular disulfide bonds and modified with substance P(SP) peptide as the targeting ligand. The fabricated SP-HSA-PTX NPs exhibited satisfactory drug-loading content(7.89%) and entrapment efficiency(85.7%) with a spherical structure(about 150 nm) and zeta potential of -12.0 mV. The in vitro drug release from SP-HSA-PTX NPs occurred in a redox-responsive manner. Due to the targeting effect of the SP peptide, cellular uptake of SP-HSA-PTX NPs into brain capillary endothelial cells(BCECs) and U87 cells was greatly improved.The low IC_(50), prolonged survival period and the obvious pro-apoptotic effect shown by TUNEL analysis all demonstrated that the fabricated SP-HSA-PTX NPs showed a satisfactory anti-tumor effect and could serve as a novel strategy for GBM treatment. | Chunhui Ruan Lisha Liu Yifei Lu Yu Zhang Xi He Xinli Chen Yujie Zhang Qinjun Chen Qin Guo Tao Sun Chen Jiang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 19 |
| 2 | Charge-reversal nanoparticles: novel targeted drug delivery carriers显示文摘Spurred by significant progress in materials chemistry and drug delivery, charge-reversal nanocarriers are being developed to deliver anticancer formulations in spatial-, temporal- and dosagecontrolled approaches. Charge-reversal nanoparticles can release their drug payload in response to specific stimuli that alter the charge on their surface. They can elude clearance from the circulation and be activated by protonation, enzymatic cleavage, or a molecular conformational change. In this review, we discuss the physiological basis for, and recent advances in the design of charge-reversal nanoparticles that are able to control drug biodistribution in response to specific stimuli, endogenous factors(changes in p H,redox gradients, or enzyme concentration) or exogenous factors(light or thermos-stimulation). | Xinli Chen Lisha Liu Chen Jiang | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 9 |
| 3 | Mechanistic studies of the transport of peimine in the Caco-2 cell model显示文摘Fritillaria thunbergii Miq. has been widely used in traditional Chinese medicine for its expectorant, antitussive, antiinflammatory and analgesic properties. Moreover, modern pharmacological studies have demonstrated that F. thunbergii Miq. has efficacy in the treatment of leukemia and cancers of the liver and cervix. Although the alkaloid, peimine, is largely responsible for these pharmacological effects, it has very low oral bioavailability. The aim of this study was to investigate the intestinal absorption of peimine in Caco-2 cell monolayers. Having demonstrated that peimine is non-toxic to Caco-2 cells at concentrations o200 μmol/L, the effect of peimine concentration, p H, temperature, efflux transport protein inhibitors and EDTA-Na_2 on peimine transport were studied. The results show that peimine transport is concentration-dependent; that at p H 6.0 and 7.4, the P_(app(AP-BL))of peimine is not significantly different but the Papp(BL-AP)) is; that both Papp(AP-BL)and P_(app(BL-AP))at 4 1C are significantly higher than their corresponding values at 37 1C; that the P-glycoprotein(P-gp) inhibitors, verapamil and cyclosporin A, increase absorption of peimine; and that EDTA-Na2 has no discernible effect. In summary,the results demonstrate that the intestinal absorption of peimine across Caco-2 cell monolayers involves active transport and that peimine is a substrate of P-gp. | Lihua Chen Xueping Lu Xinli Liang Dandan Hong Zhiyu Guan Yongmei Guan Weifeng Zhu | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 8 |
| 4 | Fate of PM2.5-bound PAHs in Xiangyang, central China during 2018 Chinese spring festival: Influence of fireworks burning and air-mass transport显示文摘Variations of levels,possible source and air mass transmission were investigated for 16 USEPA priority-controlled PAHs in PM2.5 during 2018 Chinese Spring Festival(CSF)in Xiangyang City,central China which is the North-South pollutant airmass transport channel of China.Totally 37 samples were collected.Mass concentrations of 16 PAHs for the Pre–CSF day(Pre–CSFD),during the CSF day(CSFD)and after the CSF day(Af–CSFD)are 33.78±17.68 ng/m3,22.98±6.49 ng/m3,and 8.99±4.44 ng/m3,respectively.High resolution samples showed that 16 PAHs are higher in the morning(06:00–11:00)or afternoon(11:30–16:30),than those in the evening(17:00–22:00)and at night(22:30–05:30),whereas the result is reversed during the CSFD.Fireworks burning can obviously increase the mass concentration of PAHs.Air mass trajectory indicated that Xiangyang is a sink area of pollutants for northwest and southeast,and the sources of the northeast and southwest.The air mass only can be transmitted out through northeast and southwest.It is effective for improvement of air quality in Wuhan and Hunan to control fireworks emission in Henan and local areas.Fireworks burning was an important source for PAHs during CSFD,biomass,coal combustion,and traffic emission were the main sources of PAHs for Pre–CSFD and Af–CSFD periods.The health risk on the CSFD was higher than the acceptable levels,especially during the intensive fireworks burning,the risk value far exceed 1.0×10^-4,controlling burning fireworks is required. | Tianpeng Hu Yao Mao Weijie Liu Cheng Cheng Mingming Shi Zhanle Chen Qian Tian Jiaquan Zhang Shihua Qi Xinli Xing | 2020 | Journal of Environmental Sciences2020，32，11： | 6 |
| 5 | GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy显示文摘Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. The delivery of anti-miR21 sequences has significant potential for cancer treatment. Nevertheless, since anti-miR21 sequences are extremely unstable and they need to obtain certain concentration to function, it is intensely difficult to build an effective delivery system for them.The purpose of this work is to construct a self-assembled glutathione(GSH)-responsive system with tumor accumulation capacity for effective anti-miR21 delivery and cancer therapy. A novel drug delivery nanosphere carrying millions of anti-miR21 sequences was developed through the rolling circle transcription(RCT) method. GSH-responsive cationic polymer polyethyleneimine(pOEI) was synthesized to protect the nanosphere from degradation by Dicer or other RNase in normal cells and optimize the pompon-like nanoparticle to suitable size. Dehydroascorbic acid(DHA), a targeting molecule, which is a substrate of glucose transporter 1(GLUT 1) and highly expressed on malignant tumor cells, was connected to pOEI through PEG, and then the polymer was used for contracting a RNA nanospheres into nanopompons. The anti-miR21 nanopompons showed its potential for effective cancer therapy. | Qin Guo Chao Li Wenxi Zhou Xinli Chen Yu Zhang Yifei Lu Yujie Zhang Qinjun Chen Donghui Liang Tao Sun Chen Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 6 | 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury显示文摘Previous studies have reported a neuroprotective effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls TUNEL results revealed that neural cell swelling, brain tissue necrosis and cell apoptosis occurred around the injured tissue. Moreover, the number of Bax-, Bcl-2- and caspase-3-positive cells increased at 6 hours after diffuse axonal injury, and peaked at 24 hours. However, brain injury was attenuated, the number of apoptotic cells reduced, Bax and caspase-3 expression decreased, and Bcl-2 expression increased at 6, 12, 24, 72 and 168 hours after diffuse axonal injury in normal temperature control and in 8-OH-DPAT-intervention rats. The difference was most significant at 24 hours. All indices in 8-OH-DPAT-intervention rats were better than those in the constant temperature group. These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. This effect is associated with a decrease in brain temperature. | Zhenli Mao Zhenquan Song Gang Li Wei Lv Xu Zhao Bin Li Xinli Feng Youli Chen | 2013 | Neural Regeneration Research2013，8，2： | 3 |
| 7 | A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy显示文摘 | Xinli Zhang Chen Chen | 2012 | Endocrine2012，，3： | 3 |
| 8 | Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein显示文摘Doppel (Dpl ) 由于结构、生物化学的类似是象蛋白质一样的 prion (PrP ) ;然而, Dpl 和 PrP 的自然功能仍然保持不清楚。在这研究,编码 Dpl 蛋白质的一个 531-bp 人 PRND 基因序列从人的外部血白细胞被放大。全身、各种各样的截断的人的 Dpl 和 PrP 蛋白质从 Escherichia 被表示并且净化 coli。全身的 Dpl 的补充导致了显著 cytotoxicity,和负责的区域到人的 neuroblastoma 房间 SH-SY5Y 上因为它的 cytotoxicity 在 Dpl 的中间的片断被印射[氨基酸(aa ) 81122 ] 。有趣地,导致 Dpl 的 cytotoxicity 被全身的野类型的 PrP 的存在反对。PrP 异种的碎片上的分析证明 N 终端碎裂(aa 2390 ) PrP 为保护的活动负责。有 Dpl 在 SH-SY5Y 房间上导致了象 Dpl 一样 cytotoxicity 的类似的第二等的结构的截断的 PrP (PrP32121 ) 。而且,铜离子的绑定能在导致 Dpl 的 cytotoxicity 上提高 PrP 的反对效果。Apoptosis 试金表明 Dpl 导致的 cytotoxicity 通过 apoptotic 机制发生了。这些结果建议 Dpl 的功能对 PrP 而非 synergistic 对抗。 | Ping Li Chenfang Dong Yanjun Lei Bing Shan Xinli Xiao Huiying Jiang Xin Wang Chen Gao Qi Shi Kun Xu Chan Tian Jun Han Xiaoping Dong | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 3 |
| 9 | Porous graphene paper for supercapacitor applications显示文摘Graphene paper shows a great promise for the electrical energy storage. However, the high stability, purity and specific surface area have become stringent requirements for supercapacitor applications. Finding methods to tackle these problems is rather challenging. Here, we develop a facile method to prepare porous graphene papers with a thickness 0.5 mm by a thermal shock to the layer-structure graphene paper self-assembled on Cu foil under nitrogen flowing. The as-prepared porous graphene paper exhibits a large specific capacitance of 100 F g^(-1)at the scan rate of 100 m V s^(-1)with high stability and purity without any residual chemical reagents, showing a promising potential for supercapacitor applications. The high electrochemical properties are mainly attributed to the high-specific area and the improved conductivity of the porous graphene paper performed by the multieffect of reducing, cleaving and expanding to the layer-structure graphene paper by high-energy thermal heating during the thermal shock process. This work paves a pathway to the facile preparation of porous graphene paper for supercapacitor applications. | Qi Li Xinli Guo Yao Zhang Weijie Zhang Chuang Ge Li Zhao Xiaojuan Wang Hongyi Zhang Jian Chen Zengmei Wang Litao Sun | 2017 | Journal of Materials Science & Technology2017，33，8： | 2 |
| 10 | Chromosome doubling mediates superior drought tolerance in Lycium ruthenicum via abscisic acid signaling显示文摘Plants are continuously affected by unfavorable external stimuli,which influences their productivity and growth.Differences in gene composition and expression patterns lead homologous polyploid plants to exhibit different physiological phenomena,among which enhanced environmental adaptability is a powerful phenotype conferred by polyploidization.The mechanisms underlying the differences in stress tolerance between diploids and autotetraploids at the molecular level remain unclear.In this research,a full-length transcription profile obtained via the singlemolecule real-time(SMRT)sequencing of high-quality single RNA molecules for use as background was combined with next-generation transcriptome and proteome technologies to probe the variation in the molecular mechanisms of autotetraploids.Tetraploids exhibited an increase in ABA content of 78.4%under natural conditions and a superior stress-resistance phenotype under severe drought stress compared with diploids.The substantial differences in the transcriptome profiles observed between diploids and autotetraploids under normal growth conditions were mainly related to ABA biosynthesis and signal transduction pathways,and 9-cis-epoxycarotenoid dioxygenase 1(NCED1)and NCED2,which encode key synthetic enzymes,were significantly upregulated.The increased expression of the ABREbinding factor 5-like(ABF5-like)gene was a pivotal factor in promoting the activation of the ABA signaling pathway and downstream target genes.In addition,ABA strongly induced the expression of osmotic proteins to increase the stress tolerance of the plants at the translational level.We consider the intrinsic mechanisms by which ABA affects drought resistance in tetraploids and diploids to understand the physiological and molecular mechanisms that enhance abiotic stress tolerance in polyploid plants. | Shupei Rao Yuru Tian Xinli Xia Yue Li Jinhuan Chen | 2020 | Horticulture Research2020，7，1： | 2 |
| 11 | Au nanoparticles decorated graphene/nickel foam nanocomposite for sensitive detection of hydrogen peroxide显示文摘The Au nanoparticles decorated graphene(AuNPs@Gr)/nickel foam(Gr/NiF) nanocomposite(AuNPs@Gr/NiF) was prepared by chemical vapor deposition followed by electrophoretic deposition of AuNPs on Gr/NiF. The morphology, microstructure and sensing performance of the as-prepared AuNPs@Gr/NiF nanocomposite were characterized and measured, respectively by scanning electron microscope, transmission electron microscope, ultraviolet visible spectroscopy and chemical workstation. The asprepared AuNPs@Gr/NiF nanocomposite was used as the electrode to construct a chemical sensor for the detection of hydrogen peroxide(H_2O_2). The results showed that the AuNPs distributed homogenously and stably on the surface of Gr/NiF. The chemical sensor exhibits a sensitive and selective performance to the detection of H_2O_2. | Xiaojuan Wang Xinli Guo Jian Chen Chuang Ge Hongyi Zhang Yuanyuan Liu Li Zhao Yao Zhang Zengmei Wang Litao Sun | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 12 | Advances and perspectives in catalytic oxidation of hydrocarbons in liquid phase显示文摘This review article summarizes recent advances in catalytic oxidation of hydrocarbons,especially presents two strategies for activation of C-H bonds or molecular oxygen.Based on our own research results,the applications of the two methods in the oxidation of cyclohexane,toluene and ethyl benzene,etc.are introduced,and the perspectives of the two methods are also discussed. | Zhou Lipeng Yang Guanyu Zhang Wei Sun Zhiqiang Gao Jin Miao Hong Chen Chen Ma Hong Li Xiaoqiang Zhang Qiaohong Wang Feng Tong Xinli Xu Jie | 2007 | Progress in Natural Science:Materials International2007，17，9： | 2 |
| 13 | Direct growth of graphene on vertically standing glass by a metal-free chemical vapor deposition method显示文摘A new method to directly grow graphene on quartz glass substrate by atmospheric-pressure chemical vapor deposition(CVD) without using any catalyst was developed. The prime feature of this method is to build a vertical-glass model in the quartz tube to significantly increase the collision probability of the carbon precursors and reactive fragments between each other with the glass surface. The growth rate of high-quality graphene on glass remarkably increases compared with the conventional gas flow CVD technique. The optical transmittance and sheet resistance of the graphene glass can be readily adjusted by regulating growth time. When growth time is 35 min, the graphene glass presents an intriguing sheet resistance of about 1.48 kΩ sq^(-1) at a transmittance of 93.08% and exhibits an excellent hydrophobic performance. The method is simple and scalable, and might stimulate various potential applications of transparent and conductive graphene glass in practical fields. | Zhongtao Chen Xinli Guo Long Zhu Long Li Yuanyuan Liu Li Zhao Weijie Zhang Jian Chen Yao Zhang Yuhong Zhao | 2018 | Journal of Materials Science & Technology2018，34，10： | 2 |
| 14 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 15 | Novel Tungsten- Containing Mesoporous HMS Material: Its Synthesis, Charac-terization and Catalytic Application in the Selective Oxidation of Cyclopentene to Glutaraldehyde by Aqueous H2 O2 显示文摘 | Yang Xinli Dai Weilin Chen Hui | 2005 | Appl Catal A2005，283，12： | 1 |
| 16 | Feasibility and safety of combined interventional procedures in elderly patients with complex cardiovascular diseases:experience of a single medical center显示文摘Objectives:To report the clinical experience of combined interventional procedures in the treatment of elderly patients with coexisting two or more cardiovascular diseases in our medical center, and to assess the feasibility, safety and therapeutic efficacy of this management strategy. Methods : Patients were selected to the study if: 1) age >65 years; 2) with coexistence of two or more cardiovascular diseases which are indications for interventional therapy; 3) patients' general condition and organ functions allow the performance of combined multiple procedures; 4) the predicted procedure time is within 150 min; 5) the predicted contrast medium dosage is within 300 ml. The criteria we analyzed included procedural type, rocedural time, fluoroscopy time, dosage of contrast medium, success rates of the procedures, complications and in-hospital mortality. All patients were followed up for 30.4 ± 9.3 months,to determine the all-cause mortality, recurrence rates and adverse cardiac events. Results : From January 2000 to December 2004,combined interventional procedures were performed on 136 patients, with 2 procedures on 134 patients and 3 procedures on 2 patients.The mean procedure time was 115.4±11.6 min, the mean fluoroscopy time was 35.7±9.3 min, and the mean dosage of contrast medium used was 183.6±19.4 ml. Procedural success rate was 100%, no procedure related death or major complications occurred.Conclusion: Performed by a competent team, combined interventional procedures in elderly patients with multiple cardiovascular diseases were feasible and relatively safe. | Caiyi LU Shiwen WANG Xinli WU Qiao XUE Taohong HU Muyang YAN Rui CHEN Zhongren ZHAO Haiyun WU | 2005 | Journal of Geriatric Cardiology2005，2，3： | 1 |
| 17 | Diversity of Cultivated and Uncultivated Actinobacterial Endophytes in the Stems and Roots of Rice显示文摘 | Xinli Tian Lixiang Cao Hongming Tan Weiqing Han Ming Chen Yuhuan Liu Shining Zhou | 2007 | Microbial Ecology2007，，4： | 1 |
| 18 | Global identification of genes associated with xylan biosynthesis in cotton fiber显示文摘Background:Mature cotton fiber secondary cell wall comprises largely of cellulose(>90%)and small amounts of xylan and lignin.Little is known about the cotton fiber xylan biosynthesis by far.Results:To comprehensively survey xylan biosynthetic genes in cotton fiber,we identified five IRX9,five IRX10,one IRX14,six IRX15,two FRA8,one PARVUS,eight GUX,four GXM,two RWA,two AXY9,13 TBL genes by using phylogenetic analysis coupled with expression profile analysis and co-expression analyses.In addition,we also identified two GT61 members,two GT47 members,and two DUF579 family members whose homologs in Arabidopsis were not functionally characterized.These 55 genes were regarded as the most probable genes to be involved in fiber xylan biosynthesis.Further complementation analysis indicated that one IRX10 like and two FRA8 related genes were able to partially recover the irregular xylem phenotype conferred by the xylan deficiency in their respective Arabidopsis mutant.We conclude that these genes are functional orthologs of respective genes that are implicated in GX biosynthesis.Conclusion:The list of 55 cotton genes presented here provides not only a solid basis to uncover the biosynthesis of xylan in cotton fiber,but also a genetic resource potentially useful for future studies aiming at fiber improvement via biotechnological approaches. | CHEN Feng GUO Yanjun CHEN Li GAN Xinli LIU Min LI Juan XU Wenliang | 2020 | Journal of Cotton Research2020，3，3： | 1 |
| 19 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 20 | Temporal and spatial distribution of metabotropic glutamate receptor 5 during development in the rat cortex and hippocampus显示文摘Metabotropic glutamate receptor 5 (mGluR5) is expressed by neurons in zones of active neurogenesis and is involved in the development of neural stem cells in vivo and in vitro.We examined the expression of mGluR5 in the cortex and hippocampus of rats during various prenatal and postnatal periods using immunohistochemistry.During prenatal development,mGluR5 was primarily localized to neuronal somas in the forebrain.During early postnatal periods,the receptor was mainly present on somas in the cortex.mGluR5 immunostaining was visible in apical dendrites and in the neuropil of neurons and persisted throughout postnatal development.During this period,pyramidal neurons were strongly labeled for the receptor.In the hippocampal CA1 region,mGluR5 immunoreactivity was more intense in the stratum oriens,stratum radiatum,and lacunosum moleculare at P0,P5 and P10 relative to P60.mGluR5 expression increased significantly in the molecular layer and decreased significantly in the granule cell layer of the dentate gyrus at P5,P10 and P60 in comparison with P0.Furthermore,some mGluR5-positive cells were also bromodeoxyuridine-or NeuroD-positive in the dentate gyrus at P14.These results demonstrate that mGluR5 has a differential expression pattern in the cortex and hippocampus during early growth,suggesting a role for this receptor in the control of domain specific brain developmental events. | Xinli Xiao Ming Hu Pengbo Yang Lin Zhang Xinlin Chen Yong Liu | 2011 | Neural Regeneration Research2011，6，17： | 1 |
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