|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 2 | Effects of antimicrobial and antioxidant activities of spice extracts on raw chicken meat quality显示文摘The antimicrobial and antioxidant effects of two spice extracts and their combination on raw chicken meat during storage for 15 days at 4◦C were studied.Raw chicken meat was treated with BHT(positive control),rosemary(RO),cloves(CL),and their combination,and the results were compared to those obtained for raw chicken meat without any additive(negative control).The antioxidant and antimicrobial activities of spice extracts were determined.The total phenolic and total flavonoid contents of rosemary was lower than those of cloves.Cloves exhibited a higher DPPH radical scavenging activity than that of rosemary.However,the ferrous ion-chelating effect of rosemary was significantly higher than that of cloves.The pH,instrumental colour(CIE L*,a*,b*),total viable counts(TVC),lactic acid bacteria(LAB)counts,Enterobacteriaceae counts,Pseudomonas spp.counts and 2-thiobarbituric acid reactive substances(TBARS)were determined at 3-day intervals over a period of 15 days.The bacterial counts of T-RO-CL samples were lower than those of control samples during storage.T-RO-CL samples maintained significantly(P<0.05)higher L*,a*and b*values during storage.The TBARS values of T-RO-CL samples were the lowest among the samples.These results demonstrate that spice extracts are highly effective against microbial growth and lipid oxidation and show potential as a natural antioxidant in raw chicken meats. | Huiyun Zhang Jingjuan Wu Xinyu Guo | 2016 | Food Science and Human Wellness2016，5，1： | 17 |
| 3 | A study on key technologies of unmanned driving显示文摘 | Xinyu Zhang Hongbo Gao Mu Guo Guopeng Li Yuchao Liu Deyi Li | 2016 | CAAI Transactions on Intelligence Technology2016，1，1： | 14 |
| 4 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 5 | MVS-Pheno:A Portable and Low-Cost Phenotyping Platform for Maize Shoots Using Multiview Stereo 3D Reconstruction显示文摘Plant phenotyping technologies play important roles in plant research and agriculture.Detailed phenotypes of individual plants can guide the optimization of shoot architecture for plant breeding and are useful to analyze the morphological differences in response to environments for crop cultivation.Accordingly,high-throughput phenotyping technologies for individual plants grown in field conditions are urgently needed,and MVS-Pheno,a portable and low-cost phenotyping platform for individual plants,was developed.The platform is composed of four major components:a semiautomatic multiview stereo(MVS)image acquisition device,a data acquisition console,data processing and phenotype extraction software for maize shoots,and a data management system.The platform’s device is detachable and adjustable according to the size of the target shoot.Image sequences for each maize shoot can be captured within 60-120 seconds,yielding 3D point clouds of shoots are reconstructed using MVS-based commercial software,and the phenotypic traits at the organ and individual plant levels are then extracted by the software.The correlation coefficient(R^(2))between the extracted and manually measured plant height,leaf width,and leaf area values are 0.99,0.87,and 0.93,respectively.A data management system has also been developed to store and manage the acquired raw data,reconstructed point clouds,agronomic information,and resulting phenotypic traits.The platform offers an optional solution for high-throughput phenotyping of field-grown plants,which is especially useful for large populations or experiments across many different ecological regions. | Sheng Wu Weiliang Wen Yongjian Wang Jiangchuan Fan Chuanyu Wang Wenbo Gou Xinyu Guo | 2020 | Plant Phenomics2020，2，1： | 11 |
| 6 | Application of a PCA-DBN-based surrogate model to robust aerodynamic design optimization显示文摘An efficient method employing a Principal Component Analysis(PCA)-Deep Belief Network(DBN)-based surrogate model is developed for robust aerodynamic design optimization in this study.In order to reduce the number of design variables for aerodynamic optimizations,the PCA technique is implemented to the geometric parameters obtained by parameterization method.For the purpose of predicting aerodynamic parameters,the DBN model is established with the reduced design variables as input and the aerodynamic parameters as output,and it is trained using the k-step contrastive divergence algorithm.The established PCA-DBN-based surrogate model is validated through predicting lift-to-drag ratios of a set of airfoils,and the results indicate that the PCA-DBN-based surrogate model is reliable and obtains more accurate predictions than three other surrogate models.Then the efficient optimization method is established by embedding the PCA-DBN-based surrogate model into an improved Particle Swarm Optimization(PSO)framework,and applied to the robust aerodynamic design optimizations of Natural Laminar Flow(NLF)airfoil and transonic wing.The optimization results indicate that the PCA-DBN-based surrogate model works very well as a prediction model in the robust optimization processes of both NLF airfoil and transonic wing.By employing the PCA-DBN-based surrogate model,the developed efficient method improves the optimization efficiency obviously. | Jun TAO Gang SUN Liqiang GUO Xinyu WANG | 2020 | Chinese Journal of Aeronautics2020，33，6： | 10 |
| 7 | High-throughput phenotyping: Breaking through the bottleneck in future crop breeding显示文摘With the rapid development of genetic analysis techniques and crop population size,phenotyping has become the bottleneck restricting crop breeding.Breaking through this bottleneck will require phenomics,defined as the accurate,high-throughput acquisition and analysis of multi-dimensional phenotypes during crop growth at organism-wide levels,ranging from cells to organs,individual plants,plots,and fields.Here we offer an overview of crop phenomics research from technological and platform viewpoints at various scales,including microscopic,ground-based,and aerial phenotyping and phenotypic data analysis.We describe recent applications of high-throughput phenotyping platforms for abiotic/biotic stress and yield assessment.Finally,we discuss current challenges and offer perspectives on future phenomics research. | Peng Song Jinglu Wang Xinyu Guo Wanneng Yang Chunjiang Zhao | 2021 | The Crop Journal2021，9，3： | 10 |
| 8 | Overexpression of micro RNA_(40)8 enhances photosynthesis, growth, and seed yield in diverse plants显示文摘The ability of a plant to produce grain, fruit, or forage depends ultimately on photosynthesis. There have been few attempts, however, to study micro RNAs, which are a class of endogenous small RNAs post-transcriptionally programming gene expression, in relation to photosynthetic traits. We focused on miR_(40)8, one of the most conserved plant miRNAs, and overexpressed it in parallel in Arabidopsis, tobacco, and rice. The transgenic plants all exhibited increased copper content in the chloroplast, elevated abundance of plastocyanin,and an induction of photosynthetic genes. By means of gas exchange and optical spectroscopy analyses, we showed that higher expression of miR_(40)8 leads to enhanced photosynthesis through improving efficiency of irradiation utilization and the capacity for carbon dioxide fixation. Consequently, miR_(40)8 hyper-accumulating plants exhibited higher rate of vegetative growth. An enlargement of seed size was also observed in all three species overproducing miR_(40)8. Moreover, we conducted a 2-year-two-location field trial and observed miR_(40)8 overexpression in rice significantly increased yield, which was primarily attributed to an elevation in grain weight. Taken together, these results demonstrate that miR_(40)8 is a positive regulator of photosynthesis and that its genetic engineering is a promising route for enhancing photosynthetic performance and yield in diverse plants. | Jiawei Pan Dahui Huang Zhonglong Guo Zheng Kuang He Zhang Xinyu Xie Zengfeng Ma Shaopei Gao Manuel T.Lerdau Chengcai Chu Lei Li | 2018 | Journal of Integrative Plant Biology2018，60，4： | 8 |
| 9 | Research on microstructure in as-cast 7A55 aluminum alloy and its evolution during homogenization显示文摘The microstructure of the as-cast 7A55 aluminum alloy and its evolution during homogenization were investigated by means of optical microscopy (OM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and differential scanning calorimetry (DSC) analysis. The results indicate that the microstructure of the as-cast 7A55 aluminum alloy mainly consists of the dendritic network of aluminum solid solution, Al/AlZnMgCu eutectic phases, and intermetallic compounds MgZn2, Al2CuMg, Al7Cu2Fe, and Al23CuFe4. After homogenization at 470°C for 48 h, Al/AlZnMgCu eutectic phases are dissolved into the matrix, and a small amount of high melting-point secondary phases were formed, which results in an increasing of the starting melting temperature of 7A55 aluminum alloy. The high melting-point secondary phases were eliminated mostly when the homogenization time achieved to 72 h. Therefore, the reasonable homogenization heat treatment process for 7A55 aluminum alloy ingots was chosen as 470°C/72 h. | LV Xinyu GUO Erjun LI Zhihui WANG Guojun | 2011 | Rare Metals2011，30，6： | 8 |
| 10 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 11 | Scalable microfabrication of three-dimensional porous interconnected graphene scaffolds with carbon spheres for high-performance all carbon-based micro-supercapacitors显示文摘As one of the most important micro energy storage devices(MESDs),graphene-based micro-supercapacitors(G-MSCs)possess the advantages of excellent flexibility,long cycle life,affordability and high reliability.In most cases,constructing three-dimensional(3D)graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials.In this work,conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes,and further by regulating the composition of inks,carbon spheres(CSs)at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes.The fabricated all carbon-based MSC with the optimal mass loading of CSs(0.406 mg cm^(-2))exhibits a high specific areal capacitance of 17.01mF cm^(-2)at the scan rate of 10mV s^(-1)and a capacitance retention of 93.14%after 10000 cycles at the scan rate of 500 mV s^(-1).The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. | Yiming Chen Minghao Guo Liang He Wei Yang Lin Xu Jiashen Meng Xiaocong Tian Xinyu Ma Qiang Yu Kaichun Yang Xufeng Hong Liqiang Mai | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 12 | A brief introduction to the FUTang Updating medical REcords(FUTURE)database显示文摘Introduction Futang Research Center of Pediatric Development(FRCPD),the first nonprofit social service organization engaging in pediatric research in China,was founded in May 2013.Until August 2021,FRCPD has 40 tertiary children’s hospitals,accounting for about 65.6%of all national public children’s hospitals,which was reported to be 61 in China Health Statistical Yearbook(2020).The hospitals are distributed in 30 provinces,autonomous regions,and municipalities(except for Tibet autonomous region),and most of them are in the capital of the province,forming a broad frontline representing the best quality of health care for the diagnosis and treatment of children’s disease in China.Based on the idea of sharing,FRCPD realized the exchange of experts,medical resources,research findings,educational events,preventive strategies,and management experiences among members.In the long run,FRCPD aims to continuously promote the quality of healthcare and medical service capability for children in China. | Xinyu Wang Yueping Zeng Jian Tian Hui Xu Fei Song Yongli Guo Xin Xu Guoshuang Feng Xin Ni | 2021 | Pediatric Investigation2021，5，3： | 6 |
| 13 | Modulating the threshold voltage of oxide nanowire field-effect transistors by a Ga^+ ion beam显示文摘在这份报纸,我们报导一个方法改变 SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>由 Ga 的 3 只 nanowire 晶体管<啜class=“ a-plus-plus ”>+离子照耀。不同于在更早的报告的结果, SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>在在 Ga 以后的否定的门电压方向的 3 nanowire 地效果晶体管(联邦货物税)移动<啜class=“ a-plus-plus “>+离子照耀。更小的阀值电压,由 Ga 完成了 < 啜 class= “ a-plus-plus ” >+ 离子照耀,为高效、低电压的操作被要求。阀值电压移动能被归因于 Ga 引起的表面缺点的降级 < 啜 class= “ a-plus-plus ” >+ 离子照耀。在照耀以后,当前的开/关比率稍微衰退,但是离 10 仍然靠近 < 啜 class= “ a-plus-plus ” > 6 。结果显示那 Ga < 啜 class= “ a-plus-plus ” >+ 离子横梁照耀在改进氧化物 nanowire 联邦货物税的表演起一个重要作用。 | Wenqing Li Lei Liao Xiangheng Xiao Xinyue Zhao Zhigao Dai Shishang Guo Wei Wu Ying Shi Jinxia Xu Feng Ren Changzhong Jiang | 2014 | Nano Research2014，7，11： | 5 |
| 14 | PRODUCTS RANKING THROUGH ASPECT-BASED SENTIMENT ANALYSIS OF ONLINE HETEROGENEOUS REVIEWS显示文摘 | Chonghui Guo Zhonglian Du Xinyue Kou | 2018 | Journal of Systems Science and Systems Engineering2018，27，5： | 5 |
| 15 | Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation显示文摘Pancreatic ductal adenocarcinoma(PDAC)has poor prognosis due to limited therapeutic options.This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets.We have identified HNF4G gene whose silencing most effectively repressed PDAC cell invasiveness.HNF4G overexpression is induced by the deficiency of transcriptional factor and tumor suppressor SMAD4.Increased HNF4G are correlated with SMAD4 deficiency in PDAC tumor samples and associated with metastasis and poor survival time in xenograft animal model and in patients with PDAC(log-rank P=0.036;HR=1.60,95%CI=1.03–2.47).We have found that Metformin suppresses HNF4G activity via AMPK-mediated phosphorylation-coupled ubiquitination degradation and inhibits in vitro invasion and in vivo metastasis of PDAC cells with SMAD4 deficiency.Furthermore,Metformin treatment significantly improve clinical outcomes and survival in patients with SMAD4-deficient PDAC(log-rank P=0.022;HR=0.31,95%CI=0.14–0.68)but not in patients with SMAD4-normal PDAC.Pathway analysis shows that HNF4G may act in PDAC through the cell-cell junction pathway.These results indicate that SMAD4 deficiency-induced overexpression of HNF4G plays a critical oncogenic role in PDAC progression and metastasis but may form a druggable target for Metformin treatment. | Chengcheng Wang Taiping Zhang Quan Liao Menghua Dai Junchao Guo Xinyu Yang Wen Tan Dongxin Lin Chen Wu Yupei Zhao | 2021 | Protein & Cell2021，12，2： | 5 |
| 16 | 2019年度大气科学领域项目评审与研究成果分析显示文摘2018年6月,第八届国家自然科学基金委员会(以下简称自然科学基金委)第一次全体委员会议审议通过了新时代基金深化改革的总体目标和改革思路,通过确立基于“鼓励探索、突出原创;聚焦前沿、独辟蹊径;需求牵引、突破瓶颈;共性导向、交叉融通”4类科学问题属性分类的资助导向。“大气科学”学科被列为而上项冃分类评审试点改革学科。因此,大气学科处2019年的分类评审工作主要以“落实资助导向、推动精准资助”为总体思路,以鼓励和支持原创性、交叉性的科学研究,扶持薄弱学科.促进各学科均衡、协调和可持续发展为原则.开展相关工作。 | 李积明 刘哲 郭郁葱 彭怡然 闻新宇 Li Jiming Liu Zhe Guo Yucong Peng Yiran Wen Xinyu | 2019 | 地球科学进展2019，34，11： | 5 |
| 17 | Heat transfer and fluid flow and their effects on the solidification microstructure in full-penetration laser welding of aluminum sheet显示文摘Understanding the behaviors of heat transfer and fluid flow in weld pool and their effects on the solidification microstructure are significant for performance improvement of laser welds.This paper develops a three-dimensional numerical model to understand the multi-physical processes such as heat transfer,melt convection and solidification behavior in full-penetration laser welding of thin 5083 aluminum sheet.Solidification parameters including temperature gradient G and solidification rate R,and their combined forms are evaluated to interpret solidification microstructure.The predicted weld dimensions and the microstructure morphology and scale agree well with experiments.Results indicate that heat conduction is the dominant mechanism of heat transfer in weld pool,and melt convection plays a critical role in microstructure scale.The mushy zone shape/size and solidification parameters can be modulated by changing process parameters.Dendritic structures form because of the low G/R value.The scale of dendritic structures can be reduced by increasing GR via decreasing heat input.The columnar to equiaxed transition is predicted quantitatively via the process related G^3/R.These findings illustrate how heat transfer and fluid flow affect the solidification parameters and hence the microstructure,and show how to improve microstructure by optimizing the process. | Shaoning Geng Ping Jiang Xinyu Shao Lingyu Guo Xuesong Gao | 2020 | Journal of Materials Science & Technology2020，42，11： | 5 |
| 18 | Fatigue crack propagation behavior of Ni-based superalloys after overloading at elevated temperatures显示文摘The fatigue crack propagation behavior of three superalloys subjected to a single overloading at elevated temperatures was investigated. The fatigue crack propagation rate FCPR versus stress intensity factor range data da/dN—ΔK were calculated using the two-point secant method. It was found that the crack growth rates of the investigated materials were retarded after overloading with an overload ratio R OL=1.6. The size of the plastic zone in the front of the crack tip and its relation to loading level were discussed. The overload retardation effects are attributed to crack closure. The fatigue damage in the plastic zone can also be a factor to explain the overload retardation. | Xinyue Huang Liang Wang Yunming Hu Guangping Guo David Salmon Ying Li Wenxia Zhao | 2016 | Progress in Natural Science:Materials International2016，26，2： | 4 |
| 19 | Physicochemical properties,antimicrobial activity and oil release of fish gelatin films incorporated with cinnamon essential oil显示文摘Fish skin gelatin films incorporated with various concentrations of cinnamon essential oil(CEO)were prepared and characterized.The results showed that tensile strength(TS),elongation at break(EAB),and water content(WC)of the gelatin based film decreased with the increasing concentrations of CEO,but water vapor permeability(WVP)increased.Addition of CEO improved light barrier property of the film.The Scanning electron microscope(SEM)showed that the heterogeneous surface and porous formation appeared in gelatin-CEO films.Fourier transform infrared spectroscopy analyses(FTIR-ATR)spectra indicated the interactions existed between gelatin and CEO.The gelatin-CEO films exhibited good inhibitory effects against the tested microorganisms(Escherichia coli,Staphylococcus aureus,Aspergillus niger,Rhizopus oryzae,and Paecilomyces varioti)and their antifungal activity seemed to be more effective than the resistance to bacterial growth.In vitro release studies showed an initial burst effect of CEO release and that subsequently slowed down at 40℃,but the initial burst release was not obvious at 4℃.The obtained results suggested that incorporation of CEO as a natural antimicrobial agent into gelatin film has potential for developing as active food packaging. | Jiulin Wu Xinyu Sun Xiaoban Guo Shangying Ge Qiqing Zhang | 2017 | Aquaculture and Fisheries2017，2，4： | 4 |
| 20 | Short fixation with a 3‐rod technique for posterior hemivertebra resection in children younger than 5 years old显示文摘Importance Congenital hemivertebra is commonly treated with posterior hemivertebra resection with bilateral transpedicular fixation.However,implant‐related complications are common in children younger than 5 years old who undergo this surgical procedure.Objective To present the preliminary clinical and radiological outcomes of children younger than 5 years old treated by posterior hemivertebra resection and 3‐rod fixation technique.Methods From January 2016 to December 2017,14 consecutive patients of congenital scoliosis with 16 hemivertebrae were retrospectively reviewed,including 5 girls and 9 boys,aged between 25 and 55 months old(average,37.6 months).All patients underwent posterior hemivertebra resection with short fixation with bilateral pedicle screws and a convex lamina hook.Surgical complications and corrective outcomes were assessed based on the clinical charts and spinal radiographs with a minimum 24‐month follow‐up.Results The mean Cobb angle of the main curve was 38.4°before surgery,8.5°after surgery,and 8.7°at final follow‐up.In the compensatory cranial curve,the preoperative Cobb angle of 16.8°was corrected to 8.1°postoperatively and was 10.3°at final follow‐up.In the compensatory caudal curve,the preoperative Cobb angle of 15.9°improved to 5.3°postoperatively and was 7.8°at final follow‐up.The segmental kyphosis was corrected from 13.5°to 0.5°and was 1.1°at final follow‐up.There were no crankshaft phenomena,no proximal kyphosis,and no complications related to the instrumentation.Interpretation Posterior hemivertebra resection with instrumentation with bilateral pedicle screws and a convex lamina hook can achieve rigid fixation and deformity correction. | Dong Guo Ziming Yao Xinyu Qi Chengxin Li Xuejun Zhang | 2020 | Pediatric Investigation2020，4，2： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员