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| 1 | Community Structure and Seasonal Variation of Soil Arthropods in the Forest-Steppe Ecotone of the Mountainous Region in Northern Hebei,China显示文摘Soil fauna have been receiving more and more attention because they play an important role in nutrient cycling.However,there is a lack of information on soil arthropods in the forest-steppe ecotone in the mountainous region of northern Hebei,which makes it difficult to meet the need of protecting biodiversity in this area.Soil arthropod communities were investigated in the forest-steppe ecotone in northern Hebei province to provide basic information on changes in mountain soil fertility,which could promote the development of soil arthropod communities in mountain ecotones.From the preliminary identification,a total of 7994 individual soil arthropods were collected,which belonged to 25 groups,6 classes and 24 orders.Acarina,Hymenoptera and Collembola were the dominant groups in the ecotone.The number of Acarina was higher than Collembola,and this phenomenon was obviously different from other areas in the same climate zone.The increased abundance of rare groups in the Forest zone with the richer vegetation,higher arthropod abundance and more substantial litter depth,could be interpreted as a reaction to the suitable soil environment and food supply.And these rare groups were sensitive to environmental changes,which could be regarded as biotic indicators for evaluating soil quality.The analysis of community diversity showed that the abundance index (d),the Shannon-Wiener index (H'),the evenness index (J) and the density-group index (DG) were significantly higher in the forest zone,lower in the forest-steppe zone,and lowest in the meadow-steppe zone.Seasonal variations in community composition correlated with changes in average air temperature and precipitation in this ecotone.Groups and individuals of soil arthropod communities in the three zones were present in greater numbers in the middle of the rainy season than in the early or late periods of the rainy season as a whole.At the same time,seasonal changes in soil arthropod communities from different plots were also influenced by habitat condition. | ZHU Xinyu GAO Baojia YUAN Shengliang HU Yunchuan | 2010 | Journal of Mountain Science2010，7，2： | 17 |
| 2 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 3 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 4 | MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors显示文摘胃肠的 stromal 肿瘤(大意) 是胃肠的道的最普通的间充质的肿瘤之一。尽管 imatinib 改进结果,药抵抗为扩大耐心的幸存仍然是主要问题。药目标的基因变化是为 imatinib 抵抗的已知的机制。然而,它不能 imatinib 抵抗的现象解释所有,并且众多的另外的机制被建议了在各种各样的模型系统说明 imatinib 抵抗。在这研究,我们使用了屏蔽差别的基于反应的数组途径表示了的 SYBR 绿的量的聚合酶链在主要大意病人和 imatinib 抵抗的病人之间的 miRNAs。选择候选人 miRNAs 在 12 个大意病人的一个队被验证。我们发现 miR-320a 的那低表情与 imatinib 抵抗的短时间被相关,并且为 imatinib 抵抗建议了 miR-320a 的潜在的机制。 | Xiaodong Gao Kuntang Shen Cuizhong Wang Jiaqian Ling Hongshan Wang Yong Fang Yuan Shi Yingyong Hou Jin Qin Yihong Sun Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 9 |
| 5 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 6 | Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring显示文摘科学、商业的进展将高要求放为便携电子学。然而,便携电子学的电源供应, breathability,和大量生产仍然有需要被克服的许多挑战。在这研究,一个自我动力的基于 nanofiber 的摩擦电传感器(SNTS ) 被批规模制造技术用 electrospinning 制作并且为经由呼吸监视监视的健康打印屏幕。典型地,一个拱门结构的 SNTS 被 nanofiber 膜和一个 Ag nanoparticle 电极装配。nanofibers 的堆积和 Ag nanoparticles 的传导性的网络越过整个设备保证一条煤气的隧道。当时, SNTS 的煤气的渗透象 6.16 mm/s 一样高,它有压到优势的优点与由密封演员组电影组成的通常使用的便携设备相比。由于 nanofiber 膜的柔软,不管它是否被弄弯,扭曲,或合拢, SNTS 显示出优秀电子输出性能。优异性质 SNTS 的皮友好,自我力量,和批制造例如 breathability,在保健监视和多功能的聪明的系统为他们的申请提供巨大的潜力。 | Ran Cao diaona Wang Shuyu Zhao Wei Yang Zuqing Yuan Yingying Yin Xinyu Du Nian-Wu Li Xiuling Zhang Xiuyan Li Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，7： | 8 |
| 7 | Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases显示文摘Objective: The safety of the simultaneous resection of synchronous colorectal cancer liver metastases(SCRLM) is still being debated.However, this simultaneous operative approach is more commonly adopted at present than in the past.Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study.Methods: All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study.Short-term and long-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy.Results: Among the 73 patients diagnosed with SCRLM, simultaneous colorectal and hepatic resection was performed in 60 patients(82.2%), while delayed hepatic resection was performed in 13 patients(17.8%).The mortality rate was zero.The postoperative complication rate after delayed resection was higher than, but not significantly different from, that after simultaneous resection(46% vs.23%, P=0.166).The duration of operating time(240 vs.420 min, P<0.05) and postoperative hospital stay time(11 vs.18 days, P<0.05) were shorter in the simultaneous resection group.After the initial treatments were given, the 1-, 2-, and 3-year survival rates in the simultaneous resection group were 77%, 59%, and 53%, respectively, whereas those in the delayed resection group were 67%, 42%, and 10%, respectively.The 5-year survival rate in the simultaneous resection group was 23%; overall survival differed significantly between the two groups(P=0.037).Median disease-free survival(DFS) times were 19.1 months in the simultaneous resection group and 8.8 months in the delayed resection group.DFS differed significantly between the two groups.Conclusions: Simultaneous colorectal and hepatic resection is safe and exhibits advantages in the longtime survival of patients. | Yuan Li Xinyu Bi Jianjun Zhao Zhen Huang Jianguo Zhou Zhiyu Li Yefan Zhang Hong Zhao Jianqiang Cai | 2016 | Chinese Journal of Cancer Research2016，28，5： | 7 |
| 8 | Information retrieval methods for high resolution γ-ray spectra显示文摘A program based on MATLAB 7.0 platform was developed to locate characteristic peak position and calculate net area of characteristic peak.The formula for the calculation of relative standard deviation of net peak area by Sterlinski’s method was found excellent in searching single peaks and resolving overlapping peaks in high resolution gamma-ray spectrum.Gaussian function fitting method using Levenberg-Marquardt algorithm was applied to calculate net area of peaks.A standard test spectrum supplied by the IAEA in 1995 was analyzed by the program and another two widely used commercial software.The analysis results show the program was superior to the latter two in searching single peaks and resolving overlapping peaks.The optimized fitting indexes are found between 0.962 and 0.996,which shows that the program adopted is feasible and accurate for extracting the net peak area in high resolution gamma-ray spectra. | WU Hexi ZHANG Huaiqiang LIU Qingcheng YANG Bo WEI Qianglin YUAN Xinyu | 2012 | Nuclear Science and Techniques2012，23，6： | 6 |
| 9 | WFRFT modulation recognition based on HOC and optimal order searching algorithm显示文摘A hybrid carrier(HC) scheme based on weighted-type fractional Fourier transform(WFRFT) has been proposed recently.While most of the works focus on HC scheme's inherent characteristics, little attention is paid to the WFRFT modulation recognition.In this paper, a new theory is provided to recognize the WFRFT modulation based on higher order cumulants(HOC). First, it is deduced that the optimal WFRFT received order can be obtained through the minimization of 4 th-order cumulants, C_(42). Then, a combinatorial searching algorithm is designed to minimize C_(42).Finally, simulation results show that the designed scheme has a high recognition rate and the combinatorial searching algorithm is effective and reliable. | LIANG Yuan DA Xinyu WU Jialiang XU Ruiyang ZHANG Zhe LIU Hujun | 2018 | Journal of Systems Engineering and Electronics2018，29，3： | 6 |
| 10 | Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty显示文摘Keratoplasty is the gold standard treatment for visual impairment caused by corneal damage.The use of suturing as the bonding method is the source of many complications following keratoplasty.Currently available corneal adhesives do not have both adequate adhesive strength and acceptable biocompatibility.Herein,we developed a photocurable bioadhesive hydrogel which was composed of gelatin methacryloyl and oxidized dextran for sutureless keratoplasty.The bioadhesive hydrogel exhibited high light transmittance,resistance to enzymatic degradation and excellent biocompatibility.It also had higher adhesive strength than commercial adhesives(fibrin glue).In a rabbit model of lamellar keratoplasty,donor corneal grafts could be closely bonded to the recipient corneal bed and remained attached for 56 days by using of this in situ photopolymerized bioadhesive hydrogel.The operated cornea maintained transparent and noninflamed.Sutureless keratoplasty using bioadhesive hydrogel allowed rapid graft re-epithelialization,typically within 7 days.In vivo confocal microscopic and histological evaluation of the operated cornea did not show any apparent abnormalities in terms of corneal cells and ultrastructure.Thus,this bioadhesive hydrogel is exhibited to be an appealing alternative to sutures for keratoplasty and other corneal surgeries. | Xuan Zhao Saiqun Li Xinyue Du Weihua Li Qian Wang Dalian He Jin Yuan | 2022 | Bioactive Materials2022，7，2： | 4 |
| 11 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 12 | Evaluation of COC183B2 antibody targeting ovarian cancer by near-infrared fluorescence imaging显示文摘Objective: To evaluate the imaging potential of a novel near-infrared(NIR) probe conjugated to COC183 B2 monoclonal antibodies(MAb) in ovarian cancer(OC).Methods: The expression of OC183 B2 antigen in OC was determined by immunohistochemical(IHC) staining using tissue microarrays with the H-score system and immunofluorescence(IF) staining of tumor cell lines.Imaging probes with the NIR fluorescent dye cyanine 7(Cy7) conjugated to COC183 B2 Mab were chemically engineered. OC183 B2-positive human OC cells(SKOV3-Luc) were injected subcutaneously into BALB/c nude mice. Bioluminescent imaging(BLI) was performed to detect tumor location and growth. COC183 B2-Cy7 at 1.1,3.3, 10, or 30 μg were used for in vivo fluorescence imaging, and phosphate-buffered saline(PBS), free Cy7 dye and mouse isotype immunoglobulin G(IgG)-Cy7(delivered at the same doses as COC183 B2-Cy7) were used as controls.Results: The expression of OC183 B2 with a high H-score was more prevalent in OC tissue than fallopian tube(FT) tissue. Among 417 OC patients, the expression of OC183 B2 was significantly correlated with the histological subtype, histological grade, residual tumor size, relapse state and survival status. IF staining demonstrated that COC183 B2 specifically expressed in SKOV3 cells but not HeLa cells. In vivo NIR fluorescence imaging indicated that COC183 B2-Cy7 was mainly distributed in the xenograft and liver with optimal tumor-to-background(T/B)ratios in the xenograft at 30 μg dose. The highest fluorescent signals in the tumor were observed at 96 h postinjection(hpi). Ex vivo fluorescence imaging revealed the fluorescent signals mainly from the tumor and liver. IHC analysis confirmed that xenografts were OC183 B2 positive.Conclusions: COC183 B2 is a good candidate for NIR fluorescence imaging and imaging-guided surgery in OC. | Chen Zhang Xinyu Ling Yanxiu Guo Cunzhong Yuan Hongyan Cheng Xue Ye Ruiqiong Ma Yinli Zhang Yi Li Xiaohong Chang Beihua Kong Tao Liu Heng Cui | 2019 | Chinese Journal of Cancer Research2019，31，4： | 4 |
| 13 | An Association Study on the Cognitive Function and the Cerebral Grey Matter Volume of Patients with First-Episode Schizophrenia显示文摘 | Xinyue ZHANG Jingjing YAO Yiding LV Xiaoxin ZHAO Yuan LI Yuxiu SUI Zhiping DAI | 2018 | 上海精神医学2018，30，3： | 4 |
| 14 | Comparison of yield performance between direct-seeded and transplanted double-season rice using ultrashort-duration varieties in central China显示文摘Labor scarcity requires double-season rice to be planted by direct seeding as an alternative to transplanting. Only ultrashort-duration varieties can be used in direct-seeded, double-season rice(DSD) in central China where thermal time is limited. Whether ultrashort-duration varieties grown in DSD can be as productive and efficient in nitrogen(N) use as transplanted double-season rice(TPD) remains unclear. Field experiments were conducted in Hubei province, central China with two establishment methods(DSD,TPD) and three N rates in the early and late seasons of 2017 and 2018. Nitrogen treatments included zero-N control(N0), total N rate of 60 kg N ha;with equal splits at basal, midtillering, and panicle initiation(N1), and weekly N application at 15 kg ha;from seeding/transplanting to heading(N2). Both early-and late-season rice under DSD matured within 95 days, on average 9 days shorter than rice under TPD. The grain yield of DSD was comparable to or higher than that of TDP in both seasons, although the daily yield was significantly higher under DSD than under TDP. Before heading, DSD had higher leaf area,stem number, intercepted radiation, and radiation use efficiency than TPD, which compensated for the negative effect of short growth duration on biomass production. Total dry weight and harvest index under DSD were comparable to or higher than those under TDP. In general, the recovery efficiency of fertilizer-N under DSD was higher than that under TPD, but the reverse was true for physiological N use efficiency. Thus, there was no significant difference in agronomic N use efficiency between DSD and TPD. These results suggested that DSD with ultrashort-duration varieties is a promising alternative to TPD in central China for maintaining high grain yield and N fertilizer use efficiency with less labor input. | Le Xu Shen Yuan Xinyu Wang Zhifeng Chen Xiaoxiao Li Jing Cao Fei Wang Jianliang Huang Shaobing Peng | 2022 | The Crop Journal2022，10，2： | 4 |
| 15 | H19 promotes pancreatic cancer metastasis by derepressing let-7’s suppression on its target HMGA2-mediated EMT显示文摘 | Chenchao Ma Kate Nong Hongda Zhu Weiwei Wang Xinyu Huang Zhou Yuan Kaixing Ai | 2014 | Tumor Biology2014，，9： | 3 |
| 16 | MXene-composited highly stretchable,sensitive and durable hydrogel for flexible strain sensors显示文摘The flourishing development in flexible electronics has provoked intensive research in flexible strain sensors to realize accurate perception acquisition under different external stimuli.However,building hydrogel-based strain sensors with high stretchability and sensitivity remains a great challenge.Herein,MXene nanosheets were composited into polyacrylamide-sodium alginate matrix to construct mechanical robust and sensitive double networked hydrogel strain sensor.The hydrophilic MXene nanosheets formed strong interactions with the polymer matrix and endowed the hydrogel with excellent tensile properties(3150%),compliant mechanical strength(2.03 kPa^(-1)in Young’s Module)and long-lasting stability and fatigue resistance(1000 dynamic cycles under 1,600%strain).Due to the highly oriented MXene-based three dimensional conductive networks,the hydrogel sensor achieved extremely high tensile sensitivity(18.15 in gauge factor)and compression sensitivity(0.38 kPa^(-1)below 3 kPa).MXene hydrogel-based strain sensors also displayed negligible hysteresis in electromechanical performance,typical frequent-independent feature and rapid response time to external stimuli.Moreover,the sensor exhibited accurate response to different scales of human movements,providing potential application in speech recognition,expression recognition and handwriting verification. | Wei Yuan Xinyu Qu Yao Lu Wen Zhao Yanfang Ren Qian Wang Wenjun Wang Xiaochen Dong | 2021 | Chinese Chemical Letters2021，32，6： | 3 |
| 17 | Possibility of women treated with fertility-sparing surgery fornon-epithelial ovarian tumors to safely and successfully becomepregnant--a Chinese retrospective cohort study among 148cases显示文摘This study was performed to evaluate the oncological and reproductive outcomes of childbearing-agewomen treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred andforty eight non-epithelial ovarian tumor women treated with FSS between January I, 2000 and August 31, 2015from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overallsurvival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023),whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associatedwith PFS and OS (P 〈 0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), nonedeveloped amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestationsincluding 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis afterFSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followedby ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase thePFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility. | Bin Yang Yan Yu Jing Chen Yan Zhang Ye Yin Nan Yu Ge Chen Shifei Zhu Haiyan Huang Yongqun Yuan Jihui Ai Xinyu Wang Kezhen Li | 2018 | Frontiers of Medicine2018，12，5： | 3 |
| 18 | Predicting the grades of Astragali radix using mass spectrometrybased metabolomics and machine learning显示文摘Astragali radix(AR,the dried root of Astragalus)is a popular herbal remedy in both China and the United States.The commercially available AR is commonly classified into premium graded(PG)and ungraded(UG)ones only according to the appearance.To uncover novel sensitive and specific markers for AR grading,we took the integrated mass spectrometry-based untargeted and targeted metabolomics approaches to characterize chemical features of PG and UG samples in a discovery set(n=16 batches).A series of five differential compounds were screened out by univariate statistical analysis,including arginine,calycosin,ononin,formononetin,and astragalosideⅣ,most of which were observed to be accumulated in PG samples except for astragalosideⅣ.Then,we performed machine learning on the quantification data of five compounds and constructed a logistic regression prediction model.Finally,the external validation in an independent validation set of AR(n=20 batches)verified that the five compounds,as well as the model,had strong capability to distinguish the two grades of AR,with the prediction accuracy>90%.Our findings present a panel of meaningful candidate markers that would significantly catalyze the innovation in AR grading. | Xinyue Yu Jingxue Nai Huimin Guo Xuping Yang Xiaoying Deng Xia Yuan Yunfei Hua Yuan Tian Fengguo Xu Zunjian Zhang Yin Huang | 2021 | Journal of Pharmaceutical Analysis2021，11，5： | 2 |
| 19 | Ultra-robust triboelectric nanogenerator for harvesting rotary mechanical energy显示文摘 | Xinyu Du Nianwu Li Yuebo Liu Jiaona Wang Zuqing Yuan Yingying Yin Ran Cao Shuyu Zhao Bin Wang Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，5： | 2 |
| 20 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
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