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| 1 | 新疆望峰金矿成矿流体研究及其成因意义显示文摘新疆望峰金矿,产于中天山结晶基底中的韧性剪切带内。围岩蚀变和流体包裹体研究表明,成矿过程包括了3个阶段,从早到晚有石英黄铁矿阶段、多金属硫化物阶段和石英碳酸盐阶段,温度分别集中在360~520℃、240~360℃和120~240℃;矿化以第Ⅱ阶段为主。成矿流体的δ18O值变化于1.15‰~2.70‰之间,属于变质热液与大气降水热液的混合流体。包裹体成分表明成矿流体来源较浅,但有利于金矿化;CO2/H2O比值多大于0.026,也有利于成矿。而包裹体捕获压力表明成矿作用发生在5.6~1.2km深度范围,主要发生在1.9km左右;矿化过程与地壳抬升伸展的过程一致,自然亦与碰撞造山体制的矿化规律一致。因此,古生代末期的碰撞造山作用导致了望峰金矿的形成,冰达坂断裂两侧是寻找望峰式金矿的有利地带。石英红外光谱分析表明,CO2光密度(D2)及其与H2O光密度(D1)的比值(D2/D1)普遍较高,指示矿化较强;D2>0.55和D2/D10.26是该区富金样品的标志。 | Chen Yanjing 1) Li Xin 1) Jing Jun 2) Gao Xiuli 1) Chen Huayong 1) Wu Xidan 2) Wu Dehua 2) ( 1) Department of Geology, Peking University 2)Team 15 of Gold Headquarters, MMIC, Urumqi ) | 1998 | 地球学报(中国地质科学院院报)1998，19，2： | 18 |
| 2 | Influence of Long-Term Fertilization on Selenium Accumulation in Soil and Uptake by Crops显示文摘Continuous applications of organic and inorganic fertilizers can affect soil and food quality with respect to selenium(Se) concentrations.A long-term(over 20 years) experimental field study,started in 1989,was conducted to investigate the changes in soil Se fractions and its uptake by crops,as affected by different fertilizer practices,in the North China Plain with an annual crop rotation of winter wheat and summer maize.The long-term experiment was arranged in a complete randomized block design consisting of 4replications with 7 fertilizer treatments:1) organic compost(OC),2) half organic compost plus half N-P-K chemical fertilizers(OC+ NPK),3) N-P-K fertilizers(NPK),4) N-P fertilizers(NP),5) P-K fertilizers(PK),6) N-K fertilizers(NK),and 7) an un-amended control.Soil samples from the surface(20 cm) were collected in 1989,1994,1999,2004 and 2009 to characterize Se and other soil properties.In 2009,the average soil Se concentrations in the treatments(149 ± 8 μg kg^(-1)) were higher than those in the soil samples collected in 1989 at the beginning of the experiment(112 ± 4 μg kg^(-1)),and decreased in the order of OC > OC + NPK > NPK≈NP > PK ≈NK > control.Sequential extraction showed the oxidizable fraction(50.06%± 3.94%) was the dominant form of Se in the soil,followed by the residual fraction(24.12%± 2.89%),exchangeable fraction(15.09%± 4.34%) and Fe-Mn oxides fraction(10.73%± 4.04%).With an increase of soil K,the exchangeable Se concentrations in the soil increased.The Se concentrations in the soil tillage layer(0-20 cm) were mainly related to soil organic carbon(SOC),although different contributions came from atmospheric deposition,irrigation and fertilizers.With the accumulation of SOC,the uptakes of soil Se by two crops were inhibited.For the OC and OC + NPK treatments,Se concentrations in wheat grains were lower than the critical standard of Se in stable food(100 μg kg^(-1)).Additionally,Se concentrations in grains were also decreased by the deficiencies of major soil nutrients,especially P. | WANG Qingyun ZHANG Jiabao ZHAO Bingzi XIN Xiuli DENG Xihai Hailin ZHANG | 2016 | Pedosphere2016，26，1： | 12 |
| 3 | Multi-scale thermodynamic analysis method for 2D SiC/SiC composite turbine guide vanes显示文摘Ceramic Matrix Composite(CMC) turbine guide vanes possess multi-scale stress and strain with inhomogeneity at the microscopic scale.Given that the macroscopic distribution cannot reflect the microscopic stress fluctuation, the macroscopic method fails to meet the requirements of stress and strain analysis of CMC turbine guide vanes.Furthermore, the complete thermodynamic properties of 2 D woven SiC/SiC-CMC cannot be obtained through experimentation.Accordingly,a method to calculate the thermodynamic properties of CMC and analyze multi-scale stress and strain of the turbine guide vanes should be established.In this study, the multi-scale thermodynamic analysis is investigated.The thermodynamic properties of Chemical Vapor Infiltration(CVI) processed SiC/SiC-CMC are predicted by a Representative Volume Element(RVE) model with porosity, leading to the result that the relative error between the calculated in-plane tensile modulus and the experimental value is 4.2%.The macroscopic response of a guide vane under given conditions is predicted.The relative error between the predicted strain on the trailing edge and the experimental value is 9.7%.The calculation of the stress distribution of micro-scale RVE shows that the maximum value of microscopic stress, which is located in the interlayer matrix, is more than 1.5 times that of macroscopic stress in the same direction and the microscopic stress distribution of the interlayer matrix is related to the pore distribution of the composite. | Xin LIU Xiuli SHEN Longdong GONG Peng LI | 2018 | Chinese Journal of Aeronautics2018，31，1： | 9 |
| 4 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 5 | Soil Characteristics Overwhelm Cultivar Effects on the Structure and Assembly of Root-Associated Microbiomes of Modern Maize显示文摘Modern breeding primarily targets crop yield traits and is likely to influence root-associated microbiomes, which play significant roles in plant growth and health. The relative importance of soil and cultivar factors in shaping root-associated microbiomes of modern maize (Zea mays L.) remains uncertain. We conducted a pot experiment in a controlled environment using three soils (Mollisol, Inceptisol, and Ultisol) and four contrasting cultivars, Denghai 605, Nonghua 816, Qiaoyu 8, and Zhengdan 958, which are widely planted in China. We used 16S rRNA gene amplicon sequencing to characterize the bacterial communities in the bulk soil, rhizosphere, and endosphere. Our results showed that the four cultivars had different shoot biomass and root exudate total organic carbon and organic acid contents. The microbiomes in the bulk soil, rhizosphere, and endosphere were different. We observed apparent community divergence between soils rather than cultivars, within which edaphic factors substantially contributed to microbiome variation. Moreover, permutational multivariate analysis of variance corroborated significant contributions of soil type but not cultivar on the root-associated microbiome structure. Differential abundance analysis confirmed that each soil presented a distinct root microbiome, while network analysis indicated different co-occurrence patterns of the root microbiome among the three soils. The core root microbiome members are implicated in plant growth promotion and nutrient acquisition in the roots. In conclusion, root-associated microbiomes of modern maize are much more controlled by soil characteristics than by cultivar root exudation. Our study is anticipated to help improve breeding strategies through integrative interactions of soils, cultivars, and their associated microbiomes. | CHEN Lin XIN Xiuli ZHANG Jiabao Marc REDMILE-GORDON NIE Guangsen WANG Qingyun | 2019 | Pedosphere2019，29，3： | 2 |
| 6 | An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro显示文摘The destruction of proteins via the ubiquitin-proteasome system is amulti-step,complex process involving polyubiquitination of substrate proteins,follow ed by proteolytic degradation by the m acrom olecular 26S proteasome complex.Inhibitors of the proteasome prom ote the accum ulation of proteins that are deleterious to cell survival and are prom ising anticancer agents.Oprozomib(OPZ),an oral second-generation proteasome inhibitor,has been shown to inhibit the grow th of several cancers in preclinical and clinical trials,including m ultiple m yelom a and head and neck cancers,but its effects on lung cancer has not yet been determ ined.In this study,we evaluated the inhibitory effects of OPZ on lung cancer cell lines in vitro.The results showed that OPZ significantly suppressed cell proliferation and strongly induced apoptosis in both tested lung cancer cells independent of p53 expression.OPZ was able to cause obvious caspase 3 and PARP cleavages and stabilize p53 and its transcriptional targets p21,PUMA,and Noxa.Moreover,OPZ was capable of sensitizing lung cancer cells to the conventional chem otherapeutic drug cisplatin.Our study provides preclinical data and sheds light on the potential applications of proteasome inhibitor OPZ in lung cancer treatment. | Hongge Zhu Tianhai Wang Zhou Xin Yiyi Zhan Guoming Gu Xiaoqin Li Xiuli Wang Shune Yang Chunling Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 2 |
| 7 | Effect of 'Drug Holiday' an blood pressure control: a randomized double - blind comparatlve trial of amlodipine versus felodipine extended release in Chinese patients with mild to moderate essential hypertension显示文摘 | DAYI Hu XIULI ZHAO XIN HE | 2001 | Heart Drug2001，1，： | 1 |
| 8 | Responses of Soil Bacterial Diversity to Fertilization are Driven by Local Environmental Context Across China显示文摘Soil microbial diversity is extremely vulnerable to fertilization,which is one of the main anthropogenic activities associated with global changes.Yet we know little about how and why soil microbial diversity responds to fertilization across contrasting local ecological contexts.This knowledge is fundamental for predicting changes in soil microbial diversity in response to ongoing global changes.We analyzed soils from ten 20-year field fertilization(organic and/or inorganic)experiments across China and found that the national-scale responses of soil bacterial diversity to fertilization are dependent on ecological context.In acidic soils from regions with high precipitation and soil fertility,inorganic fertilization can result in further acidification,resulting in negative impacts on soil bacterial diversity.In comparison,organic fer-tilization causes a smaller disturbance to soil bacterial diversity.Despite the overall role of environmental contexts in driving soil microbial diversity,a small group of bacterial taxa were found to respond to fer-tilization in a consistent way across contrasting regions throughout China.Taxa such as Nitrosospira and Nitrososphaera,which benefit from nitrogen fertilizer addition,as well as Chitinophagaceae,Bacilli,and phototrophic bacteria,which respond positively to organic fertilization,could be used as bioindicators for soil fertility in response to fertilization at the national scale.Overall,our work provides new insights into the importance of local environmental context in determining the responses of soil microbial diver-sity to fertilization,and identifies regions with acidic soils wherein soil microbial diversity is more vul-nerable to fertilization at the national scale. | Youzhi Feng Manuel Delgado-Baquerizo Yongguan Zhu Xiaozeng Han Xiaori Han Xiuli Xin Wei Li Zhibing Guo Tinghui Dang Chenhua Li Bo Zhu Zejiang Cai Daming Li Jiabao Zhang | 2022 | Engineering2022，8，5： | 1 |
| 9 | Morphology and properties of hollow - fiber membrane made by PAN mixing with small amount of PVDF显示文摘 | Yin Xiuli Cheng Hongbin Wang Xin | 1998 | J Membr Sci1998，149，： | 1 |
| 10 | Effect of poor-quality irrigation water on potassium release from soils under long-term fertilization 显示文摘 | Li Ruan Jiabao Zhang Xiuli Xin | 2014 | Acta Agriculturae Scandinavica2014，，64： | 1 |
| 11 | Evidence for ‘silicon’ within the cell walls of suspension‐cultured rice cells显示文摘 | Congwu He Lijun Wang Jian Liu Xin Liu Xiuli Li Jie Ma Yongjun Lin Fangsen Xu | 2013 | New Phytol2013，，3： | 1 |
| 12 | Growth of laser single-crystals Er: YVO4 by floating zone method显示文摘 | Xiuli Yan Xin Wu Jianfeng Zhou | 2000 | Journal of Crystal Growth2000，220，4： | 1 |
| 13 | Synthesis of three-dimensionally ordered macroporous manganese dioxideecarbon nanocomposites for supercapacitors 显示文摘 | Zhi Liu Xiuli Tan Xin Gao | 2014 | Journal of Power Sources2014，267，： | 1 |
| 14 | Effect of “Drug Holiday” on blood pressure control: a randomized double-blind comparative trial of amlodipine versus felodipine extended release in Chinese patients with mild to moderate essential hypertension显示文摘 | Dayi Hu XIUli Zhao Xin He | 2001 | Heart Drug2001，1，： | 1 |
| 15 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 16 | How different long‐term fertilization strategies influence crop yield and soil properties in a maize field in the North China Plain显示文摘 | Bingzi Zhao Ji Chen Jiabao Zhang Xiuli Xin Xiying Hao | 2013 | Bodenk2013，，1： | 1 |
| 17 | Synthesis of three-dimensionally ordered macroporous manganese dioxide–carbon nanocomposites for supercapacitors显示文摘 | Zhi Liu Xiuli Tan Xin Gao Lihong Song | 2014 | Journal of Power Sources2014，，： | 1 |
| 18 | Effect of“Drug Holiday”onblood pressure control:a randomized double-blind comparative trial ofamiodipine versus felodipine extended release in Chinese patients withmild to moderate essential hypertension显示文摘 | DAYI HU XIULI ZHAO XIN HE | 2001 | Heart Drug2001，，1： | 1 |
| 19 | Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants显示文摘SARS-CoV-2 continues to threaten human society by generating novel variants via mutation and recombination.The high number of mutations that appeared in emerging variants not only enhanced their immune-escaping ability but also made it difficult to predict the pathogenicity and virulence based on viral nucleotide sequences.Molecular markers for evaluating the pathogenicity of new variants are therefore needed.By comparing host responses to wild-type and variants with attenuated pathogenicity at proteome and metabolome levels,six key molecules on the polyamine biosynthesis pathway including putrescine,SAM,dc-SAM,ODC1,SAMS,and SAMDC were found to be differentially upregulated and associated with pathogenicity of variants.To validate our discovery,human airway organoids were subsequently used which recapitulates SARS-CoV-2 replication in the airway epithelial cells of COVID-19 patients.Using ODC1 as a proof-ofconcept,differential activation of polyamine biosynthesis was found to be modulated by the renin-angiotensin system(RAS)and positively associated with ACE2 activity.Further experiments demonstrated that ODC1 expression could be differentially activated upon a panel of SARS-CoV-2 variants of concern(VOCs)and was found to be correlated with each VOCs’pathogenic properties.Particularly,the presented study revealed the discriminative ability of key molecules on polyamine biosynthesis as a predictive marker for virulence evaluation and assessment of SARS-CoV-2 variants in cell or organoid models.Our work,therefore,presented a practical strategy that could be potentially applied as an evaluation tool for the pathogenicity of current and emerging SARS-CoV-2 variants. | Guangshan Xie Lin Zhu Siwen Liu Cun Li Xin Diao Yanhao Zhang Xiuli Su Yuanyuan Song Guodong Cao Li Zhong Pui Wang Xiaojuan Liu Bobo Wing-Yee Mok Shusheng Zhang Dong-Yan Jin Jie Zhou Honglin Chen Zongwei Cai | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 20 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
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